ISTAVEL 50mg Tablet 10's
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Introduction About ISTAVEL 50MG TABLET
What is ISTAVEL 50mg Tablet?
ISTAVEL 50mg Tablet supports the management of blood sugar levels by enhancing the body's natural insulin response after meals and reducing excess sugar production by the liver. It belongs to a class of medicines called DPP-4 inhibitors that help regulate glucose levels in adults with type 2 diabetes mellitus.
Inform your doctor about existing medical conditions before using ISTAVEL 50mg Tablet. It is not recommended for individuals under 18 years of age. Do not exceed the prescribed dose or discontinue medication without consulting your doctor. Report any unusual symptoms or side effects to your healthcare provider promptly.
It is important to limit alcohol consumption while on ISTAVEL 50mg Tablet, as it can increase the risk of low blood sugar. You may need regular tests, such as kidney function and blood glucose levels, to ensure the medication is working effectively.
Effective glycemic management with ISTAVEL 50mg Tablet works best when combined with a balanced diet, regular exercise, and regular medical check-ups. This approach helps maintain overall metabolic health and supports a better quality of life.
The possible side effects are headache, nausea, or muscle discomfort. Serious side effects are rare but should be reported to a healthcare professional immediately.
Key Composition
- Sitagliptin 50mg
Uses Of ISTAVEL 50MG TABLET
- Manage Type II Diabetes mellitus
Benefits of ISTAVEL 50MG TABLET
- Helps maintain balanced blood glucose levels
- Can be used alone or alongside other diabetes care measures
- Generally weight-neutral without causing significant fluctuations
- Supports reduction of risks related to high blood sugar
Precautions and Important Information
- Inform your doctor about existing medical conditions before use
- Not recommended for individuals under 18 years of age
- Do not exceed the prescribed dose or discontinue medication without consulting your doctor
- Report any unusual symptoms or side effects to your healthcare provider promptly
How ISTAVEL 50mg Tablet Supports Blood Sugar Control
- ISTAVEL 50mg Tablet supports blood sugar control primarily through the active ingredient Sitagliptin, which belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors
- By preserving the action of incretin hormones, ISTAVEL enhances insulin release when blood sugar levels are elevated and manages unnecessary insulin secretion when blood sugar is normal or low, thereby minimizing the risk of hypoglycemia
How ISTAVEL 50MG TABLET Works
- ISTAVEL 50mg Tablet works in the body primarily by inhibiting the enzyme dipeptidyl peptidase-4 (DPP-4), which is responsible for breaking down incretin hormones such as GLP-1 (glucagon-like peptide-1) and GIP (gastric inhibitory peptide)
- By blocking DPP-4, ISTAVEL helps increase and prolong the action of incretins, resulting in higher insulin levels when blood sugar is elevated after meals, and reducing glucagon secretion to limit unnecessary glucose release from the liver. This glucose-dependent mechanism ensures that insulin is released primarily when needed, minimizing the risk of hypoglycemia
- ISTAVEL supports better insulin sensitivity in muscle and fat cells, improving glucose uptake and utilization by the body. Through these combined effects enhanced insulin secretion, decreased glucagon production, and improved peripheral glucose use
- ISTAVEL 50mg helps maintain more stable blood sugar levels throughout the day in people with type 2 diabetes
- Overall, ISTAVEL’s mechanism facilitates natural hormonal regulation of glucose metabolism, complementing lifestyle measures to support effective blood sugar control
Mechanism of ISTAVEL: Fasting vs. Postprandial Effects
- ISTAVEL 50mg Tablet (Sitagliptin) exhibits a dual mechanism of action that helps regulate blood sugar levels during both fasting and postprandial (after meal) states. During fasting periods, such as overnight or between meals, ISTAVEL reduces excessive glucose production by the liver by inhibiting the release of glucagon, a hormone that raises blood sugar. This action helps manage elevated blood glucose levels when the body is at rest
- Postprandially, after eating, ISTAVEL works by enhancing the levels of incretin hormones like GLP-1 (glucagon-like peptide-1) and GIP (gastric inhibitory peptide) which are naturally released in response to food intake. These hormones stimulate the pancreas to secrete insulin in a glucose-dependent manner. At the same time, ISTAVEL suppresses glucagon secretion, reducing unnecessary glucose release from the liver during this period
- By preserving incretin hormone activity through the inhibition of the DPP-4 enzyme, ISTAVEL supports a balanced insulin and glucagon response tailored to blood glucose levels throughout the day. This mechanism acts to lower both fasting and post-meal blood sugar without causing excessive insulin secretion or hypoglycemia. The combined fasting and postprandial effects support stable glycemic control, crucial for managing type 2 diabetes effectively
- Overall, ISTAVEL’s mode of action enhances the body’s natural glucose regulatory processes, maintains blood sugar within a healthier range, and complements lifestyle measures like diet and exercise to promote metabolic balance
How to use ISTAVEL 50MG TABLET
Take ISTAVEL 50mg Tablet once daily, at the same time each day, with or without food. Swallow the tablet whole with water as directed by your healthcare professional. Regular intake as prescribed helps achieve optimal blood sugar control.
1. Recommended Dosage for ISTAVEL 50mg Tablet
The typical dose recommended by doctors is 100mg once daily. However, for some patients, especially those with kidney problems, a lower dose of 50mg once daily may be prescribed. It is important to follow the dosage instructions provided by your healthcare provider based on your specific health condition and blood sugar levels.
2. Can ISTAVEL 50mg Tablet Be Taken With or Without Food?
ISTAVEL 50mg Tablet can be taken with or without food, providing flexibility to fit into your daily routine. It is advisable to take the medication at the same time every day to maintain consistent blood levels and optimize its effectiveness.
3. Is it safe to take ISTAVEL 50mg Tablet with food or on an empty stomach?
It is safe to take ISTAVEL 50mg Tablet with or without food. This flexibility allows patients to conveniently incorporate the medication into their daily routine without worrying about meal timings. However, for individuals who have a sensitive stomach, taking ISTAVEL 50mg Tablet with food might help reduce the chance of any stomach discomfort.
What if I forgot to take ISTAVEL 50MG TABLET
If you forget to take your dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take two doses at once to make up for the missed dose, as this could increase the risk of side effects like low blood sugar.
Side Effects Of ISTAVEL 50MG TABLET
Possible side effects
- Headache
- Nausea
- Muscle discomfort
When to consult your doctor?
- Severe allergic reactions
- Pancreatitis symptoms
- Kidney problems
- Hypoglycemia (low blood sugar)
- Severe joint pain
- Upper respiratory infections such as fever, persistent cough
How To Manage Side Effects
Headache
To manage headache associated with ISTAVEL 50mg Tablet, ensure adequate hydration, maintain regular sleep patterns, and avoid triggering factors such as stress or caffeine excess. Over-the-counter pain relievers like acetaminophen may be used after consulting with a healthcare provider. If headaches persist or become severe, medical consultation is necessary to rule out other causes and consider medication adjustments.
Muscle Spasms
For muscle discomfort, gentle stretching, light physical activity, and warm baths may provide relief. Monitoring the severity and frequency of muscle aches is important, and any severe or persistent muscle pain accompanied by weakness should prompt immediate medical evaluation.
Nausea And Vomiting
- Eat Small, Frequent Meals: Avoid heavy or greasy foods. Opt for bland foods like crackers, toast, or bananas.
- Stay Hydrated: Sip on clear fluids like water, ginger tea, or electrolyte drinks, Avoid caffeinated and carbonated beverages.
- Ginger: Ginger is a natural remedy for nausea. Try ginger tea, ginger candies, or ginger ale (ensure it contains real ginger).
- Avoid Strong Odors: Minimize exposure to smells that might trigger nausea, such as perfumes or cooking odors
Warning & Precautions
Pregnancy
Consult your doctorThere is limited information regarding its safety in pregnant women, so it is generally advised to consult a healthcare provider before using ISTAVEL 50mg Tablet, if you are pregnant or planning to become pregnant.
Breastfeeding
Consult your doctorIstavel 50mg Tablet may pass into breast milk, and its effects on a nursing infant are not well-established, hence breastfeeding mothers are usually advised to avoid this medication unless specifically instructed by their doctor.
Driving and Using Machines
Use with CautionDo not drive or operate any heavy machines if you experience any dizziness while using Istavel 50m Tablet.
Alcohol
Consult your doctorAlcohol consumption should be limited or avoided while taking ISTAVEL 50mg Tablet because alcohol can interfere with blood sugar control and increase the risk of hypoglycemia (low blood sugar), especially when combined with this medication.
Kidney
Use with CautionISTAVEL 50MG TABLET should be used with caution in patients with kidney disease and your dose will be adjusted if needed depending upon kidney function.
Allergy
ContraindicatedDo not take Istavel 50mg Tablet if you are allergic to Sitagliptin or any other ingredients of this medicine.
Use In Pediatrics
ContraindicatedISTAVEL 50MG TABLET is not recommended for use in children and adolescents (under 18 years of age).
Use In Geriatrics
Use with CautionISTAVEL 50MG TABLET should be used with caution in elderly patients (aged 65 years or above), especially in patients with impaired kidney function.
Other Warnings for ISTAVEL 50MG TABLET
Before taking ISTAVEL 50MG TABLET inform your doctor if you have:
- inflammation of pancreas
- gallstones
- excessive levels of fat in blood
- type 1 diabetes
- diabetic ketoacidosis
Safety Advice
- Follow your doctor's instructions regarding the exact dosage.
- Do not exceed the recommended daily dosage.
- It is important to follow the prescribed dosage for optimal results.
- Never adjust the dosage without your doctor’s approval.
- If you feel the medication is not working or experience side effects, consult your doctor immediately.
- The typical recommended dose of ISTAVEL 50MG TABLET for adults is 100mg once daily
- It can lead to hypoglycemia (low blood sugar) when taken with other antidiabetic medications, alcohol, or if a meal is delayed or missed.
- Always keep some sugary snacks or fruit juice with you in case you experience symptoms of hypoglycemia, like cold sweats, pale skin, shaking, or anxiety.
- Use caution when driving or operating machinery until you understand how ISTAVEL 50MG TABLET affects you.
- Let your doctor know if you experience joint pain or develop symptoms like stomach pain, nausea, or vomiting.
- It is important to keep exercising regularly, maintain a healthy diet, and continue taking your other diabetes medications alongside this one.
- The chances of weight gain and low blood sugar is lower compared to other diabetes medications.
- Make sure to check your blood sugar levels regularly while taking this medication.
Diet and Lifestyle Advice
What are some lifestyle and dietary recommendations for individuals taking ISTAVEL 50MG TABLET?
|
Category |
Recommendations |
|
ISTAVEL 50MG TABLET(Medication) |
ISTAVEL 50MG TABLET(Sitagliptin) is taken once daily, usually with or without food. It works by regulating blood sugar levels. Follow your healthcare provider's prescription guidelines. |
|
Diet |
1. Balanced Carbohydrates: Focus on whole grains, legumes, vegetables, and fruits. Limit refined sugars and processed carbs. |
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2. Low Glycemic Foods: Include foods like leafy greens, berries, nuts, and seeds to help stabilize blood sugar. |
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3. Lean Proteins: Choose lean meats, fish, tofu, and legumes. Avoid fatty meats or processed proteins. |
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4. Healthy Fats: Use olive oil, avocado, nuts, and seeds in moderation. Avoid trans fats and limit saturated fats. |
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5. Portion Control: Eating smaller, more frequent meals can help manage blood sugar levels. |
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Lifestyle |
1. Exercise: Aim for at least 150 minutes of moderate-intensity exercise per week (e.g., walking, swimming, cycling). |
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2. Stress Management: Stress can affect blood sugar. Practices like yoga, meditation, or deep breathing can help. |
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3. Sleep: Aim for 7-9 hours of quality sleep each night. Poor sleep can disrupt blood sugar control. |
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4. Regular Monitoring: Keep track of blood glucose levels regularly, as directed by your healthcare provider, to ensure ISTAVEL 50MG TABLET is working effectively. |
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Hydration |
Drink plenty of water. Dehydration can cause blood sugar levels to rise. Aim for 6-8 cups per day, more if exercising or in hot climates. |
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Weight Management |
Maintaining a healthy weight helps with insulin sensitivity. A balanced diet combined with regular exercise can help achieve and maintain weight loss. |
|
Alcohol Consumption |
If consuming alcohol, do so in moderation. Alcohol can cause blood sugar fluctuations, so it is important to monitor your levels after drinking. |
Drug - Drug interaction
|
Interacting Drug/Class |
Effect/Risk |
Precaution/Advice |
|
Insulin, Sulfonylureas |
Increased risk of low blood sugar (hypoglycemia) |
Monitor blood glucose, may need dose adjustments |
|
Metformin |
Generally safe, used in combination |
Monitor for side effects |
|
Digoxin |
Increased level of digoxin |
Clinical monitoring, may need dose adjustment |
|
CYP3A4 inhibitors (e.g., ketoconazole) |
May increase sitagliptin concentration |
Monitor for increased side effects |
|
Rifampin (antibiotic) |
May reduce sitagliptin effectiveness |
Frequent glucose monitoring, possible dose change |
|
Thiazide diuretics |
Possible effect on blood glucose control |
Blood sugar monitoring |
|
Alcohol |
Enhanced hypoglycemia risk when combined |
Limit/avoid alcohol, monitor symptoms |
|
Other DPP-4 inhibitors |
Excessive enzyme inhibition risk |
Avoid combination |
Drug - Food interaction
|
Food/Drink |
Interaction/Effect |
Advice |
|
Regular food |
No significant interaction; does not alter efficacy |
Take with or without food |
|
Alcohol |
Increased risk of hypoglycemia |
Limit/avoid, monitor blood sugar |
Synopsis
| Drug | : | Sitagliptin |
| Pharmacological Category | : | Dipeptidyl Peptidase-4 Inhibitors |
| Therapeutic Indication | : | Type-2 Diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
Storage
- Store at room temperature
- Keep out of reach of children
FAQs About ISTAVEL 50MG TABLET
Q: What is ISTAVEL 50MG TABLET used for?
A:ISTAVEL 50MG TABLET is primarily used to manage type 2 diabetes. It helps control blood sugar levels by regulating the amount of insulin the body produces after eating.
Q: How does ISTAVEL 50MG TABLET?
A: ISTAVEL 50MG TABLET works by inhibiting the enzyme DPP-4 (dipeptidyl peptidase-4), which helps to increase insulin release when blood sugar is high. It also decreases the amount of sugar the liver releases into the bloodstream.
Q: What is the recommended dosage for ISTAVEL 50MG TABLET?
A: The typical dosage of ISTAVEL 50MG TABLET is 100mg once a day, taken with or without food. Your doctor may adjust your dose based on your condition.
Q: Can I take ISTAVEL 50MG TABLET with other diabetes medications?
A: Yes, ISTAVEL 50MG TABLET can be taken in combination with other diabetes medications like metformin, insulin, or sulfonylureas. However, always follow your doctor's instructions for the best management plan.
Q: What are the common side effects of ISTAVEL 50MG TABLET?
A: Some common side effects of ISTAVEL 50MG TABLET include headache, upper respiratory infections, sore throat, and diarrhea. If you experience any severe side effects like low blood sugar (hypoglycemia) or swelling of the face, lips, or throat, seek medical attention immediately.
Q: Can ISTAVEL 50MG TABLET cause weight loss?
A: Weight loss is not a common side effect of ISTAVEL 50MG TABLET. However, some people may experience a slight weight reduction due to improved blood sugar control, but it is not typically significant.
Q: Is it safe to use ISTAVEL 50MG TABLET during pregnancy or breastfeeding?
A: The safety of ISTAVEL 50MG TABLET during pregnancy or breastfeeding is not well-established. It is important to consult your doctor to assess the risks and benefits if you are pregnant, planning to become pregnant, or breastfeeding.
Q: What should I do if I miss a dose of ISTAVEL 50MG TABLET?
A: If you miss a dose of ISTAVEL 50MG TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose as scheduled. Do not take two doses at once.
Q: Can ISTAVEL 50MG TABLET cause kidney problems?
A: ISTAVEL 50MG TABLET may affect kidney function, especially in people with pre-existing kidney problems. It is important to have regular kidney function tests while using ISTAVEL 50MG TABLET. Your doctor may adjust the dose if needed.
Q: Is ISTAVEL 50MG TABLET effective in lowering blood sugar levels?
A: Yes, when taken as prescribed, ISTAVEL 50MG TABLET is effective in lowering blood sugar levels by improving the body's insulin response after meals.
Q: What happens if I take too much ISTAVEL 50MG TABLET?
A: An overdose of ISTAVEL 50MG TABLET may lead to symptoms like low blood sugar (hypoglycemia). If you suspect an overdose, contact your doctor, or go to the nearest emergency room.
Q: How should I store ISTAVEL 50MG TABLET?
A: Store ISTAVEL 50MG TABLET at room temperature, away from moisture and heat. Keep them in their original packaging and out of reach of children.
Q: How long does it take for ISTAVEL 50MG TABLET to show effects?
A: ISTAVEL 50MG TABLET usually starts working within a few hours of taking it, but you may not notice immediate changes in your blood sugar levels. It can take 1 to 2 weeks to see a noticeable improvement in blood sugar control. However, the full therapeutic effects can take several weeks to manifest as your body adjusts to the medication.
Q: When should I take ISTAVEL 50MG TABLET, morning or night?
A: ISTAVEL 50MG TABLET can be taken at any time of the day, either in the morning or at night, as long as it’s taken consistently at the same time every day. It can be taken with or without food. The key is to follow your doctor’s advice and maintain a regular schedule for optimal effectiveness.
Q: Is Sitagliptin safe for long-term use?
A: Yes, Sitagliptin (the active ingredient) is generally considered safe for long-term use when taken as prescribed. However, like any medication, it may have potential risks over time. Long-term use requires regular monitoring of kidney function, blood sugar levels, and overall health. Always consult your doctor for personalized guidance and to ensure you are managing the medication properly.
Q: Where can I buy ISTAVEL 50MG TABLET online?
A: You can buy ISTAVEL 50MG TABLET online at Netmeds. Just visit their website and search for the product, and you will find options to purchase it directly from there.
References
1. Joseph T. DiPiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke, Barbara G. Wells, and L. Michael Posey. Diabetes Mellitus. Pharmacotherapy: A Pathophysiologic Approach. Eighth edition. Page-1263, 1264.
2. Plosker GL. Sitagliptin: A review of its use in patients with type 2 diabetes mellitus. NIH, National Library of Medicine, National Center for Biotechnology Information Pubmed.gov. February 2014. [Accessed on 13th November 2025] 
3. PubChem Compound Summary for CID 4369359, Sitagliptin. National Center for Biotechnology Information. May 2022. [Accessed on 13th November 2025] 
4. Merck Sharp & Dohme Corp. Sitagliptin. [Revised in December 2020] [Accessed on 13th November 2025]
5. Merck Sharp & Dohme Corp., Sitagliptin. [Revised in December 2021] [Accessed on 13th November 2025]
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