Lara SA Tablet 10'S
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Introduction About LARA SA TABLET
LARA SA TABLET is a combination of S(-)Amlodipine and Losartan which belongs to the group of medicines called Antihypertensive agents. It is used to manage hypertension (high blood pressure) when management with single agents is not effective.
It also helps in reducing the risk of heart attack, heart failure or stroke and can protect the function of kidneys particularly in patients who have both hypertension and diabetes.
During management with LARA SA TABLET your doctor will constantly monitor your kidney functions, blood pressure, electrolyte levels and blood sugar levels to avoid the risk of unwanted side effects. Avoid eating grapefruit or drinking grapefruit juice while taking LARA SA TABLET as it may severely decrease your blood pressure.
Before taking LARA SA TABLET inform your doctor if you have any heart, liver or kidney problems. You must also inform your doctor if you have diabetes, low blood pressure or are severely dehydrated due to excessive vomiting or diarrhea.
LARA SA TABLET is also not suitable for use in pregnant or breastfeeding women as it may cause serious harm to the growing baby and nursing infants. Stop taking LARA SA TABLET and inform your doctor immediately if you become pregnant while undergoing therapy with this medicine.
The most common side effects of taking LARA SA TABLET are low blood pressure, dizziness, tiredness, headache, sleepiness, swollen ankles and flushing. Contact your doctor if any of these side effect worsens.
Uses Of LARA SA TABLET
- Manage hypertension (high blood pressure)
- Prevents the risk of heart attack or stroke
- Protects kidney functions in patients who have both hypertension and diabetes
How LARA SA TABLET Works
LARA SA TABLET is an antihypertensive medicine. It relaxes your blood vessels and improves blood flow across them. This improves blood supply to the vital organs of the body (such as heart, brain or kidneys). As a result, it reduces the strain on the heart and helps the heart to pump blood more smoothly across blood vessels with less pressure. It also protects kidney functions and reduces the risk of kidney damage among diabetic patients.
How to use LARA SA TABLET
Take LARA SA TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Try to take LARA SA TABLET at the same time each day. LARA SA TABLET can be taken with or without food.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition.
Continue to take LARA SA TABLET for the stipulated duration instructed by your doctor without any interruption to achieve better results.
Side Effects Of LARA SA TABLET
Common
- low blood pressure
- swelling of ankles and legs (edema)
- headache, dizziness
- nausea, vomiting, stomach pain, constipation, diarrhea, indigestion
- sleepiness or lack of sleep
- abnormal heartbeat (fast or slow)
- muscle cramps
- flushing (warmth and redness of face and neck)
- feeling tired or weak
- vision problems
- cough, sinus infections, nasal congestion
- high blood potassium levels
- low blood sugar levels
Uncommon
- urinary tract infections, difficulty in passing urine, urge to urinate
- feeling depressed or anxious, changes in mood
- vertigo (spinning sensation), shakiness
- orthostatic hypotension (dizziness while standing up from sitting or lying position)
- increased sweating
- back pain, tingling of numbness of body parts
- changes in taste
- ringing in the ears
- dry nose, dry mouth
- hair loss
- impotence (inability to obtain an erection), breast enlargement in men
- changes in body weight
- anemia
Rare
Stop taking LARA SA TABLET and contact your doctor immediately if you experience any of the following side effects such as:
- signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth, or throat which can lead to difficulty in breathing or swallowing)
- severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane)
- chest pain, shortness of breath
- inflammation of pancreas (causing severe stomach pain that radiates to the back side of the body)
- sepsis (infection of blood characterized by sever signs of illness and fever)
- skin rashes or lesions
- eye pain or decrease in vision
How To Manage Side Effects
Nausea and vomiting:
Take LARA SA TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Warning & Precautions
Pregnancy
LARA SA TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Therefore, inform your doctor before taking LARA SA TABLET if you are pregnant, think you may be pregnant or planning to have a baby. If you become pregnant while undergoing therapy with LARA SA TABLET, stop taking it and consult your doctor immediately.
Breastfeeding
LARA SA TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or handle any heavy tools or machines if you experience dizziness or drowsiness after taking LARA SA TABLET.
Alcohol
Avoid consumption of alcohol while taking LARA SA TABLET as it might make you feel dizzier and drowsier.
Kidney
LARA SA TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems (such as kidney transplant, narrowing of renal arteries). Therefore, consult your doctor before taking it.
Liver
LARA SA TABLET is not recommended for use in patients with severe liver impairment (such as cholestasis, jaundice, biliary obstruction). It should be used with caution in patients with mild to moderate liver problems. Therefore, consult your doctor before taking it.
Allergy
Do not take LARA SA TABLET if you are allergic to S(-)Amlodipine or Losartan.
Lungs
LARA SA TABLET should be used with caution in patients with breathing problems. Therefore, consult your doctor before taking it.
Heart Disease
LARA SA TABLET is not recommended for use in patients with serious heart problem (such as heart failure or heart attack). It should be used with caution in patients with heart problems (such as irregular heart rhythm and problems with heart muscles or valves). Therefore, consult your doctor before taking it.
Others
LARA SA TABLET is not recommended for use if you:
- have cardiogenic shock (heart cannot pump blood suddenly)
- have diabetes related kidney problems
Before taking LARA SA TABLET, inform your doctor if you:
- have primary hyperaldosteronism (problems in adrenal gland)
- have low blood pressure
- are severely dehydrated (due to diarrhea, vomiting or excess sweating)
- are on a low-salt diet
- have diabetes
- have hyperkalemia (high blood potassium levels)
- have narrowing of arteries
- have had skin cancer
- have had gout in the past
Use in pediatrics:
LARA SA TABLET is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor for advice.
Use in geriatrics:
LARA SA TABLET should be used with caution in the elderly patients. Therefore, consult your doctor before taking it.
Interactions
A. Drug - Drug interactions:
Before taking LARA SA TABLET inform your doctor if you are taking any of the following medicines such as:
- medicines used to manage bacterial infections (Ex. erythromycin, clarithromycin, trimethoprim, rifampicin)
- medicine used to manage HIV infection (Ex. indinavir, ritonavir, saquinavir)
- medicines used to manage fungal infections (Ex. itraconazole, ketoconazole and fluconazole)
- medicines used for heart problems (such as verapamil, diltiazem)
- dantrolene (a medicine used to manage muscle spasms)
- medicines to suppress immune system (Ex. cyclosporin, tacrolimus, sirolimus, temsirolimus and everolimus)
- simvastatin, cholestyramine and colestipol (medicines to lower the cholesterol)
- potassium supplements or potassium-sparing diuretics such as spironolactone, triamterene or amiloride (used to retain or increase potassium levels in the body)
- antidepressants (medicines used to manage depression) such as lithium, citalopram, fluoxetine, paroxetine, nefazodone, St. John’s wort
- heparin (a medicine used for blood thinning)
- other medicines used to manage elevated blood pressure (such as aliskiren, bosentan, methyldopa, guanethidine, captopril, enalapril, lisinopril, verapamil, diltiazem, losartan, valsartan)
- antipsychotics (used to manage serious mental illnesses) Ex. clozapine, risperidone
- medicines used to relieve pain (Ex. morphine, aspirin, diclofenac, diflunisal, celecoxib, valdecoxib)
- baclofen (a medicine used for muscle spasms)
- amifostine (a medicine used to protect kidney functions)
B. Drug-Food interactions:
Do not eat grapefruit or drink grapefruit juice while taking LARA SA TABLET as it may increase the risk of side effects.
Overdosage:
If you or anyone else accidentally took more LARA SA TABLET, consult your doctor immediately. Overdosage may cause low blood pressure, abnormal heartbeat and dizziness.
Synopsis
| Drug | : | Amlodipine, Losartan |
| Pharmacological Category | : | Calcium channel blocker, Anginotensin II Receptor Blocker |
| Therapeutic Indication | : | Hypertension, Management of Heart Attack, Stroke, Kidney damage |
| Dosage Forms | : | Tablet |
More Information
- Keep LARA SA TABLET out of reach of children
- Store LARA SA TABLET at room temperature
FAQs About LARA SA TABLET
Q: What are the uses of LARA SA TABLET?
A: LARA SA TABLET is used to manage hypertension. It can also be used to manage the risk of heart attack or stroke and can protect kidney functions among diabetic patients.
Q: What type of a medicine is LARA SA TABLET?
A: LARA SA TABLET is an antihypertensive medicine. It relaxes your blood vessels and improves blood flow across them. This improves blood supply to the vital organs of the body (such as heart, brain or kidneys). As a result, it reduces the strain on the heart and helps the heart to pump blood more smoothly across blood vessels with less pressure. It also protects kidney functions and reduces the risk of kidney damage among diabetic patients.
Q: What happens when I stop taking LARA SA TABLET?
A: Do not stop taking LARA SA TABLET without consulting your doctor as your blood pressure may raise once again. Make sure to take LARA SA TABLET for the stipulated duration recommended by your doctor to achieve maximum results.
Q: What is the best time to take LARA SA TABLET?
A: LARA SA TABLET can be taken with or without meals. Your doctor will decide the best time for you to take LARA SA TABLET based on your age, body weight and disease condition.
Q: What to do if I forgot to take a dose of LARA SA TABLET?
A: If you forgot to take a dose of LARA SA TABLET, take it as soon as you remember. However, if it is time for the next dose of LARA SA TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of LARA SA TABLET to compensate the missed ones.
Q: What precautions should be followed while taking LARA SA TABLET?
A: Before taking LARA SA TABLET, inform your doctor if you have any heart, liver or kidney problems. You must also inform your doctor if you have diabetes, low blood pressure or are severely dehydrated. Stop taking LARA SA TABLET and consult your doctor immediately if you become pregnant. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail.
Q: Can I consume alcohol while taking LARA SA TABLET?
A: Avoid consumption of alcohol while taking LARA SA TABLET as it might make you feel dizzier and drowsier.
Q: What happens if I accidentally take more LARA SA TABLET?
A: If you or anyone else accidentally took more LARA SA TABLET, consult your doctor immediately. Overdosage may cause low blood pressure, abnormal heartbeat, fainting, drowsiness, nausea, vomiting or confusion.
Q: Can I take LARA SA TABLET daily?
A: Take LARA SA TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take LARA SA TABLET every day or not.
Q: Is LARA SA TABLET safe to use in diabetic patients?
A: LARA SA TABLET may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before taking LARA SA TABLET as a precaution. Your doctor will closely monitor you blood sugar levels to avoid the risk of side effects.
Q: What are the side effects of LARA SA TABLET?
A: The most common side effects of taking LARA SA TABLET are low blood pressure, dizziness, tiredness, headache, sleepiness, swollen ankles, and flushing. Contact your doctor if any of these side effect worsens.
Q: Can I stop taking LARA SA TABLET once my symptoms subside?
A: No. Do not stop taking LARA SA TABLET without consulting your doctor. As hypertension is a chronic condition, long term management may be necessary to control its symptoms. Therefore, take LARA SA TABLET as advised by your doctor for the stipulated duration. Premature discontinuation of therapy may increase your blood pressure once again.
Q: Can LARA SA TABLET be taken during pregnancy?
A: LARA SA TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Therefore, inform your doctor before taking LARA SA TABLET if you are pregnant, think you may be pregnant or planning to have a baby. If you become pregnant while undergoing therapy with LARA SA TABLET, stop taking it and consult your doctor immediately.
Q: Is LARA SA TABLET safe to use in kidney disease?
A: LARA SA TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems (such as kidney transplant, narrowing of renal arteries). Your doctor will access your health condition and suggest a suitable dose for you. Therefore, it is important to inform your doctor if you have any kidney problems before taking LARA SA TABLET as a precaution.
Q: Can the use of LARA SA TABLET affect the liver?
A: Yes. LARA SA TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it is strictly not recommended for use in patients with severe liver diseases. It should be used with caution in patients with other minor liver problems. Consult your doctor before taking it.
References
1. KD. Tripathi. Antihypertensive Drugs. Drugs Affecting Renin-Angiotensin System and Plasma Kinins. Essentials of medical pharmacology. Seventh edition. 2013. Page – 506, 561 & 562.
2. Alberto F. Rubio-Guerra, Ana K. Garro-Almendaro, and Montserrat B. Duran-Salgado. Effect of losartan combined with amlodipine or with a thiazide on uric acid levels in hypertensive patients. Therapeutic Advances in Cardiovascular Disease. December 2016. [Accessed on 4th January 2023] https://journals.sagepub.com/doi/10.1177/1753944716678538
3. Dr. Reddy’s Laboratories (UK) Ltd. Electronic Medicines Compendium (EMC). [Revised in August 2018] [Accessed on 4th January 2023] https://www.medicines.org.uk/emc/files/pil.3478.pdf
4. Bristol Laboratories Ltd. Electronic Medicines Compendium (EMC). [Revised in August 2018] [Accessed on 4th January 2023] https://www.medicines.org.uk/emc/product/11442/smpc#DOCREVISION
5. Dexcel Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in July 2019] [Accessed on 4th January 2023] https://www.medicines.org.uk/emc/files/pil.9045.pdf
6. Torrent Pharmaceuticals Ltd. Esam-LT. (Losartan Potassium and S-Amlodipine Besylate Tablet). [Revised in October 2014] [Accessed on 4th January 2023] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1744.pdf
7. Central Drugs Standard Control Organization. S(-) Amlodipine-2.5mg/2.5mg +Losartan Potassium 25mg/50mg tablet. October 2002. [Accessed on 4th January 2023] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
Useful Diagnostic Tests
- Kidney Function Test
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