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Introduction About HUMALOG MIX25 CARTRIDGE
HUMALOG MIX25 CARTRIDGE contains Insulin lispro which belongs to the group of medicines called Antidiabetics. It is used in adults and children for the management of diabetes mellitus.
Diabetes mellitus is a disease where the body does not produce enough insulin to control the level of the blood sugar, due to which there is high blood sugar levels causing increased thirst, frequent urination, extreme hunger, unexplained weight loss, fatigue, irritability, blurred vision, slow-healing sores, frequent infections, increased ketone levels in urine.
Along with HUMALOG MIX25 CARTRIDGE management, your doctor might want you to make certain lifestyle changes like eating a healthy diet, not skipping meals, maintaining weight, quitting alcohol and smoking and exercising regularly.
Before using HUMALOG MIX25 CARTRIDGE, inform your doctor if you have low blood sugar, kidney, liver, or heart problems, if you exercise more, are ill or going abroad. Avoid consumption of alcohol while using HUMALOG MIX25 CARTRIDGE.
Inform your doctor if you are pregnant or breastfeeding before using HUMALOG MIX25 CARTRIDGE. Your doctor will prescribe the right dose of HUMALOG MIX25 CARTRIDGE for your child depending on their age, body weight, and disease condition.
The most common side effects of using HUMALOG MIX25 CARTRIDGE are skin allergy at injection site, pain, swelling, itching, redness, etc. Consult your doctor if symptoms do not reduce over time.
Uses Of HUMALOG MIX25 CARTRIDGE
- Management of diabetes mellitus (Type I and II)
How HUMALOG MIX25 CARTRIDGE Works
HUMALOG MIX25 CARTRIDGE lowers blood glucose by enhancing uptake of glucose into skeletal muscle and adipose tissue and inhibiting the output of glucose from the liver.
How to use HUMALOG MIX25 CARTRIDGE
Use HUMALOG MIX25 CARTRIDGE as advised by your physician. It should only be injected under the skin (subcutaneous injection). Do not administer HUMALOG MIX25 CARTRIDGE into a vein or muscle. The best areas to inject are the front of your waist (abdomen), upper arms, buttocks, or the front of your thighs. HUMALOG MIX25 CARTRIDGE can be given at any time during the day, but at the same time each day.
Change the place within the area where you inject it every day to reduce the risk of developing changes under the skin. Your doctor will decide an appropriate dose and duration of HUMALOG MIX25 CARTRIDGE for you depending upon your age, body weight and disease condition. Do not stop using HUMALOG MIX25 CARTRIDGE unless your doctor advises you to stop.
Side Effects Of HUMALOG MIX25 CARTRIDGE
Common
- low blood sugar levels (tiredness, fast heartbeat, nervousness, shakiness, nausea, headache, cold sweat)
- local reaction (redness, swelling or itching around the area of the insulin injection)
Uncommon
- lipodystrophy (fatty tissue at injection site may either shrink or thicken)
- cutaneous amyloidosis (lumps under the skin)
Stop using HUMALOG MIX25 CARTRIDGE and contact your doctor immediately if you experience any of the following side effects:
- severe allergy (rash over the whole body, blood pressure dropping, difficulty in breathing, heart beating fast, wheezing, sweating)
- signs of heart failure (unusual shortness of breath or rapid increase in weight or localized swelling)
- diabetic ketoacidosis (sleepiness, no appetite, flushed face, fruity smelling breath, thirst, nausea, vomiting, heavy breathing, fast pulse)
How To Manage Side Effects
Headache
Drink plenty of water and get adequate rest. Try to be relaxed and stress free. Call your doctor before taking any medicine for headache. If headache persists, consult your doctor.
Hypoglycemia
Drink a fruit juice, or have eat glucose tablets, sugar or drink a sugary drink. Then eat fruit, biscuits, or a sandwich, as advised by your doctor and have some rest. Check your blood sugar after 10 minutes. If it's still low, take another sugary snack, or drink, and check the blood sugar again. If the sugar levels do not improve, contact your doctor.
Nausea And Vomiting
Take regular sips of a cold drink. Have ginger or peppermint tea. Stick to simple meals. Avoid eating oily or spicy foods. If symptom persists, contact your doctor.
Warning & Precautions
Pregnancy
Use with CautionHUMALOG MIX25 CARTRIDGE should be used with caution in pregnant women. Dose will be adjusted by your doctor. Consult your doctor for advice.
Breastfeeding
Use with CautionHUMALOG MIX25 CARTRIDGE should be used with caution in breastfeeding women. Dose will be adjusted by your doctor. Consult your doctor for advice.
Driving and Using Machines
Use with CautionDo not drive or use machines if your blood sugar levels drop while using HUMALOG MIX25 CARTRIDGE as it can affect your ability to concentrate or react.
Alcohol
Consult your doctorAvoid consumption of alcohol while receiving HUMALOG MIX25 CARTRIDGE as it can raise or lower your blood sugar levels.
Kidney
Use with CautionHUMALOG MIX25 CARTRIDGE should be used with caution in patients with kidney problems. Consult your doctor for advice.
Liver
Use with CautionHUMALOG MIX25 CARTRIDGE should be used with caution in patients with liver problems. Consult your doctor for advice.
Allergy
ContraindicatedBefore using HUMALOG MIX25 CARTRIDGE, inform your doctor if you are allergic to Insulin lispro, or any of the other ingredients in this medicine.
Heart Disease
Use with CautionHUMALOG MIX25 CARTRIDGE should be used with caution in patients with heart disease or stroke. Consult your doctor for advice.
Use In Pediatrics
Consult your doctorYour doctor will prescribe the right dose of HUMALOG MIX25 CARTRIDGE for your child depending on their age, body weight, and disease condition.
Use In Geriatrics
Use with CautionHUMALOG MIX25 CARTRIDGE should be used with caution in elderly patients (above 65 years of age). Dose will be adjusted, and regular blood and kidney tests will be conducted. Consult your doctor for advice.
Others
HUMALOG MIX25 CARTRIDGE is not recommended for use if you:
- have hypoglycemia (low blood sugar)
Before using HUMALOG MIX25 CARTRIDGE, inform your doctor if you:
- have recently been ill
- are exercising more than usual
- are going abroad
- are visually impaired
Interactions
A. Drug-Drug interactions:
Before using HUMALOG MIX25 CARTRIDGE, inform your doctor if you are taking any of the following medicines:
- birth control pills (Ex. desogestrel, ethinyl estradiol)
- medicines used to manage inflammation (Ex. prednisone, dexamethasone)
- medicines used to manage thyroid gland disorders (Ex. liothyronine, liotrix)
- other antidiabetic agents (Ex. metformin, repaglinide, pioglitazone)
- acetylsalicylic acid (used to relieve pain and lower fever)
- antibiotics (Ex. sulfadiazine, sulfamethizole)
- octreotide (used to manage growth disorders)
- antiasthmatic agents (Ex. salbutamol, terbutaline)
- ritodrine (used to manage premature labour)
- Heart medicines (Ex. metoprolol, atenolol, enalapril, captopril, losartan)
- danazol (medicine acting on ovulation)
- antidepressants (Ex. phenelzine, selegiline)
Overdosage:
If you or anyone else accidentally inject too much of HUMALOG MIX25 CARTRIDGE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are low blood sugar causing shallow breathing or pale skin.
Synopsis
| Drug | : | Insulin lispro |
| Pharmacological Category | : | Antidiabetic drug |
| Therapeutic Indication | : | Diabetes mellitus |
| Dosage Forms | : | Injection, Cartridge, Pen |
More Information
- Keep HUMALOG MIX25 CARTRIDGE out of reach of children
- Store HUMALOG MIX25 CARTRIDGE at temperature below 30°C
FAQs About HUMALOG MIX25 CARTRIDGE
Q: Can I stop using HUMALOG MIX25 CARTRIDGE?
A: Do not stop using HUMALOG MIX25 CARTRIDGE without talking to your doctor. If you stop using HUMALOG MIX25 CARTRIDGE, it could lead to a very high blood sugar level (severe hyperglycemia). Do not change your insulin unless your doctor advice you to.
Q: What to do if I experience low blood sugar during management with HUMALOG MIX25 CARTRIDGE?
A: If you experience low blood sugar while using HUMALOG MIX25 CARTRIDGE, take glucose tablets or another high sugar snack (sweets, biscuits, fruit juice). If possible, measure your blood sugar and rest. Keep glucose tablets or sugary snacks with you.
Q: Can I use HUMALOG MIX25 CARTRIDGE during pregnancy?
A: If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before using HUMALOG MIX25 CARTRIDGE. Careful control of your diabetes, particularly management of hypoglycemia, is important for the baby’s health. Consult your doctor for advice.
Q: Can HUMALOG MIX25 CARTRIDGE be used in patients with kidney and liver problems?
A: HUMALOG MIX25 CARTRIDGE should be used with caution in patients with liver and kidney disease. Your dose will be adjusted depending upon your age, body weight and disease condition. Consult your doctor for advice.
Q: What if I forget to inject a dose of HUMALOG MIX25 CARTRIDGE?
A: If you forget to inject a dose of HUMALOG MIX25 CARTRIDGE, your blood sugar may get too high (hyperglycemia). Fluctuations in your sugar levels may cause headaches, nausea, vomiting, loss of fluids (dehydration) or unconsciousness. See your doctor in such case.
References
1. KD Tripathi. Insulin, Oral Hypoglycemic Drugs and Glucagon. Essentials of medical pharmacology. Eighth Edition. 2019. Page –287.
2. Frits Holleman, and Joost B.L. Hoekstra. Insulin Lispro. The New England Journal of Medicine. July 1997. [Accessed on 23rd January 2024] https://www.nejm.org/doi/full/10.1056/NEJM199707173370307
3. Michelle I. Wilde & Donna McTavish. A Review of its Pharmacological Properties and Therapeutic Use in the Management of Diabetes Mellitus. Springer Link. October 2012. [Accessed on 23rd January 2024] https://link.springer.com/article/10.2165/00003495-199754040-00006
4. Lilly France S.A.S. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 23rd January 2024] https://www.medicines.org.uk/emc/files/pil.7464.pdf , https://www.medicines.org.uk/emc/product/7464/smpc
5. Lilly France S.A.S. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 23rd January 2024] https://www.medicines.org.uk/emc/files/pil.3725.pdf, https://www.medicines.org.uk/emc/product/3725/smpc
6. Eli Lilly Canada Inc. Humalog (Insulin Lispro). [Revised in April 2021] [Accessed on 23rd January 2024] https://pi.lilly.com/ca/humalog-ca-pm.pdf
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Insulin-Fasting
- Netmeds Diabetic Checkup
- Advance Diabetes Monitoring (Senior Female)
- Jaanch Diabetic Profile Basic
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