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Introduction About HEPTRAL 400MG TABLET
HEPTRAL 400MG TABLET contains S-Adenosyl-L-Methionine which belongs to the group of medicines called Amino acid derivatives. It is used to manage liver problems such as intrahepatic cholestasis (ICP; block in bile flow), liver cirrhosis, hepatitis and alcoholic liver disease in adults.
It can also be used to manage ICP of pregnancy and can reduce the fatigue caused by chronic liver problems. It also helps to reduce joint pain (osteoarthritis), fibromyalgia (severe muscle pain with memory and mood problems), anxiety, depression and other mental illnesses.
Before taking HEPTRAL 400MG TABLET inform your doctor if you have any kidney problems. You must also inform your doctor if you have bipolar disorder or a previous history of suicidal thoughts as a precaution.
Vitamins such as folic acid and vitamin B12 are essential to enhance the effects of S-Adenosyl-L-Methionine in your body. Therefore, inform your doctor if you have any vitamin deficiencies or anemia as a precaution. You doctor may advise you to take B-vitamin supplements (folic acid and vitamin B12) along with this medicine.
During management with HEPTRAL 400MG TABLET your doctor will routinely monitor the levels of ammonia, folic acid and vitamin B12 in your blood as a precaution and adjust the dose accordingly.
Do not take HEPTRAL 400MG TABLET without consulting your doctor if you are pregnant or breastfeeding. The most common side effects of taking HEPTRAL 400MG TABLET are nausea, stomach pain and diarrhea. Consult your doctor if they trouble you.
Uses Of HEPTRAL 400MG TABLET
It is used in adults to manage:
- intrahepatic cholestasis (ICP) in patients with or without liver disease
- intrahepatic cholestasis during pregnancy
- liver diseases (liver cirrhosis, hepatitis and alcoholic liver disease)
- fatigue caused due to chronic liver problems
- anxiety, depression and other mental illnesses
- osteoarthritis (joint pain)
- fibromyalgia (severe muscle pain causing memory and mood changes)
How HEPTRAL 400MG TABLET Works
HEPTRAL 400MG TABLET protects your liver against various toxins (free radicals) and helps your liver to function normally. It improves the levels of glutathione (an antioxidant) in the liver which helps in managing further liver cell damage.
It also increases the levels of certain chemical messengers (such as dopamine, noradrenaline, adrenaline, serotonin, melatonin) in the brain that can stabilize mood and mental health. It can also reduce the production of certain chemicals in the body that causes pain and inflammation.
How to use HEPTRAL 400MG TABLET
Take HEPTRAL 400MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. It is preferably taken before meals.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Side Effects Of HEPTRAL 400MG TABLET
Common
- Nausea
- Stomach pain
- Diarrhea
- Bloating
- Stomach discomfort
Rare
Stop taking HEPTRAL 400MG TABLET and consult your doctor immediately if you experience any of the following side effects:
- signs of serotonin syndrome (such as feeling agitated, hallucinations, confusion, loss of consciousness, fast heartbeat, feeling dizzy, increased sweating, flushing, tremors, stiff muscles or muscle twitching, loss of coordination, nausea, vomiting, diarrhea or seizures)
- signs of allergic reactions (such as skin rash, swelling of the hands, face, tongue, neck or throat, increased fluid in tissues, fast heart rate, difficulty in breathing)
- worsening of depression
How To Manage Side Effects
Nausea or vomiting:
Take this medicine with or just after meals. Stick to simple meals. Avoid eating rich or spicy food. Contact your doctor if nausea worsens.
Diarrhoea:
Drink fluids, such as water or fruit juice in enough quantity to keep yourself hydrated. Don’t take any medicine on your own for managing diarrhoea without talking to your doctor. Contact your doctor if diarrhoea worsen.
Warning & Precautions
Pregnancy
HEPTRAL 400MG TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
Breastfeeding
HEPTRAL 400MG TABLET is not recommended for use in breastfeeding women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any heavy tools or machines if you experience dizziness after taking HEPTRAL 400MG TABLET as a precaution.
Kidney
HEPTRAL 400MG TABLET should be used with caution in patients with kidney diseases. Therefore, consult your doctor before taking it.
Allergy
Do not take HEPTRAL 400MG TABLET if you are allergic to S-Adenosyl-L-Methionine.
Others
HEPTRAL 400MG TABLET is not recommended for use if you:
- have bipolar disease (alternative episodes of happiness and sadness)
Before taking HEPTRAL 400MG TABLET, inform your doctor if you:
- have anemia (low RBC in blood)
- have vitamin B12 or folic acid deficiency
- have a previous history of suicidal thoughts
Use in pediatrics:
The safety and effectiveness of HEPTRAL 400MG TABLET have not been established in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice before taking it.
Use in geriatrics:
HEPTRAL 400MG TABLET should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking HEPTRAL 400MG TABLET, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to manage depression (Ex. phenelzine, iproniazid, isocarboxazid, nialamide, tranylcypromine, moclobemide, fluoxetine, paroxetine, clomipramine, amitriptyline, imipramine etc.)
- levodopa (a medicine used to manage Parkinson’s disease)
- tryptophan (an amino acid used to induce sleep)
Overdosage:
If you or anyone else accidentally took more HEPTRAL 400MG TABLET, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | S-Adenosyl-L-Methionine |
| Pharmacological Category | : | Amino acid Derivatives |
| Therapeutic Indication | : | Liver disease, Depression, Osteoarthritis |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep HEPTRAL 400MG TABLET out of sight and reach of children
- Store HEPTRAL 400MG TABLET below 25°C
FAQs About HEPTRAL 400MG TABLET
Q: What is the use of Heptral 400mg Tablet?
A: Heptral 400mg Tablet is used to manage liver problems such as intrahepatic cholestasis (ICP; block in bile flow), liver cirrhosis, hepatitis, and alcoholic liver disease in adults. It can also be used to manage ICP of pregnancy and reduce fatigue caused by chronic liver problems. Additionally, it may help reduce joint pain (osteoarthritis), fibromyalgia, anxiety, depression, and other mental health conditions.
Q: Can Heptral 400mg Tablet reduce liver damage?
A: Yes. Heptral 400mg Tablet protects the liver against toxins (free radicals) and helps it function normally. It also increases glutathione levels in the liver, which helps reduce further liver cell damage.
Q: What is the best time to take Heptral 400mg Tablet?
A: Take Heptral 400mg Tablet at approximately the same time every day. It can be taken in the morning or evening as directed by your doctor. Taking it at the same time daily helps maintain its effectiveness and improves adherence.
Q: Can Heptral 400mg Tablet be used to reduce anxiety?
A: Yes. Heptral 400mg Tablet has been shown to help reduce anxiety by increasing the levels of certain brain chemicals that regulate mood and mental health.
Q: How does Heptral 400mg Tablet work?
A: Heptral 400mg Tablet protects the liver from toxins and supports normal liver function. It also increases levels of brain chemicals such as dopamine, noradrenaline, adrenaline, serotonin, and melatonin, which can help stabilize mood and mental health. Additionally, it may reduce the production of chemicals responsible for pain and inflammation.
Q: Can Heptral 400mg Tablet be used in children?
A: The safety and effectiveness of Heptral 400mg Tablet have not been established in children and adolescents below 18 years of age. Consult a doctor before use in this age group.
Q: What should I do if I forget to take a dose of Heptral 400mg Tablet?
A: Take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed dose.
Q: Will taking a higher dose of Heptral 400mg Tablet than prescribed be beneficial?
A: No. Taking a higher dose will not improve effectiveness and may increase the risk of toxicity. Always take the medicine exactly as prescribed by your doctor.
Q: Can Heptral 400mg Tablet be taken daily?
A: Yes. Heptral 400mg Tablet can be taken daily as directed by your doctor. If you have any concerns, consult your healthcare provider.
Q: Can Heptral 400mg Tablet be used in pregnant women?
A: Heptral 400mg Tablet is not recommended during pregnancy unless considered necessary by the physician. Consult your doctor before taking this medicine if you are pregnant.
Q: How should I take Heptral 400mg Tablet?
A: Take Heptral 400mg Tablet as advised by your physician, preferably before meals. Swallow the tablet whole with a glass of water. Do not crush, chew, or break it.
Q: Can I stop taking Heptral 400mg Tablet once I start feeling better?
A: No. Do not stop taking Heptral 400mg Tablet without consulting your doctor, as your symptoms may return.
Q: What are the side effects of Heptral 400mg Tablet?
A: The most common side effects include nausea, stomach pain, and diarrhoea. Consult your doctor if these side effects persist or become troublesome.
Q: Is Heptral 400mg Tablet safe?
A: Yes. Heptral 400mg Tablet is generally safe when taken at the dose prescribed by your doctor. Do not change the dosage without medical advice.
References
1. Harsh Mohan. The Liver, Biliary Tract and Exocrine Pancreas. Textbook of Pathology. 6th Edition. 2010. Page – 599.
2. Anup Sharma, MD, PhD, Patricia Gerbarg, MD, Teodoro Bottiglieri, PhD, Lila Massoumi, MD, Linda L. Carpenter, MD, Helen Lavretsky, MD, Philip R. Muskin, MD, Richard P. Brown, MD and David Mischoulon, MD, PhD. S-Adenosylmethionine (SAMe) for neuropsychiatric disorders: A Clinician-Oriented Review of Research. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2017. [Accessed on 25th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501081/
3. AbbVie S.r.L. Abbott Laboratories. Ademetionine butanedisulfonate (Transmetil). [Accessed on 25th November 2022] https://www.medicine.abbott/content/dam/bss/divisionalsites/epd/productpdf/Transmetil%20500mg.pdf
4. La Renon Healthcare Private Limited. Methosam. Ademetionine Enteric Coated Tablets 200mg. [Accessed on 25th November 2022] https://www.larenon.com/wp-content/uploads/2022/04/METHOSAM-LBL-Depression.pdf
5. La Renon Healthcare Private Limited. Cirrosam. Ademetionine Enteric Coated Tablets 400mg. [Accessed on 25th November 2022] https://www.larenon.com/wp-content/uploads/2022/04/Cirrosam-LBL.pdf
6. La Renon Healthcare Private Limited. CIRROSAM (S-Adenosyl L-Methionine 400 mg tablets). [Accessed on 25th November 2022] https://www.larenon.com/wp-content/uploads/2020/06/cirrosam-lbl_Final.pdf
7. Abbott. Heptral 200/400. MIMS.com. [Accessed on 25th November 2022] https://www.mims.com/singapore/drug/info/heptral%20200-400?type=full
8. Central Drug Standard Control Organisation (CDSCO). Ademetionine enteric coated Tablets.200mg/400mg. [Revised in September 2010] [Accessed on 25th November 2022] https://cdscoonline.gov.in/CDSCO/Drugs
9. Leeford Healthcare. Lesamy 200. [Accessed on 25th November 2022] https://www.leeford.in/product/715/lesamy-200
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