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Introduction About GRANILET SYRUP
GRANILET SYRUP contains a medicine Granisetron which belongs to a group of medicines called Anti-emetics. It is used to manage or manage nausea (feeling sick) and vomiting (being sick) caused by other medical managements such as chemotherapy or radiation management for cancer and after surgery.
Before taking GRANILET SYRUP inform your doctor if you have heart diseases, blockage in your stomach or intestines, electrolyte abnormalities, galactose intolerance, lactase deficiency or glucose-galactose malabsorption.
GRANILET SYRUP is not recommended for use in pregnant and breast-feeding women. Consult with your doctor before taking. GRANILET SYRUP should not be used in children below 2 years of age. GRANILET SYRUP can be used in elderly people (65 years and older). However, consult with your doctor before taking.
The most common side effects are headache, constipation, problems sleeping (insomnia) and diarrhoea. Consult with your doctor if any of these worsen or doesn’t improve.
Uses Of GRANILET SYRUP
Prevents or manages:
- Nausea and vomiting caused chemotherapy or radiotherapy
How GRANILET SYRUP Works
GRANILET SYRUP acts by inhibiting a receptor called 5-HT3 receptors present which present both in brain and gastrointestinal tract. This inhibition of 5-HT3 receptors in turn inhibits the stimulation of the vomiting centre, managing nausea and vomiting.
How to use GRANILET SYRUP
Always take GRANILET SYRUP as directed by your physician. Swallow the medicine as a whole with a plenty of water and do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your conditions.
Side Effects Of GRANILET SYRUP
Common
- headache
- constipation
- problems sleeping (insomnia)
- changes in liver function tests (pain in abdomen, nausea, vomiting, jaundice)
- diarrhoea
Rare
Stop taking GRANILET SYRUP and inform your doctor immediately if you experience any of the following side effects:
- changes in the heartbeat, chest pain, irregular heartbeat and changes seen on ECG readings (electrical recordings of the heart)
- swelling of the hands, feet, ankles, face, lips and mouth or throat, which may cause difficulty in swallowing or breathing
- rash or itching
- fainting
- serotonin syndrome symptoms such as diarrheoa, nausea, vomiting, high temperature and blood pressure, excessive sweating and rapid heartbeat, agitation, confusion, hallucination, shivering, muscles shakes, jerks or stiffness, loss of coordination and restlessness
How To Manage Side Effects
Diarrhoea:
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. Ask for your doctor’s advice if diarrhoea doesn’t improve.
Headache:
Try to take rest and don’t involve yourself in exertive activities. Rest in a quiet and dark room. Apply a pain-relieving balm on your forehead. Ask for your doctor’s advice if headache doesn’t improve.
Constipation:
Eat plenty of fiber rich foods such as vegetables, fresh fruits and cereals and drink plenty of water. Exercise more regularly. Ask for your doctor’s advice if constipation doesn’t improve.
Warning & Precautions
Pregnancy
GRANILET SYRUP is not recommended for use in pregnant women. Consult your doctor before taking it.
Breastfeeding
GRANILET SYRUP is not recommended for use in breastfeeding women. Consult your doctor before taking it.
Driving and Using Machines
GRANILET SYRUP should not affect your ability to drive or operate machinery.
Allergy
Do not take GRANILET SYRUP if you are allergic (hypersensitive) to Granisetron or any other ingredients of this medicine.
Heart Disease
GRANILET SYRUP should be used with caution in patients suffering from heart diseases. Consult your doctor for advice before taking GRANILET SYRUP.
Others
Before taking GRANILET SYRUP, inform your doctor if you have:
- blockage in the intestine (stomach-ache, wind, feeling or being sick or difficulty passing stools)
- electrolyte abnormalities (potassium, sodium or calcium)
- serotonin syndrome
- been or are being managed for cancer with a medicine that might cause damage your heart
- lactose intolerance
Use in Pediatrics:
GRANILET SYRUP is not recommended for use in children below 2 years of age. Consult with your child’s doctor before giving this to your child.
Use in Geriatrics:
GRANILET SYRUP can be used in elderly people (65 years and older). However, consult with your doctor before taking.
Interactions
A. Drug - Drug interactions:
Before taking GRANILET SYRUP, inform your doctor if you are taking any of the following medicines:
- other 5-HT3 receptor antagonist such as dolasetron or ondansetron (used to manage nausea and vomiting)
- diltiazem, amlodipine (medicines used to manage an irregular heartbeat)
- phenobarbital (used to manage epilepsy)
- ketoconazole (used to manage fungal infections)
- paroxetine, sertraline, fluvoxamine, citalopram, venlafaxine, duloxetine, escitalopram (used to manage depression and/or anxiety)
- buprenorphine, tramadol (used to manage acute and chronic pain)
Overdosage:
If you or anyone else accidentally take too much of GRANILET SYRUP, consult your doctor immediately. Symptoms of overdose includes mild headaches.
Synopsis
| Drug | : | Granisetron |
| Pharmacological Category | : | 5-HT3 Receptor Antagonist |
| Therapeutic Indication | : | Nausea and vomiting caused chemotherapy or radiotherapy |
| Dosage Forms | : | Tablet, Syrup, Suspension, Injection |
More Information
- Keep GRANILET SYRUP out of reach from children
- Store GRANILET SYRUP at room temperature below 30°C
FAQs About GRANILET SYRUP
What is GRANILET SYRUP and why is it prescribed?
GRANILET SYRUP contains a medicine Granisetron. It is used to manage or manage nausea (feeling sick) and vomiting (being sick) caused by other medical managements such as chemotherapy or radiation management for cancer.
Does GRANILET SYRUP cause constipation?
Yes, GRANILET SYRUP may cause constipation in some individuals. Eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Exercise more regularly. Ask for your doctor’s advice if constipation doesn’t improve.
Can I stop taking GRANILET SYRUP when my symptoms are relieved?
Do not stop taking GRANILET SYRUP before the management is finished. If you stop taking GRANILET SYRUP, your symptoms may return. Ask for your doctor’s advice if you wish to stop taking this medicine.
Can I take GRANILET SYRUP during heart disease?
GRANILET SYRUP should be used with caution in patients suffering from heart disease. Consult your doctor for advice before taking GRANILET SYRUP.
What is the best time to take GRANILET SYRUP?
Always take GRANILET SYRUP as directed by your physician. GRANILET SYRUP can be taken with or without food. Your doctor will decide the correct dose and duration for you depending upon your conditions.
References
1. KD. Tripathi. Antiemetic, Prokinetic and Digestant Drug. Essentials of medical pharmacology. Seventh edition. 2013. Page –669.
2. NIH National Library of Medicine, National center for biotechnology information. Granisetron. Pubchem. [Accessed on 26th November 2022]. https://pubchem.ncbi.nlm.nih.gov/compound/Granisetron-hydrochloride
3. Anh L. Ngo, Vwaire Orhurhu, Ivan Urits, Edwin O. Delfin, Medha Sharma, Mark R. Jones, Omar Viswanath, Richard D. Urman. Extended release granisetron: Review of pharmacologic considerations and clinical role in the perioperative setting. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. September 2019. [Accessed on 26th November 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625288/
4. Matti Aapro. Granisetron: an update on its clinical use in the management of nausea and vomiting. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. [Accessed on 26th November 2022]. https://pubmed.ncbi.nlm.nih.gov/15561811/
5. Generics [UK] Limited. Electronic Medicines Compendium (EMC). [Revised on Jan 2021]. [Accessed on 26th November 2022]. https://www.medicines.org.uk/emc/files/pil.2685.pdf
6. Atnahs Pharma UK Limited. Health Products Regulatory Authority (HPRA). [Revised in March 2021]. [Accessed on 26th November 2022]. http://www.hpra.ie/img/uploaded/swedocuments/Licence_PA22657-003-003_23032021132538.pdf
7. Natco Pharma Ltd. Granisetron Tablets. Dailymed. [Revised in May 2022]. [Accessed on 26th November 2022]. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=df4b6775-4337-41e0-815a-b064d98c3fe1
8. Aspen Pharmacare. Granisetron. [Revised in January 2022]. [Accessed on 26th November 2022]. https://pi-pil-repository.sahpra.org.za/wp-content/uploads/2022/03/1.3.2_Aspen-Granisetron_27-January-2022_EPIL.pdf
9. Atnahs Pharma UK Limited. Kytril (Granisetron). Pharmanovia. [Accessed on 26th November 2022]. https://pharmanovia.com/product/kytril/
10. Intra life. Cool – Time (Granisetron). [Accessed on 26th November 2022]. https://intralifeindia.com/product_detail.php?id=829
11. Drug Bank. Granisetron. [Accessed on 26th November 2022]. https://go.drugbank.com/drugs/DB00889
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