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Introduction About ISOGEN 125MG CAPSULE
ISOGEN 125MG CAPSULE contains Palbociclib which belongs to the group of medicines called Kinase inhibitors. It is used to manage men and women with certain types of breast cancer (hormone receptor-positive, human epidermal growth factor receptor 2-negative) which have spread beyond the original tumour or to other organs. Also, for women, it is given together with aromatase inhibitors or flustering who have received prior endocrine therapy.
In pre- or perimenopausal women, endocrine therapy should be combined with a luteinizing hormone-releasing hormone (LHRH) agonist. Breast cancer is defined as a malignancy (abnormal cells divide without control and can invade nearby tissues) originating from breast tissue, with symptoms like a painless lump and swelling, redness, warmth, and hardening of the skin.
Before taking ISOGEN 125MG CAPSULE, inform your doctor if you have liver, lung, heart, or kidney problems. ISOGEN 125MG CAPSULE is not recommended for use during pregnancy and breastfeeding; therefore, consult your doctor before taking it. ISOGEN 125MG CAPSULE is not recommended in children and adolescents (below the age of 18 years).
The most common side effects of taking ISOGEN 125MG CAPSULE are infections, tiredness, rash, hair loss, decreased appetite, inflammation of the mouth and lips, nausea, vomiting, diarrhoea, weakness, fever, and dry skin. Contact your doctor if any of your symptoms get worse or persist.
Uses Of ISOGEN 125MG CAPSULE
- Manage certain types of breast cancer (hormone receptor-positive, human epidermal growth factor receptor 2-negative) that have spread beyond the original tumour or to other organs
How ISOGEN 125MG CAPSULE Works
ISOGEN 125MG CAPSULE blocks certain proteins (cyclin-dependent kinase 4 and 6) that regulate cell growth and division. Blocking these proteins can slow down the growth of cancer cells and delay the advancement of your cancer.
How to use ISOGEN 125MG CAPSULE
Take ISOGEN 125MG CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will determine the correct dose and duration for you depending on your age, body weight, and disease condition. Do not stop taking ISOGEN 125MG CAPSULE unless your doctor advises you to stop.
Overdose
If you or anyone else accidentally take too much of ISOGEN 125MG CAPSULE, consult your doctor immediately or visit the nearby hospital.
Side Effects Of ISOGEN 125MG CAPSULE
Common side effects of ISOGEN 125MG CAPSULE:
- infections
- drop in the number of white blood cells, red blood cells, and blood platelets
- tiredness
- decreased appetite
- inflammation of the mouth and lips, nausea, vomiting, diarrhoea
- rash
- hair loss
- weakness
- fever
- abnormalities in liver tests
- dry skin
- blurred vision, increased tearing, dry eye
- altered taste
- nosebleed
Stop taking ISOGEN 125MG CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- serious blood disorder (fever, chills, weakness, shortness of breath, bleeding, or easy bruising)
- inflammation of the lungs (difficulty breathing, dry cough or chest pain)
How To Manage Side Effects
Diarrhea
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.
Nausea And Vomiting
Take ISOGEN 125MG CAPSULE with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like it, you do not need to eat or avoid any specific foods. Do not take any medicine for vomiting without asking your doctor.
Warning & Precautions
Pregnancy
ContraindicatedISOGEN 125MG CAPSULE is not recommended for use in pregnant women. Women of childbearing potential taking this medicine or their male partners should use adequate contraceptives. Consult your doctor before taking it.
Breastfeeding
ContraindicatedISOGEN 125MG CAPSULE is not recommended during breastfeeding, as it is not known if it is excreted in breast milk. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you experience tiredness after taking ISOGEN 125MG CAPSULE.
Kidney
Use with CautionISOGEN 125MG CAPSULE should be taken with caution in patients with kidney impairment. Consult your doctor before taking it.
Liver
Use with CautionISOGEN 125MG CAPSULE should be taken with caution in patients with liver impairment. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take ISOGEN 125MG CAPSULE if you are allergic to Palbociclib.
Use In Pediatrics
ContraindicatedISOGEN 125MG CAPSULE is not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before taking it.
Other Warnings for ISOGEN 125MG CAPSULE
Before taking ISOGEN 125MG CAPSULE, inform your doctor if you:
- have fertility problems (in men)
Drug - Drug interaction
Before taking ISOGEN 125MG CAPSULE, inform your doctor if you are taking any of the following medicine:
- medicines used to manage viral infections (Ex. lopinavir, indinavir, nelfinavir, ritonavir, telaprevir, saquinavir)
- medicines used to manage bacterial infections (Ex. clarithromycin and telithromycin)
- medicines used to manage fungal infections (Ex. voriconazole, itraconazole, ketoconazole, posaconazole)
- nefazodone (used to manage depression)
- quinidine (used to manage irregular heartbeat)
- colchicine (used to manage gout)
- medicines used to lower blood cholesterol levels (Ex. pravastatin, rosuvastatin)
- sulfasalazine (used to manage ulcerative colitis)
- medicines used to manage severe pain (Ex. alfentanil, fentanyl)
- medicines used after organ transplant (Ex. cyclosporine, everolimus, tacrolimus, sirolimus)
- medicines used to manage migraine (Ex. dihydroergotamine and ergotamine)
- pimozide (used to manage motor or verbal tics)
- digoxin (used to manage heart insufficiency)
- dabigatran (used to manage blood clots)
- medicines used to manage fits (Ex. carbamazepine and phenytoin)
- enzalutamide (used to manage prostate cancer)
- rifampin (used to manage tuberculosis)
- St. John’s Wort (used to manage depression)
Drug - Food interaction
Avoid drinking grapefruit juice while taking ISOGEN 125MG CAPSULE as it may increase the risk of side effects.
Synopsis
|
Drug |
Palbociclib |
|
Pharmacological Category |
Cyclin-dependent kinase (CDK) 4/6 inhibitor |
|
Therapeutic Indication |
Breast cancer |
|
Dosage Forms |
Capsule |
More Information
Storage
- Keep ISOGEN 125MG CAPSULE out of reach of children
- Store below 30°C
FAQs About ISOGEN 125MG CAPSULE
Q: Can ISOGEN 125MG CAPSULE be used by men?
A: Yes. ISOGEN 125MG CAPSULE is used by men to manage certain types of breast cancer that have spread beyond the original tumour or to other organs. If you have any questions about how this medicine works or why it has been given to you, ask your doctor.
Q: Can ISOGEN 125MG CAPSULE increase the risk of infections?
A: ISOGEN 125MG CAPSULE may cause a drop in the number of white blood cells and weaken your immune system. Therefore, you may be at greater risk of getting infected while you are taking it. You will have regular blood tests during the management to check if ISOGEN 125MG CAPSULE affects your blood cells. Inform your doctor if you get any signs or symptoms of an infection, like a fever.
Q: Can ISOGEN 125MG CAPSULE cause diarrhoea?
A: Yes. Diarrhoea is a common side effect of ISOGEN 125MG CAPSULE. Drink lots of fluids, such as water or fruit juice, to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. If you experience persistent diarrhoea, consult your doctor.
Q: Can I take ISOGEN 125MG CAPSULE on an empty stomach?
A: Take ISOGEN 125MG CAPSULE as advised by your physician. It may be taken with food, preferably a meal, to ensure consistent exposure to the medicine. Avoid drinking grapefruit juice while taking ISOGEN 125MG CAPSULE as it may increase the risk of side effects.
Q: Can I plan to have a baby while taking ISOGEN 125MG CAPSULE?
A: You should avoid having a baby while taking ISOGEN 125MG CAPSULE. Women of childbearing potential taking this medicine or their male partners should use adequate contraceptives. These methods should be used during management and for at least 3 weeks after completing therapy for females and for at least 14 weeks for males. Discuss contraception with your doctor while you are taking this medicine.
Q: Does ISOGEN 125MG CAPSULE affect male fertility?
A: ISOGEN 125MG CAPSULE may decrease fertility in men. Therefore, men may consider sperm preservation before taking this medicine. Consult your doctor regarding any further queries.
Q: What if I forget to take a dose of ISOGEN 125MG CAPSULE?
A: If you forget to take a dose of ISOGEN 125MG CAPSULE or vomit, take it as soon as you remember. Do not take the medicine twice to make up for the forgotten dose.
References
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Breast Cancer. Pharmacotherapy Handbook. Ninth edition. Page-619.
2. M/s. Pfizer Manufacturing Deutschland GmbH Betriebsstatte. Palbociclib. [Revised in October 2021] [Accessed on 27th Augsut 2026] 
3. Palbociclib. Chemocare. [Accessed on 27th Augsut 2026] 