INTRODUCTION

IVF M 75IU INJECTION contains Menotrophin which belongs to the group of medicines called Gonadotropins. It is used to treat infertility in both men and women. In women, it helps in egg (ovum) growth and stimulates the release of the matured eggs from the ovaries into the uterus. This helps in treating ovulation problems in women with polycystic ovarian disease (PCOD) especially in those who are not responding appropriately with other medicines (Ex. clomiphene citrate).

It also helps in the growth and development of several egg follicles in women undergoing fertility treatments. In men, it improves sperm count and corrects fertility problems.

Before receiving IVF M 75IU INJECTION inform your doctor if you have thyroid problems, adrenal gland problems, high blood prolactin levels, fibroids in uterus, any tumours in the breasts, uterus, testes, prostate, pituitary gland or hypothalamus, heavy vaginal bleeding, or blood clots. Your doctor may also ask you to reduce body weight to achieve better results.

You must also inform your doctor if you have any damage in the fallopian tubes, as treatment with IVF M 75IU INJECTION may cause ectopic pregnancy (pregnancy outside of the womb) in such cases.

IVF M 75IU INJECTION is not recommended for use in pregnant or breastfeeding women. The most common side effects of receiving IVF M 75IU INJECTION are stomach pain or swelling, nausea, headache, and injection site reactions (such as pain, redness, and swelling). Consult your doctor if they worsen.

USES OF IVF M 75IU INJECTION

Treats infertility in men and women
Promotes egg growth and release in women with PCOD
Helps women to produce multiple eggs prior to fertility treatments
Improves sperm count in men

HOW IVF M 75IU INJECTION WORKS

IVF M 75IU INJECTION stimulates your body to release sufficient amount of sex hormones (Estrogen and Progesterone in females and Testosterone in males) to maintain normal reproductive functions. In women, it helps in the growth and maturation of the eggs followed by their release from the ovaries into the uterus (ovulation). This improves the chances of pregnancy among women facing difficulties in becoming pregnant. In men, it improves the levels of testosterone (male hormone) which in turn improves sperm count and reduces fertility problems.

DIRECTIONS FOR USE

IVF M 75IU INJECTION will be given to you only by a doctor or a nurse into the muscles (intramuscularly) or under the skin (subcutaneously). It can also be self-administered by the patient if instructed by the doctor. Carefully follow the instructions given by your doctor in case of self-administration.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF IVF M 75IU INJECTION

COMMON

injection site reactions (pain, redness, itching or swelling)
headache
nausea
stomach pain or swelling
pelvic pain

UNCOMMON

vomiting, stomach discomfort, diarrhoea
tiredness, dizziness
hot flushes
breast enlargement and pain, nipple discharge

RARE

skin rash, acne

Contact your doctor immediately if you experience any of the following side effects after receiving IVF M 75IU INJECTION:

signs of ovarian hyperstimulation syndrome (such as lower abdominal pain with sensation of nausea or vomiting, weight gain, difficulty in breathing, difficulty in passing urine, enlarged ovaries and fluid build-up in chest or abdomen)
signs of allergic reactions (such as skin rash, itching, swelling of the eyes, face, lips, tongue or throat leading to difficulty in breathing or swallowing)

HOW TO MANAGE SIDE EFFECTS

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Injection Site Reactions

Place an ice pack on the affected area. Do not frequently move the injection site. Consult your doctor if the symptom did not improve.

Nausea And Vomiting

Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your symptom worsens.

WARNING & PRECAUTIONS

PREGNANCY

Contraindicated

IVF M 75IU INJECTION is not recommended for use in pregnant women. Therefore, consult your doctor before receiving it.

BREASTFEEDING

Contraindicated

IVF M 75IU INJECTION is not recommended for use in breastfeeding women. Therefore, consult your doctor before receiving it.

DRIVING AND USING MACHINES

Use with Caution

IVF M 75IU INJECTION does not affect your ability to drive or operate machinery. However, do not drive or handle any heavy tools or machines if your ability is affected by IVF M 75IU INJECTION.

ALCOHOL

Consult your doctor

Avoid consumption of alcohol before receiving IVF M 75IU INJECTION.

ALLERGY

Contraindicated

Talk to your doctor before receiving IVF M 75IU INJECTION if you are allergic to Menotrophin.

USE IN PEDIATRICS

Contraindicated

IVF M 75IU INJECTION is not intended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice before receiving it.

USE IN GERIATRICS

Use with Caution

IVF M 75IU INJECTION should be used with caution in elderly patients (aged 65 years or older). Therefore, consult your doctor before receiving it.

OTHERS

IVF M 75IU INJECTION is not recommended for use if you:

have any tumours in the breasts, uterus, pituitary gland or hypothalamus
have polycystic ovarian disease or enlarged ovaries
have undiagnosable vaginal bleeding
had an early menopause
have any malformation of sex organs that hinders pregnancy
have fibroids in the uterus
had uterus removal
have cancer in testicles or in prostate gland

Before receiving IVF M 75IU INJECTION, inform your doctor if you:

have an underactive thyroid gland
have an underactive adrenal gland (glands responsible for regulating sex hormones)
have hyperprolactinemia (high levels of a hormone called prolactin in blood)
have blood clots in the body or have a family history of blood clots
are overweight
have damaged fallopian tubes

INTERACTIONS

A. Drug-Drug interactions:

Before receiving IVF M 75IU INJECTION, inform your doctor if you are taking any of the following medicines:

Clomiphene citrate (another medicine used in the treatment of female infertility)

Overdosage:

IVF M 75IU INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

SYNOPSIS

Drug	:	Menotrophin
Pharmacological Category	:	Gonadotrophins
Therapeutic Indication	:	Infertility
Dosage Forms	:	Injection, Pre-filled syringes

MORE INFORMATION

Keep IVF M 75IU INJECTION out of reach of children
Store IVF M 75IU INJECTION at room temperature

FAQs ABOUT IVF M 75IU INJECTION

Q: What is the use of IVF M 75IU INJECTION?

A: GBNKEYWORD] is used to treat infertility in both men and women. It helps in egg (ovum) growth and egg release from the ovaries into the uterus. This helps in treating ovulation problems in women with polycystic ovarian disease (PCOD) and other reproductive problems. In men, improves sperm count and corrects fertility problems.

Q: How IVF M 75IU INJECTION works?

A: IVF M 75IU INJECTION stimulates your body to release sufficient amount of sex hormones (Estrogen and Progesterone in females and Testosterone in males) to maintain normal reproductive functions. In women, it helps in the growth and maturation of the eggs followed by their release from the ovaries into the uterus (ovulation). This improves the chances of pregnancy among women facing difficulties in becoming pregnant. In men, it improves the levels of testosterone (male hormone) which in turn improves sperm count and reduces fertility problems.

Q: How IVF M 75IU INJECTION is administered?

A: IVF M 75IU INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously) or under the skin (subcutaneously). It can also be self-administered by the patients if advised by the physician. Carefully, follow the instructions given by the doctor in case of self-administration.

Q: What precautions must be followed while receiving IVF M 75IU INJECTION?

A: Before receiving IVF M 75IU INJECTION inform your doctor if you have any unexplained vaginal bleeding, blood clot problems or any tumours in the testes, prostate, brain, breast, uterus or ovaries. You must also inform your doctor if you have any damage in the fallopian tubes, as treatment with IVF M 75IU INJECTION may cause ectopic pregnancy (pregnancy outside of the womb) in such cases. IVF M 75IU INJECTION should not be used in pregnant women after successful conception. Regularly visit your doctor and perform all blood tests and ultrasounds recommended by him/her without fail.

Q: Is IVF M 75IU INJECTION safe?

A: IVF M 75IU INJECTION is considered safe at the doses administered by the physician. However, consult your doctor if you experience any unusual side effects

Q: What are the common side effects of receiving IVF M 75IU INJECTION?

A: The most common side effects of receiving IVF M 75IU INJECTION are stomach pain, nausea, headache and injection site reactions (such as pain, redness, and swelling). Consult your doctor if they worsen.

Q: Can I stop receiving IVF M 75IU INJECTION once my symptoms subside?

A: Do not stop taking IVF M 75IU INJECTION without consulting your doctor. You need to receive IVF M 75IU INJECTION for the duration recommended by your doctor to achieve better results.

Q: Can I use IVF M 75IU INJECTION during pregnancy?

A: IVF M 75IU INJECTION is not recommended for use in pregnant women. Therefore, consult your doctor before receiving it.

Q: Can IVF M 75IU INJECTION be used in children?

A: IVF M 75IU INJECTION is not intended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice before receiving it.

REFERENCES

1. KD. Tripathi. Anterior Pituitary Hormones. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 241.

2. Jared C. Robins, M.D., Andrew F. Khair, Ph.D., M.B.A.,,∗ Eric A. Widra, M.D.,c Michael M. Alper, M.D.,d Winnie W. Nelson, Pharm.D., M.S., M.B.A.,b Eric D. Foster, Ph.D.,b Anshul Sinha, B.Tech.,b Masakazu Ando, Ph.D.,b Patrick W. Heiser, Ph.D.,b and Gaurang S. Daftary, M.D., M.B.A. Economic evaluation of highly purified human menotropin or recombinant follicle-stimulating hormone for controlled ovarian stimulation in high-responder patients: analysis of the Menopur in Gonadotropin-releasing Hormone Antagonist Single Embryo Transfer–High Responder (MEGASET-HR) trial. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2020. [Accessed on 10th February 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244378/

3. Ferring Pharmaceuticals Ltd. Menopur 75IU. Electronics Medicines Compendium. [Revised in August 2019]. [Accessed on 10th February 2023] https://www.medicines.org.uk/emc/files/pil.1294.pdf

4. Ferring Pharmaceuticals Ltd. Menopur 150IU. Electronics Medicines Compendium. [Revised in August 2019]. [Accessed on 10th February 2023] https://www.medicines.org.uk/emc/files/pil.4260.pdf

5. Ferring Pharmaceuticals Ltd. Menopur 600IU. Electronics Medicines Compendium. [Revised in March 2022]. [Accessed on 10th February 2023] https://www.medicines.org.uk/emc/files/pil.4595.pdf

6. Ferring Pharmaceuticals Ltd. REPRONEXÒ (MENOTROPINS FOR INJECTION, USP) FOR SUBCUTANEOUS INJECTION AND INTRAMUSCULAR INJECTION. U.S. Food and Drug Administration. [Accessed on 10th February 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/1999/21047lbl.pdf

USEFUL DIAGNOSTIC TESTS

Anti-Mullerian Hormone
Glycosylated Haemoglobin
Testosterone Total
Thyroid Stimulating Hormone

AUTHOR DETAILS

Written By Srilekha. R, B.Pharm
Last updated on 11 Feb 2023 | 06:41 PM(IST)

IVF M 75iu Injection 1's

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