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Introduction About KEPPRA 500MG TABLET
Keppra 500mg Tablet contains levetiracetam, an anticonvulsant medicine commonly prescribed to help manage seizures in people with epilepsy. It can be used alone or together with other seizure control medicines. The active ingredient, levetiracetam, works by binding to the synaptic vesicle protein 2A (SV2A) in the brain, which helps regulate neurotransmitter release and balances abnormal electrical activity linked to seizures.
Keppra 500mg Tablet can be taken with or without food, but for best results, try to take it at the same time every day. The dose prescribed will vary based on your medical condition and response to the medication. Your healthcare provider will determine the most suitable dose for you. Keppra 500mg Tablet is generally recommended for long-term use, and it is important to continue the medication as directed, even if you feel well. Missing or stopping doses without consulting your doctor may lead to an increase in seizure episodes.
Common side effects of Keppra 500mg Tablet include headache, irritation, drowsiness, behaviour changes such as increased aggression, difficulties with coordination, reduced appetite, dizziness and fatigue. These side effects are usually more noticeable during the first few weeks but tend to decrease as your body adjusts to the medication. Most side effects do not require medical attention, but some can be serious. A small number of people taking this medicine have experienced thoughts of self-harm or suicidal ideation. It is important to contact your healthcare provider promptly if you notice any worsening mood changes or unusual behaviours.
Before taking Keppra 500mg Tablet, inform your doctor if you have kidney problems, a history of depression, or thoughts of self-harm. Also, let your doctor know if you are pregnant, planning to become pregnant, or breastfeeding. Your healthcare provider may recommend regular blood tests to monitor kidney function while you use this medication to ensure safe and effective use.
Uses Of KEPPRA 500MG TABLET
Benefits of KEPPRA 500MG TABLET
01)Supports Seizure Control by Balancing Brain Activity: Keppra 500mg Tablet helps regulate abnormal electrical impulses in the brain to support improved seizure management in epilepsy patients.
02)Unique Mechanism of Action: Levetiracetam, the active ingredient, binds to synaptic vesicle protein 2A (SV2A) in the brain, which modulates neurotransmitter release and stabilizes nerve activity linked to seizures.
03)Enhances Quality of Life: By reducing seizure frequency and severity, this medicine supports better daily functioning and independence for people living with epilepsy.
04)Suitable for Various Seizure Types: Effective for managing partial-onset, myoclonic, and tonic-clonic seizures, either alone or combined with other seizure control medicines.
05)Consistent Daily Dosing for Best Results: Formulated for twice-daily intake with or without food, maintaining steady medication levels to support ongoing seizure control.
06)Recommended Long-Term Use: Keppra 500mg Tablet is generally advised for continued use as prescribed by your healthcare provider to maintain seizure stability.
How KEPPRA 500MG TABLET Works
How Does Keppra 500mg Tablet Work?
Keppra 500mg Tablet helps regulate abnormal electrical activity in the brain that contributes to seizures, supporting improved management of epilepsy.
Mechanism of Action of Levetiracetam
Levetiracetam, the active ingredient in Keppra, selectively binds to synaptic vesicle protein 2A (SV2A) in the brain. This action modulates neurotransmitter release and stabilizes nerve cell activity associated with seizures.
What Makes Keppra Unique for Epilepsy?
Keppra’s unique mechanism targets SV2A, a key protein involved in synaptic vesicle release, allowing it to selectively influence abnormal nerve signals without affecting normal brain activity. This distinct action contributes to its effectiveness and tolerability.
Brain Activity Stabilization with Keppra
By modulating neurotransmitter release via SV2A binding, Keppra helps reduce the synchronization of abnormal burst firing in neurons, contributing to a more balanced brain electrical environment.
Keppra Tablet and Neurotransmitter Regulation
Keppra influences key neurotransmitter systems by regulating vesicle-mediated release, impacting excitatory and inhibitory signals in the brain to support seizure control.
How to use KEPPRA 500MG TABLET
How to take Keppra 500mg Tablet
- Take Keppra 500mg Tablet exactly as prescribed by your healthcare provider.
- It can be taken with or without food but try to take it at the same times every day to maintain steady medicine levels in your body.
Recommended Keppra Dosage & Schedule
- For adults and adolescents aged 16 years and older, a common starting dose is 500mg twice daily.
- Your doctor may adjust the dose based on how you respond, with typical maintenance doses ranging up to 1500mg twice daily.
- The tablets should be swallowed whole without chewing or crushing.
Dosage Adjustments for Age & Condition
- Dosage may be adjusted for children based on body weight, with specific dosing schedules for infants and young children.
- Dose modifications may also be necessary for patients with kidney problems, and your doctor will advise accordingly.
Dosage for Different Age Groups
- Adults and Adolescents (≥16 years): Typically start at 500mg twice daily.
- Children: Dosage is weight-based, commonly started at lower mg/kg doses and gradually increased.
- Infants: Oral solution is preferred, with careful dosing by weight.
What if I forgot to take KEPPRA 500MG TABLET
If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not take a double dose to make up for a missed one. In case of overdose, seek immediate medical help.
Side Effects Of KEPPRA 500MG TABLET
Like all medicines, Keppra 500mg Tablet may cause certain side effects in some individuals, although not everybody gets them.
Common:
- Headache
- Irritation
- Drowsiness
- Behaviour changes such as increased aggression, difficulties with coordination
- Reduced appetite
- Dizziness
- Fatigue
When to consult your doctor?
- Severe allergic reactions symptoms such as swelling of the face, lips, tongue, or throat
- Difficulty breathing or shortness of breath
- Severe skin reactions symptoms such as rash, blistering, peeling, or widespread redness (Stevens-Johnson syndrome, toxic epidermal necrolysis)
- Sudden mood or behaviour changes symptoms such as increased irritability, aggression, depression, or suicidal thoughts
- Confusion, hallucinations, or extreme drowsiness
- Problems with balance, coordination, or walking
- Unusual bleeding or bruising
- Persistent fever, chills, or signs of infection
- Seizures that worsen or increase in frequency
- Fainting or loss of consciousness
- Severe muscle stiffness, twitching, or uncontrolled movements
- Signs of kidney problems such as swelling in legs/ankles, decreased urine output, or intense fatigue
How To Manage Side Effects
Dizziness Or Drowsiness
- Sit or Lie Down: If you feel dizzy, sit down, or lie down immediately to reduce falling. Keep your head still and close your eyes if needed.
- Hydrate: Dehydration can cause dizziness, so drink water or electrolyte-replenishing drinks like sports drinks.
- Avoid Sudden Movements: When standing or sitting, do so slowly to avoid triggering dizziness. Take your time when getting up.
- Eat Small, Regular Meals: Low blood sugar can cause dizziness, so eat small meals throughout the day and avoid skipping meals.
- Fresh Air: Sometimes dizziness can be alleviated by taking slow, deep breaths in a well-ventilated area.
- Consult Your Doctor: If constipation persists or becomes severe, seek medical advice for possible adjustments or supportive management.
Warning & Precautions
Pregnancy
Monitoring requiredKEPPRA 500MG TABLET should be used during pregnancy only when clearly necessary as determined by your doctor. Regular monitoring and dose adjustments may be required due to changes in medication levels during pregnancy. Consult your doctor if you are pregnant or planning to conceive before taking this medicine.
Breastfeeding
ContraindicatedKEPPRA 500MG TABLET is generally not recommended during breastfeeding due to the potential for increased side effects in the infant. If use is essential, discuss closely with your healthcare provider to assess risks and benefits. Consult with your doctor before taking it.
Driving and Using Machines
Use with CautionAvoid driving or operating heavy machinery if you experience drowsiness or dizziness after taking KEPPRA 500MG TABLET. Use caution until you know how this medication affects you.
Alcohol
Consult your doctorConsult your doctor before consuming alcohol while on KEPPRA 500MG TABLET as alcohol may enhance side effects like dizziness and drowsiness.
Kidney
Use with CautionKEPPRA 500MG TABLET should be used with caution in patients with kidney impairment. Your healthcare provider will adjust the dose accordingly and monitor kidney function regularly. Consult with your doctor before taking it.
Allergy
ContraindicatedDo not take KEPPRA 500MG TABLET if you are allergic to levetiracetam or any other ingredient in the medicine.
Heart Disease
Use with CautionKEPPRA 500MG TABLET should be used with caution if you have a history or family history of heart rhythm problems or are prone to irregular heartbeat. Inform your healthcare provider for appropriate monitoring. Consult with your doctor before taking it.
Use In Pediatrics
Consult your doctorKEPPRA 500MG TABLET is not recommended as monotherapy in children and adolescents under 16 years of age. However, it may be used in combination with other medicines, with dosage based on age, weight, and condition as prescribed by your doctor. Consult your paediatrician before giving it.
Use In Geriatrics
Use with CautionOlder adults should use KEPPRA 500MG TABLET cautiously, following the dosing instructions provided by their healthcare provider to avoid potential side effects related to age. Consult with your doctor before taking it.
Other Warnings for KEPPRA 500MG TABLET
Before taking Keppra 500mg Tablet, inform your doctor if you have:
- any imbalance in your body’s salt levels
Diet and Lifestyle Advice
|
Lifestyle Tip |
Description |
|
Take Medication Consistently |
Take Keppra 500mg Tablet at the same time every day to maintain steady levels and effectiveness. |
|
Avoid Alcohol |
Alcohol can increase side effects like drowsiness and dizziness; avoid or limit alcohol intake. |
|
Monitor Mental Health |
Watch for mood changes, depression, or suicidal thoughts and report any concerns to your doctor. |
|
Avoid Driving if Drowsy |
Do not drive or operate machines if you feel sleepy, dizzy, or less alert after taking Keppra. |
|
Get Adequate Sleep |
Ensure regular and sufficient sleep to help reduce seizure frequency and support overall health. |
|
Maintain a Healthy Diet |
Eat balanced meals and stay hydrated to support medication tolerance and general well-being. |
|
Avoid Sudden Discontinuation |
Do not stop Keppra suddenly, consult your doctor for advice on gradual dose reduction if needed. |
|
Inform Doctor of Kidney or Heart Issues |
Report any kidney or heart problems before and during management for proper dose adjustment. |
|
Manage Stress and Practice Relaxation |
Incorporate stress-relief techniques like yoga or meditation to support better seizure control. |
Drug - Drug interaction
01)Benzodiazepines (e.g., Alprazolam, Lorazepam)
Interaction: Concurrent use with Keppra may increase the risk of side effects such as excessive sleepiness and sedation.
Effects: Heightened central nervous system depression leading to dizziness, drowsiness, and impaired coordination.
Management: Close monitoring by healthcare providers; dose adjustments may be necessary to minimize side effects.
02)Carbamazepine (Tegretol)
Interaction: Taking Keppra alongside carbamazepine can increase the likelihood of carbamazepine-related side effects.
Effects: Increased dizziness, nausea, vision changes, and unsteadiness.
Management: Inform your doctor about any worsened side effects; they may lower the carbamazepine dose.
03)Certain Antidepressants (e.g., Amitriptyline, Mirtazapine)
Interaction: Co-administration may increase sedation and reduce effectiveness of either medication.
Effects: Increased sleepiness, mood changes, and possibly reduced seizure control or depression management.
Management: Monitor for mood changes and sedation; consult your doctor for dose adjustments.
04)Sedating Antihistamines (e.g., Diphenhydramine)
Interaction: Combined use may enhance drowsiness and dizziness.
Effects: Increased risk of sedation and impaired alertness.
Management: Use caution when taking together; avoid operating machinery until effects are known.
Drug - Food interaction
01)Alcohol
Interaction: Consuming alcohol while taking Keppra may increase side effects such as dizziness, drowsiness, and impaired coordination.
Effects: Enhanced sedation and reduced alertness, leading to higher risk of accidents.
Management: Avoid or limit alcohol intake during management with Keppra to minimize side effects.
02)Food in General
Interaction: Keppra may be taken with or without food without affecting its absorption or effectiveness.
Effects: Food has minimal impact on medication levels or side effects.
Management: Take Keppra consistently at the same time daily, with or without meals, as advised by your doctor.
03)Herbal Supplements and Vitamins
Interaction: There are no specific known interactions between Keppra and common herbal supplements or vitamins.
Effects: Potential unknown risks exist, some herbs that cause drowsiness may enhance Keppra’s sedative effects.
Management: Consult your healthcare provider before starting any new supplements or vitamins while on Keppra.
Synopsis
|
Drug |
: |
Levetiracetam |
|
Pharmacological Category |
: |
Anticonvulsants |
|
Therapeutic Indication |
: |
|
|
Dosage Forms |
: |
Tablet, Injection, Infusion, Syrup, Suspension, Oral Suspension, Solution |
More Information
FAQs About KEPPRA 500MG TABLET
Q: What is Keppra 500mg Tablet used for?
A: Keppra 500mg Tablet supports management of different types of seizures associated with epilepsy, including partial-onset, myoclonic, and primary generalized tonic-clonic seizures. It works by moderating abnormal electrical activity in the brain to help maintain seizure control.
Q: How does Keppra 500mg Tablet work in epilepsy management?
A: Keppra contains levetiracetam which binds to specific proteins in the brain to regulate neurotransmitter release and stabilize electrical signals, helping to manage seizure activity effectively.
Q: Can Keppra 500mg Tablet be used alone or with other seizure medicines?
A: Yes, Keppra 500mg Tablet can be used as monotherapy or in combination with other anti-epileptic drugs based on the doctor’s recommendation and patient condition.
Q: What are common side effects of Keppra 500mg Tablet?
A: Common side effects include headache, dizziness, sleepiness, irritability, fatigue, and behavioural changes. Most side effects lessen as the body adjusts to the medication.
Q: Is Keppra 500mg Tablet safe during pregnancy and breastfeeding?
A: Keppra should be used during pregnancy only when clearly necessary and under medical supervision. It is generally not recommended for breastfeeding women due to the potential risk of side effects in the infant.
Q: How should Keppra 500mg Tablet be taken?
A: It should be taken exactly as prescribed by your doctor, at the same times each day, with or without food. Do not stop or miss doses unexpectedly to avoid worsening seizure control.
Q: What should I do if I forget to take a dose?
A: It should be taken exactly as prescribed by your doctor, at the same times each day, with or without food. Do not stop or miss doses unexpectedly to avoid worsening seizure control.
References
1. K.D. Tripathi. Antiepileptic Drugs. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 420.
2. Bassel Abou-Khalil. Levetiracetam in the treatment of epilepsy. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. June 2008. [Accessed on 23rd Sept 2025] 
3. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in June 2023] [Accessed on 23rd Sept 2025] 
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