HINEX Injection 1's

Introduction About HINEX INJECTION

HINEX INJECTION is a combination of Cefoperazone and Sulbactam, which belongs to the group of medicines called Antibiotics. It is used to manage various bacterial infections such as respiratory tract infections, urinary tract infections (upper and lower), intra-abdominal infections, septicaemia (serious bloodstream infection), meningitis (inflammation of brain and spinal cord membranes, typically caused by an infection), and skin and soft tissue infections.

It is also used to manage bone and joint infections, gonorrhoea (sexually transmitted bacterial infection), endometritis (inflammation of the uterine lining due to infection), pelvic inflammatory disease (infection of the female reproductive organs), and other infections of the genital tract.

Bacterial infections are caused by the multiplication of specific harmful strains of bacteria anywhere in the body. It is characterized by symptoms such as fever, nausea, vomiting, headache, tiredness, and swollen lymph nodes in the neck, armpits, groin, or elsewhere.

Before receiving HINEX INJECTION, inform your doctor if you have impaired kidney function, severe biliary obstruction (blockage of the bile ducts), severe liver disease, or malabsorption conditions, and have a schedule for laboratory tests (such as measuring glucose in the urine).

HINEX INJECTION should be used with caution in pregnant and breastfeeding women only if advised by the doctor. Also, it should be used with caution in children and elderly patients.

The most common side effects of receiving HINEX INJECTION are diarrhea, nausea, and vomiting. Inform your doctor if any of these side effects bother you.

Uses Of HINEX INJECTION

Manages bacterial infections such as:

• Respiratory tract infections
• Urinary tract infections (upper and lower)
• Intra-abdominal infections
• Septicaemia
• Meningitis
• Skin and soft tissue infections
• Bone and joint infections
• Pelvic inflammatory disease
• Endometritis
• Gonorrhoea
• Other infections of the genital tract

How HINEX INJECTION Works

HINEX INJECTION contains cefoperazone and sulbactam. Cefoperazone works by stopping the formation of bacterial cell coverings, which makes the bacteria susceptible to killing. Sulbactam works by reducing bacterial resistance and enhancing the activity of cefoperazone against the bacteria. Together, they help to manage various bacterial infections.

How to use HINEX INJECTION

HINEX INJECTION will be given to you only by a doctor or a nurse, either into the vein (intravenously) or muscle (intramuscularly). Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and severity of the infection.

Side Effects Of HINEX INJECTION

How To Manage Side Effects

Diarrhea

Keep yourself hydrated by drinking lots of fluids, such as water or fruit juices. If the symptom does not improve, inform your doctor.

Headache

Apply a hot or cold water bag to your head. Drink plenty of fluids. Try taking rest in a quiet and dark room. Apply pain-relieving balm on your forehead if necessary. Inform your doctor if the headache does not reduce.

Nausea And Vomiting

Take regular sips of cold drinks. Stick to simple meals. Avoid eating oily, fried, or spicy foods. Do not lie down or sleep immediately after eating. If nausea does not improve, inform your doctor.

Warning & Precautions

Pregnancy

Monitoring required

HINEX INJECTION should be used during pregnancy only if considered clearly necessary. Consult your doctor before receiving HINEX INJECTION.

Breastfeeding

Use with Caution

HINEX INJECTION should be used with caution in breast-feeding women, as a small amount of this medicine is excreted in the breast milk. Consult your doctor before receiving HINEX INJECTION.

Driving and Using Machines

Safe

HINEX INJECTION does not affect your ability to drive or use machinery.

Alcohol

Contraindicated

Avoid consuming alcohol while receiving HINEX INJECTION because it may cause flushing, sweating, headaches, and an increase in the heartbeat.

Kidney

Use with Caution

HINEX INJECTION should be used with caution in patients with impaired kidney function. Consult your doctor before receiving HINEX INJECTION.

Liver

Use with Caution

HINEX INJECTION should be used with caution in patients with severe biliary obstruction (blockage of the bile ducts) and severe liver disease. Consult your doctor before receiving HINEX INJECTION.

Allergy

Contraindicated

Do not receive HINEX INJECTION if you are allergic to cefoperazone, sulbactam, beta-lactam antibiotics (such as Penicillins and cephalosporins (Ex. cefuroxime)) or any other ingredients of this medicine.

Use In Pediatrics

Use with Caution

HINEX INJECTION should be used with caution in children. Your child’s doctor may adjust the dose depending upon the child's body weight. Consult your child’s doctor for advice.

Use In Geriatrics

Use with Caution

HINEX INJECTION should be used with caution in elderly patients. Consult your doctor before receiving it.

Interactions

A. Drug-Drug interactions:

Before receiving HINEX INJECTION, inform your doctor if you are taking any of the following medicines:

• Medicines used to manage bacterial infections, such as aminoglycosides (Ex. gentamicin, tobramycin, amikacin, and streptomycin)
• Oral anti-coagulants (Ex. warfarin) (used to manage or manage blood clots)

Overdosage:

HINEX INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms, such as neurologic effects (such as fits).

Synopsis

More Information

FAQs About HINEX INJECTION

Q: What is HINEX INJECTION used for?

A: HINEX INJECTION is a combination of Cefoperazone and Sulbactam, which belongs to the group of medicines called antibiotics. It is used to manage several bacterial infections such as respiratory tract infections, urinary tract infections (upper and lower), intra-abdominal infections, septicaemia, meningitis, skin and soft tissue infections, bone and joint infections, gonorrhoea, endometritis, pelvic inflammatory disease, and other infections of the genital tract.

Q: How does HINEX INJECTION work?

A: HINEX INJECTION contains cefoperazone and sulbactam. Cefoperazone works by stopping the formation of bacterial cell coverings, which makes the bacteria susceptible to killing. Sulbactam works by reducing bacterial resistance and enhancing the activity of cefoperazone against the bacteria. Together, they help to manage various bacterial infections.

Q: Is HINEX INJECTION safe for kidneys?

A: HINEX INJECTION should be used with caution in patients with impaired kidney function. Consult your doctor before receiving HINEX INJECTION.

Q: How HINEX INJECTION is administered?

A: HINEX INJECTION will be given to you only by a doctor or a nurse, either into the vein (intravenously) or muscle (intramuscularly). Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and severity of the infection.

Q: Is HINEX INJECTION safe to use in patients with liver disease?

A: HINEX INJECTION should be used with caution in patients with severe biliary obstruction (blockage of the bile ducts) and severe liver disease. Consult your doctor for advice before receiving HINEX INJECTION.

Q: What are the side effects of HINEX INJECTION?

A: The most common side effects of receiving HINEX INJECTION are diarrhea, nausea, vomiting, and coagulopathy (impairment in the blood's ability to clot). Inform your doctor if any of these side effects bother you.

Q: Is HINEX INJECTION safe during pregnancy?

A: HINEX INJECTION should be used during pregnancy only if considered clearly necessary. Consult your doctor before receiving HINEX INJECTION.

Q: Can HINEX INJECTION be used in children?

A: HINEX INJECTION should be used with caution in children. Your child’s doctor may adjust the dose depending upon the child's body weight. Consult your child’s doctor for advice.

Q: Who should not use HINEX INJECTION?

A: Do not receive HINEX INJECTION if you are allergic to cefoperazone, sulbactam, beta-lactam antibiotics (such as Penicillins and cephalosporins (Ex. cefuroxime)) or any other ingredients of this medicine.

Q: What precautions must be taken while using HINEX INJECTION?

A: Before receiving HINEX INJECTION, inform your doctor if you have impaired kidney function, severe biliary obstruction (blockage of the bile ducts), severe liver disease, poor diet and malabsorption conditions, or have any scheduled laboratory tests (such as measuring glucose in the urine).

References

1. Conan MacDougall. Penicillins, Cephalosporins, and Other Beta-Lactam Antibiotics. Goodman & Gilman’s: The Pharmacological Basics of Therapeutics. 13th Edition. New York McGraw Hill Medical, 2018. Page – 1023-1038.

2. Lan, Shao-Huan, Shen-Peng Chang, Chih-Cheng Lai, Li-Chin Lu, and Hung-Jen Tang. Efficacy and safety of cefoperazone-sulbactam in empiric therapy for febrile neutropenia: A systemic review and meta-analysis. National Library of Medicine. February 2020. [Accessed on 23rd July 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034635/

3. Chiang, Tsung-Ta, Hung-Jen Tang, Cheng-Hsun Chiu, Te-Li Chen, Mao-Wang Ho, Chen-Hsiang Lee, Wang-Huei Sheng, and Ya-Sung Yang. Antimicrobial activities of cefoperazone-sulbactam in comparison to cefoperazone against clinical organisms from medical centers in Taiwan. Journal of Medical Sciences. December 2016. [Accessed on 23rd July 2024] https://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2016;volume=36;issue=6;spage=229;epage=233;aulast=Chiang;aid=JMedSci_2016_36_6_229_196365

4. Pfizer Limited. Electronic Medicines Compendium (EMC). [Revised in April 2020] [Accessed on 23rd July 2024] https://labeling.pfizer.com/ShowLabeling.aspx?id=14800#:~:text=mEq)%20per%20gram.-,Sulbactam%20is%20an%20off%2Dwhite%20crystalline%20powder%20which%20is%20highly,(1.5%20mEq)%20per%20gram.

Useful Diagnostic Tests

• Complete Blood Count (CBC)/ Hemogram
• Kidney Function Test (KFT)
• Peripheral Smear Examination By Pathologist
• Serum Electrolytes/ Electrolytes Profile
• Culture & Sensitivity, Blood
• Healthy Midlife Checkup
• Senior Citizen Checkup - Female
• Senior Citizen Checkup - Male
• Women Health Checkup - Essential
• Full Body Checkup – Gold

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Salem Gill - MBBS

Last updated on 26 Jul 2024 | 11:25 AM(IST)