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Introduction About KABVIE 10 TABLET
KABVIE 10 TABLET is used in the management of Gastro-intestinal reflux disease (GERD), reflux or erosive esophagitis, heartburn, acidity, stomach ulcers and other complications caused due to excessive stomach acid secretions. It can also be used as an adjunctive therapy for eradication of Helicobacter pylori infection in combination with antibiotics (like amoxicillin and clarithromycin).
KABVIE 10 TABLET contains Vonoprazan which is a Potassium Competitive Acid Blocker (P-CAB). It works by blocking a specific protein in the stomach lining which is crucial for producing stomach acid. By inhibiting it, vonoprazan effectively reduces the amount of acid the stomach produces.
Vonoprazan reduces stomach acid more effectively than traditional proton pump inhibitors (PPIs), creating a less acidic environment which helps the antibiotics work better by increasing their stability and concentration in the stomach, making it easier to eradicate the H. pylori bacteria. KABVIE 10 TABLET is suitable for use only in adults.
Before taking KABVIE 10 TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have low blood magnesium levels, calcium and potassium levels or if you are pregnant or breastfeeding.
The most common side effects of taking KABVIE 10 TABLET are stomach pain, indigestion, diarrhea, constipation, bloating, high blood pressure, headache, changes in taste sense, vaginal yeast infection and cold-like symptoms. Consult your doctor if any of these side effects trouble you.
Uses Of KABVIE 10 TABLET
Management of Gastrointestinal problems such as:
- GERD and its signs like heartburn, acidity, indigestion
- Reflux or erosive esophagitis
- Stomach ulcers and duodenal ulcers
- Adjunctive therapy for H. pylori infection in combination with antibiotics
How KABVIE 10 TABLET Works
KABVIE 10 TABLET contains Vonoprazan which works by blocking a specific protein in the stomach lining called the potassium ion transporter. This protein is crucial for producing stomach acid. By inhibiting it, vonoprazan effectively reduces the amount of acid the stomach produces. This helps in managing conditions like acid reflux, stomach ulcers, and other acid-related disorders by allowing the stomach and esophagus to heal.
For H. pylori infection eradication, vonoprazan is used as part of a combination therapy with antibiotics. Vonoprazan reduces stomach acid more effectively than traditional proton pump inhibitors (PPIs), creating a less acidic environment. This enhanced acid suppression helps the antibiotics work better by increasing their stability and concentration in the stomach, making it easier to eradicate the H. pylori bacteria and promote healing of the stomach lining.
How to use KABVIE 10 TABLET
Take KABVIE 10 TABLET as advised by your physician. It can be taken with or without food. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and health condition. Do not stop taking KABVIE 10 TABLET without consulting your doctor.
Side Effects Of KABVIE 10 TABLET
Common
- inflammation of stomach, indigestion, diarrhea, constipation
- stomach bloating, stomach pain, nausea
- high blood pressure
- urinary tract infection
- headache, changes in taste sense
- vaginal yeast infection
- cold-like symptoms
Stop taking KABVIE 10 TABLET and inform your doctor immediately if you experience any of the following side effects:
- Kidney problem (such as acute tubulointerstitial nephritis causing low urine output and bloody urine)
- Severe diarrhea with stomach pain and fever
- Bone fractures (hip, wrist, or spine)
- Severe skin reactions causing skin rashes, blistering, peeling, or bleeding on any part of your skin (including your lips, eyes, mouth, nose, genital, hands, or feet) with fever, chills, body aches, breathing difficulties and enlarged lymph nodes
- Low vitamin-B12 levels causing irregular heartbeat, shortness of breath, lightheadedness, tingling or numbness in the arms and legs, muscle weakness, pale skin, feeling tired, or mood changes
- Low magnesium levels in the body (such as seizures, dizziness, irregular heartbeat, jitteriness, muscle aches or weakness, or spasms of the hands, feet, or voice)
- Stomach growths (fundic gland polyps)
How To Manage Side Effects
Dizziness Or Drowsiness
Stay hydrated and avoid sudden movements like standing up quickly, which can worsen the dizziness. Try to move slowly and sit down if you feel lightheaded. Resting with your head elevated can also help. Eating small, balanced meals throughout the day can keep your blood sugar stable, reducing dizziness. Ensure your home is free of tripping hazards and keep a stable object nearby to hold onto if needed. If dizziness persists or worsens, consult your healthcare provider for further guidance.
Nausea And Vomiting
Eat small, frequent meals instead of large ones, and avoid greasy, spicy, or strong-smelling foods. Stay hydrated by sipping clear liquids like water, ginger ale, or herbal teas throughout the day. Ginger, either in tea, candies, or as a supplement, can help reduce nausea. Resting in an upright position after eating can also minimize symptoms. If prescribed by your doctor, take anti-nausea medications as directed. Additionally, relaxation techniques such as deep breathing, meditation, or gentle distractions like listening to music can help manage nausea. Always consult your healthcare provider for personalized advice.
Warning & Precautions
Pregnancy
Consult your doctorIt is not known whether Vonoprazan can harm the unborn baby. Therefore, inform your doctor if you are pregnant or think you may be pregnant before taking KABVIE 10 TABLET as a precaution. If you became pregnant while under therapy with KABVIE 10 TABLET, inform your doctor immediately.
Breastfeeding
Consult your doctorIt is not known whether Vonoprazan can pass through breast milk. Therefore, inform your doctor before taking KABVIE 10 TABLET if you are breastfeeding or planning to breastfeed.
Kidney
Use with CautionKABVIE 10 TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor for advice.
Liver
Use with CautionKABVIE 10 TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor for advice.
Allergy
ContraindicatedDo not take KABVIE 10 TABLET if you are allergic to Vonoprazan.
Use In Pediatrics
Consult your doctorThe safety and effectiveness of KABVIE 10 TABLET have not been established in children and adolescents (aged 18 years or below). Therefore, consult your doctor for advice.
Others
Before taking KABVIE 10 TABLET, inform your doctor if you:
- Have low magnesium levels in the blood
- Have low calcium or potassium levels in the blood
- Are taking medicines to increase urine output
Interactions
A. Drug-Drug Interactions:
- Rilpivirine (an Anti-HIV medicine)
Overdosage:
If you or anyone else accidentally taken too many doses of KABVIE 10 TABLET, contact your doctor immediately or visit the hospital straight away.
Synopsis
| Drug | : | Vonoprazan |
| Pharmacological Category | : | Potassium-competitive acid blocker (P-CAB) |
| Therapeutic Indication | : | Stomach ulcers,GERD, H. Pylori infection |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep KABVIE 10 TABLET out of reach of children
- Store KABVIE 10 TABLET at room temperature
FAQs About KABVIE 10 TABLET
Q: What is KABVIE 10 TABLET used for?
A: KABVIE 10 TABLET is used in the management of Gastro-intestinal reflux disease (GERD), reflux or erosive esophagitis, heartburn, acidity, stomach ulcers and other complications caused due to excessive stomach acid secretions. It can also be used as an adjunctive therapy for eradication of Helicobacter pylori infection in combination with antibiotics (like amoxicillin and clarithromycin).
Q: How long should I take KABVIE 10 TABLET?
A: You need to take KABVIE 10 TABLET for the stipulated duration prescribed by your doctor. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: What is the best time to take KABVIE 10 TABLET?
A: KABVIE 10 TABLET can be taken with or without meals. If you are doubtful, consult your doctor for advice.
Q: What to do if I forgot to take a dose of KABVIE 10 TABLET?
A: If you forgot to take a dose of KABVIE 10 TABLET, take it as soon as you remember. However, if it is time for the next dose of KABVIE 10 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of KABVIE 10 TABLET to compensate the missed ones.
Q: Can I stop taking KABVIE 10 TABLET without consulting your doctor?
A: No. You should not stop taking KABVIE 10 TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using KABVIE 10 TABLET, consult your doctor for advice.
Q: Will taking a higher dose of KABVIE 10 TABLET be more effective?
A: No, taking a higher dose of KABVIE 10 TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: What are the most common side effects of taking KABVIE 10 TABLET?
A: The most common side effects of taking KABVIE 10 TABLET are stomach pain, indigestion, diarrhea, constipation, bloating, high blood pressure, headache, changes in taste sense, vaginal yeast infection and cold-like symptoms. Consult your doctor if any of these side effects trouble you.
Q: Can KABVIE 10 TABLET cause constipation?
A: Yes. Constipation is a common side effect of using KABVIE 10 TABLET. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if this side effect bothers you.
Q: Can KABVIE 10 TABLET be used in pregnant women?
A: It is not known whether Vonoprazan can harm the unborn baby. Therefore, inform your doctor if you are pregnant or think you may be pregnant before taking KABVIE 10 TABLET as a precaution. If you became pregnant while under therapy with KABVIE 10 TABLET, inform your doctor immediately.
Q: How to take KABVIE 10 TABLET?
A: Take KABVIE 10 TABLET as advised by your physician. It can be taken with or without food. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Q: How much KABVIE 10 TABLET should I take?
A: KABVIE 10 TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.
References
1. Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date. PMC. PubMed Central. National Library of Medicine. National Center for Biotechnology Information. January 2018. [Accessed on 23rd August 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784563/
2. VOQUEZNA (vonoprazan) tablets, for oral use. Phathom Pharmaceuticals, Inc. U.S. Food and Drug Administration. [Revised in November 2023]. [Accessed on 23rd August 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/215151s000lbl.pdf
3. VOQUEZNA® (voe kwez nah) (vonoprazan) tablets, for oral use. Patient Information. Phathom Pharmaceuticals, Inc [Revised in July 2024]. [Accessed on 23rd August 2024] https://www.phathompharma.com/wp-content/uploads/VOQUEZNA-Patient-Information.pdf
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