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Introduction About HP KIT
HP KIT is a combination of Amoxicillin, Omeprazole, and Tinidazole which belongs to the group of medicines called Anti-Helicobacter pylori drugs. It is used to manage infections caused by a bacteria called Helicobacter pylori, which is often found in the stomach of the affected individual. Infected patients are initially asymptomatic, with inflammation and ulceration developing later, causing abdominal pain, nausea, vomiting, and upset stomach.
During the course of the management, your doctor might regularly monitor your condition to avoid any untoward side effects. HP KIT is not recommended for children younger than 1 year or weighing less than 10 kgs. Before taking HP KIT, inform your doctor if you have any blood disease, liver, kidney, or skin problems, fever, sore throat, swollen glands, or extreme tiredness.
HP KIT is generally not recommended for use in pregnant and breastfeeding women, unless advised by your doctor. The most common side effects of taking HP KIT are decreased appetite, headache, diarrhoea, nausea, abdominal pain, skin rash, etc. Contact your doctor if any of the above side effects worsen.
Uses Of HP KIT
- It is used to manage Helicobacter pylori infections
How HP KIT Works
HP KIT decreases the amount of H. pylori and relieves gastric symptoms where amoxicillin inhibits certain proteins required in cell wall biosynthesis resulting in the death of the bacteria, omeprazole reduces the amount of acid produced by your stomach, and tinidazole releases certain chemicals that damage the bacterial DNA and causes cell death.
How to use HP KIT
Take HP KIT as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of HP KIT for you depending on your age, body weight and disease condition.
Side Effects Of HP KIT
Common
- decreased appetite, vomiting, diarrhoea, nausea, abdominal pain, constipation, gas
- headaches
- spinning sensation
- allergic skin inflammation
- noncancerous tumors in the stomach
Uncommon
- swollen feet and ankles
- sleep disturbance
- dizziness, tingling feeling, sleepiness
- changes in liver function tests
- hives
- feeling generally unwell, lacking energy
- increased risk of hip, wrist or spine fracture
Rare
- low blood sodium levels (weakness, vomiting, cramps)
- agitation, confusion or depression
- taste changes
- blurred eyesight
- dry mouth
- inflammation inside the mouth
- hair loss
- skin rash on sun exposure
- muscle pains
- too much sweating
- thrush (fungal gut infection)
Stop taking HP KIT and contact your doctor immediately if you experience any of the following side effects:
- serious allergic reaction (sudden onset of wheezing or breathlessness, swelling of the lips, face, tongue and throat, shock, body rash and itching, trouble swallowing)
- dizziness, lightheadedness, coordination problems, peripheral nervous system disorder, fits
- erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (red skin with blisters or peeling, lips, eyes, mouth, nose or genital bleeding, fever, tiredness)
- low red or white blood cells or platelets (breathlessness, tiredness, dizziness, bleeding, bruising)
- immune deficiency (infection with fever, severely decreased general condition, pain in the neck, throat or mouth, trouble urinating)
- rash or red pinpoint flat round spots under the skin or bruising with joint pain and kidney problems
- a delayed allergic reaction (rashes, fever, joint pains, enlarged lymph nodes especially under the arms)
- other severe skin reactions (changes in skin colour, bumps under the skin, pustules, pain, scaling along with fever, headaches and body aches)
- Jarisch-Herxheimer reaction (fever, chills, headache, muscle pain, skin rash)
- inflammation of the colon (diarrhoea (sometimes with blood), pain, fever)
- serious liver side effects (severe diarrhoea with bleeding, blisters, redness or bruising of the skin, dark urine or pale faeces, yellow skin or the whites of the eyes, tiredness)
- a lot of weight loss without any reason
- stomach pain or indigestion
- vomiting food or blood
How To Manage Side Effects
Bloating
Eat smaller and more frequent meals. Eat and drink slowly, and exercise regularly. If flatulence does not improve, contact your doctor.
Constipation
Eat plenty of fiber-rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. If constipation does not improve, contact your doctor.
Diarrhea
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. If diarrhoea does not improve, contact your doctor.
Headache
Drink an ample amount of water. Get adequate rest. Try to be relaxed and stress-free. Ask your doctor before taking any medicine for headaches. If the headache does not improve, contact your doctor.
Loss Of Appetite
Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Eat a nutritious snack which is rich in calories and protein, such as dried fruit and nuts. If your appetite does not improve, contact your doctor.
Nausea And Vomiting
In case of nausea, take HP KIT with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. If nausea does not improve, contact your doctor.
In case of vomiting, get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like it – you do not need to eat or avoid any specific foods. Do not take any medicine for vomiting without asking your doctor. If vomiting does not improve, contact your doctor.
Stomach Pain
Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heating pad on your stomach. If the stomach pain does not improve, contact your doctor.
Warning & Precautions
Pregnancy
Consult your doctorHP KIT is not recommended for use during the first trimester of pregnancy. HP KIT should be used during the second and third trimesters only if your doctor finds it necessary. Consult your doctor before taking it.
Breastfeeding
Consult your doctorYou should not breastfeed during and at least three days after completion of HP KIT> management. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or use any machines if you experience allergic reactions, dizziness, visual disturbances, or fits after taking HP KIT.
Alcohol
ContraindicatedAvoid consumption of alcohol with HP KIT as it may increase the risk of getting side effects.
Kidney
Use with CautionHP KIT should be used with caution in patients with kidney problems, patients not urinating regularly, and those about to have any urine test. Consult your doctor before taking it.
Liver
Use with CautionHP KIT should be used with caution in patients with severe liver problems or in those about to have any blood test for liver function. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take HP KIT if you are allergic to Amoxicillin, Omeprazole, Tinidazole, or any of the other ingredients of this medicine.
Use In Pediatrics
ContraindicatedHP KIT is not recommended for children younger than 1 year or weighing less than 10 kg. Consult your doctor before taking it.
Use In Geriatrics
Use with CautionHP KIT should be used with caution in elderly patients as they may be at risk of getting liver side effects. Consult your doctor before taking it.
Others
HP KIT is not recommended for use if you:
- have or had any blood disease
- have organic neurological disorders
- are allergic to any other antibiotic
Before taking HP KIT, inform your doctor if you:
- ever had a skin reaction after taking a medicine used to reduce stomach acid
- have poor vitamin B12 (cobalamin) absorption
- are going to have a blood test (Chromogranin A)
- have osteoporosis (a bone problem)
- have glandular fever (fever, sore throat, swollen glands, extreme tiredness)
- are going to have oestriol tests (used during pregnancy to check the baby’s development)
Interactions
A. Drug-Drug interactions:
Before taking HP KIT, inform your doctor if you are taking any of the following medicine:
- medicines used for blood thinning (Ex. warfarin, acenocoumarol, dicoumarol, anisindione, phenindione, phenprocoumon)
- medicines used to manage fungal infections (Ex. ketoconazole, itraconazole, posaconazole, voriconazole)
- digoxin (used to manage heart problems)
- diazepam (used to manage anxiety, muscle cramps, or fits)
- phenytoin (used to manage fits)
- medicines used to manage bacterial infections (Ex. rifampicin, clarithromycin, tetracycline)
- medicines used to manage HIV (Ex. atazanavir, nelfinavir, saquinavir)
- tacrolimus (used after organ transplantation to manage rejection)
- methotrexate (used to manage arthritis or psoriasis)
- St John’s wort (used in depression)
- cilostazol (used to manage intermittent claudication)
- clopidogrel (used to manage blood clots)
- erltinib (used in certain cancers)
- medicines used to manage inflammation and immune reactions (Ex. hydrocortisone, prednisolone)
- medicines used to manage gout (Ex. allopurinol, probenecid)
Overdosage:
Contact your doctor immediately if you or anyone else accidentally took too much of HP KIT. Symptoms of HP KIT overdose include nausea, vomiting, dizziness, stomach pain, diarrhoea, headache, depression, confusion, cloudy urine, and trouble urinating.
Synopsis
| Drug | : | Amoxicillin, Omeprazole, Tinidazole |
| Pharmacological Category | : | Beta lactam antibiotic, Proton pump inhibitor, Nitroimidazole |
| Therapeutic Indication | : | Helicobacter pylori infection |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep HP KIT out of reach from children
- Store HP KIT at room temperature
FAQs About HP KIT
Q: What is the use of HP KIT?
A: HP KIT is used to manage infections caused by a bacteria called Helicobacter pylori in the stomach.
Q: What are the side effects of HP KIT?
A: The common side effects associated with the use of HP KIT are decreased appetite, vomiting, diarrhea, nausea, abdominal pain, constipation, gas, headaches, spinning sensations, allergic skin inflammation, and noncancerous tumours in the stomach.
Q: How does HP KIT work?
A: HP KIT decreases the amount of H. pylori and relieves gastric symptoms; amoxicillin inhibits certain proteins required in cell wall biosynthesis, resulting in the death of the bacteria, omeprazole reduces the amount of acid produced by your stomach, and tinidazole releases certain chemicals that damage the bacterial DNA and cause cell death.
Q: Can HP KIT be used on infants?
A: No. HP KIT is not recommended for use in children younger than 1 year and weighing less than 10 kg. Your doctor will decide on the correct dose of HP KIT or select a suitable alternative therapy for your child.
Q: What if I forget to take a dose of HP KIT?
A: If you forget to take a dose of HP KIT, take it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not take HP KIT twice to make up for a forgotten dose.
Q: Can I stop taking HP KIT on my own?
A: Continue taking HP KIT until your doctor tells you to stop, unless you experience any unwanted effects, worsening of your condition, or any new symptoms. In such a case, contact your doctor right away.
Q: Can HP KIT be crushed?
A: No. Do not break, crush, or chew HP KIT. Simply swallow it whole with a glass of water. Consult your doctor on how to use HP KIT if you or your child have trouble swallowing.
Q: Can HP KIT cause vomiting?
A: Yes. Vomiting is a common side effect of HP KIT. In such cases, get adequate rest and drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like it; you do not need to eat or avoid any specific foods. Do not take any medicine for vomiting without asking your doctor. Tell your doctor if you have continuous vomiting.
Q: What precautions do I need to follow while taking HP KIT?
A: Patients taking HP KIT must inform their doctor about their pre-existing conditions, like any blood disease, liver, kidney, or skin problems, fever, sore throat, swollen glands, or extreme tiredness. Patients should also inform the doctor if they are pregnant, breastfeeding, or have any allergies. Consult your doctor if you experience anything different.
Q: Can HP KIT be taken during pregnancy?
A: HP KIT is not recommended for use during the first trimester of pregnancy, and it should be used during the second and third trimesters only if your doctor finds it necessary. If you are pregnant, think you may be pregnant, or are planning to get pregnant, consult your doctor before taking this medicine. Inform your doctor immediately if you become pregnant during management with HP KIT.
Q: Can I drive a car after taking HP KIT?
A: Do not drive or use any machines if you experience allergic reactions, dizziness, visual disturbances, or fits after taking HP KIT. Consult your doctor if you feel any side effects during management with HP KIT that may stop you from driving or using machines.
Q: Can I take other medicines with HP KIT?
A: Before taking HP KIT, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, non-prescription, or any herbal medicine, as these might interact with each other and cause serious side effects.
References
1. KD. Tripathi. Drugs for Peptic Ulcer and GERD. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 658.
2. Nirzar S. Parikh; Rajni Ahlawat. Helicobacter pylori. StatPearls [Internet]. StatPearls Publishing. August 2021. [Accessed on 6th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK534233/
3. Thijs JC, Van Zwet AA, Thijs WJ, Van der Wouden EJ, Kooy A. One-week triple therapy with omeprazole, amoxicillin and tinidazole for Helicobacter pylori infection: the significance of imidazole resistance. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. April 1997. [Accessed on 6th July 2022] https://pubmed.ncbi.nlm.nih.gov/9146767/
4. Laboratorios Liconsa S.A. Electronic Medicines Compendium (EMC). [Revised in October 2018] [Accessed on 6th July 2022] https://www.medicines.org.uk/emc/files/pil.5944.pdf
5. GlaxoSmithKline. Amoxicillin. [Accessed on 6th July 2022] https://www.ema.europa.eu/en/documents/referral/amoxil-article-30-referral-annex-iii_en.pdf
6. Gracure Pharmaceuticals Ltd. Tinidazole. [Revised in September 2020] [Accessed on 6th July 2022] https://exphar.com/wp-content/uploads/2021/02/TINAZOL_Leaflet_EN.pdf
Useful Diagnostic Tests
- Stool antigen test
- Stool PCR test
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