IMEGLYN 500 Tablet 10's

Introduction About IMEGLYN 500 TABLET

IMEGLYN 500 Tablet contains Imeglimin Hydrochloride 500 mg, an oral antidiabetic medicine prescribed for the management of type 2 diabetes mellitus in adults. It is generally recommended when diet and regular physical activity alone are insufficient to maintain blood glucose levels within the desired range. The medicine may be prescribed alone or alongside other antidiabetic medicines, depending on individual medical requirements and the doctor's assessment.

Imeglimin works through multiple mechanisms involved in glucose regulation. It helps improve insulin secretion in response to elevated blood glucose levels and enhances the body's sensitivity to insulin. It also influences mitochondrial functions involved in cellular energy metabolism, supporting better blood glucose regulation. These actions help maintain glucose balance when used as part of an appropriate diabetes management plan.

IMEGLYN 500 Tablet should be used under medical supervision, particularly in individuals with kidney-related conditions or other underlying health concerns. Patients with a history of severe ketosis, diabetic coma, type 1 diabetes, or severe infections should inform their doctor before starting this medicine. Regular monitoring of blood glucose levels and kidney function may be recommended during its use. Individuals taking other antidiabetic medicines should also inform their doctor to help assess the risk of low blood glucose levels.

IMEGLYN 500 Tablet should be taken exactly as directed by the doctor. The tablet should be swallowed whole with water and may be taken with or without food, as advised. The dosage and duration depend on individual blood glucose levels, kidney function, and the overall diabetes management plan. Patients should not change the prescribed dose or stop taking the medicine without consulting their doctor. During pregnancy or breastfeeding, its use should be discussed with a doctor to evaluate its suitability and potential risks.

The commonly reported side effects of IMEGLYN 500 Tablet may include nausea, diarrhoea, constipation, weakness, and symptoms associated with low blood glucose, such as excessive hunger and sweating. The likelihood of low blood glucose may increase when the medicine is used with certain other antidiabetic medicines. If any side effect persists, becomes troublesome, or is accompanied by symptoms of severe low blood glucose, seek medical advice promptly.

Uses Of IMEGLYN 500 TABLET

It is used to manage:

• Type 2 diabetes mellitus (high blood glucose levels)

Benefits of IMEGLYN 500 TABLET

Supports Mitochondrial Function

Imeglimin influences mitochondrial processes involved in cellular energy metabolism, which are important for normal glucose regulation.

Supports Glucose-Responsive Insulin Secretion

Imeglimin helps support insulin release from pancreatic beta cells in response to glucose, contributing to the body's natural glucose-regulating processes.

Influences Insulin Sensitivity

Imeglimin may improve the body's response to insulin, supporting the processes involved in glucose uptake and utilisation.

Supports Glucose Metabolism

By influencing insulin secretion and insulin action, Imeglimin acts on complementary pathways involved in maintaining glucose balance.

How IMEGLYN 500 TABLET Works

Action on Mitochondrial Energy Metabolism

Imeglimin influences mitochondrial processes involved in cellular energy production, which play a role in the body's metabolic functions.

Regulation of Insulin Secretion

Imeglimin supports glucose-responsive insulin release from pancreatic beta cells, helping regulate the body's insulin response to changing glucose levels.

Improvement of Insulin Action

Imeglimin may enhance insulin-mediated activity in body tissues, influencing how glucose is taken up and utilised by cells.

Overall Mechanism of Action

Imeglimin acts on pathways associated with mitochondrial function, insulin secretion, and insulin action. Its precise molecular mechanism is not fully established.

How to use IMEGLYN 500 TABLET

Recommended Dosage

• Take IMEGLYN 500 Tablet in the dose and frequency prescribed by your doctor.
• Follow your doctor's instructions regarding dosage adjustments based on your individual requirements and kidney function.

How to Take IMEGLYN 500 Tablet

• Swallow the tablet with water, following the product-specific instructions.
• Do not crush, chew, or break the tablet unless advised by your doctor or permitted by the product instructions.

When to Take IMEGLYN 500 Tablet

• Take the medicine according to the schedule prescribed by your doctor.
• Maintain a consistent dosing routine as instructed.

Taking IMEGLYN 500 Tablet With or Without Food

• Follow the food-related instructions provided with the medicine.
• Ask your doctor or pharmacist if you are unsure whether to take it before, during, or after meals.

What if I forgot to take IMEGLYN 500 TABLET

• Follow the missed-dose instructions in the package leaflet or consult your doctor.
• Do not take an extra dose to compensate for a missed dose.

Side Effects Of IMEGLYN 500 TABLET

Common Side Effects

• Nausea
• Vomiting
• Diarrhoea
• Abdominal discomfort
• Constipation
• Weakness or fatigue

WHEN TO CONSULT A DOCTOR:

• Symptoms of severe low blood glucose, such as confusion, fainting, or seizures, particularly when taking other antidiabetic medicines
• Severe or persistent vomiting or diarrhoea
• Signs of a serious allergic reaction, such as swelling of the face or throat or difficulty breathing
• Severe abdominal discomfort accompanied by unusual weakness or rapid breathing
• Persistent or worsening side effects that interfere with daily activities

How To Manage Side Effects

Diarrhea

• Drink lots of fluids, such as water or fruit juices, to keep yourself hydrated. Do not take any medicine on your own to manage diarrhea. Contact your doctor if your diarrhea does not improve.

Nausea And Vomiting

• Eat Small, Frequent Meals: Eat smaller meals throughout the day instead of having large meals at once.
• Choose Light Foods: Prefer bland foods such as toast, rice, or crackers and avoid oily or spicy foods.
• Stay Hydrated: Drink water regularly in small sips to maintain hydration.
• Avoid Strong Smells: Stay away from strong food odours that may worsen nausea.
• Consult Your Doctor: Seek medical advice if nausea persists or interferes with your daily activities.

Warning & Precautions

Pregnancy

Use with Caution

IMEGLYN 500 Tablet should be used during pregnancy only if specifically recommended by your doctor after carefully assessing the potential risks and benefits. Consult your doctor before taking this medicine .

Breastfeeding

Consult your doctor

IMEGLYN 500 Tablet should be used while breastfeeding only if recommended by your doctor after assessing the potential risks and benefits. Consult your doctor before taking this medicine.

Driving and Using Machines

Use with Caution

Do not drive or operate machinery if you experience dizziness, weakness, or any other symptoms that may affect your alertness while taking IMEGLYN 500 Tablet. Consult your doctor if these symptoms persist or interfere with your daily activities.

Alcohol

Consult your doctor

Avoid consuming alcohol while taking IMEGLYN 500 Tablet, as it may affect blood glucose regulation and increase the risk of metabolic complications. Consult your doctor for further advice if you have any underlying health conditions.

Kidney

Use with Caution

IMEGLYN 500 Tablet should be used with caution in patients with impaired kidney function, as the medicine is primarily eliminated through the kidneys. Inform your doctor if you have kidney disease, as kidney function assessment may be required before and during use.

Liver

Consult your doctor

Inform your doctor if you have liver disease before taking IMEGLYN 500 Tablet. Your doctor will assess your condition and determine whether this medicine is suitable for you and whether additional monitoring is required during use.

Allergy

Contraindicated

Do not take IMEGLYN 500 Tablet if you are allergic to imeglimin or any of its ingredients. Inform your doctor about previous allergic reactions to medicines. Seek immediate medical attention if you develop facial swelling, throat swelling, or difficulty breathing.

Lungs

Consult your doctor

IMEGLYN 500 Tablet should be taken only after consulting your doctor if you have a serious respiratory condition associated with reduced oxygen levels, as this may increase the risk of lactic acidosis.

Heart Disease

Consult your doctor

IMEGLYN 500 Tablet should be taken only after consulting your doctor if you have serious heart disease or cardiovascular complications, as reduced blood circulation or oxygen supply to tissues may increase the risk of metabolic complications.

Use In Pediatrics

Contraindicated

IMEGLYN 500 Tablet is not recommended for children unless specifically advised by a specialist, as its safety and effectiveness in paediatric patients have not been established.

Use In Geriatrics

Consult your doctor

IMEGLYN 500 Tablet should be used under medical supervision in older adults, as age-related changes in kidney function may affect the elimination of imeglimin. Kidney function and overall medical suitability should be assessed before and during use as recommended by your doctor.

Other Warnings for IMEGLYN 500 TABLET

Before Taking IMEGLYN 500 Tablet, Inform Your Doctor If You Have:

• Type 1 diabetes mellitus
• Ketosis or a history of diabetic ketoacidosis
• Diabetic coma or precoma
• A serious infection or severe dehydration
• A planned surgical procedure or recent serious injury

Who should not take IMEGLYN 500 TABLET

• Use for the management of type 1 diabetes mellitus or diabetic ketoacidosis, as this medicine is not indicated for these conditions.

Diet and Lifestyle Advice

IMEGLYN 500 Tablet contains imeglimin, which is used to help manage blood glucose levels in adults with type 2 diabetes mellitus. Following a balanced diet, staying physically active, and monitoring blood glucose regularly can support diabetes management alongside the medicine as prescribed by your doctor.

Diet Recommendations

• Choose High-Fibre Foods: Include whole grains, millets, oats, pulses, beans, and green leafy vegetables to support blood glucose management.
• Eat Balanced Meals: Include vegetables, appropriate portions of whole grains, and protein sources such as lentils, eggs, fish, or lean meat.
• Limit Sugary Foods: Reduce sweets, sugary drinks, sweetened juices, and foods containing added sugar.
• Control Portion Sizes: Avoid oversized meals and maintain consistent meal timings to support better glucose regulation.
• Choose Healthy Fats: Prefer nuts, seeds, and unsaturated vegetable oils while limiting fried foods and foods high in saturated fats.
• Stay Hydrated: Drink water regularly and limit sugar-sweetened beverages.

Lifestyle Recommendations

• Exercise Regularly: Aim for around 150 minutes of moderate physical activity per week, such as brisk walking, if approved by your doctor.
• Maintain a Healthy Weight: If you are overweight, gradual weight reduction may help improve insulin sensitivity and blood glucose control.
• Monitor Blood Glucose: Check blood glucose as recommended by your doctor and attend scheduled follow-up appointments.
• Take Medicines as Prescribed: Take IMEGLYN 500 Tablet according to your doctor's instructions. Do not change the dose or stop taking it without medical advice.
• Get Adequate Sleep: Maintain a regular sleep schedule and aim for sufficient restful sleep.
• Avoid Smoking and Limit Alcohol: Smoking increases cardiovascular risks, while alcohol may affect blood glucose levels and interact with some diabetes medicines.

Drug - Drug interaction

cytochrome P450 (CYP) Enzyme-Metabolised Medicines

Interaction: Imeglimin has shown little or no clinically significant inhibition or induction of the major CYP enzymes involved in drug metabolism.

Effects: Clinically significant interactions through these CYP enzymes are considered unlikely based on available studies.

Management: Inform your doctor about all medicines you are taking before starting IMEGLYN 500 Tablet.

Organic Cation Transporter (OCT1 and OCT2) Substrates or Inhibitors

Interaction: Imeglimin interacts with OCT1 and OCT2 transporters involved in the movement of certain medicines across cell membranes.

Effects: Clinical studies have not identified clinically significant interactions with medicines that use or inhibit these transporters.

Management: Inform your doctor about any medicines you take so that potential interactions can be assessed.

Multidrug and Toxin Extrusion (MATE1 and MATE2-K) Substrates or Inhibitors

Interaction: Imeglimin is a substrate of MATE1 and MATE2-K transporters, which are involved in drug transport and elimination.

Effects: Available studies have not identified clinically significant interactions with medicines that use or inhibit these transporters.

Management: Consult your doctor before starting or changing any medicine while taking IMEGLYN 500 Tablet.

Synopsis

More Information

1. Why Is Regular Physical Activity Important While Taking IMEGLYN 500 Tablet?

Regular physical activity supports glucose utilisation, improves insulin sensitivity, and promotes cardiovascular health. Combining exercise with a balanced diet and prescribed medication can contribute to better management of type 2 diabetes.

Improved Insulin Sensitivity

Physical activity helps muscles use glucose more effectively, supporting blood glucose regulation.

Support for Healthy Body Weight

Regular exercise combined with balanced eating habits can help maintain a healthy body weight and support metabolic health.

Benefits of Aerobic Exercise

Activities such as walking, cycling, and swimming can improve cardiovascular fitness and support overall well-being.

Role of Strength Training

Appropriate resistance exercises help maintain muscle strength and support glucose utilisation by muscle tissue.

Importance of Exercise Safety

Adults with type 2 diabetes may aim for at least 150 minutes of moderate-intensity physical activity per week, depending on their health and doctor's advice. Individuals taking other antidiabetic medicines should discuss precautions against exercise-related low blood glucose with their doctor.

FAQs About IMEGLYN 500 TABLET

References

1. V Pirags 1, H Lebovitz, P Fouqueray.Imeglimin, a novel glimin oral antidiabetic, exhibits a good efficacy and safety profile in type 2 diabetic patients. National Library of Medicine, National Center for Biotechnology Information. PubMed central. [Accessed date 12/10/2026]

2. Synokem Pharmaceuticals Ltd.Imeglimin Hydrochloride 500mg Film Coated tablet. [Revised date 03.11.2022]. [Accessed date 12/10/2026]

3. sterispharma.IMEGLIMON 500, [Accessed date 12/10/2026]

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 08 Jul 2024 | 10:31 AM(IST)