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Introduction About JONTIL D TABLET

JONTIL D TABLET contains a combination of Diacerein and Gucosamine sulfate potassium chloride which belongs to the group of medicines called Nonsteroidal anti-inflammatory drugs (NSAIDs). It is used to manage osteoarthritis of the knee.

Osteoarthritis is a type of joint degeneration that occurs when the protective cartilage that cushions the ends of the bones wears down over time and generates symptoms such as stiffness, pain in movement, tenderness, swelling, bone spurs, crackling sound while walking.

Before taking JONTIL D TABLET inform your doctor if you have liver, kidney, heart, intestine, abdominal disease, asthma, or suffer from impaired glucose tolerance, or severe issues with the joints. Avoid consumption of alcohol during this management as it can increase liver damage.

JONTIL D TABLET is not recommended for use in pregnant and breastfeeding women. It is not recommended for use in children and adolescents below 18 years of age. JONTIL D TABLET should be used with caution in the elderly above 65 years of age.

The most common side effects of taking JONTIL D TABLET are diarrhea, abdominal pain, flatulence, headache, and nausea. Consult your doctor if symptoms do not show improvement.

Uses Of JONTIL D TABLET

Manage osteoarthritis of the knee

How JONTIL D TABLET Works

JONTIL D TABLET works by relieving symptoms of osteoarthritis in which diacerein works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that plays a role in the development of symptoms of osteoarthritis and glucosamine sulfate potassium chloride delays many inflammation-induced catabolic processes in the cartilage and promotes the formation of cartilage.

How to use JONTIL D TABLET

Take JONTIL D TABLET as advised by your physician. Swallow the medicine with water. Do not crush or chew the medicine. Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.

Side Effects Of JONTIL D TABLET

Common

soft stools
abdominal pain
frequent bowel movements
flatulence
skin effects such as rash, itching, eczema
discoloration of urine
headache, tiredness
nausea
indigestion
constipation

Uncommon

flushing
increase in liver enzymes levels in blood tests
discoloration of colon mucosa

Rare

Stop taking JONTIL D TABLET and contact your doctor immediately if you experience any of the following side effects:

abdominal pain, jaundice, changes in the color of the urine (from yellow-orange to red or even brown), pigmentation of the intestinal mucosa, reduced consciousness or itching of the skin occur (signs of liver disease)
severe diarrhea
swollen face, tongue and/or pharynx and/or difficulty swallowing or hives together with difficulties breathing (angioedema)

How To Manage Side Effects

Bloating

Eat smaller and more frequent meals, and exercise regularly. If the symptom does not show improvement, consult your doctor.

Constipation

Eat lots of fiber-rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. If the symptom does not show improvement, consult your doctor.

Diarrhea

Drink lots of water or fruit juice to keep yourself hydrated. If the symptom does not show improvement, consult your doctor.

Headache

Avoid bright lights, drink more water and take a rest. If the symptom does not show improvement, consult your doctor.

Nausea And Vomiting

JONTIL D TABLET should be used with caution in the elderly above 65 years of age as they are more vulnerable to diarrheal problems and other side effects. Consult your doctor before taking it.

Others

JONTIL D TABLET is not recommended for use if you:

are allergic to shellfish, peanuts, soya

Before taking JONTIL D TABLET, inform your doctor if you:

suffer from impaired glucose tolerance
have joint swelling, warmth and redness, painfulness, persistent joint stiffness, pain at rest, pain in more than one joint, increased body temperature and decrease in body weight (can be symptoms of rheumatoid arthritis, systemic lupus, gout, tumors)
suffer ulcerative colitis or Crohn’s disease
suffer from intestinal obstruction or pseudo-obstruction.
have abdominal disorders
intolerant to certain sugars

Interactions

A. Drug-Drug interactions:

Before taking JONTIL D TABLET, inform your doctor if you are taking any of the following medicine:

warfarin (a medicine used to thin the blood)
medicines for diabetes (Ex. metformin, glipizide)
tetracycline (an antibiotic against bacterial infections)
antacids (medicines for managing stomach acidity)
a diuretic or cardiac glycosides (Ex. digitoxin, digoxin)
laxatives (Ex. bisacodyl)

Overdosage:

If you or anyone else accidentally take too much of JONTIL D TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are intense diarrhea, dizziness, headache, nausea, vomiting, constipation, and joint pain.

Synopsis

Drug	:	Diacerein, Gucosamine
Pharmacological Category	:	Anthraquinone, Anti inflammatory
Therapeutic Indication	:	Osteoarthritis
Dosage Forms	:	Tablet

More Information

Keep JONTIL D TABLET out of reach from children
Store at room temperature

FAQs About JONTIL D TABLET

Q: What is JONTIL D TABLET used for?

A: JONTIL D TABLET is used to manage osteoarthritis of the knee. Osteoarthritis is a type of joint degeneration that occurs when the protective cartilage that cushions the ends of the bones wears down over time and generates symptoms such as stiffness, and pain in movement.

Q: How does JONTIL D TABLET work?

A: JONTIL D TABLET works by relieving symptoms of osteoarthritis in which diacerein works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that plays a role in the development of symptoms of osteoarthritis and glucosamine sulfate potassium chloride delays many inflammation-induced catabolic processes in the cartilage and promotes the formation of cartilage.

Q: What if I accidentally take more of JONTIL D TABLET?

A: If you or anyone else accidentally take too much of JONTIL D TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are intense diarrhea, dizziness, headache, nausea, vomiting, constipation, and joint pain.

Q: Can JONTIL D TABLET be used in elderly patients?

A: JONTIL D TABLETshould be used with caution in the elderly above 65 years of age as they are more vulnerable to diarrheal problems and other side effects. Consult your doctor before taking.

Q: Can JONTIL D TABLET be used in children?

A: JONTIL D TABLETis not recommended for use in children and adolescents below 18 years of age. Consult your doctor before taking this medicine.

References

1. KD Tripathi. Nonsteroidal Antiinflammatory Drugs and Antipyretic-Analgesics. Essentials of medical pharmacology. Eighth Edition. 2019. Page –220-224.

2. Jörg Jerosch. Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids. [Accessed on 5th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150191/

3. Johanne Martel-Pelletier. Effects of Diacerein at the Molecular Level in the Osteoarthritis Disease Process. [Accessed on 5th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383474/

4. Chanelle Medical. Health Products Regulatory Authority (HPRA). [Revised in May 2016] [Accessed on 5th August 2022] https://www.hpra.ie/img/uploaded/swedocuments/2171814.PA1521_003_003.1a94fbbc-f593-4a32-a58c-5f8f8bb39b75.000001PIL%201500mg.160824.pdf

5. Chanelle Medical. Health Products Regulatory Authority (HPRA). [Revised in May 2016] [Accessed on 5th August 2022] https://www.hpra.ie/img/uploaded/swedocuments/2171814.PA1521_003_002.cb4ba0a2-1887-4c40-afe6-e19cea656342.000001750mg%20PIL%20.160824.pdf

6. TRB PHARMA S.A. Diacerein [Revised in April 2019] [Accessed on 5th August 2022] https://myhealthbox.eu/en/view/3364878/1066595e9806313ef81279755226ab79/leaflet

7. Trima Israel Pharmaceutical Products Maabarot Ltd. Diacerein. [Revised in November 2015] [Accessed on 5th August 2022] https://myhealthbox.eu/en/view/3529427/469334cbb76f29e848cd1e9f1a64d1ac/leaflet

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed For Accuracy By Dr. Narayanasetty Sai Swaroop - Pharm.D

Last updated on 24 Feb 2023 | 04:08 PM(IST)

Lab updated