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Introduction About HEPAKIND 450 TABLET
HEPAKIND 450 TABLET is used in the management of gall stones and primary biliary cirrhosis (damage of bile ducts in the liver leading to the buildup of bile). It can also be used for liver disease associated with cystic fibrosis in children aged 6 to less than 18 years.
It contains Ursodeoxycholic Acid, which is a liver health supplement that works by removing toxins from the liver, thereby improving its function. For gall stone dissolution, HEPAKIND 450 TABLET works by reducing cholesterol produced by the gall bladder
HEPAKIND 450 TABLET should be used only under medical supervision. It can be taken with or without meals.
HEPAKIND 450 TABLET is not recommended for use in patients with allergies to bile acids, calcified gallstones, inflammation of the gallbladder or the bile ducts, blockage of the common bile duct or cystic duct, frequent cramp-like pains in the upper abdomen, low bile flow in children, or improper function of the gall bladder. HEPAKIND 450 TABLET should be used with caution in patients with liver diseases.
HEPAKIND 450 TABLET should be taken during pregnancy only if clearly advised by the doctor and should be used with caution in breast-feeding women. Ask for your doctor’s advice before taking. HEPAKIND 450 TABLET can be used in children, adolescents, and the elderly. Your doctor will decide the correct dose and duration of therapy with HEPAKIND 450 TABLET for you.
The most common side effects of taking HEPAKIND 450 TABLET are soft, loose stools or diarrhea. Consult your doctor if the symptoms worsen or don’t improve.
How HEPAKIND 450 TABLET Works
HEPAKIND 450 TABLET supports liver detoxification by increasing the bile flow through the liver and protects liver cells. It is concentrated in bile and decreases biliary cholesterol by suppressing the formation of new cholesterol by inhibiting its intestinal absorption. The reduced cholesterol levels lead to gradually solubilization of cholesterol from gallstones, resulting in their dissolution.
How to use HEPAKIND 450 TABLET
- Always use HEPAKIND 450 TABLET exactly as prescribed by your doctor. Take this medicine with or after meals.
- For Tablet, Capsule: Swallow the medicine with a glass of water or milk. Do not crush or chew the medicine.
- For Dispersible Tablet: Disperse the medicine in the specified quantity of water as mentioned in the label. Consume the mixture immediately after reconstitution.
- Your doctor will decide the right dose and duration of HEPAKIND 450 TABLET for you depending upon your age, body weight and severity of disease condition.
- Continue to take HEPAKIND 450 TABLET for the stipulated duration prescribed by your doctor to achieve better results.
- If you feel that the effect of HEPAKIND 450 TABLET is too strong or too weak for you, please talk to your doctor.
Side Effects Of HEPAKIND 450 TABLET
Common Side Effects of HEPAKIND 450 TABLET:
- Soft, loose stools
- Diarrhoea
Stop taking HEPAKIND 450 TABLET and contact your doctor immediately if you experience any of the following side effects:
- Persistent diarrhoea
Warning & Precautions
Pregnancy
Monitoring requiredHEPAKIND 450 TABLET should be used in pregnant women only if considered clearly necessary by the doctor.
Breastfeeding
Use with CautionHEPAKIND 450 TABLET should be used with caution in breastfeeding women as it is not known if it passes through breast milk.
Driving and Using Machines
Use with CautionHEPAKIND 450 TABLET has no or negligible effect on driving or using machine.
Liver
Use with CautionHEPAKIND 450 TABLET should be used with caution in patients with liver diseases. Your doctor might advise you for frequent liver examination and tests during the management.
Allergy
ContraindicatedDo not take HEPAKIND 450 TABLET if you are allergic to allergic to Ursodeoxycholic Acid or bile acids or any other components of this medicine.
Use In Pediatrics
Consult your doctorHEPAKIND 450 TABLET should be used in children only if prescribed by the physician. It should not be used in children with biliary atresia (blockage in bile duct) or in children having poor bile flow, even after surgery.
Use In Geriatrics
Monitoring requiredHEPAKIND 450 TABLET can be used in elderly patients under medical supervision.
Others
HEPAKIND 450 TABLET is not recommended for use if you:
- Have improper functioning of gall bladder
- Have calcified gallstones which are visible on an x-ray
- Have an acute inflammation of the biliary tract or gall bladder
- Have a blockage of the cystic duct or common bile duct (obstruction of the biliary tract)
- Experience frequent cramp-like pains in the upper abdomen
Interactions
A. Drug-Drug interactions:
Before taking HEPAKIND 450 TABLET, inform your doctor if you are taking any of the following medicines:
- Contraceptives (Ex. levonorgestrel, ethinyl estradiol)
- Antacids (Ex. aluminium hydroxide)
- Antilipidemic (Ex. cholestyramine, clofibrate, and colestipol)
- Anti-infective (Ex. ciprofloxacin, dapsone)
- Antihypertensives (Ex. nitrendipine, rosuvastatin)
- Immunosuppressants (Ex. ciclosporin)
Overdosage:
If you or anyone else takes too much of HEPAKIND 450 TABLET, consult your doctor immediately or visit the nearby hospital. The symptom of overdosage is diarrhea.
Synopsis
| Drug | : | Ursodeoxycholic Acid |
| Pharmacological Category | : | Cholagogues and Choleretics |
| Therapeutic Indication | : | Biliary cirrhosis, Gallstones, Liver diseases associated with cystic fibrosis |
| Dosage Forms | : | Tablet, Dispersible tablet, Suspension, Syrup |
More Information
Gall stones are hardened deposits mostly made up of cholesterol that can form in the gallbladder and can cause sharp, intense pain in the upper right part of the abdomen.
Cystic fibrosis is a disease that affects the cells that produce mucus, sweat, and digestive juices and causes these fluids to become thick and sticky, resulting in plugged-up tubes, ducts, and passageways.
FAQs About HEPAKIND 450 TABLET
Q: What is HEPAKIND 450 TABLET used for?
A: HEPAKIND 450 TABLET is a liver care supplement used for liver detoxification and promotes liver wellness support, liver health restoration, and liver health enhancement.
Q: Why is HEPAKIND 450 TABLET prescribed?
A: HEPAKIND 450 TABLET is a liver cleanse supplement used in the management of primary biliary cirrhosis (PBC). It can also be used in the dissolution of cholesterol gallstones and to manage liver conditions associated with cystic fibrosis in children aged 6 to 18 years.
Q: Do I need to undergo any diagnostic tests before or while getting managed with HEPAKIND 450 TABLET?
A: During or while the management with HEPAKIND 450 TABLET, your doctor might ask you to get several diagnostic tests done, such as a liver function test and a gall bladder scan.
Q: Can I stop taking HEPAKIND 450 TABLET on my own?
A: Do not stop taking HEPAKIND 450 TABLET unless advised by your doctor. Your doctor might advise you on how long you should continue to take HEPAKIND 450 TABLET. From time to time, you will need to consult your doctor to review your management and assess your symptoms.
Q: Can HEPAKIND 450 TABLET cause diarrhoea?
A: Diarrhoea is the most common side effect of HEPAKIND 450 TABLET. It may occur as a result of an overdose as well. If you do suffer from diarrhea, make sure you drink enough liquids to replace your fluid and electrolyte balance and stay hydrated. Stop taking HEPAKIND 450 TABLET and inform your doctor immediately if you have persistent diarrhea.
Q: What is the best time to take HEPAKIND 450 TABLET?
A: Take HEPAKIND 450 TABLET with or after meals. For tablet or capsule, swallow HEPAKIND 450 TABLET with a glass of water or milk. Do not crush or chew the medicine. For the dispersible tablet, disperse HEPAKIND 450 TABLET in the specified quantity of water as mentioned in the label. Consume the mixture immediately after reconstitution. If you feel that the effect of HEPAKIND 450 TABLET is too strong or too weak for you, please talk to your doctor.
Q: What is the role of HEPAKIND 450 TABLET in fatty liver?
A: HEPAKIND 450 TABLET targets the liver, where it becomes concentrated in the bile produced. Consequently, it inhibits the liver's synthesis and release of cholesterol, resulting in decreased cholesterol levels in the bile. Additionally, it manages the intestines from absorbing bile salts and cholesterol. This dual action lowers cholesterol saturation in bile, facilitating the gradual dissolution of gallstones and reducing their size over time until they completely dissolve. Moreover, by enhancing bile flow through the liver, this medication lowers elevated liver enzyme levels, thus safeguarding liver cells.
Q: When should I take HEPAKIND 450 TABLET?
A: Your doctor may advise you to take 2 to 3 doses daily, with the last dose recommended at bedtime. HEPAKIND 450 TABLET is best taken with water or milk and can be consumed with or after meals. The appropriate timing for taking this medication may vary based on your specific condition. Ideally, the doses should be spaced at 6-hour intervals, such as at 8 a.m., 2 p.m., and 8 p.m.
Q: Does HEPAKIND 450 TABLET cause weight gain?
A: Weight gain may be associated with the use of HEPAKIND 450 TABLET, particularly when prescribed for liver disease characterized by chronic bile stasis in the small bile ducts of the liver. In such cases, the normal flow of bile from the liver to the small intestine is hindered. It's important to note that the likelihood of weight gain varies among individuals, depending on the specific disease. If you notice any weight gain, it is advisable to consult your doctor for guidance.
Q: Can we use HEPAKIND 450 TABLET for kidney stones?
A: No, HEPAKIND 450 TABLET is used for dissolving gallstones and not kidney stones.
Q: Does HEPAKIND 450 TABLET cause constipation?
A: Constipation is one of the common side effects of taking this medicine. However, it is usually short-lived and disappears on its own. If this side effect does not resolve on its own, consult your doctor.
Q: Is it safe to buy HEPAKIND 450 TABLET from online pharmacies like Netmeds in India?
A: Generally, it is safe to buy HEPAKIND 450 TABLET from reputable online pharmacies like Netmeds in India. Netmeds adheres to strict regulations to ensure the quality and authenticity of the medications. Netmeds has made buying online medicines easier for consumers and is one of India's leading online pharmacies.
References
- KD. Tripathi. Antiemetic, Prokinetic and Digestant drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page - 671.
- Glenmark Pharmaceuticals Europe Limited. Electronic Medicine Compendium (EMC). [Revised in March 2019] [Accessed on 10th July 2024] click here
- ABC Farmaceutici S.p.A. Health Products Regulatory Authority (HPRA). [Revised in July 2021] [Accessed 10th July 2024] click here
- Glenmark Pharmaceuticals Europe Limited. Electronic Medicine Compendium (EMC). [Revised in March 2019]. [Accessed on 10th July 2024] click here
- DM Pharma. Ursodeoxycholic Acid. [Accessed on 10th July 2024] click here
- MIMS. Ursodeoxycholic Acid (Ursodiol). [Accessed on 10th July 2024] click here




