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Introduction About LAZID E KIT
LAZID E KIT is a combination of Efavirenz, Lamivudine, Zidovudine which belongs to the group of medicines called Antiretroviral drugs. It is used for the management of human immunodeficiency virus (HIV) infection in adults.
HIV is the Human Immunodeficiency Virus which severely damages the immune system and lead to Acquired Immune Deficiency Syndrome (AIDS) which is characterized by fever, chills, rash, night sweat, muscle aches, sore throat, fatigue.
LAZID E KIT should be used in caution with patient having liver, kidney and heart disease. Consult your doctor for advice before taking the medicine.
LAZID E KIT should be used with caution in pregnant woman. It is not recommended for use in breastfeeding women as it may pass through the breastmilk. Consult your doctor for advice before taking the medicine.
LAZID E KIT is not recommended for use in children. Consult your doctor for advice. LAZID E KIT should be used with caution in patients above 65 years of age.
The most common side effects of taking LAZID E KIT are dizziness, nausea, headache, diarrhea. Consult your doctor if the side effects worsens or persists for a longer duration.
Uses Of LAZID E KIT
- Used to manage human immunodeficiency virus (HIV) infection
How LAZID E KIT Works
LAZID E KIT contains Efavirenz, Lamivudine, Zidovudine which collectively works against the HIV infection by blocking the action of the reverse transcriptase enzyme, which is essential for the virus to multiply and therefore it reduces the amount of HIV in the body.
How to use LAZID E KIT
Take LAZID E KIT as advised by your physician. Swallow this medicine do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of LAZID E KIT
Common
- skin rash
- abnormal dreams
- tiredness or malaise
- fatigue
- dizziness
- nausea or vomiting
- trouble in sleeping, insomnia (lack of sleep)
- headache
- fever or chills
- difficulty concentrating
- diarrhea
- anorexia (loss of appetite) or decreased appetite
- abdominal pain, abdominal cramps
- dyspepsia (upper abdominal discomfort)
- weakness, numbness and pain from nerve damage
- depressive disorders
- nasal signs and symptoms like cough
- myalgia (muscle pain)
- arthralgia (joint pain)
Rare
Stop taking LAZID E KIT and contact your doctor immediately if you experience any of the following side effects:
- signs of lactic acidosis such as feeling of weakness or tiredness, cold, muscle pain, dizziness or light-headedness, breathing problems, fast or irregular heartbeat
- signs of serious liver problems like yellowing of skin or the white part of eyes (jaundice), nausea (feel sick), dark urine, light coloured stools, abdominal pain
- worsening of hepatitis B virus (HBV) with signs of fever, joint pain, dark urine
- signs of serious mental health problems like feeling sad or hopeless, anxiety, restlessness, hallucinations, self-harming thoughts
- signs of nervous system problems like dizziness, trouble in concentrating and sleeping, unusual dreams, lack of coordination
- skin rash with or without itching, peeling skin, mouth sores, fever, swelling of your face, red or inflamed eyes, like pink eye (conjunctivitis), blisters or skin lesions
- anemia
- seizures (fits)
- changes in immune system
- changes in body fat seen as increased amount of fat in the upper back and neck, breast and around the main part of your body
- risk of inflammation of the pancreas (pancreatitis)
How To Manage Side Effects
Diarrhoea:
To avoid dehydration in your body, drink plenty of fluids such as water, fruit juices or electrolytes. If the condition worsens, consult your physician immediately.
Nausea or Vomiting:
Take this medicine with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if there is no improvement in symptoms.
Headache:
Apply hot or cold-water bag on your head. Try to take rest in a quiet and dark room. Drink tea or coffee. Massage the scalp or head with mild pressure. Consult your doctor for advice.
Skin rash:
Try to avoid hot showers because it may cause skin irritation. Avoid frequent contact and rubbing over the affected area. Use sunscreen and protective clothing when outdoors. If this symptom does not get better, speak to a doctor.
Warning & Precautions
Pregnancy
LAZID E KIT should be used with caution in pregnant woman or if you are planning to become pregnant. Women should use effective contraception during management with LAZID E KIT and for 12 weeks after discontinuing. Consult your doctor before taking it.
Breastfeeding
LAZID E KIT is not recommended for use in breastfeeding women as it may pass through the breastmilk. Consult your doctor for advice before taking LAZID E KIT.
Driving and Using Machines
Do not drive or operate any machines if you feel dizziness or trouble in concentrating after taking LAZID E KIT. Consult your doctor before taking LAZID E KIT.
Alcohol
Avoid consumption of alcohol as it may increase the risk of side effects. Consult your doctor for advice.
Kidney
LAZID E KIT should be taken with caution in patients having kidney problems. Consult your doctor before taking LAZID E KIT.
Liver
LAZID E KIT should be taken with caution in patients having liver problems, including hepatitis B or C virus infection. Consult your doctor before taking LAZID E KIT.
Allergy
Do not take LAZID E KIT if you are allergic to Efavirenz, Lamivudine, Zidovudine or any other ingredients of this medicine.
Heart Disease
LAZID E KIT should be taken with caution in patients having heart problems. Consult your doctor before taking LAZID E KIT.
Others
Before taking LAZID E KIT, inform your doctor if you:
- have diabetes
- have or ever had a mental health problem
- have a history of seizures
Use in Pediatrics:
LAZID E KIT is not recommended for use in children. Consult your doctor before taking LAZID E KIT.
Use in Geriatrics:
LAZID E KIT should be used with caution in elderly patients above 65 years of age. Before taking LAZID E KIT, consult your doctor for advice.
Interactions
A. Drug - Drug interactions:
- medicines used to manage HIV infection (Ex. emtricitabine, tenofovir disoproxil fumarate)
Overdosage:
If you or anyone else accidentally takes too much of LAZID E KIT, consult your doctor immediately or visit nearby hospital.
Synopsis
| Drug | : | Efavirenz, Lamivudine, Zidovudine |
| Pharmacological Category | : | Antiretroviral drugs |
| Therapeutic Indication | : | Human immunodeficiency virus infection |
| Dosage Forms | : | Tablet, Kit |
More Information
- Keep LAZID E KIT out of reach of children
- Store at room temperature
FAQs About LAZID E KIT
Q: How does LAZID E KIT works?
A: LAZID E KIT contains Efavirenz, Lamivudine, Zidovudine which collectively works against the HIV infection by blocking the action of the reverse transcriptase enzyme, which is essential for the virus to multiply and therefore it reduces the amount of HIV in the body.
Q: Can LAZID E KIT be given to children and elderly patients?
A: LAZID E KIT is not recommended for use in children and it should be used with caution in elderly patients above 65 years of age. Before taking LAZID E KIT consult your doctor.
Q: Can LAZID E KIT be used during pregnancy?
A: LAZID E KIT should be used with caution in pregnant woman or if you are planning to become pregnant. Women should use effective contraception during management with LAZID E KIT and for 12 weeks after discontinuing. Consult your doctor before taking it.
Q: Does LAZID E KIT cause dizziness?
A: Yes, dizziness is one of the common side effects of LAZID E KIT. When you feel dizzy, lie or sit down immediately. If you're experiencing a severe episode of vertigo, lie in a dark and quite place with eyes closed. Vehicle driving should be avoided if you experience frequent dizziness without warning. Talk to your doctor if the symptom worsens.
Q: Does LAZID E KIT be given to patients with liver, kidney and heart disease?
A: LAZID E KIT should be used with caution in patients having liver problems including hepatitis B or C virus infection, kidney and heart problems. Consult your doctor before taking LAZID E KIT.
References
1. KD. Tripathi. Antiretroviral drugs. Essentials of medical pharmacology. Eighth edition. 2019. Page –861-863.
2. Natella Y. Rakhmanina and John N. van den Anker. Efavirenz in the Therapy of HIV Infection. National Library of Medicine, National center for biotechnology information. PubMed Central. Revised in January 2011. [Accessed 5th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810555/
3. Katherine Taylor; Kristina Fritz; Mayur Parmar. Lamivudine. National Library of Medicine, National center for biotechnology information. StatPearls. May 2013. [Accessed 5th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK559252/
4. Zachary Edwards, Curtis J Ingold. Zidovudine. National Library of Medicine, National center for biotechnology information. StatPearls. June 2022. [Accessed 5th July 2022] https://www.statpearls.com/ArticleLibrary/viewarticle/31466#/
5. Cipla Ltd. Revised in July 2020. [Accessed 5th July 2022] https://ciplamed.com/content/duovir-e-kit
Useful Diagnostic Tests
- Antibody test
- Complete blood count
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