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Introduction About LABETA INJECTION
LABETA INJECTION contains Labetalol which belongs to the group of medicines called Alpha, Beta Adrenergic Antagonists. It is used to manage hypertension (including high blood pressure during pregnancy). It can also be used to control blood pressure during anesthesia.
Hypertension (also known as high blood pressure) is a medical condition in which the force of the blood exerted against the walls of the artery remains very high, and as a result it may lead to severe damage to the blood vessels supplying vital organs, such as heart, kidney or brain. If left unmanageed, it may cause serious complications such as heart attack, heart failure, stroke or even blindness.
Before receiving LABETA INJECTION inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have Prinzmetal angina, diabetes or if you are scheduled for any surgery (including cataract surgery) in the upcoming days as a precaution.
LABETA INJECTION is not recommended for use in patients with asthma, hypotension (low blood pressure) or shock. It is also not suitable for use in patients with heart block, history of heart attack or heart failure.
LABETA INJECTION should be used in pregnant or breastfeeding women only if considered necessary by the physician. Therefore, consult your doctor before receiving it.
The most common side effects of receiving LABETA INJECTION are problems in erection or ejaculation and dizziness. Consult your doctor if any of these side effect troubles you.
Uses Of LABETA INJECTION
- Manage hypertension (including high blood pressure during pregnancy)
- Controls blood pressure during anesthesia
How LABETA INJECTION Works
LABETA INJECTION is an alpha, beta-blocker. It works by blocking the actions of certain chemical messengers (such as adrenaline and noradrenaline) in our body that controls the functions of the heart, brain, kidneys and lungs. This action relaxes the blood vessels supplying the heart and improves blood flow and oxygen supply, reduces the strain on the heart and helps the heart to pump blood more efficiently with less pressure.
How to use LABETA INJECTION
LABETA INJECTION will be given to you only by a doctor or a nurse into a vein (intravenously).
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition.
Side Effects Of LABETA INJECTION
Common
- erectile dysfunction, ejaculation problems
- dizziness while standing up
- nasal congestion
- raised liver enzymes in the blood
Uncommon
- difficulty in breathing
Rare
- very slow heartbeat
Stop receiving LABETA INJECTION and contact your doctor immediately if you experience any of the following side effects such as:
- signs of allergic reactions (such as skin rash, swelling of the face, lips, mouth, or throat which can lead to difficulty in breathing or swallowing)
- difficulty in breathing, swollen ankles, abnormal heart rate
- severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane, joint pain with fever)
- signs of liver problems (yellowing of skin and whites of the eye, dark urine and pale stools)
- lung inflammation causing cough and breathing problems
How To Manage Side Effects
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Warning & Precautions
Pregnancy
LABETA INJECTION should be used during pregnancy only if considered necessary by the physician. Therefore, consult your doctor before receiving it.
Breastfeeding
LABETA INJECTION may excrete in breast milk. Therefore, it should be used in breastfeeding women only if considered necessary by the physician. Consult your doctor for advice before receiving it.
Driving and Using Machines
Do not drive or operate any heavy tools or machines if you feel dizzy or tired after receiving LABETA INJECTION.
Alcohol
Avoid consumption of alcohol while receiving LABETA INJECTION as it might make you feel dizzier and drowsier.
Kidney
LABETA INJECTION should be used with caution in patients with kidney problems. Therefore, consult your doctor before receiving it.
Liver
LABETA INJECTION should be used with caution in patients with liver problems. Therefore, consult your doctor before receiving it.
Allergy
Do not take LABETA INJECTION if you are allergic to labetalol.
Lungs
LABETA INJECTION is not recommended to use in patients with asthma or COPD. It should be used with caution in patients with other lung diseases. Therefore, consult your doctor before receiving it.
Heart Disease
LABETA INJECTION is not recommended for use in patients with heart problems (such as slow heart rate, heart failure, heart block or heart rhythm disorder). Therefore, consult your doctor before receiving it.
Others
LABETA INJECTION is not recommended for use if you:
- have low blood pressure
- have cardiogenic shock (heart cannot pump blood suddenly)
- have severe problems in blood circulation
- are on a strict fasting diet or not eating properly
- have Prinzmetal’s angina (a type of chest pain)
- have phaeochromocytoma (tumors of adrenal gland)
Before receiving LABETA INJECTION, inform your doctor if you:
- have poor blood circulation (Ex. Raynaud’s disease)
- are planning for any surgery (including cataract surgery)
- have diabetes
- have overactive thyroid gland
- have an increased acidity of the blood (metabolic acidosis)
- are going for any urine test
Use in pediatrics:
LABETA INJECTION is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before receiving it.
Use in geriatrics:
LABETA INJECTION should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before receiving it.
Interactions
A. Drug-Drug interactions:
Before receiving LABETA INJECTION, inform your doctor if you are taking any of the following medicines such as:
- other medicines used in the management of hypertension and other heart problems (Ex. nifedipine, nisoldipine, nicardipine, isradipine, lacidipine, verapamil, diltiazem, hydralazine, clonidine, enalapril, lisinopril, ramipril, disopyramide, quinidine, amiodarone, isoprenaline, dobutamine, propafenone and digoxin)
- other beta-blockers (used to manage heart problems) Ex. atenolol, propranolol
- medicines used to manage diabetes (Ex. insulin, metformin, glimepiride)
- adrenaline (a medicine that can stimulate the heart)
- medicine used to relieve pain and inflammation (Ex. ibuprofen, indomethacin, hydrocortisone)
- anesthetics (used to cause numbness of body parts or loss of consciousness) Ex. lignocaine, sevoflurane
- medicines used to manage migraine headaches (Ex. ergotamine, dihydroergotamine or rizatriptan)
- medicine used in the management of mental illness (Ex. chlorpromazine, thioridazine, haloperidol)
- cimetidine, aluminium hydroxide gel (medicine used for stomach problems)
- barbiturates (medicine used to reduce anxiety and to induce sleep) Ex. phenobarbitone, pentobarbitone
- medicines used to manage depression (Ex. imipramine, amitriptyline)
- medicines used to manage memory problems (Ex. donepezil, galantamine, rivastigmine)
Overdosage:
LABETA INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Labetalol |
| Pharmacological Category | : | Alpha, Beta Adrenergic Antagonists |
| Therapeutic Indication | : | Hypertension |
| Dosage Forms | : | Tablet, Capsule, Injection |
More Information
- Keep LABETA INJECTION out of reach of children
- Store LABETA INJECTION at room temperature
FAQs About LABETA INJECTION
Can LABETA INJECTION used in asthmatic patients?
No, LABETA INJECTION cannot be used in patients suffering from asthma. This is because using it can cause breathing problems, which may trigger an asthma attack. Always inform your doctor if you have or ever had asthma or any kind of difficulty breathing difficulty, before starting management with LABETA INJECTION.
Does LABETA INJECTION make you feel sleepy?
LABETA INJECTION may occasionally can cause dizziness or tiredness while receiving it. Don't drive, use machinery, or perform any activities that require alertness. If this occurs to you, consult your doctor for opinion.
When can I expect relief in my symptoms after receiving LABETA INJECTION?
LABETA INJECTION usually starts working within a few hours of receiving it. However, to notice considerable changes in the symptoms of high blood pressure or heart conditions, it may take a week. You will not be able to notice any difference, but that does not mean it is not working. However, keep receiving LABETA INJECTION as prescribed by your doctor to get its full benefits.
What are the uses of LABETA INJECTION?
LABETA INJECTION It is used to manage hypertension including high blood pressure during pregnancy. It can also be used to control blood pressure during anesthesia.
What type of a medicine is LABETA INJECTION?
LABETA INJECTION is an alpha, beta-blocker. It works by blocking the actions of certain chemical messengers (such as adrenaline and noradrenaline) in our body that controls the functions of the heart, brain, kidneys and lungs. This action relaxes the blood vessels supplying the heart and improves blood flow and oxygen supply, reduces the strain on the heart and helps the heart to pump blood more efficiently with less pressure.
What happens when I stop receiving LABETA INJECTION?
Do not stop receiving therapy with LABETA INJECTION without consulting your doctor as your symptoms may re-appear once again. Make sure to take LABETA INJECTION for the stipulated duration recommended by your doctor to achieve maximum results.
What precautions should be followed while receiving LABETA INJECTION?
Before receiving LABETA INJECTION inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any other types of anginas (such as Prinzmetal angina), psoriasis, diabetes or if you are scheduled for any surgery (including cataract surgery) in the upcoming days as a precaution. LABETA INJECTION is not recommended for use in patients with asthma, hypotension (low blood pressure) or shock. It is also not suitable for use in patients with heart block, history of heart attack or heart failure. Do not take LABETA INJECTION without consulting your doctor if you are pregnant or breastfeeding. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail.
Can I consume alcohol while receiving LABETA INJECTION?
Avoid consumption of alcohol while receiving LABETA INJECTION as it might make you feel dizzier and drowsier.
Can I take LABETA INJECTION daily?
Take LABETA INJECTION as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take LABETA INJECTION every day or not.
Is LABETA INJECTION safe to use in diabetic patients?
LABETA INJECTION may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before receiving LABETA INJECTION as a precaution. Your doctor will closely monitor you blood sugar levels to avoid the risk of side effects.
What are the side effects of LABETA INJECTION?
The most common side effects of receiving LABETA INJECTION are problems in erection or ejaculation and dizziness. Consult your doctor if any of these side effect troubles you.
Can I stop receiving LABETA INJECTION once my symptoms subside?
No. Do not stop receiving LABETA INJECTION without consulting your doctor as it may make your symptoms reappear. Therefore, take LABETA INJECTION as advised by your doctor for the stipulated duration.
Can LABETA INJECTION be taken during pregnancy?
LABETA INJECTION should be used during pregnancy only if considered necessary by the physician. Therefore, consult your doctor before receiving it.
Is LABETA INJECTION safe to use in kidney disease?
LABETA INJECTION should be used with caution in patients with kidney problems. Your doctor will access your health condition and suggest a suitable dose for you.
Can the use of LABETA INJECTION affect the liver?
Yes. LABETA INJECTION may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before receiving it.
Can the use of LABETA INJECTION affect my sexual life?
LABETA INJECTION may cause problems in erection and ejaculation in some individuals. Consult your doctor if it troubles you.
References
1. KD. Tripathi. Adrenergic drugs and drugs acting on glaucoma. Essentials of medical pharmacology. 7th Edition. 2019. Page –151.
2. Louise M. Webster, Jenny E. Myers, Catherine Nelson-Piercy, Kate Harding, J. Kennedy Cruickshank, Ingrid Watt-Coote, Asma Khalil, Cornelia Wiesender, Paul T. Seed and Lucy C. Chappell. Labetalol Versus Nifedipine as Antihypertensive Treatment for Chronic Hypertension in Pregnancy. Journal of Hypertension. September 2017. [Accessed on 9th November 2022] https://www.ahajournals.org/doi/10.1161/hypertensionaha.117.09972
3. Prof Thomas Easterling, MD, Prof Shuchita Mundle, MD, Hillary Bracken, PhD, Seema Parvekar, MD, Sulabha Mool, DGO, Prof Laura A Magee, MD, Prof Peter von Dadelszen, Dphil Tara Shochet, PhD, Prof Beverly Winikoff, MD. Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open label, randomized controlled trial. The Lancet. September 2019. [Accessed on 9th November 2022] https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31282-6/fulltext
4. Synchrony Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in January 2022]. [Accessed on 9th November 2022] https://www.medicines.org.uk/emc/files/pil.10831.pdf
Useful Diagnostic Tests
- Kidney Function Test
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