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INTRODUCTION ABOUT ISOLIN 2MG INJECTION
ISOLIN 2MG INJECTION contains Isoprenaline which belongs to the group of medicines called Sympathomimetics. It is used for the management of slow heart rate in patients who are waiting for the insertion of a pacemaker or when the use of pacemaker is contraindicated.
It is also used in sudden fainting with loss of consciousness caused by a slowing of heart rate, also called as Stokes-Adams syndrome. Your doctor might want you to take certain tests prior to the management with this medicine.
ISOLIN 2MG INJECTION is not recommended for use if you have certain heart rhythm disorders, forms of angina pectoris or digitalis intoxication, heart is stressed (atrial or ventricular hyperexcitability), heart attack, chest pain or irregular heartbeat (ventricular arrhythmia) that requires management.
Before receiving ISOLIN 2MG INJECTION inform your doctor if you have kidney, heart problems, diabetes, overactive thyroid gland, convulsive disorders or low blood volume. It should be used with caution in pregnant women. ISOLIN 2MG INJECTION is not recommended for use in breastfeeding women. The common side effects of ISOLIN 2MG INJECTION are nausea, headache, hot flashes. Consult your doctor if symptoms do not improve.
USES OF ISOLIN 2MG INJECTION
- Used to manage Adams Stokes attacks (sudden fainting and loss of consciousness)
- Used for the management of slow heart rate in patients waiting for the insertion of a pacemaker
HOW ISOLIN 2MG INJECTION WORKS
ISOLIN 2MG INJECTION activates beta-1 adrenergic receptors which lead to increased strength of contractility, conduction of nerve impulses, speed of relaxation and rate in the heart. Thus, increasing the blood pressure.
DIRECTIONS FOR USE
ISOLIN 2MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF ISOLIN 2MG INJECTION
COMMON
- increased heart rate
- nausea
- flushing
- headache
HOW TO MANAGE SIDE EFFECTS
Nausea:
Take routine meals and do not eat spicy or oily foods. Drink enough water. Consult your doctor if symptoms do not improve.
Headache:
Avoid bright lights, rest and relax. Apply balm on your forehead. Consult your doctor if symptoms do not improve.
WARNING & PRECAUTIONS
PREGNANCY
ISOLIN 2MG INJECTION should be used with caution in pregnant women or women planning to have a baby only if considered necessary by your doctor. Consult your doctor for advice.
BREASTFEEDING
ISOLIN 2MG INJECTION is not recommended in breastfeeding women. Consult your doctor for advice.
KIDNEY
ISOLIN 2MG INJECTION should be used with caution in patients with kidney disease. Consult your doctor for advice.
ALLERGY
Do not receive ISOLIN 2MG INJECTION if you are allergic to Isoprenaline or any other ingredients of this medicine.
HEART DISEASE
ISOLIN 2MG INJECTION is not recommended for use in patients with heart rhythm disorders, forms of angina pectoris or digitalis intoxication, when heart is stressed (atrial or ventricular hyperexcitability), heart attack, chest pain or irregular heartbeat (ventricular arrhythmia) that requires> management.
ISOLIN 2MG INJECTION should be used with caution in patients with heart problems. Consult your doctor for advice.
OTHERS
Before receiving ISOLIN 2MG INJECTION inform your doctor if you:
- have diabetes
- have overactive thyroid gland
- have convulsive disorders
- have low blood volume
Use in paediatrics:
Safety and efficacy of ISOLIN 2MG INJECTION has not been established in children.
INTERACTIONS
A. Drug-Drug interactions:
Before receiving ISOLIN 2MG INJECTION inform your physician if you are taking any of the following medicines:
- other cardiac or central nervous system stimulants
- adrenaline, digitalis (a medicine used in intensive care to manage heart problems)
- monoamine oxidase inhibitors (MAOIs) (Ex. isocarboxazid), imipramine (medicines used to manage depression)
- sulphates, such as salicylamide (painkiller)
- entacapone (used for Parkinson’s disease)
- doxapram (used in intensive care to increase respiratory rate)
- ergotamine (to manage acute migraine attacks)
- sympathomimetic vasoconstrictors (such as oxytocin) used during labor
- chloroform, cyclopropane or halothane anaesthetics (used in surgery)
Overdosage:
ISOLIN 2MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and so you are unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms nausea, headaches, extra heart beats and heart rate acceleration.
SYNOPSIS
| Drug | : | Isoprenaline |
| Pharmacological Category | : | Non-selective beta-adrenergic receptor agonist |
| Therapeutic Indication | : | Slow heart rate, Stokes-Adams syndrome |
| Dosage Forms | : | Injection |
MORE INFORMATION
- Keep out of reach of children
- Store at 20-25°C
FAQs ABOUT ISOLIN 2MG INJECTION
Q: Is ISOLIN 2MG INJECTION addictive?
A: No, ISOLIN 2MG INJECTION is not an addictive. It is a non-selective beta-adrenergic receptor agonist. Consult your doctor for more information on the dose and duration.
Q: How does ISOLIN 2MG INJECTION work?
A: ISOLIN 2MG INJECTION activates beta-1 adrenergic receptors which lead to increased strength of contractility, conduction of nerve impulses, speed of relaxation and rate in the heart. Thus, increasing the blood pressure.
Q: What is ISOLIN 2MG INJECTION used for?
A: ISOLIN 2MG INJECTION is used for the management of slow heart rate in patients who are waiting for the insertion of a pacemaker or when the use of pacemaker is contraindicated. It is also used in sudden fainting with loss of consciousness caused by a slowing of heart rate, also called as Stokes-Adams syndrome.
Q: Can ISOLIN 2MG INJECTION be used in pregnancy?
A: ISOLIN 2MG INJECTION should be used with caution in pregnant women or women planning to have a baby only if considered necessary by your doctor. Consult your doctor for advice.
Q: Can ISOLIN 2MG INJECTION be used in children?
A: Safety and effectiveness of ISOLIN 2MG INJECTION in children has not been established yet. Consult your doctor for advice before receiving this medicine.
REFERENCES
1. KD. Tripathi. Adrenergic system and drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 131-135.
2. Thomas C Westfall and David P. Westfall. Adrenergic agonists and antagonists. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 250.
3. S Mostafa Shid Moosavi, Edward J Johns. The effect of isoprenaline infusion on renal renin and angiotensinogen gene expression in the anaesthetised rat. NIH National Library of Medicine, National Centre for Biotechnology information. Pubmed.gov. March 2003. [Accessed on 18th March 2022] https://pubmed.ncbi.nlm.nih.gov/12621527/
4. H Hatzinikolaou, L M Rodriguez, J L Smeets, C Timmermans, G Vrouchos, G Grecas, H J Wellens. Isoprenaline and inducibility of atrioventricular nodal re-entrant tachycardia. NIH National Library of Medicine, National Centre for Biotechnology information. Pubmed.gov. February 1998. [Accessed on 18th March 2022] https://pubmed.ncbi.nlm.nih.gov/9538310/
5. s.a.l.f. Laboratorio Farmacologico S.p.A. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 18th March 2022] https://www.medicines.org.uk/emc/files/pil.12511.pdf, https://www.medicines.org.uk/emc/product/12511/smpc
6. Hospira, Inc., U.S Food and Drug Administration. [Revised on March 2013] [Accessed on 18th March 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/010515s031lbl.pdf
7. Drugbank. Isoprenaline. [Revised in January 2022] [Accessed on 18th March 2022] https://go.drugbank.com/drugs/DB01064
USEFUL DIAGNOSTIC TESTS
- Electrolytes Profile
- Electrocardiogram (ECG)
- Blood pressure
AUTHOR DETAILS
