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Introduction About HUMAN MIXTARD 30/70 40IU INJECTION
HUMAN MIXTARD 30/70 40IU INJECTION contains Biphasic Isophane Insulin which belongs to the group of medicines called Antidiabetic agents. It improves glycemic control in patients with diabetes mellitus (both type I and type II).
Biphasic Isophane Insulin is a pre-mixed combination of Regular (soluble) insulin and Isophane (NPH) insulin. It is a fast-acting medicine where it begins to lower blood sugar levels within 30 minutes. Therefore, inject the medicine 30 minutes before meal and make sure to have your meals within the next 30 minutes.
Talk to your doctor before starting therapy with HUMAN MIXTARD 30/70 40IU INJECTION if you have any liver, kidney or heart problems. You must also inform your doctor if you have any hormonal problems, made sudden changes to your diet or perform intense exercise as a precaution. Do not use this medicine if you have hypoglycemia (low blood sugar levels). Consult your doctor before using this medicine if you are pregnant or breastfeeding.
The most common side effects of receiving HUMAN MIXTARD 30/70 40IU INJECTION are low blood sugar levels, pain, redness, itching, swelling or thickening at the injection site, lump formation under the skin and swelling of body parts. Consult your doctor if any of these side effect troubles you.
Uses Of HUMAN MIXTARD 30/70 40IU INJECTION
- Improves glycemic control in patients with diabetes mellitus (both type I and type II)
How HUMAN MIXTARD 30/70 40IU INJECTION Works
HUMAN MIXTARD 30/70 40IU INJECTION helps your body to make utilize of the circulating blood glucose. It helps in the transport of glucose from the blood into the muscles and fat tissues. It also stops the production of glucose by the liver. As a result, it controls blood sugar levels and improve glycemic control in patients with diabetes mellitus.
How to use HUMAN MIXTARD 30/70 40IU INJECTION
Use HUMAN MIXTARD 30/70 40IU INJECTION under careful medical supervision. Inject HUMAN MIXTARD 30/70 40IU INJECTION into your thighs, buttocks, upper arm, or abdomen (i.e., subcutaneously). Do not administer this medicine into the vein or muscle directly. It should be administered at least 10 minutes before meals. Eat a meal or snack containing carbohydrates within 20 minutes of the injection to avoid low blood sugar.
Before administration, roll the vial/cartridge between your hands until the liquid becomes uniformly white and cloudy. While injecting, keep the needle under the skin for at least 6 seconds to make sure that the entire dose is injected.
Prior to the administration, visualize the cartridge/vial for any visible particulate matter and discoloration. Discard the needle and syringe after use and do not share your needles with others to avoid the risk of transmission of infections.
Avoid repeatedly injecting the medicine at the same site to manage skin damage. Instead, rotate the injection site. Make sure to consult your doctor before changing the injection site as a precaution.
HUMAN MIXTARD 30/70 40IU INJECTION should not be mixed with any other insulins before use. Do not stop therapy with HUMAN MIXTARD 30/70 40IU INJECTION without consulting your doctor. Your doctor will decide correct dose and frequency of administration depending upon your age, body weight and health condition.
Side Effects Of HUMAN MIXTARD 30/70 40IU INJECTION
Common
- Injection site reactions (such as pain, redness, itching or swelling)
- Lipodystrophy (shrinkage of fat tissues beneath the skin)
- Lumps under the skin
- Weight gain, swelling of body parts
- Hypoglycemia (Low blood sugar levels)
Uncommon
- Diabetic retinopathy (eye diseases due to diabetes)
- Swelling around the ankles and other joints
- Painful neuropathy (pain caused by nerve damage)
Rare
- Problem in vision
Consult your doctor immediately if you experience any of the following side effects:
- Allergic reaction (generalized skin rash with itching, sweating, and swelling of layers under the skin, difficulties in breathing, palpitation, vomiting, stomach upset, reduction in blood pressure and fainting /loss of consciousness)
- Signs of severe hypoglycemia (such as cold sweats, cool pale skin, headache, rapid heartbeat, nausea, increased hunger, temporary vision changes, drowsiness, tiredness and weakness, nervousness or tremor, anxiety, confusion and difficulty in concentrating)
How To Manage Side Effects
Hypoglycemia
Managing hypoglycemia, or low blood sugar, involves prompt action to raise blood glucose levels and manage complications. When experiencing hypoglycemia, individuals should quickly consume a source of rapidly-absorbed carbohydrates, such as glucose tablets, fruit juice, or regular soda. Waiting for about 15 minutes and rechecking blood sugar levels is crucial to ensure they rise to a safe range. If hypoglycemia persists, additional carbohydrate intake may be necessary. Once blood sugar levels stabilize, a small snack containing both carbohydrates and protein can help sustain them. Regular monitoring and consultation with a healthcare professional are essential for developing a personalized plan to manage hypoglycemia effectively. In severe cases, emergency assistance may be required.
Injection Site Reactions
Managing injection site reactions is essential for individuals who regularly administer injections. To alleviate discomfort and minimize potential issues, it is crucial to follow proper injection techniques. Rotate injection sites to manage overuse of a single area, allowing tissues to heal. Use a clean, sterile needle and syringe for each injection. Apply an ice pack to the injection site before and after administration to reduce pain and swelling. If redness, swelling, or irritation persists, consult a healthcare professional for guidance. It is essential to report any severe or persistent reactions to ensure appropriate adjustments to the injection routine and to manage potential complications.
Warning & Precautions
Pregnancy
Consult your doctorHUMAN MIXTARD 30/70 40IU INJECTION can be used during pregnancy only if considered necessary by the physician. Therefore, consult your doctor before administration.
Breastfeeding
SafeHUMAN MIXTARD 30/70 40IU INJECTION is considered safe for use during breastfeeding. However, consult your doctor before administration.
Driving and Using Machines
Use with CautionAs, HUMAN MIXTARD 30/70 40IU INJECTION can cause hypoglycemia, it may affect your ability to concentrate and focus. Therefore, be cautious to avoid the risk of hypoglycemia while driving or handling heavy machines.
Alcohol
ContraindicatedAvoid consumption of alcohol while taking this medicine as it could aggravate your existing disease condition.
Kidney
Use with CautionHUMAN MIXTARD 30/70 40IU INJECTION should be used with caution in patients with kidney problems. Therefore, consult your doctor before administration.
Liver
Use with CautionHUMAN MIXTARD 30/70 40IU INJECTION should be used with caution in patients with liver problems. Therefore, consult your doctor before administration.
Allergy
ContraindicatedTalk to your doctor before receiving HUMAN MIXTARD 30/70 40IU INJECTION if you are allergic to Regular insulin, Isophane insulin or to any other Human insulin (Ex. Lente, ultra-Lente).
Heart Disease
Use with CautionHUMAN MIXTARD 30/70 40IU INJECTION should be taken with caution in patients with heart disease. Therefore, consult your doctor before administration.
Use In Pediatrics
Consult your doctorHUMAN MIXTARD 30/70 40IU INJECTION can be used in children and adolescents (aged below 18 years) if prescribed by the physician. Therefore, consult your doctor before administration.
Use In Geriatrics
Monitoring requiredHUMAN MIXTARD 30/70 40IU INJECTION should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before administration. Proper dose adjustments and careful monitoring of blood glucose levels and kidney functions are required in such patients.
Others
HUMAN MIXTARD 30/70 40IU INJECTION is not recommended for use if you:
- Have or at risk of developing hypoglycemia (low blood sugar levels)
Talk to your doctor before receiving HUMAN MIXTARD 30/70 40IU INJECTION if you:
- Have problems in adrenal, pituitary or thyroid glands
- Have recently changed your diet plan and lifestyle
- Are exercising more than usual
- Recently became ill or had any infections
- Are planning to go abroad (as mealtime and injection timings may get changed)
Interactions
A. Drug-Drug interactions:
Before HUMAN MIXTARD 30/70 40IU INJECTION is administered, inform your doctor if you are taking any of the following medicines such as:
- Other antidiabetic agents (Ex. tolbutamide, glibenclamide, glipizide), biguanides (Ex. metformin, phenformin), thiazolidinediones (Ex. pioglitazone), DPP-4 inhibitors (Ex. sitagliptin, vildagliptin) or SGLT-2 inhibitors (Ex. remogliflozin)
- Antidepressants (Ex. rasagiline, selegiline, phenelzine)
- Heart medicines (Ex. propranolol, atenolol, nebivolol) or ACE inhibitors (Ex. captopril, enalapril, lisinopril)
- Salicylates (used to relieve pain or fever) Ex. aspirin
- Anabolic steroids (used to build muscle and improve athlete performance) Ex. testosterone, nandrolone, oxandrolone
- Sulfonamide antibiotics (Ex. sulfasalazine, sulfadiazine, sulfamethoxazole)
- Oral contraceptives (birth control pills) Ex. mifepristone,
- Thiazide diuretics (Ex. chlorothiazide, hydrochlorothiazide)
- Glucocorticoids (used to manage inflammation) Ex. cortisone, betamethasone, beclomethasone, dexamethasone, budesonide, prednisone
- Thyroid hormones (used to manage thyroid deficiency) Ex. thyroxine, triiodothyronine
- Sympathomimetic agents (used to manage asthma or other circulatory disorders) Ex. ephedrine, adrenaline, salbutamol, or terbutaline
- Growth hormone (a hormone used to increase skeletal and somatic growth in the body)
- Danazol (a medicine used for endometriosis)
- Octreotide (used to manage diarrhea)
- Lanreotide (a medicine used to manage abnormal body growth)
B. Interaction with food or drink:
HUMAN MIXTARD 30/70 40IU INJECTION should be administered 30 minutes before a meal.
Overdosage:
If you or anyone else took too much of this medicine, contact your doctor immediately or go to a hospital straight away as it may cause severe hypoglycemia. Symptoms of hypoglycemia might include fainting, feel unwell, sweating, vomiting, difficulty in breathing, fast heartbeat, and dizziness.
Synopsis
| Drug | : | Biphasic Isophane Insulin |
| Pharmacological Category | : | Antidiabitic agent |
| Therapeutic Indication | : | Diabetes mellitus |
| Dosage Forms | : | Injection, Cartridge, Pen |
More Information
Storage
- Keep out of reach of children
- Store the unopened pack in the refrigerator at 2-8°C. Do not freeze
- During use or when carried as a spare, keep it at room temperature
- Always place the vial/cartridge in the outer carton to protect from light
FAQs About HUMAN MIXTARD 30/70 40IU INJECTION
Q: What is HUMAN MIXTARD 30/70 40IU INJECTION used for?
A: HUMAN MIXTARD 30/70 40IU INJECTION is used in the management of type I & II diabetes mellitus.
Q: Should HUMAN MIXTARD 30/70 40IU INJECTION be refrigerated?
A: Yes. An unopened pack must be stored in the refrigerator (2°C–8°C). During use or while carrying as a spare, keep it at room temperature to ensure uniform resuspension.
Q: Can HUMAN MIXTARD 30/70 40IU INJECTION be mixed with other insulins?
A: No. HUMAN MIXTARD 30/70 40IU INJECTION is already a pre-mixed combination of regular insulin and isophane insulin and therefore should not be mixed with other insulins. For more information regarding the direction of use, contact your doctor.
Q: Is HUMAN MIXTARD 30/70 40IU INJECTION safe during pregnancy?
A: HUMAN MIXTARD 30/70 40IU INJECTION can be used during pregnancy if prescribed by the physician. Therefore, consult your doctor before administration.
Q: How long does it take for HUMAN MIXTARD 30/70 40IU INJECTION to start working?
A: HUMAN MIXTARD 30/70 40IU INJECTION is a fast-acting medicine where it begins to lower blood sugar levels about 30 minutes post-administration, and its effect would last for about 24 hours.
Q: Can HUMAN MIXTARD 30/70 40IU INJECTION be given intravenously?
A: No. HUMAN MIXTARD 30/70 40IU INJECTION is meant for subcutaneous use only (i.e., thighs, buttocks, abdomen, or upper arms). It should not be directly injected into the vein or muscle, as it may cause severe hypoglycemia.
Q: What is the best area for injecting HUMAN MIXTARD 30/70 40IU INJECTION? Should I inject it at the same site every day?
A: The best place for injecting this medicine is in front of your thighs, buttocks, abdomen, or upper arms. The insulin would work more quickly if it were injected into the waist (abdomen). Do not repeatedly inject the medicine at the same site. Instead, rotate the injection sites within the same area to avoid the risk of developing lumps or skin pitting.
Q: What are the most common side effects of taking HUMAN MIXTARD 30/70 40IU INJECTION?
A: The most common side effects of receiving HUMAN MIXTARD 30/70 40IU INJECTION are low blood sugar levels, pain, redness, itching, swelling or thickening at the injection site, lump formation under the skin, and swelling of body parts. Consult your doctor if any of these side effects trouble you.
Q: Can I stop therapy with HUMAN MIXTARD 30/70 40IU INJECTION without consulting your doctor?
A: No. You should not stop therapy with HUMAN MIXTARD 30/70 40IU INJECTION without consulting your doctor because it may lead to a reversal of symptoms. If you feel better after using HUMAN MIXTARD 30/70 40IU INJECTION, consult your doctor for advice.
Q: Will taking a higher dose of HUMAN MIXTARD 30/70 40IU INJECTION be more effective?
A: No, taking a higher dose of HUMAN MIXTARD 30/70 40IU INJECTION will not be effective; rather, it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I take medication for high blood pressure along with HUMAN MIXTARD 30/70 40IU INJECTION?
A: It is not advisable to take medicines to control blood pressure while taking HUMAN MIXTARD 30/70 40IU INJECTION without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive medications along with HUMAN MIXTARD 30/70 40IU INJECTION, as they have known interactions with HUMAN MIXTARD 30/70 40IU INJECTION.
Q: What precautions must be taken while using HUMAN MIXTARD 30/70 40IU INJECTION?
A: Before taking HUMAN MIXTARD 30/70 40IU INJECTION, inform your doctor if you have liver, kidney disease, heart disease, problems in the adrenal, pituitary, or thyroid glands, or a recent history of illness or infection.
Q: Can HUMAN MIXTARD 30/70 40IU INJECTION be used with children?
A: HUMAN MIXTARD 30/70 40IU INJECTION can be used in children and adolescents (aged below 18 years) if prescribed by the physician. Therefore, consult your doctor before administration.
Q: Where can I purchase HUMAN MIXTARD 30/70 40IU INJECTION conveniently?
A: You can buy HUMAN MIXTARD 30/70 40IU INJECTION online through platforms like Netmeds, an online pharmacy, which offers a hassle-free way to get your medications delivered to your doorstep.
References
1. KD. Tripathi. Insulin, Oral Hypoglycemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 263-264 & 266-269.
2. Jaime A. Davidson, Daniel Einhorn, Pamela Allweiss, Thomas M. Flood, Alan J. Garber, Mariano J. Garcia, Charles B. Kahn, Norman G. Soler, John R. White, William J. Huster. Effect of Premixed NPH and Regular Insulin on Glucose Control and Health-Related Quality of Life in Patients with Type 2 Diabetes Mellitus. AACE Endocrine practice. [Revised in August 1996]. [Accessed on 11th April 2024] https://www.endocrinepractice.org/article/S1530-891X(20)43520-7/pdf
3. Biocon Ltd. Biphasic Isophane Insulin Injection IP. Insugen-50/50 100 IU Refill. [Revised in July 2020]. [Accessed on 11th April 2024] https://www.biocon.com/docs/domestic-market-pi/metabolics/INSUGEN-50%2050%20REFILL%20PI.pdf
5. Novo Nordisk A/S. Mixtard 30 40 IU/ml (international units/ml) suspension for injection in vial. European Medical Agency. [Revised in September 2007]. [Accessed on 11th April 2024] https://www.ema.europa.eu/en/documents/product-information/mixtard-epar-product-information_en.pdf
6. Sanofi-Aventis Deutschland GmbH. Biphasic Isophane Insulin Injection I.P. [Revised in March 2017]. [Accessed on 11th April 2024] https://www.sanofi.in/dam/jcr:23695177-c3f1-4924-9907-de78b1c3acef/Insuman_PI.pdf
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Insulin-Fasting
- Netmeds Diabetic Checkup
- Advance Diabetes Monitoring (Senior Female)
- Jaanch Diabetic Profile Basic
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