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Introduction About LABETOPAL INJECTION
LABETOPAL INJECTION is used to lower severely increased blood pressure, especially prior to a surgery, during pregnancy, when under anaesthesia or following a heart attack. It contains Labetalol as an active ingredient which is an alpha, beta adrenergic blocker. It relaxes the blood vessels supplying the heart and improves blood flow and oxygen supply, reduces the strain on the heart and helps the heart to pump blood more efficiently with less pressure.
LABETOPAL INJECTION should be used under medical supervision. It will be given to you only by a doctor or a nurse into a vein (intravenously). Before receiving LABETOPAL INJECTION inform your doctor if you have any liver or kidney problems.
LABETOPAL INJECTION is not recommended for use in patients with heart block or sick sinus syndrome, cardiogenic shock, uncontrollable heart failure, on-going low blood pressure, very slow heart rate or Prinzmetal angina.
You must also inform your doctor if you have Prinzmetal angina, diabetes or if you are scheduled for any surgery (including cataract surgery) in the upcoming days as a precaution.
LABETOPAL INJECTION is not recommended for use in patients with asthma, hypotension (low blood pressure) or shock. It is also not suitable for use in patients with heart block, history of heart attack or heart failure.
LABETOPAL INJECTION should be used in pregnant or breastfeeding women only if considered necessary by the physician. Therefore, consult your doctor before receiving it.
The most common side effects of receiving LABETOPAL INJECTION are erectile dysfunction, ejaculation problems, dizziness while standing up, nasal congestion and raised liver enzymes in the blood. Consult your doctor if any of these side effect troubles you.
Uses Of LABETOPAL INJECTION
- Used in the management of severe hypertension
How LABETOPAL INJECTION Works
LABETOPAL INJECTION contains labetalol as an active ingredient which is an alpha, beta adrenergic blocker. It works by blocking the actions of certain chemical messengers (such as adrenaline and noradrenaline) in our body that controls the functions of the heart, brain, kidneys and lungs. This action relaxes the blood vessels supplying the heart and improves blood flow and oxygen supply, reduces the strain on the heart and helps the heart to pump blood more efficiently with less pressure.
How to use LABETOPAL INJECTION
LABETOPAL INJECTION will be given to you only by a doctor or a nurse into a vein (intravenously).
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition.
Side Effects Of LABETOPAL INJECTION
Common
- erectile dysfunction, ejaculation problems
- dizziness while standing up
- nasal congestion
- raised liver enzymes in the blood
Uncommon
- difficulty in breathing
Rare
- very slow heartbeat
Stop receiving LABETOPAL INJECTION and contact your doctor immediately if you experience any of the following side effects such as:
- signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth, or throat which can lead to difficulty in breathing or swallowing)
- difficulty in breathing, swollen ankles, abnormal heart rate
- severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane, joint pain with fever)
- signs of liver problems (yellowing of skin and whites of the eye, dark urine and pale stools)
- lung inflammation causing cough and breathing problems
How To Manage Side Effects
Dizziness Or Drowsiness
Ensure you stay hydrated, as dehydration is a common trigger. Eating regular, balanced meals helps maintain stable blood sugar levels. When feeling dizzy, sit or lie down immediately to prevent falls. Move slowly when changing positions to avoid sudden drops in blood pressure. Avoiding alcohol, caffeine, and smoking can also reduce dizziness. Additionally, manage stress through relaxation techniques like deep breathing or meditation. If dizziness persists or is severe, consult a healthcare professional to rule out serious conditions and receive appropriate management.
Warning & Precautions
Pregnancy
Monitoring requiredLABETOPAL INJECTION may affect the growing fetus. Therefore, it should be used in pregnant women only when rapid control of blood pressure is necessary. Your doctor will prescribe LABETOPAL INJECTION after evaluating the potential risks and benefits.
Breastfeeding
Consult your doctorLABETOPAL INJECTION may excrete in breast milk. Therefore, it should be used in breastfeeding women only if considered necessary by the physician. Consult your doctor for advice before receiving it.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy tools or machines if you feel dizzy or tired after receiving LABETOPAL INJECTION.
Alcohol
Consult your doctorAvoid consumption of alcohol while receiving LABETOPAL INJECTION as it might make you feel dizzier and drowsier.
Kidney
Use with CautionLABETOPAL INJECTION should be used with caution in patients with kidney problems. Therefore, consult your doctor before receiving it.
Liver
Use with CautionLABETOPAL INJECTION should be used with caution in patients with liver problems. Therefore, consult your doctor before receiving it.
Allergy
ContraindicatedDo not receive LABETOPAL INJECTION if you are allergic to labetalol.
Lungs
Consult your doctorLABETOPAL INJECTION is not recommended to use in patients with asthma or COPD. It should be used with caution in patients with other lung diseases or respiratory problems. Therefore, consult your doctor before receiving it.
Heart Disease
ContraindicatedLABETOPAL INJECTION is not recommended for use in patients with heart block or sick sinus syndrome (unless you have a pacemaker), cardiogenic shock, uncontrollable heart failure, on-going low blood pressure, very slow heart rate or Prinzmetal angina. It should be used with caution in patients with heart failure, ischemic heart disease, poor left ventricular systolic function or first-degree atrio-ventricular block. Therefore, inform your doctor about your pre-existing heart conditions before receiving LABETOPAL INJECTION.
Use In Pediatrics
ContraindicatedLABETOPAL INJECTION is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before administration.
Use In Geriatrics
Use with CautionLABETOPAL INJECTION should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before receiving it.
Others
LABETOPAL INJECTION is not recommended for use if you:
- have severe problems in blood circulation
- are on a strict fasting diet or not eating properly
- have phaeochromocytoma (tumors of adrenal gland)
Before receiving LABETOPAL INJECTION, inform your doctor if you:
- have poor blood circulation (Ex. Raynaud’s disease)
- are planning for any surgery (including cataract surgery)
- have diabetes
- have overactive thyroid gland
- have an increased acidity of the blood (metabolic acidosis)
- are going for any urine test
Interactions
A. Drug-Drug interactions:
Before receiving LABETOPAL INJECTION, inform your doctor if you are taking any of the following medicines such as:
- Cardiac medicines (Ex. nifedipine, nisoldipine, nicardipine, isradipine, lacidipine, verapamil, diltiazem, hydralazine, clonidine, enalapril, lisinopril, ramipril, disopyramide, quinidine, amiodarone, isoprenaline, dobutamine, propafenone and digoxin)
- Other beta-blockers Ex. atenolol, propranolol
- Antidiabetic agents (Ex. insulin, metformin, glimepiride)
- adrenaline (a medicine that can stimulate the heart)
- Pain killers (Ex. ibuprofen, indomethacin, hydrocortisone)
- anesthetics (Ex. lignocaine, sevoflurane)
- Migraine medicines (Ex. ergotamine, dihydroergotamine or rizatriptan)
- Antipsychotic medicines (Ex. chlorpromazine, thioridazine, haloperidol)
- Stomach ulcer medicines (such as cimetidine, aluminium hydroxide gel)
- Sleep inducing agents (Ex. phenobarbitone, pentobarbitone)
- Antidepressants (Ex. imipramine, amitriptyline)
- Memory enhancers (Ex. donepezil, galantamine, rivastigmine)
Overdosage:
LABETOPAL INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms like extreme dizziness and slow pulse.
Synopsis
| Drug | : | Labetalol |
| Pharmacological Category | : | Alpha, Beta Adrenergic Antagonists |
| Therapeutic Indication | : | Hypertension |
| Dosage Forms | : | Tablet, Capsule, Injection |
More Information
Storage
- Keep LABETOPAL INJECTION out of reach of children
- Store LABETOPAL INJECTION at room temperature
FAQs About LABETOPAL INJECTION
Q: Can LABETOPAL INJECTION used in asthmatic patients?
A: No, LABETOPAL INJECTION cannot be used in patients suffering from asthma. This is because using it can cause breathing problems, which may trigger an asthma attack. Always inform your doctor if you have or ever had asthma or any kind of difficulty breathing difficulty, before starting management with LABETOPAL INJECTION.
Q: Does LABETOPAL INJECTION make you feel sleepy?
A: LABETOPAL INJECTION may occasionally can cause dizziness or tiredness while receiving it. Don't drive, use machinery, or perform any activities that require alertness. If this occurs to you, consult your doctor for opinion.
Q: What are the uses of LABETOPAL INJECTION?
A: LABETOPAL INJECTION is used to lower severely increased blood pressure, especially prior to a surgery, during pregnancy, when under anaesthesia or following a heart attack.
Q: What type of a medicine is LABETOPAL INJECTION?
A: LABETOPAL INJECTION is an alpha, beta adrenergic-blocker. It works by blocking the actions of certain chemical messengers (such as adrenaline and noradrenaline) in our body that controls the functions of the heart, brain, kidneys and lungs. This action relaxes the blood vessels supplying the heart and improves blood flow and oxygen supply, reduces the strain on the heart and helps the heart to pump blood more efficiently with less pressure.
Q: What precautions should be followed while receiving LABETOPAL INJECTION?
A: Before receiving LABETOPAL INJECTION inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any other types of anginas (such as Prinzmetal angina), psoriasis, diabetes or if you are scheduled for any surgery (including cataract surgery) in the upcoming days as a precaution. LABETOPAL INJECTION is not recommended for use in patients with asthma, hypotension (low blood pressure) or shock. It is also not suitable for use in patients with heart block, history of heart attack or heart failure. Do not take LABETOPAL INJECTION without consulting your doctor if you are pregnant or breastfeeding. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail.
Q: Can I consume alcohol while receiving LABETOPAL INJECTION?
A: Avoid consumption of alcohol while receiving LABETOPAL INJECTION as it might make you feel dizzier and drowsier.
Q: Can I take LABETOPAL INJECTION daily?
A: Take LABETOPAL INJECTION as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take LABETOPAL INJECTION every day or not.
Q: Is LABETOPAL INJECTION safe to use in diabetic patients?
A: LABETOPAL INJECTION may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before receiving LABETOPAL INJECTION as a precaution. Your doctor will closely monitor you blood sugar levels to avoid the risk of side effects.
What are the side effects of LABETOPAL INJECTION?
A: The most common side effects of receiving LABETOPAL INJECTION are erectile dysfunction, ejaculation problems, dizziness while standing up, nasal congestion and raised liver enzymes in the blood. Consult your doctor if any of these side effect troubles you.
Q: Can I stop receiving LABETOPAL INJECTION once my symptoms subside?
A: No. Do not stop receiving LABETOPAL INJECTION without consulting your doctor as it may make your symptoms reappear. Therefore, take LABETOPAL INJECTION as advised by your doctor for the stipulated duration.
Q: Can LABETOPAL INJECTION be taken during pregnancy?
A: LABETOPAL INJECTION may affect the growing fetus. Therefore, it should be used in pregnant women only when rapid control of blood pressure is necessary. Your doctor will prescribe LABETOPAL INJECTION after evaluating the potential risks and benefits.
Q: Is LABETOPAL INJECTION safe to use in kidney disease?
A: LABETOPAL INJECTION should be used with caution in patients with kidney problems. Your doctor will access your health condition and suggest a suitable dose for you.
Q: Can the use of LABETOPAL INJECTION affect the liver?
A: Yes. LABETOPAL INJECTION may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before receiving it.
Q: Can the use of LABETOPAL INJECTION affect my sexual life?
A: LABETOPAL INJECTION may cause problems in erection and ejaculation in some individuals. Consult your doctor if it troubles you.
References
- KD. Tripathi. Antiadrenergic drugs and drugs acting on glaucoma. Essentials of medical pharmacology. 7th Edition. 2019. Page –151.
- Labetalol. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2023. [Accessed on 18th May 2024]. https://www.ncbi.nlm.nih.gov/books/NBK534787/
- Labetalol 5 mg / ml solution for injection/infusion. Synchrony Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in January 2024]. [Accessed on 18th May 2024] https://www.medicines.org.uk/emc/files/pil.10831.pdf
- RPH Pharmaceuticals AB. Labetalol Hydrochloride 5mg/ml Solution for Injection. Electronic Medicines Compendium (EMC). [Revised in February 2023]. [Accessed on 18th May 2024]. https://www.medicines.org.uk/emc/files/pil.9165.pdf
Useful Diagnostic Tests
- Kidney Function Test (KFT)
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