Gravitor Tablet 10'S

Introduction About GRAVITOR 60MG TABLET

GRAVITOR TABLET contains Pyridostigmine which belongs to the group of medicines called Cholinesterase Inhibitors. It is widely used in india to manage conditions such as myasthenia gravis (a disease-causing muscle weakness and tiredness), paralytic ileus (paralysis of intestinal muscles), and postoperative urinary retention. This medicine helps in strengthening muscles, supporting bowel function, and stimulating bladder muscles. Pyridostigmine works by blocking the enzyme acetylcholinesterase, which breaks down acetylcholine, thereby increasing acetylcholine levels at nerve endings to enhance muscle contraction and improve muscle strength.

Take Gravitor Tablet on an empty stomach, preferably at the same time each day. Use the medicine exactly as directed by your doctor regarding the dose and duration. If you forget to take a dose, take it as soon as you recall. Do not skip any doses and ensure you complete the full course of management. Never discontinue this medication suddenly without medical advice.

Common side effects of Gravitor Tablet include nausea, vomiting, excessive salivation, diarrhea, blurred vision, shortness of breath, watery eyes, abdominal pain, and changes in urination frequency. Other possible side effects are muscle cramps and twitching, sweating, headache, dizziness, runny nose, and heartburn. It may also cause dizziness and drowsiness, so avoid activities requiring focus and attention, such as driving or operating machinery.

Before taking Gravitor Tablet, inform your doctor if you have any kidney problems, Parkinson’s disease, asthma, or stomach disorders. This medicine may cause a drop in blood pressure, so it is important to monitor it and consult your doctor if you experience any discomfort. As Gravitor Tablet can cause diarrhea, make sure to drink plenty of fluids to stay hydrated. Also, notify your doctor if you are pregnant, planning to conceive, or breastfeeding before taking this medication.

Uses Of GRAVITOR 60MG TABLET

• Myasthenia gravis
• Paralytic ileus
• Postoperative urinary retention

Benefits of GRAVITOR 60MG TABLET

1)Enhances Muscle Strength and Coordination: Gravitor Tablet improves communication between nerves and muscles by increasing acetylcholine levels. This helps reduce muscle weakness and fatigue, enabling better control of muscles involved in activities like walking, speaking, and swallowing.

2)Supports Digestive Health: By stimulating the intestinal muscles, Gravitor Tablet promotes healthy muscle contractions in the digestive tract. This aids in relieving paralytic ileus by restoring normal bowel motility and improving digestion.

3)Aids Postoperative Bladder Function: Gravitor Tablet helps in restoring proper coordination between bladder muscles and nerves, making it easier to empty the bladder after surgery and reducing urinary retention issues.

4)Consistent Symptom Relief: With regular use as prescribed, the medication supports sustained improvement of symptoms associated with neuromuscular disorders, helping patients maintain a better quality of life.

5)Well-Tolerated with Medical Supervision: Most side effects are mild and manageable under medical guidance. When taken appropriately, Gravitor ensures safe and effective management for muscle-related conditions.

How GRAVITOR 60MG TABLET Works

Gravitor Tablet contains Pyridostigmine, which helps improve muscle strength by enhancing communication between nerves and muscles. It is used to manage conditions where muscle weakness occurs due to impaired nerve signals.

Mechanism of Action: Gravitor Tablet

Pyridostigmine works by inhibiting the enzyme acetylcholinesterase, which breaks down acetylcholine, a chemical messenger essential for muscle activation. By reducing acetylcholine breakdown, the medicine increases its availability at nerve endings to stimulate muscle contraction.

Science Behind Nerve-Muscle Communication

Muscle movement is controlled by signals transmitted from nerves to muscle fibers through neurotransmitters like acetylcholine. When a nerve impulse arrives, acetylcholine is released to activate muscle contraction. Proper levels of acetylcholine are critical for normal muscle function.

Gravitor Tablet and Acetylcholine

Gravitor Tablet increases acetylcholine levels at neuromuscular junctions by blocking acetylcholinesterase, the enzyme that degrades acetylcholine. This prolongs the action of acetylcholine, ensuring muscles receive stronger and more sustained stimulation.

Understanding Cholinesterase Inhibitors

Pyridostigmine, the active ingredient in Gravitor, belongs to a class of drugs called cholinesterase inhibitors. These drugs reduce the breakdown of acetylcholine, boosting nerve-muscle communication and improving muscle strength in diseases like myasthenia gravis.

Role of Pyridostigmine in Muscle Strength

By increasing acetylcholine availability, Pyridostigmine enhances the ability of muscles to contract and sustain force. This helps reduce symptoms of muscle weakness and fatigue, enabling better control over voluntary movements.

Enhanced Neurotransmission: What It Means

Enhanced neurotransmission refers to improved signal transmission from nerves to muscles. Gravitor Tablet supports this process by lowering acetylcholine degradation, which leads to improved muscle activation and alleviates weakness.

Supporting Healthy Muscle Function

Regular use of Gravitor Tablet helps maintain sufficient acetylcholine levels, supporting healthy muscle function and coordination. This is particularly important for patients suffering from neuromuscular conditions that cause muscle fatigue and weakness.

How to use GRAVITOR 60MG TABLET

Gravitor Tablet should be taken exactly as prescribed by your doctor. To achieve the best results, take the tablet on an empty stomach, ideally at the same time each day. Swallow the tablet whole without crushing or chewing it.

Dosage Guidelines and Administration

• The usual adult dosage for conditions like myasthenia gravis ranges from 60 mg to 1500 mg per day, divided into several doses spaced evenly to provide consistent symptom control.
• Dosage varies according to individual factors such as age, body weight, and severity of the condition.
• Your doctor will determine the appropriate dose for you and may adjust it based on your response to management.

How to Take Gravitor Tablet Safely

• Take the tablet with a full glass of water on an empty stomach for optimal absorption.
• Do not alter the dose or stop taking the medication suddenly without consulting your healthcare provider.
• Store the medication in a cool, dry place away from direct sunlight.

When and How Much to Take

• Typically, Gravitor is taken during the day when maximum muscle strength is needed, after waking up and 30 to 60 minutes before meals.
• Follow your doctor’s instructions on exact timing and quantity according to your health status.

Step-by-Step Dosing Instructions

1. Take your prescribed dose at the same times each day.
2. Swallow the tablet whole with water on an empty stomach.
3. Do not skip doses, take missed doses as soon as you remember unless it is near the next scheduled dose.
4. Complete the full course even if you start feeling better.

Dosage Advice for Elderly or Special Groups

• Elderly patients should use Gravitor Tablet under close medical supervision, as they may be more sensitive to side effects.
• Dose adjustments may be needed in patients with kidney problems or other underlying health conditions.
• Consult your doctor for personalized dosage based on your health profile.

Important Administration Tips

• Do not chew, crush, or break the tablet.
• Maintain a consistent schedule to keep stable drug levels in your body.
• Stay hydrated, especially if experiencing side effects like diarrhea.
• Inform your doctor of any other medications you are taking to avoid interactions.

What if I forgot to take GRAVITOR 60MG TABLET

• Take the missed dose as soon as you remember.
• If it is almost time for your next dose, skip the missed dose.
• Do not double the dose to make up for a missed one.

Side Effects Of GRAVITOR 60MG TABLET

Like all medicines, Gravitor Tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Gravitor Tablet are:

• Nausea
• Vomiting
• Excessive salivation
• Diarrhea
• Blurred vision
• Shortness of breath
• Watery eyes
• Abdominal pain
• Changes in urination frequency
• Muscle cramps and twitching
• Sweating
• Headache
• Dizziness
• Runny nose
• Heartburn

When to consult your doctor?

• Allergic reaction symptoms such as sudden wheeziness, trouble breathing, swelling of the eyelids, face or lips, rash, or itching affecting your whole body.
• Cholinergic Crisis symptoms such as visual disturbance, more than normal tear or phlegm production, irregular heartbeat, rash, too much sweating, shaking, sudden urgency to urinate, muscle weakness, difficulty in breathing.

How To Manage Side Effects

Diarrhea

• Stay Hydrated: Drink plenty of clear fluids like water, oral rehydration solutions, or clear broths to replace lost fluids and reduce dehydration.
• Eat Light, Simple Foods: Choose bland foods such as bananas, rice, toast, or applesauce. Avoid fatty, spicy, or high-fiber foods until your symptoms improve.
• Rest: Give your body time to recover by resting as much as possible.
• Avoid Dairy and Caffeine: These can sometimes make diarrhea worse, so limit milk, cheese, coffee, and caffeinated drinks until you feel better.
• Monitor Symptoms: If diarrhea lasts more than a couple of days, becomes severe, or is accompanied by symptoms like fever, blood in the stool, or dehydration (such as dizziness or decreased urination), contact your doctor.

Headache

• Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
• Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
• Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
• Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
• Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

Nausea And Vomiting

• Eat Small, Frequent Meals: Avoid heavy or greasy foods. Opt for bland foods like crackers, toast, or bananas.
• Stay Hydrated: Sip on clear fluids like water, ginger tea, or electrolyte drinks, Avoid caffeinated and carbonated beverages.
• Ginger: Ginger is a natural remedy for nausea. Try ginger tea, ginger candies, or ginger ale (ensure it contains real ginger).
• Avoid Strong Odors: Minimize exposure to smells that might trigger nausea, such as perfumes or cooking odors.

Warning & Precautions

Pregnancy

Monitoring required

GRAVITOR TABLET should be used in pregnant women only if considered necessary by your doctor. Consult your doctor before taking it.

Breastfeeding

Use with Caution

Gravitor tablet should be used with caution in breastfeeding women as a small amount is passed in the breast milk. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Gravitor Tablet may cause dizziness or drowsiness or blurred vision. Avoid driving or operating machinery unless you are fully alert.

Alcohol

Consult your doctor

Avoid consuming alcohol while taking Gravitor Tablet as it may increase dizziness and drowsiness.

Kidney

Consult your doctor

Gravitor Tablet is not recommended for use in patients who cannot pass urine because of an obstruction and should be used with caution in patients with kidney impairment. Dose adjustment may be needed. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take Gravitor Tablet if you are allergic to Pyridostigmine or any of the other ingredients of this medicine.

Lungs

Use with Caution

Gravitor should be used with caution in patients who have obstructive respiratory conditions such as bronchial asthma or chronic obstructive pulmonary disease (COPD). It is important to consult your doctor before taking this medication.

Heart Disease

Use with Caution

Gravitor Tablet should be used with caution in patients who have a slow heart rate, a recent heart attack, low blood pressure, or irregular heartbeat. It is important to consult your doctor before taking this medication.

Use In Pediatrics

Contraindicated

Gravitor Tablet is not recommended for use in individuals under 18 years of age unless prescribed by a doctor. Consult your pediatrician before giving it.

Use In Geriatrics

Use with Caution

GRAVITOR TABLET should be used with caution in elderly patients (aged above 65 years) who have irregular heartbeat or other heart conditions. Consult your doctor before taking this medicine. Older adults may be more sensitive to its side effects, and dose adjustments might be necessary based on their overall health.

Other Warnings for GRAVITOR 60MG TABLET

Before taking Gravitor Tablet, inform your doctor if you:

• suffer from Parkinson's disease
• Have stomach disorders
• have vagotonia (a disruption of the vagus nerve causing constipation, sweating and muscle cramps)
• have an overactive thyroid
• had a surgery to remove your thymus gland
• Intolerance to some sugars

Who should not take [GBNKEYWORD

Gravitor Tablet is not recommended for use if you:

• Have an obstruction in digestive or urinary tract (such as bowel or bladder obstruction)
• Have epilepsy or a history of seizures
• Have a peptic (stomach) ulcer
• Have an overactive thyroid gland (thyrotoxicosis)

Diet and Lifestyle Advice

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking GRAVITOR TABLET:

1.Aminoglycoside Antibiotics (e.g., Gentamicin, Amikacin)

• • Interaction: These antibiotics may reduce the effectiveness of Gravitor by blocking nerve-muscle communication.
  • Effects: Decreased muscle strength and reduced response to management.
  • Management: Your doctor may monitor you closely and adjust the dose of Gravitor or the antibiotic as needed.

2.Muscle Relaxants (e.g., Succinylcholine)

• • Interaction: Muscle relaxants may have an enhanced effect when taken with Gravitor.
  • Effects: Excessive muscle relaxation or weakness, potentially causing breathing difficulties.
  • Management: Use with caution under strict medical supervision. Dose adjustments may be required.

3.Anticholinergic Drugs (e.g., Atropine, Glycopyrrolate)

• • Interaction: Anticholinergic drugs oppose the effects of Gravitor by blocking acetylcholine.
  • Effects: Reduced effectiveness of Gravitor leading to worsened muscle weakness.
  • Management: Inform your doctor if you are taking anticholinergic medications; management plans may need adjustment.

4.Corticosteroids (e.g., Prednisone)

• • Interaction: Can increase muscle weakness when used with Gravitor.
  • Effects: Worsening of symptoms and reduced muscle strength.
  • Management: Regular monitoring by the doctor is necessary; dosage changes might be required.

5.Beta-Blockers (e.g., Propranolol, Atenolol)

• • Interaction: May increase the risk of bradycardia when combined with Gravitor.
  • Effects: Slow heart rate, dizziness, or fainting.
  • Management: Heart rate monitoring is essential; dose adjustments may be needed.

Synopsis

More Information

FAQs About GRAVITOR 60MG TABLET

References

1. Tilo Grosser, Emer Smyth and Garret A. FitzGerald. Anticholinergic Agents. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 213.

2. Maggi, L., & Mantegazza, R. Management of myasthenia gravis. SpringerLink. August 2012. [Accessed on 5th Aug 2025] 

3. University of Aarhus. Effect of Pyridostigmine (Mestonin) on Muscle Strength in myasthenia Gravis. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in April 2018] [Accessed on 5th Aug 2025] 

4. Actavis Group PTC ehf. Pyridostigmine. [Revised in March 2022] [Accessed on 5th Aug 2025] 

5. Bausch Health Companies Inc. Pyridostigmine. [Revised in December 2020] [Accessed on 5th Aug 2025] 

6. iNova Pharmaceuticals (Australia) Pty Limited. Pyridostigmine. [Revised in March 2021] [Accessed on 5th Aug 2025] 

Useful Diagnostic Tests

• Edrophonium test
• Electromyography (EMG)
• CT-scan
• MRI Scan

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Srikar Modepu - MBBS, MD (Diabetology)

Last updated on 06 Aug 2025 | 03:06 PM(IST)