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Introduction About JANUMET 50/500MG TABLET
JANUMET 50/500MG TABLET is a combination of Sitagliptin and Metformin which manages type 2 diabetes effectively by improving blood sugar control.
Take JANUMET 50/500MG TABLET at the same time every day with meals to maintain optimum levels in the blood. Take it once or twice a day depending on your health condition and doctor’s advice. Do not adjust the dose of JANUMET 50/500MG TABLET without consulting your doctor.
Before taking JANUMET 50/500MG TABLET, inform your doctor if you have liver or kidney problems. Also inform your doctor before taking JANUMET 50/500MG TABLET if you are severely dehydrated or suffering from type I diabetes.
Pregnant and breastfeeding women should avoid taking JANUMET 50/500MG TABLET, as it includes a risk to the growing baby and nursing infant. The most common side effects of taking JANUMET 50/500MG TABLET are nausea, stomach discomfort, gas (flatulence), constipation, dry mouth, low blood sugar levels and headache. Talk to your doctor if any of these side effects trouble you.
Drink plenty of water or fluids to maintain hydration and limit consumption of alcohol, sugary drinks to help manage blood sugar levels effectively. Eat low-calorie diet and include plenty of vegetables, greens and fibre to complement the therapy on achieving optimum blood sugar levels.
Track your blood sugar levels regulary and check with your if you require any dosage adjustments.
Uses Of JANUMET 50/500MG TABLET
- Manages type II diabetes mellitus
Benefits of JANUMET 50/500MG TABLET
- Dual Action for Blood Sugar Control – Combines Sitagliptin (DPP-4 inhibitor) and Metformin (biguanide) to effectively lower high blood sugar levels in type 2 diabetes.
- Improves Insulin Sensitivity – Helps the body use insulin more efficiently, reducing insulin resistance and promoting better glucose uptake.
- Reduces Liver Glucose Production – Metformin decreases excess glucose production in the liver, preventing blood sugar spikes.
- Supports Post-Meal Glucose Control – Sitagliptin enhances incretin hormones, leading to better insulin release and lower post-meal sugar levels.
- Weight-Neutral & Low Risk of Hypoglycemia – Unlike some diabetes medications, JANUMET 50/500MG TABLET does not cause significant weight gain and has a lower risk of low blood sugar when used correctly.
Who Should Take JANUMET 50/500MG TABLET:
- Adults with type 2 diabetes mellitus who struggle to maintain healthy blood sugar levels despite diet and exercise.
- For patients needing a combination therapy to enhance insulin function and reduce glucose production.
- However, it is not suitable for type 1 diabetes or patients with severe kidney disease.
How JANUMET 50/500MG TABLET Works
JANUMET 50/500MG TABLET is a combination of Sitagliptin and Metformin, two effective anti-diabetic medications that help control blood sugar levels in type 2 diabetes.
- Metformin, a biguanide, works by reducing glucose production in the liver, improves insulin sensitivity, and decreases sugar absorption in the intestines.
- Sitagliptin, a DPP-4 inhibitor, enhances the body's natural insulin release by preventing the breakdown of incretin hormones, which in turn help lower blood sugar levels after meals.
Together, these diabetes medications provide a dual-action approach to improve glycemic control, making JANUMET 50/500MG TABLET an effective choice for managing type 2 diabetes mellitus.
How to use JANUMET 50/500MG TABLET
JANUMET 50/500MG TABLET is a prescription medication which should be used under guidance of a medical practitioner.
How To Take JANUMET 50/500MG TABLET:
- Take one tablet as prescribed by your doctor, usually with meals to reduce stomach upset. Do not crush or chew the tablet
- Swallow the medicine whole with a glass of water
JANUMET 50/500MG TABLET Dosage for Type 2 Diabetes:
- For Adults:
- Start with one tablet daily, depending on blood sugar levels.
- For Kidney Patients:
- Dosage may need to be reduced based on kidney function.
- Consult your doctor for adjustments if you have renal issues.
When to Take JANUMET 50/500MG TABLET?
- Take once daily with a meal, preferably with breakfast
- Ensure a consistent time each day for better blood sugar control.
JANUMET 50/500MG TABLETDose Adjustment Based on Blood Sugar Levels:
- Monitor blood sugar levels regularly.
- If blood sugar is high, your doctor may increase the dose.
- If blood sugar is low, your doctor may lower the dose or suggest other adjustments.
What if I forgot to take JANUMET 50/500MG TABLET
- Take it as soon as you remember unless it's close to the time for your next dose.
- Do not double dose to make up for the missed dose.
- Consult your doctor if you miss doses frequently.
Overdose
- Seek medical help immediately
- Symptoms of overdose include severe nausea, vomiting, and low blood sugar
Side Effects Of JANUMET 50/500MG TABLET
Like all medicines, JANUMET 50/500MG TABLET may cause certain side effects in some individuals, although not everybody gets them.
Common Side Effects of JANUMET 50/500MG TABLETare:
- Nausea
- Diarrhea
- Stomach discomfort, flatulence, constipation, loss of appetite
- Headache
- Hypoglycemia (low blood sugar)
- Swelling of the hands and legs (edema)
- Metallic taste
- Drowsiness, dizziness
- Dry mouth
- Stuffy or runny nose and sore throat
- Upper respiratory infection
- Weakness
When To Seek Medical Attention?
Stop taking and consult your doctor immediately if you experience any of the following side effects:
- serious allergic reaction (such as hives, swelling of the face, lips, tongue, or throat causing difficulty breathing or swallowing)
- severe blistering of the skin (signs of an allergic skin reaction called bullous pemphigoid)
- signs of pancreatitis (severe and persistent pain in the stomach areas that might reach through to your back with or without nausea and vomiting)
- signs of lactic acidosis (cold hands or feet, dizziness or lightheadedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
JANUMET 50/500MG TABLET– Long-term Safety:
- Safe for Long-Term Use – When taken as prescribed, JANUMET 50/500MG TABLET(Sitagliptin + Metformin) is considered safe for long-term management of type 2 diabetes with regular monitoring.
- Monitoring Required for Kidney & Liver Function – regular tests to assess kidney and liver function to ensure the drug is not causing adverse effects.
- Low Risk of Hypoglycemia – JANUMET 50/500MG TABLET has a low risk of causing hypoglycemia when taken alone, making it safer for long-term use in controlled doses.
How To Manage Side Effects

Bloating
- Take with Food – Always take JANUMET 50/500MG TABLET with meals to reduce the chances of gas, bloating, or flatulence. Eating helps buffer the stomach and may ease digestive side effects.
- Avoid Gas-Producing Foods – Limit foods known to cause gas, such as beans, cabbage, carbonated drinks, onions, and dairy products. Focus on a low-fiber diet if necessary.
- Increase Water Intake – Drink plenty of water throughout the day to help digestion and prevent bloating caused by gas buildup.
- Eat Smaller, More Frequent Meals –opt for smaller portions throughout the day to aid digestion and reduce the likelihood of flatulence.
- Use Over-the-Counter Remedies – If flatulence persists, simethicone-based anti-gas medications may help relieve discomfort. However, consult your doctor before using any remedies.
Warning & Precautions

Pregnancy
ContraindicatedJANUMET 50/500MG TABLET(Sitagliptin + Metformin) is not advisable during pregnancy unless prescribed by a doctor. Limited data exist on its safety for pregnant women, and uncontrolled diabetes during pregnancy may pose risks to both the mother and baby. If you are pregnant or planning to conceive, consult your doctor for safer alternative diabetes treatments.

Breastfeeding
ContraindicatedMetformin can pass into breast milk in small amounts, while there is limited data on Sitagliptin’s presence in breast milk. Due to potential risks to the infant, JANUMET 50/500MG TABLET is generally not recommended during breastfeeding. Your doctor may recommend an alternative medication or suggest switching to formula feeding if continued use is necessary.

Driving and Using Machines
Use with CautionDriving and operating machines is not recommended if you feel dizzy after taking JANUMET 50/500MG TABLET.

Alcohol
Consult your doctorAvoid consumption of alcohol while taking JANUMET 50/500MG TABLET, as there is risk of unwanted side effects.

Kidney
Consult your doctor- JANUMET 50/500MG TABLET is not recommended for use in patients with severely reduced kidney functions.
- It should be used cautiously in patients with mild to moderate kidney diseases.
- Regular medical checkups, proper dose adjustments and careful monitoring are required in such patients. Therefore, it is advisable to previously inform your doctor if you are suffering from pre-existing kidney diseases.

Liver
Consult your doctorJANUMET 50/500MG TABLET is not recommended for use in patients with severe liver problems. It should be used cautiously in patients with gallstones. Therefore, it is advisable to previously inform your doctor if you are suffering from pre-existing liver diseases.

Allergy
ContraindicatedDo not take JANUMET 50/500MG TABLET if you are allergic to metformin or sitagliptin or any other ingredients of this medicine.

Heart Disease
Use with CautionCaution to be taken before in patients with heart diseases.

Use In Pediatrics
ContraindicatedJANUMET 50/500MG TABLET is not advisable for use in children and adolescents (aged below 18 years) due to lack of safety data. Your child’s doctor will decide whether it is necessary or not based on your child’s health status.

Use In Geriatrics
Use with CautionJANUMET 50/500MG TABLET should be used cautiously in elderly patients (aged above 65 years), especially in those who are suffering from kidney and liver diseases. It is important to inform your doctor about all your pre-existing disease conditions as a precaution.
Other Warnings for JANUMET 50/500MG TABLET
Before taking JANUMET 50/500MG TABLET, inform your doctor if you:
- have or ever had pancreatitis (inflammation of the pancreas)
- have alcohol dependence
- have high blood lipid levels
- have type I diabetes mellitus (insulin-dependent diabetes)
- are about to have a major surgery
- are fasting
- are malnourished, starved, on an irregular diet, or feeling weak
- perform extreme muscle exercises
- have a vitamin B12 deficiency
Who should not take [GBNKEYWORD
JANUMET 50/500MG TABLET is not recommended for use if you:
- have severe, uncontrollable diabetes
- have nausea, vomiting, diarrhea, or rapid weight loss
- have lactic acidosis or ketoacidosis (a buildup of lactic acid or ketones in the body)
- are dehydrated
- have any severe systemic infection
- have shock or problems in blood circulation
- have problems in breathing
- are an alcoholic
- are scheduled for any X-rays in the upcoming days
Safety Advice
Expert Tips To Follow While taking JANUMET 50/500MG TABLET:
- Consistent Dosage Schedule to be Followed– Take JANUMET 50/500MG TABLET at the same time every day with meals to help minimize stomach upset and keep blood sugar levels stable.
- Regular Blood Sugar Monitoring – Keep track of your blood sugar levels frequently, especially during the initial stages of treatment. Adjust doses as advised by your doctor based on your readings.
- Healthy Diet Maintainence– Focus on a balanced, low-GI diet with fiber-rich foods and moderate carbohydrate intake to complement JANUMET 50/500MG TABLETaction and maintain optimal blood sugar control.
- Stay Hydrated – Drink plenty of water to help prevent dehydration and enhance Metformin's effectiveness, which may be affected by a lack of hydration.
- Regular Check-ups – Schedule routine visits with your doctor for kidney and liver function tests, as JANUMET 50/500MG TABLET can affect these organs over long-term use. Regular checks ensure safe and effective management of diabetes.
These tips can help maximize JANUMET 50/500MG TABLET effectiveness and manage any potential side effects.
Diet and Lifestyle Advice
What to Eat and Avoid? – Best Foods to Complement JANUMET 50/500MG TABLET Therapy
A diabetes-friendly diet is essential to maintain stable blood glucose levels and support JANUMET 50/500MG TABLET dual action in controlling blood sugar.
Best Foods for Diabetes (Low-GI and Fiber-Rich Diet):
- Non-starchy vegetables (spinach, broccoli, bell peppers, kale) – High in fiber, low in carbs.
- Whole grains (quinoa, brown rice, oats, whole wheat) – Rich in fiber, promoting slow glucose absorption.
- Lean proteins (chicken, fish, tofu, eggs, legumes) – Helps maintain muscle mass and stabilizes blood sugar.
- Healthy fats (avocados, nuts, seeds, olive oil) – Improves insulin sensitivity and supports heart health.
- Low-GI fruits (berries, apples, oranges, pears) – Provides natural sweetness without blood sugar spikes.
- Probiotic foods (Greek yogurt, kimchi, sauerkraut) – Supports gut health and enhances glucose metabolism.
Foods to Avoid (High-GI and Processed Foods):
- Refined carbohydrates (white bread, pasta, sugary cereals) – Causes rapid blood sugar spikes.
- Sugary foods & beverages (sweets, sodas, fruit juices) – Leads to insulin resistance over time.
- Fried and processed foods (fast food, chips, packaged snacks) – High in unhealthy fats and calories.
- Excessive red and processed meats – May contribute to inflammation and insulin resistance.
- Alcohol in excess – Can interfere with Metformin’s action and lead to low blood sugar episodes (hypoglycemia).
Best Exercises for Diabetes Management:
- Brisk walking (30–45 minutes daily) – Helps lower blood sugar naturally.
- Strength training (2–3 times a week) – Improves muscle mass and insulin response.
- Yoga and stretching – Reduces stress and improves glucose metabolism.
- Cycling or swimming – Low-impact cardio that supports heart health and weight loss.
Maintaining a healthy weight is essential, as excess body fat can lead to insulin resistance. Pairing JANUMET 50/500MG TABLET with regular exercise not only enhances its benefits but also reduces the risk of diabetes complications such as heart disease and nerve damage.
Hydration and Sugar Control – Why Drinking Enough Water Helps Metformin Work Better
Proper hydration is important for diabetes management, especially when taking Metformin-based medications like JANUMET 50/500MG TABLET. Water helps in:
- Flushing excess glucose through urine.
- Enhancing Metformin’s effect by aiding its metabolism.
- Preventing dehydration, which can lead to high blood sugar levels.
How Much Water to Drink?
- Aim for at least 8–10 glasses (2–2.5 liters) per day.
- Increase intake if sweating due to exercise or hot weather.
- Avoid sugary drinks, as they spike blood glucose levels.
By following a balanced diet, regular exercise, and proper hydration, JANUMET 50/500MG TABLET users can significantly improve their blood sugar control and overall diabetes management.
Drug - Drug interaction
JANUMET 50/500MG TABLET (Sitagliptin + Metformin) may interact with other medications, impacting blood sugar levels or increasing side effects.
Medications that Increase the Risk of Low Blood Sugar (Hypoglycemia):
- Insulin or Sulfonylureas (e.g., Glimepiride, Glyburide) – May cause excessive blood sugar lowering.
- Beta-Blockers (e.g., Propranolol, Metoprolol) – Can mask symptoms of hypoglycemia.
Drugs that Increase the Risk of Lactic Acidosis (Rare but Serious Side Effect of Metformin):
- Alcohol (Excessive Use) – Can increase the risk of lactic acidosis.
- Diuretics (e.g., Furosemide, Hydrochlorothiazide) – May lead to dehydration and increase metformin buildup.
- ACE Inhibitors (e.g., Lisinopril, Ramipril) – May alter kidney function and affect metformin clearance.
- Iodinated Contrast Agents (Used in CT Scans/X-rays) – May cause kidney damage; JANUMET 50/500MG TABLET should be stopped before imaging procedures.
Drugs that May Reduce the Effectiveness of JANUMET 50/500MG TABLET:
- Corticosteroids (e.g., Prednisone, Dexamethasone) – Can increase blood sugar levels.
- Thyroid Medications (e.g., Levothyroxine) – May reduce the blood sugar-lowering effect of JANUMET 50/500MG TABLET.
Drug - Food interaction
Foods interactions with While Taking JANUMET 50/500MG TABLET:
- Excessive Alcohol – Can increase the risk of lactic acidosis and severe hypoglycemia.
- High-Sugar Foods & Refined Carbs – May spike blood sugar levels, counteracting JANUMET 50/500MG TABLET effect.
- Grapefruit Juice – May affect Sitagliptin metabolism, potentially altering its effectiveness.
- High-Fat Meals – Can delay Metformin absorption, slightly reducing its effect.
More Information
Storage
- Keep JANUMET 50/500MG TABLET out of the sight and reach of children
- Store JANUMET 50/500MG TABLET below 30°C
FAQs About JANUMET 50/500MG TABLET
Q: What is JANUMET 50/500MG TABLET?
A: JANUMET 50/500MG TABLET is a prescription medication used to manage type 2 diabetes. It combines Sitagliptin (50mg) and Metformin (500mg), which work together to help lower blood sugar levels. Sitagliptin improves insulin production and reduces sugar production by the liver, while Metformin increases the body’s sensitivity to insulin and reduces sugar absorption in the intestines.
Q: Does JANUMET 50/500MG TABLET Cause Weight Changes?
A: JANUMET 50/500MG TABLET is not linked with significant weight gain. In fact, it may even help some people lose weight when used as part of a comprehensive diabetes management plan. Metformin, one of the key ingredients, is often linked to modest weight loss, especially when combined with diet and exercise.
Q: What If I Miss a Dose of JANUMET 50/500MG TABLET?
A: If you forget a dose of JANUMET 50/500MG TABLET, take it as soon as you remember, unless it’s almost time for your next dose. In that case, skip the missed dose—do not take two doses at once. Always follow the prescribed schedule to avoid fluctuations in blood sugar levels.
Q: Can I Take JANUMET 50/500MG TABLET with BP Medications?
A: Yes, you can take JANUMET 50/500MG TABLET with blood pressure (BP) medications, but it’s necessary to monitor your blood sugar and blood pressure levels regularly. Certain BP medications, like ACE inhibitors, may affect kidney function, so ensure your doctor is aware of all your medications to make proper adjustments.
Q: Can I Take JANUMET 50/500MG TABLET with Insulin?
A: JANUMET 50/500MG TABLET can be taken with insulin for better control of type 2 diabetes. In such cases, your doctor will adjust the dosages to avoid hypoglycemia (low blood sugar).
Q: Is JANUMET 50/500MG TABLET Safe for Elderly Patients?
A: JANUMET 50/500MG TABLET can be used safely by elderly adults, but dosage adjustments may be necessary based on kidney function and other health factors. Elderly patients should be monitored closely for any adverse effects, including potential issues with kidney function or low blood sugar.
Q: How Long Does JANUMET 50/500MG TABLET Take to Act?
A: JANUMET 50/500MG TABLET typically starts to lower blood sugar levels within hours of taking the first dose. However, it may take a few weeks to see full effects and achieve optimal blood sugar control. Consistency in taking the medication as prescribed, along with diet and exercise, is key for effectiveness.
Q: Are There Any Dietary Recommendations While on JANUMET 50/500MG TABLET ?
A: While taking JANUMET 50/500MG TABLET, it’s recommended to follow a balanced, low-GI diet rich in fiber, vegetables, and whole grains. Avoid high-sugar foods and processed carbs, which may counteract JANUMET 50/500MG TABLET blood sugar-lowering effects. Staying hydrated and eating smaller, more frequent meals can also help reduce any digestive discomfort associated with Metformin.
Q: What is the Initial Dose of JANUMET 50/500MG TABLET for Adults?
A: The initial dose of JANUMET 50/500MG TABLET is typically one tablet once or twice a day with meals. Your doctor may adjust the dosage based on blood sugar levels and individual needs. Always follow the recommended dosage instructions for the best results.
Q: Can I Take JANUMET 50/500MG TABLET with Other Diabetes Medications?
A: Yes, JANUMET 50/500MG TABLET can be taken with other diabetes medications, including insulin and sulfonylureas. However, dose adjustments may be needed to avoid low blood sugar (hypoglycemia). It’s important to discuss any other medications you are taking with your doctor to ensure they work well together.
Q: Is JANUMET 50/500MG TABLET Taken Once or Twice in a Day?
A: JANUMET 50/500MG TABLET is usually taken once or twice daily, depending on the prescribed dosage and your doctor’s recommendation. It’s generally best to take it with food to help minimize stomach upset and improve absorption.
Q: What is the Maximum Dosage of JANUMET 50/500MG TABLET?
A: The maximum dosage of JANUMET 50/500MG TABLET is typically two tablets per day, with each tablet containing 50mg Sitagliptin and 500mg Metformin. Your doctorr will suggest the best dose based on your blood sugar levels and medical history.
Q: Can JANUMET 50/500MG TABLET Dosage Be Increased if Blood Sugar is Not Controlled?
A: Yes, if blood sugar is not adequately controlled, your doctor may increase the dose of JANUMET 50/500MG TABLET or add other medications to your treatment plan. Regular blood sugar monitoring is important to determine if dosage adjustments are necessary.
Q: What Are the Common Side Effects of taking JANUMET 50/500MG TABLET?
A: The most common side effects of taking JANUMET 50/500MG TABLET include gastrointestinal issues like nausea, diarrhea, and flatulence. Some people may also experience mild headaches or dizziness. These side effects usually improve over time, but contact your doctor if they persist.
Q: Can JANUMET 50/500MG TABLET Cause Stomach Problems?
A: Yes, stomach problems such as nausea, diarrhea, and bloating are common side effects of Metformin (one of the key ingredients in JANUMET 50/500MG TABLET). These effects are temporary and can be minimized by taking the tablet with food. If symptoms persist, consult your doctor.
Q: What Should I Do if I Experience Low Blood Sugar on JANUMET 50/500MG TABLET?
A: If you experience low blood sugar (hypoglycemia), symptoms may include shakiness, sweating, dizziness, or confusion. Have fast-acting carbohydrates such as glucose tablets, juice, or hard candy. Seek medical attention immediately, if symptoms don’t improve.
Q: Does taking JANUMET 50/500MG TABLET Cause Headaches or Dizziness?
A: Headaches and dizziness can be mild side effects of JANUMET 50/500MG TABLET, especially when starting treatment. If these side effects are bothersome or persist, consult your doctor for adjustments.
Q: Can JANUMET 50/500MG TABLET Cause Kidney Problems?
A: Metformin can affect kidney function, especially in people with pre-existing kidney conditions. Regular kidney function tests are suggested during long-term use of JANUMET 50/500MG TABLET to ensure there are no issues.
References
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page-274 & 275.
2. Erin L. St. Onge, Shannon Miller and Elizabeth Clements. Sitagliptin/Metformin (Janumet) as Combination Therapy in the Treatment of Type-2 Diabetes Mellitus. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2012. [Accessed on 27th June 2025]
3. Chitrabhanu Ballav and Stephen C.L. Gough. Safety and Efficacy of Sitagliptin-Metformin in Fixed Combination for the Treatment of Type 2 Diabetes Mellitus. Libertas Academica. 2013. [Accessed on 27th June 2025]
4. Merck Sharp & Dohme (UK) Limited. Electronic Medicines Compendium (EMC) [Revised in February 2022] [Accessed on 27th June 2025]
5. Merck & Co., Inc. JANUMET® (sitagliptin and metformin hydrochloride) tablets, for oral use. [Revised in July 2022] [Accessed on 27th June 2025]
6. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 27th June 2025]
7. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 27th June 2025]
8. Organon Pharma (UK) Limited. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 27th June 2025]