Boehringer Ingelheim India Pvt Ltd

Jardiance 25 Tablet 10'S

Diabetes
MRP ₹441.00 (Inclusive of all taxes)
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    Introduction About JARDIANCE 25MG TABLET

    Jardiance 25mg Tablet is an FDA-approved medication used to manage Type 2 diabetes, chronic kidney disease, heart failure, risks for hospitalization and other fatal complications caused by high blood sugar levels. It belongs to a class of drugs known as SGLT-2 inhibitors, which help reduce blood sugar levels. It also aids in heart health and weight management.

    Appropriate diet and exercise can help the body use its blood sugar better. Follow any advice given by your doctor regarding foot care. Prior to the management, your doctor may want you to take several blood tests to understand the existing condition. Before taking Jardiance Tabletinform your doctor if you have any serious liver, kidney or heart problems or type I diabetes mellitus. Jardiance 25 Tablet is not recommended in pregnant or breastfeeding women.

    Due to limited therapeutic experience, elderly patients (above 75 years of age) should consult the doctor before taking Jardiance 25 Tablet. The most common side effects are low blood sugar, genital infection, frequent urination, rash, itching, thirst, or constipation. Consult your doctor if any of the above side effects get worsen.

    Key Composition

    Jardiance 25mg Tablet contains an active ingredient called:

    Uses Of JARDIANCE 25MG TABLET

    • Type 2 Diabetes Mellitus along with diet, exercise and lifestyle changes
    • FDA approved for reducing the risk of heart failure, chronic kidney failure and risk other complications in diabetic patients (View USFDA Approval News)
    • Suitable for use in adults and in children (aged 10 years or older)
    • Not suitable for use in patients with type I diabetes

    Benefits of Jardiance in Type 2 Diabetes:

    • Helps Lower Blood Sugar: Jardiance works by reducing the amount of glucose reabsorbed in the kidneys, effectively lowering blood sugar levels.
    • Promotes Weight Loss: Although not approved for weight loss, some research studies shows that Jardiance helps promote moderate weight loss by eliminating excess glucose through urine. (Boehringer-ingelheim – Jardiance’s effects on weight loss)
    • Improves Insulin Sensitivity: Regular use of Jardiance may enhance insulin sensitivity, making it easier for the body to manage blood sugar.
    • Reduces Risk of Complications: Long-term use of Jardiance reduces the risk of developing diabetes-related complications such as heart disease and neuropathy.

    Benefits of Jardiance in Chronic Kidney Disease:

    Jardiance has proven benefits for patients with chronic kidney disease (CKD), especially in those with Type 2 Diabetes. Studies show that Jardiance helps slow down the progression of kidney damage by reducing blood sugar levels and lowering blood pressure, two key factors that contribute to kidney deterioration in diabetic patients. Additionally, it reduces the amount of protein in the urine, a sign of kidney damage.

    (View NCT03594110 clinical trial)

    Benefits of Jardiance for Cardiovascular Health:

    • Reduces Heart Failure Risk: Jardiance significantly lowers the risk of hospitalization due to heart failure, a common complication in diabetic patients.
    • Lowers Cardiovascular Mortality: Studies indicate that Jardiance can lower the risk of cardiovascular death in people with Type 2 diabetes and heart disease.
    • Improves Heart Function: By reducing blood sugar and lowering blood pressure, Jardiance helps improve overall heart function and reduces the strain on the heart.
    • Reduces the Risk of Stroke and Heart Attack: Jardiance has been proven to lower the risk of major cardiovascular events such as heart attacks, strokes, and heart failure.

    (View Jardiance by Boehringer Ingelheim for heart failure)

    How JARDIANCE 25MG TABLET Works

    Jardiance 25mg Tablet, containing the active ingredient Empagliflozin works by inhibiting the SGLT2 protein in the kidneys, which promotes urine excretion of glucose, thereby reducing blood glucose levels.

    For Type 2 Diabetes: Jardiance helps improve blood sugar control in adults and children aged 10 years and older when combined with diet and exercise. It works by reducing excess glucose in the bloodstream, making it easier to manage diabetes.

    For Heart Failure: Jardiance has been proven to reduce the risk of cardiovascular death and hospitalization in adults with heart failure. It improves heart function by decreasing fluid retention and supporting overall cardiovascular health.

    For Chronic Kidney Disease: Jardiance reduces the risk of kidney function worsening and progressing to end-stage kidney disease (ESKD). It also lowers the risk of fatal cardiovascular complications and reduces hospitalizations in adults with chronic kidney disease.

    By targeting multiple pathways, Jardiance works effectively to manage blood sugar, support heart function, and protect kidney health, offering comprehensive benefits for patients with Type 2 diabetes, heart failure, and chronic kidney disease.

    View – Jardiance mechanism of action

    How to use JARDIANCE 25MG TABLET

    • Take Jardiance 25 Tablet as advised by your physician
    • Swallow the medicine with a glass of water with or without food
    • To achieve the best results, take it at the same time every day.

    Dosage and Administration of Empagliflozin:

    The usual recommended dose is 10mg or 25mg once daily, depending on your condition and response to treatment. Always follow your healthcare provider’s instructions for the correct dosage.

    Missed Dosage instructions for Jardiance Tablet:

    If you miss a dose of Jardiance, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for the missed one.

    Overdose of empagliflozin:

    In case of an overdose, seek immediate medical attention. Symptoms may include dehydration, low blood sugar (hypoglycemia), or other complications. Contact your doctor or a poison control center right away for further advice.

    Side Effects Of JARDIANCE 25MG TABLET

    Like all medicines, JARDIANCE 25MG TABLET may cause certain side effects, although not everybody gets them.

    Common side effects of Jardiance Tablet:

    • low blood sugar levels (shaking, sweating, feeling very anxious or confused, fast heartbeat, excessive hunger, headache)
    • urinary tract infection, frequent urination
    • dehydration
    • genital yeast infection
    • itching, rash or red skin, hives
    • stretching or pain when emptying the bladder

    Stop taking Jardiance Tablet and consult your doctor immediately if you experience any of the following side effects:

    • diabetic ketoacidosis (rapid weight loss, nausea, stomach pain, too much thirst, breathlessness, confusion, tiredness, a sweet-smelling breath, a sweet or metallic taste in your mouth or a different odour to your urine or sweat)

    How To Manage Side Effects

    Managing Vaginal Yeast Infections:

    If you get vaginal infections after taking Jardiance tablet, you must inform your doctor and take necessary steps. However, here are some simple tips which you can follow along with the therapy to fasten recovery.

    1. Maintain Good Hygiene: Keep the genital area clean and dry to prevent fungal overgrowth.
    2. Wear Loose Clothing: Avoid tight or synthetic underwear; opt for cotton to improve ventilation.
    3. Use Antifungal Creams: Over-the-counter antifungal creams or suppositories (like clotrimazole) can help relieve symptoms.
    4. Avoid Scented Products: Stay away from scented soaps or feminine hygiene sprays that can irritate the area.
    5. Probiotics: Incorporate probiotic-rich foods like yogurt to help maintain a healthy vaginal pH balance.

    Managing Urinary Tract Infections (UTIs):

    If you experience managing urinary tract infections after taking Jardiance, it is important to inform your doctor and follow the recommended course of action. In the meantime, here are some simple tips you can follow alongside your treatment to help speed up recovery.

    1. Stay Hydrated: Drink plenty of water to flush out bacteria from the urinary tract.
    2. Cranberry Juice: Unsweetened cranberry juice may help reduce the risk of bacteria sticking to the bladder wall.
    3. Urinate Frequently: Avoid holding urine for long periods; empty your bladder completely when you go.
    4. Warm Compress: Apply a warm compress to your lower abdomen to relieve discomfort.
    5. Avoid Irritants: Steer clear of caffeine, alcohol, and spicy foods that can irritate the bladder.

    Warning & Precautions

    Pregnancy

    Risky

    Animal studies have indicated that empagliflozin may affect the growing baby. There are not enough human trials regarding the use of empagliflozin in pregnant women. Therefore, before taking Jardiance tablet, inform your doctor if you are pregnant or think you may be pregnant. Your doctor may prescribe you with insulins or suggest this medication after evaluating the risk and benefits of the therapy.

    Breastfeeding

    Consult your doctor

    It is not known whether empagliflozin passes into human breast milk. A risk cannot be excluded to the nursing infant. Therefore, your doctor may suggest you an alternate medicine as a precaution. Talk to your doctor for advice.

    Driving and Using Machines

    Use with Caution

    Do not drive or operate any machines if you feel dizzy after taking the medicine.

    Kidney

    Use with Caution

    Jardiance 25 Tablet should be taken with caution in patients with severe kidney disease and serious infection of the kidney.  Dose adjustment and careful monitoring are required for patients with moderate kidney disease. Therefore, consult your doctor for advice.

    Liver

    Use with Caution

    Jardiance 25 Tablet should be used with caution in patients with severe liver disease. Proper dose adjustments are required for such patients. Therefore, consult your doctor for advice.

    Allergy

    Contraindicated

    Do not take Jardiance Tablet if you are allergic to Empagliflozin or any other ingredients of this medicine.

    Use In Pediatrics

    Contraindicated

    A recent press release from the manufacturer (boehringer-ingelheim -press release), suggest that Jardiance has been approved by USFDA to manage type II diabetes in children aged 10 years or older. To know more information, talk to your doctor

    Use In Geriatrics

    Consult your doctor

    Due to limited therapeutic experience, elderly patients (above 75 years of age) should consult the doctor before taking Jardiance 25 Tablet.

    Others

    Before taking Jardiance 25 Tablet, medicine, inform your doctor if you:

    • have type 1 diabetes
    • might be at risk of dehydration
    • serious infection of the urinary tract with fever
    • have a serious infection called necrotizing fasciitis of the perineum or Fournier’s gangrene

    Interactions

    Drug-Drug interactions:

    Before taking Jardiance, inform your doctor if you are taking any of the following medicine:

    Synopsis

    Drug :   Empagliflozin 
    Pharmacological Category :   Sodium Glucose Cotransporter-2 Inhibitor
    Therapeutic Indication :  

    Type 2 Diabetes mellitus, Manage the risk of heart disease in diabetic patients          

    Dosage Forms :   Tablet

    More Information

    Jardiance vs Metformin: Which is Right for You?

    Both Jardiance and Metformin are widely used to manage Type 2 Diabetes, but they work differently and offer unique benefits.

    Category

    Jardiance

    Metformin

    Mechanism of Action

    An SGLT-2 inhibitor that removes excess sugar via urine.

    A biguanide that reduces glucose production in the liver.

    Key Benefits

    Lowers blood sugar, supports weight loss, and reduces the risk of heart and kidney complications.

    Lowers blood sugar and improves insulin sensitivity.

    Suitability

    Ideal for patients needing additional heart or kidney protection.

    First-line treatment for newly diagnosed diabetes.

    Side Effects

    Increased urination, UTIs, and risk of dehydration.

    Gastrointestinal issues like nausea and diarrhea.

    Usage

    Taken once daily, usually in combination with other medications.

    Often taken twice daily with meals.

    If you’re unsure whether Jardiance or Metformin is better for your diabetes care, consult our online expert doctors for a personalized recommendation.

    Jardiance Reviews and User Ratings:

    Category

    Details

    Effectiveness

    - Many users reported improved blood sugar levels.

    - A1c levels reduced significantly (e.g., from 11 to 7.4).

    Common Benefits

    - Effective for Type 2 Diabetes.

    - Helps with weight loss.

    - Lowers blood pressure in some cases.

    Common Side Effects

    - Increased urination.

    - Risk of yeast infections.

    - Urinary tract infections (UTIs).

    Positive Reviews

    - Users appreciated the significant drop in A1c and blood sugar levels.

    Negative Reviews

    - Some users experienced severe yeast infections or UTIs.

    - Mixed experiences with side effects.

    Overall Ratings

    - WebMD: Average rating 3.1/5 (Mixed reviews).

    - Drugs.com: Average rating 5.4/10.

    Recommendation

    - Effective for many, but side effects may vary.

    - Consult your doctor for personalized advice.

     

    Sources: drugs.com, webMD

     

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    Jardiance Alternates for Diabetes:

    Brand_name

    Active ingredient

    Actual MRP

    Discount price

    Jardiance 10mg Tablet 10'S

    Empagliflozin 10 mg

    587

    528.30 (10% cheaper)

    Gibtulio 10mg Tablet 10'S

    Empagliflozin 10 mg

    534

    480.60 (10% cheaper)

    Gibtulio 25mg Tablet 10'S

    Empagliflozin 25 mg

    647

    582.30 (10% cheaper)

    COSPIAQ 10mg Tablet 10's

    Empagliflozin 10 mg

    587

    528.30 (10% cheaper)

    COSPIAQ 25mg Tablet 10's

    Empagliflozin 25 mg

    647

    528.30 (10% cheaper)

     

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    FAQs About JARDIANCE 25MG TABLET

    Q: How to Avoid Yeast Infections on Jardiance?

    A: To avoid yeast infections while taking Jardiance, maintain good hygiene and keep the genital area clean and dry. Wear cotton underwear and loose clothing to reduce moisture buildup. Avoid scented soaps, sprays, or douches that may irritate the vaginal area. Drink plenty of water to flush out excess sugar from the body, which can contribute to yeast growth. If you notice any signs of a yeast infection, such as itching or unusual discharge, consult your doctor for appropriate treatment.

    Q: Does Jardiance Cause Weight Loss?

    A: Yes, Jardiance has been shown to aid in weight loss in some people with Type 2 Diabetes. It works by helping the body eliminate excess sugar through urine, which may also result in a reduction in overall body weight. However, weight loss effects can vary depending on diet and exercise. Always consult your healthcare provider to discuss any concerns regarding weight changes while on Jardiance.

    Q: How Long Does It Take for Jardiance to Work?

    A: Jardiance starts working within a few hours of taking it, but it may take 1-2 weeks to see noticeable changes in blood sugar levels. Full benefits, including improvements in heart and kidney health, may take several weeks to months to become evident. Regular monitoring and follow-up with your healthcare provider will ensure you’re on track with your treatment.

    Q: Can Jardiance Cause Kidney Problems?

    A: Jardiance is generally safe for the kidneys, and in fact, it has been shown to help protect kidney function in people with diabetes and chronic kidney disease. However, it can cause dehydration, which may lead to kidney problems in some individuals. It's important to stay hydrated and monitor kidney function with your doctor regularly, especially if you have pre-existing kidney conditions.

    Q: What is Jardiance Used For and How Does it Work?

    A: Jardiance is primarily used to manage Type 2 Diabetes by helping lower blood sugar levels. It works by inhibiting a protein called SGLT-2, which prevents the kidneys from reabsorbing glucose, allowing excess sugar to be eliminated through urine. Additionally, Jardiance has benefits for heart health and kidney protection.

    Q: How Does Jardiance Help with Heart Failure?

    A: Jardiance has been shown to reduce the risk of hospitalization for heart failure and improve heart function in people with Type 2 Diabetes and heart disease. It helps by reducing fluid buildup and lowering blood pressure, which can relieve strain on the heart. Jardiance is approved for heart failure treatment in certain cases, particularly in those with reduced ejection fraction.

    Q: When is the Best Time of Day to Take Jardiance?

    A: The best time to take Jardiance is usually in the morning, with or without food. Taking it at the same time each day can help establish a routine. If you experience any side effects such as frequent urination, taking it in the morning can help prevent disturbances during the night. Always follow your doctor’s instructions for optimal results.

    Q: What is the main side effect of Jardiance?

    A: The main side effect of Jardiance is an increased risk of urinary tract infections (UTIs) and genital yeast infections. This happens because the medication increases the amount of glucose excreted in the urine, creating an environment that can promote the growth of bacteria and fungi.

    Q: Is Jardiance safe for kidneys?

    A: Jardiance is generally considered safe for kidneys and has been shown to slow the progression of chronic kidney disease (CKD) in patients with type 2 diabetes. However, in patients with severe kidney disease, its use should be cautious or avoided since the medication may not be as effective and could increase the risk of adverse effects. Regular monitoring of kidney function is recommended.

    Q: Is Jardiance better than metformin?

    A: Jardiance and metformin serve different purposes in managing type 2 diabetes. Metformin is typically used as the first-line therapy and works by reducing glucose production in the liver and improving insulin sensitivity. Jardiance belongs to a newer class of drugs called SGLT2 inhibitors, which lower blood sugar by promoting glucose excretion through urine and provide additional heart and kidney benefits. The choice between them depends on the individual’s health conditions and treatment goals. In some cases, they may be prescribed together.

    Q: Can I take metformin and Jardiance together?

    A: Yes, metformin and Jardiance are often prescribed together as part of a combination therapy to manage type 2 diabetes. Metformin lowers blood sugar by improving insulin sensitivity, while Jardiance promotes glucose excretion in urine and offers additional cardiovascular and renal benefits. However, this combination should be taken only under a doctor’s guidance.

    Q: What are the positive effects of Jardiance?

    A: Jardiance offers multiple benefits beyond lowering blood sugar levels. It reduces the risk of heart failure, slows the progression of chronic kidney disease, aids in weight management by promoting calorie loss through glucose excretion, and improves overall cardiovascular health in patients with type 2 diabetes.

    Q: Why is Jardiance so expensive?

    A: The high cost of Jardiance can be attributed to extensive research and development, regulatory processes, and market dynamics associated with bringing a new medication to the market. Additionally, manufacturing costs and demand for innovative diabetes therapies contribute to its price. Discounts, insurance, or patient assistance programs may help manage the cost.

    References

    1. Jardiance (empagliflozin tablets), for oral use. Boehringer-Ingelheim. Prescribing information. Revised in September 2023. [Accessed on 18th December 2024]. Click here
    2. US FDA approves Jardiance® for the treatment of adults with chronic kidney disease. News Release. September 2024. [Accessed on 18th December 2024]. Click here
    3. Jardiance. Mechanism of action. Boehringer-Ingelheim. click here

    Author Details

    Written By Srilekha. R - B.Pharm
    Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)
    Last updated on 18 Dec 2024 | 05:15 PM(IST)
    Lab updated