Hylasto One Injection(Pfs) 6ml

Introduction About HYLASTO ONE INJECTION(PFS)

HYLASTO ONE INJECTION(PFS) contains Sodium Hyaluronate, which belongs to the group of medicines called Glycosaminoglycan. It is used to manage pain in osteoarthritis of the knee. Osteoarthritis is a type of arthritis that occurs when flexible tissue at the ends of bones wears down.

HYLASTO ONE INJECTION(PFS) is not recommended for use in patients with infection of the knee joint, infection and diseases of the skin at the injection site, or systemic bleeding disorders.

Before receiving HYLASTO ONE INJECTION(PFS), inform your doctor if you have severe inflammation of the knee, lymphatic or venous stasis (in the leg to be injected), or chondrocalcinosis (mineralization of hyaline cartilage).

If you are pregnant, planning to get pregnant, or breast-feeding, consult your doctor for advice before receiving HYLASTO ONE INJECTION(PFS).

It should be used with caution with elderly patients. Consult your doctor before receiving HYLASTO ONE INJECTION(PFS).

The most common side effects of HYLASTO ONE INJECTION(PFS) are joint pain or inflammation, injection site pain, and joint effusion. Consult your doctor if any of the side effects worsen.

Uses Of HYLASTO ONE INJECTION(PFS)

• To manage pain in osteoarthritis of the knee

How HYLASTO ONE INJECTION(PFS) Works

HYLASTO ONE INJECTION(PFS) supports tendon and bone regeneration by improving oxygen and nutrient supply to the joints. In osteoarthritis, the joints lack nutrition and become inflamed. HYLASTO ONE INJECTION(PFS) contains hyaluronic acid, which acts as a nutritional supplement and helps to reduce inflammation and degradation of joints.

How to use HYLASTO ONE INJECTION(PFS)

HYLASTO ONE INJECTION(PFS) is administered by a doctor or a nurse directly into the knee joint. Your doctor will decide the correct dose and duration of HYLASTO ONE INJECTION(PFS) for you depending upon your age and disease condition.

Side Effects Of HYLASTO ONE INJECTION(PFS)

How To Manage Side Effects

Dizziness Or Drowsiness

Lie down until the dizziness passes away, and then move slowly and carefully. Take plenty of rest and drink plenty of fluids. Consult your doctor if the symptoms worsen.

Headache

Rest and relax. Drink plenty of fluids, such as water or electrolytes. Apply a pain-relieving balm to the forehead if required. Inform your doctor if the symptom does not improve.

Skin rash Or Itching

Do not scratch the affected area. Wear protective clothing while going outdoors. Regularly moisturize your skin. Inform your doctor if the symptoms worsen.

Warning & Precautions

Pregnancy

Consult your doctor

The safety and effectiveness of HYLASTO ONE INJECTION(PFS) have not been established in pregnant women. Consult your doctor before receiving HYLASTO ONE INJECTION(PFS).

Breastfeeding

Consult your doctor

The safety and effectiveness of HYLASTO ONE INJECTION(PFS) have not been established in breast-feeding women. Consult your doctor before receiving HYLASTO ONE INJECTION(PFS).

Driving and Using Machines

Use with Caution

HYLASTO ONE INJECTION(PFS) does not affect your ability to drive or use machinery.

Allergy

Contraindicated

HYLASTO ONE INJECTION(PFS) is not recommended for use if you are allergic to sodium hyaluronate preparations. It should be used with caution in patients with avian proteins, feathers, or egg products.

Use In Pediatrics

Consult your doctor

The safety and effectiveness of HYLASTO ONE INJECTION(PFS) have not been demonstrated in children (21 years of age or younger). Consult your child’s doctor for advice.

Use In Geriatrics

Use with Caution

HYLASTO ONE INJECTION(PFS) should be used with caution with elderly patients. Consult your doctor before receiving HYLASTO ONE INJECTION(PFS).

Interactions

A. Drug-Drug Interactions:

Before receiving HYLASTO ONE INJECTION(PFS), inform your doctor if you are using any of the following medicines:

• skin disinfectants containing quaternary ammonium salts and compounds
• chlorhexidine (skin preparation agents)

Overdosage:

HYLASTO ONE INJECTION(PFS) will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms after receiving HYLASTO ONE INJECTION(PFS).  

Synopsis

More Information

• Keep out of reach of children
• Store at room temperature

FAQs About HYLASTO ONE INJECTION(PFS)

Q: What is HYLASTO ONE INJECTION(PFS) used for?

A: HYLASTO ONE INJECTION(PFS) contains Sodium Hyaluronate, which is used in the management of pain in osteoarthritis of the knee. Osteoarthritis is the wearing down of the protective tissue at the ends of bones (cartilage), which occurs gradually and worsens over time. Joint pain in the hands, neck, lower back, knees, or hips is the most common symptom.

Q: For how long should I receive HYLASTO ONE INJECTION(PFS)?

A: Your doctor might advise you on how long you should continue to receive HYLASTO ONE INJECTION(PFS). You will need to consult your doctor from time to time to review your management and assess your symptoms.

Q: How does HYLASTO ONE INJECTION(PFS) work?

A: HYLASTO ONE INJECTION(PFS) supports tendon and bone regeneration by improving oxygen and nutrient supply to the joints. In osteoarthritis, the joints lack nutrition and become inflamed. HYLASTO ONE INJECTION(PFS) contains hyaluronic acid, which acts as a nutritional supplement and helps to reduce inflammation and degradation of joints.

Q: What are the common side effects of HYLASTO ONE INJECTION(PFS)?

A: The most common side effects of receiving HYLASTO ONE INJECTION(PFS) are joint pain or inflammation, injection site pain, joint effusion, and joint disease (arthropathy). Consult your doctor if any of the side effects worsen.

Q: How is HYLASTO ONE INJECTION(PFS) administered?

A: HYLASTO ONE INJECTION(PFS) is administered by a doctor or a nurse directly into the knee joint. Your doctor will decide the correct dose and duration of HYLASTO ONE INJECTION(PFS) for you depending upon your age and disease condition.

References

1. KD. Tripathi. Section 3, Antirheumatic and Antigout Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page –210 -218.

2. Huang TL, Chang CC, Lee CH, Chen SC, Lai CH, Tsai CL. Intra-articular injections of sodium hyaluronate (Hyalgan) in osteoarthritis of the knee. a randomized, controlled, double-blind, multicenter trial in the Asian population. NIH. National Library of Medicine, National center for biotechnology information. October 2011. [Accessed on 6th February 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203101/

3. Guarda-Nardini, L., Masiero, S. and Marioni, G., 2005. Conservative treatment of temporomandibular joint osteoarthrosis: intra-articular injection of sodium hyaluronate. Journal of Oral Rehabilitation. September 2005. [Accessed on 6th February 2024] https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2842.2005.01505.x

4. Genzyme Biosurgery. Synvisc One. [Revised in September 2014] [Accessed on 6th February 2024] https://products.sanofi.us/synviscone/synviscone.pdf  

5. Fidia Farmaceutici S.p.A. Hyalgan. Health Products Regulatory Authority (HPRA). [Revised in December 2009] [Accessed on 6th February 2024] https://www.hpra.ie/img/uploaded/swedocuments/LicenseSPC_PA0814-001-001_05042016103037.pdf

6. Hanmi Pharm Co. Ltd. Synojoynt. U.S. Food & Drug Administration. [Accessed on 6th February 2024] https://www.accessdata.fda.gov/cdrh_docs/pdf17/P170016D.pdf

7. Anika Therapeutics, Inc. Monovisc. [Accessed on 6th February 2024] http://synthes.vo.llnwd.net/o16/LLNWMB8/IFUs/US/Monovisc-US-IFU_Word.pdf

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Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Srikar Modepu - MBBS, MD (Diabetology)

Last updated on 15 Feb 2024 | 04:57 PM(IST)