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Introduction About LAMIVIR 150MG TABLET
LAMIVIR 150MG TABLET contains Lamivudine which belong to the group of medicines called Anti-viral drugs. It is used to manage Human Immunodeficiency Virus (HIV) infection in adults and children.
HIV is the virus that causes Acquired Immune Deficiency Syndrome (AIDS) and other related illness. Signs and symptoms include fever, headache, muscle aches and joint pain, rash, sore throat and painful mouth sores, swollen lymph glands, mainly on the neck, diarrhea, weight loss, cough and night sweats.
LAMIVIR 150MG TABLET should be used with caution if you have ever had liver disease, including hepatitis B or C, kidney problem, pancreatitis. Consult your doctor before taking it.
LAMIVIR 150MG TABLET is not recommended for use in pregnant women unless it is considered clearly necessary. Nursing mothers must not breastfeed their infants while taking LAMIVIR 150MG TABLET. Consult your doctor before taking it.
LAMIVIR 150MG TABLET should be used with caution in children with kidney problem. It should be used with caution in elderly patients. Consult your doctor before taking it.
The most common side effects of taking LAMIVIR 150MG TABLET are headache, nausea, vomiting, stomach pain, diarrhea, tiredness, fever, etc. Contact your doctor if any of the symptoms worsen.
Uses Of LAMIVIR 150MG TABLET
- To manage HIV infection
How LAMIVIR 150MG TABLET Works
LAMIVIR 150MG TABLET inhibits the activity of enzyme (HIV-1 reverse transcriptase) which is responsible for virus replication. Thus, it helps to manage HIV from replication in the body.
How to use LAMIVIR 150MG TABLET
Take LAMIVIR 150MG TABLET as advised by your physician. Swallow the medicine with water. It can be taken with or without food. If you cannot swallow the tablets whole, you may crush and combine them with a small amount of food or drink and take all the dose immediately.
Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking LAMIVIR 150MG TABLET unless your doctor advice you to stop.
Side Effects Of LAMIVIR 150MG TABLET
Common
- headache
- nausea, vomiting, diarrhoea, stomach pain
- tiredness, lack of energy
- fever
- feeling generally unwell
- muscle pain and discomfort, joint pain
- difficulty sleeping
- cough, irritated or runny nose
- rash
- alopecia (hair loss)
Rare
- breakdown of muscle tissue
Stop taking LAMIVIR 150MG TABLET and consult with your doctor if you experience any of the following:
- serious allergic reaction such as skin rash, hives, swelling of the face, tongue or throat leading to difficulty in swallowing or breathing, chest pain
- signs and symptoms of lactic acidosis such as weight loss, feel very weak or tired, unusual muscle pain, difficulty in breathing, stomach pain, nausea and vomiting, feel cold, especially in your arms and legs, feel dizzy or light-headed, fast or irregular heartbeat
- signs and symptoms of liver disease such as yellowish discolouration of skin or the white part of your eyes (jaundice), dark or tea-coloured urine, light-coloured stools, loss of appetite, nausea, vomiting, pain or tenderness on the right side of your stomach area
- signs and symptoms of pancreatitis such as severe upper stomach-area pain, with or without nausea and vomiting
How To Manage Side Effects
Headache:
Rest and relax. Drink plenty of fluids such as water or ORS (Oral Rehydrating Solution) and apply a pain-relieving balm on the head if necessary. Contact your doctor if the headache did not improve.
Nausea and vomiting:
Take the medicine, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food. Contact your doctor if your nausea and vomiting did not improve.
Stomach pain:
Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on your stomach. Contact your doctor if the stomach pain worsens.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Do not take any medicine on your own for managing diarrhoea. Contact your doctor if your diarrhoea did not improve.
Warning & Precautions
Pregnancy
LAMIVIR 150MG TABLET is not recommended for use in pregnant women unless it is considered clearly necessary. Consult your doctor before taking it.
Breastfeeding
Women who are HIV-positive must not breast-feed, because HIV infection can be passed on to the baby in breast milk. A small amount of the ingredients in LAMIVIR 150MG TABLET can also pass into your breast milk. Hence, nursing mothers must not breastfeed their infants while taking LAMIVIR 150MG TABLET. Contact your doctor immediately if you’re breast-feeding or thinking about breast-feeding.
Driving and Using Machines
LAMIVIR 150MG TABLET is unlikely to affect your ability to drive or use machines. Consult your doctor before taking it.
Kidney
LAMIVIR 150MG TABLET should be used with caution in patients with kidney problem and may require dose adjustment. Consult your doctor before taking it.
Liver
LAMIVIR 150MG TABLET should be used with caution if you have ever had liver disease, including hepatitis B or C. Consult your doctor before taking it.
Allergy
Do not take LAMIVIR 150MG TABLET if you are allergic to lamivudine or any of the other ingredients of this medicine.
Others
Before taking LAMIVIR 150MG TABLET, inform your doctor if you:
- are seriously overweight (especially if you’re a woman)
- have pancreatitis
Use in pediatrics:
LAMIVIR 150MG TABLET should be used with caution in children with kidney problem and may require dose adjustment. Consult your doctor before taking it.
Use in geriatrics:
LAMIVIR 150MG TABLET should be used with caution in elderly patients. Consult your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking LAMIVIR 150MG TABLET, inform your doctor if you are taking any of the following medicine:
- medicines (generally liquids) containing sorbitol and other sugar alcohols (Ex. xylitol, mannitol, lactitol or maltitol)
- other medicines containing lamivudine (used to manage HIV infection or hepatitis B infection) Ex. dolutegravir and lamivudine, tenofovir and lamivudine, Emtricitabine and lamivudine
- emtricitabine (used to manage HIV infection)
- co-trimoxazole (used to manage infections)
- cladribine (used to manage hairy cell leukaemia- a type of bone marrow cancer)
- interferon alfa, ribavirin (medicines used to manage hepatitis B & C)
Overdose:
If you or anyone else accidentally take too much of LAMIVIR 150MG TABLET, contact your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Lamivudine |
| Pharmacological Category | : | Nucleoside Analogue Reverse Transcriptase Inhibitors (NRTIs) |
| Therapeutic Indication | : | HIV infection |
| Dosage Forms | : | Tablet, Solution |
More Information
- Keep LAMIVIR 150MG TABLET out of the sight and reach of children
- Store LAMIVIR 150MG TABLET below 30°C
FAQs About LAMIVIR 150MG TABLET
Is LAMIVIR 150MG TABLET safe in pregnancy?
LAMIVIR 150MG TABLET is not recommended for use in pregnant women unless it is considered clearly necessary. LAMIVIR 150MG TABLET may cause side effects in unborn babies. If you have taken LAMIVIR 150MG TABLET during your pregnancy, your doctor may request regular blood tests and other diagnostic tests to monitor the development of your child. Consult your doctor before taking it.
Does LAMIVIR 150MG TABLET manage HIV infection?
LAMIVIR 150MG TABLET does not completely manage HIV infection; it reduces the amount of virus in your body and keeps it at a low level. It also increases the CD4 cell count (important in fighting infection) in your blood.
Can I stop taking LAMIVIR 150MG TABLET?
LAMIVIR 150MG TABLET helps to control your condition. You need to keep taking it every day to stop your illness getting worse. You may still develop other infections and illnesses linked to HIV infection. Keep in touch with your doctor and do not stop taking LAMIVIR 150MG TABLET unless your doctor advice you to stop.
Can LAMIVIR 150MG TABLET cause diarrhea?
Yes. Diarrhea is a common side effect of LAMIVIR 150MG TABLET. Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Do not take any medicine on your own for managing diarrhoea. Contact your doctor if your diarrhoea did not improve.
Can LAMIVIR 150MG TABLET be crushed?
Take LAMIVIR 150MG TABLET as advised by your physician. Swallow the medicine with a glass of water. It can be taken with or without food, but if you cannot swallow the tablets whole, you may crush and mix them with a small amount of food or drink and take all the dose immediately.
What if I forget to take a dose of LAMIVIR 150MG TABLET?
If you forget to take a dose of LAMIVIR 150MG TABLET, take it as soon as you remember and then continue your management as usual. Do not take the medicine twice to make up for a forgotten dose.
Can I pass HIV to other people while taking LAMIVIR 150MG TABLET?
HIV infection is spread by sexual contact with infected person or by transfer of infected blood (for example, by sharing injection needles). You can still pass on HIV when taking LAMIVIR 150MG TABLET, although the risk is lowered by effective antiretroviral management. Consult your doctor regarding the precautions needed to avoid passing the infection to other people.
What other side effects can I have while taking LAMIVIR 150MG TABLET?
During management with LAMIVIR 150MG TABLET, there may be an increase in weight and in levels of blood fats and glucose. This is somewhat linked to restored health and lifestyle and in the case of elevation of blood fats sometimes linked to the HIV medicines. Inform your doctor if you feel any related changes, they’ll test for confirmation.
Does LAMIVIR 150MG TABLET cause changes in body fat?
Yes, LAMIVIR 150MG TABLET can cause changes in body fat in people with HIV infection. These changes may include an increased amount of fat in the upper back and neck (buffalo hump), breast and around the middle of your body (trunk). Loss of fat from the legs, arms and face may also happen. Contact your doctor if you experience any changes in your body fat.
References
1. Barbara G. Wells, Joseph T. Dipiro, Terry L. Shwinghammer, Cecily V. DiPiro. Human Immunodeficiency Virus Infection. Pharmacotherapy Handbook. Ninth edition. 2015. Page- 371.
2. KD. Tripathi. Antiviral Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 807, 808.
3. Taylor K, Fritz K, Parmar M. Lamivudine. NIH National Library of Medicine, National Center for Biotechnology Information. StatPearls. January 2022. [Accessed on 27th April 2022] https://www.ncbi.nlm.nih.gov/books/NBK559252/
4. Bethesda (MD). Lamivudine: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. April 2019. [Accessed on 27th April 2022] https://www.ncbi.nlm.nih.gov/books/NBK548553/
5. APL Swift Services (Malta) Limited. Electronic Medicines Compendium (EMC). [Revised in September 2021] [Accessed on 27th April 2022] https://www.medicines.org.uk/emc/files/pil.7066.pdf
6. Shire Pharmaceuticals Group plc. U.S. Food & Drug Administration. [Revised in September 2017] [Accessed on 27th April 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020564s37_020596s036lbl.pdf
7. Apotex Inc. Lamivudine. [Revised in October 2017] [Accessed on 27th April 2022] https://pdf.hres.ca/dpd_pm/00041729.PDF
Useful Diagnostic Tests
- Liver Function Test
- Complete Blood Count (CBC)
- Lipid profile tests
- Viral Load Test
- CD4 Count Test
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