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Introduction About INDO MG INJECTION
INDO MG INJECTION contains Indomethacin which belongs to the group of medicines called Non-Steroidal Anti-Inflammatory Drugs. It is indicated for the management of (closure) of patent ductus arteriosus in premature infants (weighing 500-1750 g) when the usual 48 hours medical management such as respiratory support, fluid restriction, diuretics, digitalis, etc. becomes ineffective.
Patent ductus arteriosus (PDA) is an opening between two blood vessels leading from the heart connected to the lungs which fails to close after birth. It is characterised by fast breathing, respiratory distress, shortness of breath, murmur, or fast heart rate.
The child should be monitored carefully at regular intervals to access the response of the therapy. INDO MG INJECTION is contraindicated in neo- nates with proven or suspected infection that is unmanageed, have active intracranial haemorrhage or gastrointestinal bleeding, thrombocytopenia, or coagulation defects.
It is also not recommended in neo- nates who have necrotizing enterocolitis (inflammation of baby’s intestine), impairment of kidney function or congenital heart disease where the patency of ductus arteriosus is necessary for satisfactory pulmonary or systemic blood flow. The most common side effect of INDO MG INJECTIONis injection site reaction such as pain, irritation, or bleeding. Inform the doctor immediately if your child experiences any other unusual side effects.
Uses Of INDO MG INJECTION
- it is used to close patent ductus arteriosus in premature infants (weighing 500-1750 g) when the usual 48 hours medical management becomes ineffective
How INDO MG INJECTION Works
INDO MG INJECTION works by managing the function of enzyme cyclooxygenase-1 and 2 which leads to the stopping of prostaglandins synthesis (chemical substances responsible for pain & inflammation) that results in reduced inflammatory reactions and relief from pain.
How to use INDO MG INJECTION
INDO MG INJECTION will be administered to a pre-mature infant only by a doctor or nurse into the vein (intravenously). The correct dose and duration of the therapy will be decided by the doctor depending upon the age, body weight and diseases condition of the infant at the time of therapy.
Side Effects Of INDO MG INJECTION
Common
- pain, irritation, or bleeding at the site of injection
- bleeding problems
Warning & Precautions
Pregnancy
INDO MG INJECTION is intended only for use in pre-mature infants.
Breastfeeding
INDO MG INJECTION is intended only for use in pre-mature infants.
Kidney
INDO MG INJECTION is not recommended for use in pre-term infants with significant impairment of renal function. Consult your doctor for advice.
Allergy
INDO MG INJECTION is not recommended for use in infant with known allergy or hypersensitivity to Indomethacin or any other ingredients of this medicine.
Heart Disease
INDO MG INJECTION is not recommended for use in pre-term infants having heart diseases such as any other congenital heart disease (such as pulmonary atresia, severe tetralogy of Fallot, severe coarctation of the aorta) where the patency of ductus arteriosus is necessary for satisfactory pulmonary or systemic blood flow.
Others
INDO MG INJECTION is not recommended for use in pre-term infants who:
- have proven or suspected infection that is unmanageed
- have bleeding (Ex. active intracranial hemorrhage or gastrointestinal bleeding)
- have thrombocytopenia (low platelet count) or coagulation defects (blood clotting problems)
- are suspected of having necrotizing enterocolitis (inflammation/perforation of intestinal tissues in premature babies)
Use in pediatrics:
INDO MG INJECTION is recommended for use in premature infants (weighing 500-1750 g). Consult your doctor before receiving INDO MG INJECTION.
Use in geriatrics:
INDO MG INJECTION is intended only for use in pre-mature infants only.
Interactions
A. Drug Interactions:
Before using INDO MG INJECTION, inform your doctor if you are taking any of the following medicines:
- digoxin (medicine used to manage heart failure)
- gentamicin, amikacin (medicine used to manage infections)
- furosemide (used to increase urine output)
- anticoagulants like warfarin, heparin (medicines used for blood thinning)
- other non-steroidal anti-inflammatory drugs (Ex. ibuprofen, aspirin)
- losartan, enalapril, ramipril (medicines used to manage high blood pressure)
Overdosage:
INDO MG INJECTION will be administered only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if there are any unusual symptoms.
Synopsis
| Drug | : | Indomethacin |
| Pharmacological Category | : | Non-Steroidal Anti-Inflammatory Drugs (Non-Selective COX-1 Inhibitor) |
| Therapeutic Indication | : | Patent ductus arteriosus |
| Dosage Forms | : | Tablet, Capsule, Injection, Gel, suppository |
More Information
- Keep out of reach of children
- Store at 25°C protected from light
FAQs About INDO MG INJECTION
What are the uses of INDO MG INJECTION?
INDO MG INJECTION is used to manage patent ductus arteriosus (heart defect caused during development of heart) in premature infants (weighing 500-1750 g) when the usual 48 hours medical management becomes ineffective.
What is patent ductus arteriosus?
Patent ductus arteriosus is a congenital heart defect mostly commonly seen in premature infants that develops soon after birth. It is characterised by a hole between the blood vessels of heart that affects the blood flows through a baby's lungs.
How INDO MG INJECTION works?
INDO MG INJECTION works by managing the function of enzyme cyclooxygenase-1 and 2 which leads to the stopping of prostaglandins synthesis (chemical substances responsible for pain & inflammation) that results in reduced inflammatory reactions and relief from pain.
Does INDO MG INJECTION be given to pregnant and breast-feeding woman?
INDO MG INJECTION is recommended for use only in premature infants. Therefore, it is not suitable for use in pregnant and breast-feeding woman. Consult your doctor.
Can INDO MG INJECTION be used in patients with heart disease?
INDO MG INJECTION is not recommended for use in pre-term infants having heart diseases such as any other congenital heart disease (such as pulmonary atresia, severe tetralogy of Fallot, severe coarctation of the aorta) where the patency of ductus arteriosus is necessary for satisfactory pulmonary or systemic blood flow.
References
1. KD. Tripathi. Nonsteroidal Anti-inflammatory Drugs and Antipyretic-Analgesics. Essentials of medical pharmacology. Eighth edition. 2013. Page – 211.
2. Akul Munjal; Abdallah E. Allam. Indomethacin. National Library of Medicine, National center for biotechnology information. Statpearls. September 2022. [Accessed 16th June 2022] https://www.ncbi.nlm.nih.gov/books/NBK555936/
3. Palmer G. Johnston, MD, Maria Gillam-Krakauer, MD, M. Paige Fuller, PharmD, BCPS, and Jeff Reese, MD. Evidence-Based Use of Indomethacin and Ibuprofen in the Neonatal Intensive Care Unit. National Library of Medicine, National center for biotechnology information. March 2013. [Accessed 16th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598606/
4. Hollister-Stier Laboratories, LLC. U.S. Food & Drug Administration (USFDA). [Revised in October 2009] [Accessed on 16th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/018878s027lbl.pdf
5. APP Pharmaceuticals, LLP. U.S. Food & Drug Administration (USFDA). [Revised in March 2010]. [Accessed on 16th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022536lbl.pdf
Useful Diagnostic Tests
- Echocardiogram
- Electrocardiogram
- Chest Xray
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