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Introduction About HEPTRAL T TABLET
HEPTRAL T TABLET contains S-Adenosyl-L-Methionine which belongs to the group of medicines called Amino acid derivatives. It is used to manage liver problems such as intrahepatic cholestasis (ICP; block in bile flow), liver cirrhosis, hepatitis and alcoholic liver disease in adults.
It can also be used to manage ICP of pregnancy and can reduce the fatigue caused by chronic liver problems. It also helps to reduce joint pain (osteoarthritis), fibromyalgia (severe muscle pain with memory and mood problems), anxiety, depression and other mental illnesses.
Before taking HEPTRAL T TABLET inform your doctor if you have any kidney problems. You must also inform your doctor if you have bipolar disorder or a previous history of suicidal thoughts as a precaution.
Vitamins such as folic acid and vitamin B12 are essential to enhance the effects of S-Adenosyl-L-Methionine in your body. Therefore, inform your doctor if you have any vitamin deficiencies or anemia as a precaution. You doctor may advise you to take B-vitamin supplements (folic acid and vitamin B12) along with this medicine.
During management with HEPTRAL T TABLET your doctor will routinely monitor the levels of ammonia, folic acid and vitamin B12 in your blood as a precaution and adjust the dose accordingly.
Do not take HEPTRAL T TABLET without consulting your doctor if you are pregnant or breastfeeding. The most common side effects of taking HEPTRAL T TABLET are nausea, stomach pain and diarrhea. Consult your doctor if they trouble you.
Uses Of HEPTRAL T TABLET
It is used in adults to manage:
- intrahepatic cholestasis (ICP) in patients with or without liver disease
- intrahepatic cholestasis during pregnancy
- liver diseases (liver cirrhosis, hepatitis and alcoholic liver disease)
- fatigue caused due to chronic liver problems
- anxiety, depression and other mental illnesses
- osteoarthritis (joint pain)
- fibromyalgia (severe muscle pain causing memory and mood changes)
How HEPTRAL T TABLET Works
HEPTRAL T TABLET protects your liver against various toxins (free radicals) and helps your liver to function normally. It improves the levels of glutathione (an antioxidant) in the liver which helps in managing further liver cell damage.
It also increases the levels of certain chemical messengers (such as dopamine, noradrenaline, adrenaline, serotonin, melatonin) in the brain that can stabilize mood and mental health. It can also reduce the production of certain chemicals in the body that causes pain and inflammation.
How to use HEPTRAL T TABLET
Take HEPTRAL T TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. It is preferably taken before meals.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Side Effects Of HEPTRAL T TABLET
Common
- Nausea
- Stomach pain
- Diarrhea
- Bloating
- Stomach discomfort
Rare
Stop taking HEPTRAL T TABLET and consult your doctor immediately if you experience any of the following side effects:
- signs of serotonin syndrome (such as feeling agitated, hallucinations, confusion, loss of consciousness, fast heartbeat, feeling dizzy, increased sweating, flushing, tremors, stiff muscles or muscle twitching, loss of coordination, nausea, vomiting, diarrhea or seizures)
- signs of allergic reactions (such as skin rash, swelling of the hands, face, tongue, neck or throat, increased fluid in tissues, fast heart rate, difficulty in breathing)
- worsening of depression
How To Manage Side Effects
Nausea or vomiting:
Take this medicine with or just after meals. Stick to simple meals. Avoid eating rich or spicy food. Contact your doctor if nausea worsens.
Diarrhoea:
Drink fluids, such as water or fruit juice in enough quantity to keep yourself hydrated. Don’t take any medicine on your own for managing diarrhoea without talking to your doctor. Contact your doctor if diarrhoea worsen.
Warning & Precautions
Pregnancy
HEPTRAL T TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
Breastfeeding
HEPTRAL T TABLET is not recommended for use in breastfeeding women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any heavy tools or machines if you experience dizziness after taking HEPTRAL T TABLET as a precaution.
Kidney
HEPTRAL T TABLET should be used with caution in patients with kidney diseases. Therefore, consult your doctor before taking it.
Allergy
Do not take HEPTRAL T TABLET if you are allergic to S-Adenosyl-L-Methionine.
Others
HEPTRAL T TABLET is not recommended for use if you:
- have bipolar disease (alternative episodes of happiness and sadness)
Before taking HEPTRAL T TABLET, inform your doctor if you:
- have anemia (low RBC in blood)
- have vitamin B12 or folic acid deficiency
- have a previous history of suicidal thoughts
Use in pediatrics:
The safety and effectiveness of HEPTRAL T TABLET have not been established in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice before taking it.
Use in geriatrics:
HEPTRAL T TABLET should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking HEPTRAL T TABLET, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to manage depression (Ex. phenelzine, iproniazid, isocarboxazid, nialamide, tranylcypromine, moclobemide, fluoxetine, paroxetine, clomipramine, amitriptyline, imipramine etc.)
- levodopa (a medicine used to manage Parkinson’s disease)
- tryptophan (an amino acid used to induce sleep)
Overdosage:
If you or anyone else accidentally took more HEPTRAL T TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | S-Adenosyl-L-Methionine |
| Pharmacological Category | : | Amino acid Derivatives |
| Therapeutic Indication | : | Liver disease, Depression, Osteoarthritis |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep HEPTRAL T TABLET out of sight and reach of children
- Store HEPTRAL T TABLET below 25°C
FAQs About HEPTRAL T TABLET
What is the use of HEPTRAL T TABLET?
HEPTRAL T TABLET is used to manage liver problems such as intrahepatic cholestasis (ICP; block in bile flow), liver cirrhosis, hepatitis and alcoholic liver disease in adults. It can also be used to manage ICP of pregnancy and can reduce the fatigue caused by chronic liver problems. It also helps to reduce joint pain (osteoarthritis), fibromyalgia (severe muscle pain with memory and mood problems), anxiety, depression and other mental illnesses.
Can [GBNKEWORD] reduce liver damage?
Yes. HEPTRAL T TABLET protects your liver against various toxins (free radicals) and helps your liver to function normally. It also improves the levels of glutathione (an antioxidant) in the liver which helps in managing further liver cell damage.
What is the best time to take HEPTRAL T TABLET?
Take HEPTRAL T TABLET approximately at the same time each day. You can take HEPTRAL T TABLET either in the morning or in the evening as per doctor’s instructions. Taking it at the same time each day will have the best effect and it would also help you remember your daily dose.
Can HEPTRAL T TABLET be used to reduce anxiety?
HEPTRAL T TABLET has been shown to reduce anxiety. It works by increasing the levels of certain chemicals within the brain that controls mood and mental health.
How does HEPTRAL T TABLET works?
HEPTRAL T TABLET protects your liver against various toxins (free radicals) and helps your liver to function normally. It also increases the levels of certain chemical messengers (such as dopamine, noradrenaline, adrenaline, serotonin, melatonin) in the brain that can stabilize mood and mental health. It can also reduce the production of certain chemicals in the body that causes pain and inflammation.
Can HEPTRAL T TABLET be used in children?
The safety and effectiveness of HEPTRAL T TABLET have not been established in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice before taking it.
What to do if I forget to take a dose of HEPTRAL T TABLET?
If you forget to take a dose of HEPTRAL T TABLET, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of HEPTRAL T TABLET to compensate a missed dose, as it could lead to toxicity.
Will taking a higher dose of HEPTRAL T TABLET than the prescribed one be beneficial?
No, taking a higher dose of HEPTRAL T TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Can HEPTRAL T TABLET be taken daily?
Yes. HEPTRAL T TABLET can be taken daily as per your doctor’s instruction. However, if you are doubtful, consult your doctor.
Can HEPTRAL T TABLET be used in pregnant women?
HEPTRAL T TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
How to take HEPTRAL T TABLET?
Take HEPTRAL T TABLET as advised by your physician. It is preferably taken before meals. Swallow the medicine with a glass of water. Do not chew or crush the medicine.
Can I stop taking HEPTRAL T TABLET once I started feeling better?
Do not stop taking HEPTRAL T TABLET without consulting your doctor as it may make your symptoms re-appear
What are the side effects of HEPTRAL T TABLET?
The most common side effects of taking HEPTRAL T TABLET are nausea, stomach pain and diarrhoea. Consult your doctor if they trouble you.
Is HEPTRAL T TABLET safe?
HEPTRAL T TABLET is safe at doses prescribed by the doctor. Do not alter the dosage of HEPTRAL T TABLET without consulting your doctor.
References
1. Harsh Mohan. The Liver, Biliary Tract and Exocrine Pancreas. Textbook of Pathology. 6th Edition. 2010. Page – 599.
2. Anup Sharma, MD, PhD, Patricia Gerbarg, MD, Teodoro Bottiglieri, PhD, Lila Massoumi, MD, Linda L. Carpenter, MD, Helen Lavretsky, MD, Philip R. Muskin, MD, Richard P. Brown, MD and David Mischoulon, MD, PhD. S-Adenosylmethionine (SAMe) for neuropsychiatric disorders: A Clinician-Oriented Review of Research. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2017. [Accessed on 25th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501081/
3. AbbVie S.r.L. Abbott Laboratories. Ademetionine butanedisulfonate (Transmetil). [Accessed on 25th November 2022] https://www.medicine.abbott/content/dam/bss/divisionalsites/epd/productpdf/Transmetil%20500mg.pdf
4. La Renon Healthcare Private Limited. Methosam. Ademetionine Enteric Coated Tablets 200mg. [Accessed on 25th November 2022] https://www.larenon.com/wp-content/uploads/2022/04/METHOSAM-LBL-Depression.pdf
5. La Renon Healthcare Private Limited. Cirrosam. Ademetionine Enteric Coated Tablets 400mg. [Accessed on 25th November 2022] https://www.larenon.com/wp-content/uploads/2022/04/Cirrosam-LBL.pdf
6. La Renon Healthcare Private Limited. CIRROSAM (S-Adenosyl L-Methionine 400 mg tablets). [Accessed on 25th November 2022] https://www.larenon.com/wp-content/uploads/2020/06/cirrosam-lbl_Final.pdf
7. Abbott. Heptral 200/400. MIMS.com. [Accessed on 25th November 2022] https://www.mims.com/singapore/drug/info/heptral%20200-400?type=full
8. Central Drug Standard Control Organisation (CDSCO). Ademetionine enteric coated Tablets.200mg/400mg. [Revised in September 2010] [Accessed on 25th November 2022] https://cdscoonline.gov.in/CDSCO/Drugs
9. Leeford Healthcare. Lesamy 200. [Accessed on 25th November 2022] https://www.leeford.in/product/715/lesamy-200
Useful Diagnostic Tests
- Liver function test
- Bilirubin Direct
- Bilirubin indirect
- Bilirubin Total
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