HEPAMERZ Infusion 10ml

Introduction About HEPAMERZ INFUSION

HEPAMERZ INFUSION contains L-Ornithine L-Aspartate which belongs to the group of medicines called Amino Acids. It is used to manage latent and prominent hepatic encephalopathy (decline in brain function as a result of liver failure) and liver cirrhosis (condition in which your liver is scarred and permanently damaged).  

During management with HEPAMERZ INFUSION, your doctor might advise you to undertake blood investigations before and during management such as kidney and liver function test to manage the risk of any unusual effects.  

Avoid consuming alcohol while receiving HEPAMERZ INFUSION. It is not recommended for use in patients with severe kidney function impairment (renal failure). Consult your doctor before receiving it.  

HEPAMERZ INFUSION should be used with caution in patients suffering from severe liver damage. HEPAMERZ INFUSION is not recommended for use in pregnant and breast-feeding women unless clearly advised by the doctor.

The common side effects of receiving HEPAMERZ INFUSION are nausea, vomiting, cough, muscle cramps and diarrhoea. Inform your doctor immediately if any of the side effect worsens or persist for a long period of time.

Uses Of HEPAMERZ INFUSION

• Manage latent and prominent hepatic encephalopathy
• Manage liver cirrhosis

How HEPAMERZ INFUSION Works

HEPAMERZ INFUSION helps in improving liver function by helping in urea synthesis in liver (important metabolic process in the body), reduces levels of ammonia from liver, muscles and brain, helps in normalizing the levels of liver enzymes. It also protects the liver from further damage by drugs, alcohol and promotes liver regeneration by increasing liver energy balance.

How to use HEPAMERZ INFUSION

HEPAMERZ INFUSION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dosage and management duration depending upon your age, body weight and disease condition.

Side Effects Of HEPAMERZ INFUSION

How To Manage Side Effects

Diarrhea

Drink lot of fluids such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Inform your doctor if the symptom gets worse.

Nausea And Vomiting

Stick to simple meals while receiving HEPAMERZ INFUSION. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Inform your doctor if the symptom does not improve.

Warning & Precautions

Pregnancy

Monitoring required

HEPAMERZ INFUSION is generally not recommended for use during pregnancy unless considered clearly necessary. Consult your doctor before receiving it.

Breastfeeding

Monitoring required

HEPAMERZ INFUSION should be used in breast-feeding women only if considered clearly necessary. Consult your doctor before receiving it.

Driving and Using Machines

Use with Caution

Avoid driving or operating machines after receiving HEPAMERZ INFUSION.

Alcohol

Consult your doctor

Avoid consumption of alcohol while receiving HEPAMERZ INFUSION.

Kidney

Contraindicated

HEPAMERZ INFUSION is not recommended for use in patients suffering from severe kidney function impairment (renal failure). Consult your doctor before receiving it.

Liver

Use with Caution

HEPAMERZ INFUSION should be used with caution in patients suffering from severe liver damage. Consult your doctor before receiving it.

Allergy

Contraindicated

Do not receive HEPAMERZ INFUSION if you are allergic to L-Ornithine L-Aspartate or any other ingredients of this medicine.

Use In Pediatrics

Consult your doctor

There is no proper information regarding the use of HEPAMERZ INFUSION in children. Consult your child’s doctor for advice.

Use In Geriatrics

Consult your doctor

There is no proper information regarding the use of HEPAMERZ INFUSION in elderly patients. Consult your doctor for advice.

Interactions

A. Drug-Drug interactions:

Before receiving HEPAMERZ INFUSION, inform your doctor if you have taken or taking any medicines including precipitation, non-prescription and herbals or vitamin supplements.

Overdosage:

HEPAMERZ INFUSION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse immediately if you experience any unusual symptoms.

Synopsis

More Information

• Store HEPAMERZ INFUSION below 25°C

FAQs About HEPAMERZ INFUSION

Q: What is HEPAMERZ INFUSION used for?

A: HEPAMERZ INFUSION is used to manage latent and prominent hepatic encephalopathy (decline in brain function as a result of liver failure) and liver cirrhosis (condition in which your liver is scarred and permanently damaged).   

Q: How does HEPAMERZ INFUSION work?

A: HEPAMERZ INFUSION helps in improving liver function by helping in urea synthesis in liver (important metabolic process in the body), reduces levels of ammonia from liver, muscles and brain, helps in normalizing the levels of liver enzymes. It also protects the liver from further damage by drugs, alcohol and promotes liver regeneration by increasing liver energy balance.

Q: Is HEPAMERZ INFUSION safe to use in patients with kidney problems?

A: HEPAMERZ INFUSION is not recommended for use in patients suffering from severe kidney function impairment (renal failure). Your doctor may monitor your kidney function test before and during management with this medicine to manage the risk of any unusual effects. Consult your doctor before receiving it.

Q: What are the common side effects of HEPAMERZ INFUSION?

A: The common side effects of receiving HEPAMERZ INFUSION are nausea, vomiting, cough, muscle cramps and diarrhoea. Inform your doctor immediately if any of the side effect worsens or persist for a long period of time.  

Q: Can HEPAMERZ INFUSION be used in pregnant and breast-feeding women?

A: HEPAMERZ INFUSION is not recommended for use in pregnant and breast-feeding women unless clearly advised by the doctor. Consult your doctor before receiving HEPAMERZ INFUSION if you are pregnant, planning to get pregnant or breast-feeding your child.

References

1. Gerald Kircheis, Stefan Luth. Pharmacokinetic and Pharmacodynamic Properties of l-Ornithine l-Aspartate (LOLA) in Hepatic Encephalopathy. National Centre for Biotechnology. Drugs. January 2019. [Accessed on 20th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416235/

2. Roger F. Butterworth, Mark J. W. McPhail. L-Ornithine L-Aspartate (LOLA) for Hepatic Encephalopathy in Cirrhosis: Results of Randomized Controlled Trials and Meta-Analyses. National Centre for Biotechnology. Drugs. January 2019. [Accessed on 20th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416237/

3. Polifarma. L-Ornithine L-Aspartate. [Revised in December 2019] [Accessed on 20th October 2022] https://www.polifarma.com.tr/media/2119/hepalornitin_spc_rev01.pdf

4. Merz Pharma GmbH & Co KGaA. L-Ornithine L-Aspartate. [Accessed on 20th October 2022] https://www.liverandbrain.com/wp-content/uploads/2019/06/HM-Patient-Information_Infusion-Concentrate_en-1.pdf

5. Zuventus Healthcare Limited. L-Ornithine L-Aspartate. [Accessed on 20th October 2022] http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=56

6. Leeford. Heplofit Injection. (L-Ornithine L-Aspartate). [Accessed on 20th October 2022] https://www.leeford.in/product/202/heplofit-injection

Useful Diagnostic Tests

• Kidney function test
• Liver function test

Author Details

Written By Dr. R. Dinesh John Rajkumar - Pharm.D

Reviewed For Accuracy By Dr. Vrushabhakumar Jitendra Shah. - MBBS

Last updated on 11 Feb 2023 | 04:57 PM(IST)