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Introduction About GRANICIP 1MG TABLET
GRANICIP 1MG TABLET contains Granisetron which belongs to a group of medicines called Anti-emetics. It is used to manage nausea and vomiting caused by other medical managements such as chemotherapy or radiation management for cancer.
Before taking GRANICIP 1MG TABLET inform your doctor if you have heart diseases, blockage in your stomach or intestines, electrolyte abnormalities, galactose intolerance, lactase deficiency or glucose-galactose malabsorption. GRANICIP 1MG TABLET is not recommended for use in pregnant and breast-feeding women. Consult with your doctor before taking.
GRANICIP 1MG TABLET should not be used in children below 2 years of age. GRANICIP 1MG TABLET can be used in elderly people (65 years and above). However, consult with your doctor before taking. The most common side effects are headache, constipation, problems sleeping (insomnia), and diarrhoea. Consult with your doctor if any of these worsen or doesn’t improve.
Uses Of GRANICIP 1MG TABLET
- It is used to manage nausea and vomiting caused by other medical managements such as chemotherapy or radiation
How GRANICIP 1MG TABLET Works
GRANICIP 1MG TABLET acts by inhibiting a receptor called 5-HT3 receptors present which present both in brain and gastrointestinal tract. This inhibition of 5-HT3 receptors in turn inhibits the stimulation of the vomiting centre, managing nausea and vomiting.
How to use GRANICIP 1MG TABLET
Always take GRANICIP 1MG TABLET as directed by your physician. Swallow the medicine with a plenty of water and do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your conditions.
Side Effects Of GRANICIP 1MG TABLET
Common
- headache
- constipation
- problems sleeping
- changes in liver function tests (pain in abdomen, nausea, vomiting, jaundice)
- diarrhoea
Stop taking GRANICIP 1MG TABLET and inform your doctor immediately if you experience any of the following side effects:
- changes in the heartbeat, chest pain, irregular heartbeat and changes seen on ECG readings (electrical recordings of the heart)
- swelling of the hands, feet, ankles, face, lips and mouth or throat, which may cause difficulty in swallowing or breathing
- rash or itching
- fainting
- serotonin syndrome symptoms such as diarrhoea, nausea, vomiting, high temperature and blood pressure, excessive sweating and rapid heartbeat, agitation, confusion, hallucination, shivering, muscles shakes, jerks or stiffness, loss of coordination and restlessness
How To Manage Side Effects
Constipation
Eat plenty of fiber rich foods such as vegetables, fresh fruits, and cereals and drink plenty of water. Exercise more regularly. Ask for your doctor’s advice if constipation doesn’t improve.
Diarrhea
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. Ask for your doctor’s advice if diarrhoea doesn’t improve.
Headache
Try to take rest and don’t involve yourself in exertive activities. Rest in a quiet and dark room. Apply a pain-relieving balm on your forehead. Ask for your doctor’s advice if headache doesn’t improve.
Warning & Precautions
Pregnancy
ContraindicatedGRANICIP 1MG TABLET is not recommended for use in pregnant women. Consult your doctor before taking it.
Breastfeeding
ContraindicatedGRANICIP 1MG TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionGRANICIP 1MG TABLET should not affect your ability to drive or operate machinery.
Allergy
ContraindicatedDo not take GRANICIP 1MG TABLET if you are allergic (hypersensitive) to Granisetron or any other ingredients of this medicine.
Heart Disease
Use with CautionGRANICIP 1MG TABLET should be used with caution in patients suffering from heart diseases. Consult your doctor for advice before taking GRANICIP 1MG TABLET.
Use In Pediatrics
ContraindicatedGRANICIP 1MG TABLET is not recommended for use in children below 2 years of age. Consult with your child’s doctor before giving this to your child.
Use In Geriatrics
Use with CautionGRANICIP 1MG TABLET can be used in elderly people (65 years and older). However, consult with your doctor before taking.
Others
Before taking GRANICIP 1MG TABLET, inform your doctor if you have:
- blockage in the intestine (stomach-ache, wind, feeling or being sick, or difficulty passing stools)
- electrolyte abnormalities (potassium, sodium, or calcium)
- serotonin syndrome
- been or are being managed for cancer with a medicine that might cause damage your heart
- lactose intolerance
Interactions
A. Drug-Drug interactions:
Before taking GRANICIP 1MG TABLET, inform your doctor if you are taking any of the following medicines:
- other 5-HT3 receptor antagonist such as dolasetron or ondansetron (used to manage nausea and vomiting)
- diltiazem, amlodipine (medicines used to manage an irregular heartbeat)
- phenobarbital (used to manage epilepsy)
- ketoconazole (used to manage fungal infections)
- paroxetine, sertraline, fluvoxamine, citalopram, venlafaxine, duloxetine, escitalopram (used to manage depression and/or anxiety)
- buprenorphine, tramadol (used to manage acute and chronic pain)
Overdosage:
If you or anyone else accidentally takes too much of GRANICIP 1MG TABLET, consult your doctor immediately. Symptoms of overdose includes mild headaches.
Synopsis
| Drug | : | Granisetron |
| Pharmacological Category | : | 5-HT3 Receptor Antagonist |
| Therapeutic Indication | : | Nausea and vomiting caused by chemotherapy or radiotherapy |
| Dosage Forms | : | Tablet, Syrup, Suspension, Injection |
More Information
Storage
- Keep GRANICIP 1MG TABLET out of reach from children
- Store GRANICIP 1MG TABLET at room temperature below 30°C
FAQs About GRANICIP 1MG TABLET
Q: What is GRANICIP 1MG TABLET and why is it prescribed?
A: GRANICIP 1MG TABLET contains Granisetron which is used to manage nausea and vomiting caused by other medical managements such as chemotherapy or radiation management for cancer.
Q: Does GRANICIP 1MG TABLET cause constipation?
A: Yes, GRANICIP 1MG TABLET may cause constipation in some individuals. Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. Ask for your doctor’s advice if constipation doesn’t improve.
Q: Can I stop taking GRANICIP 1MG TABLET when my symptoms are relieved?
A: No. Do not stop taking GRANICIP 1MG TABLET before the management is finished. If you stop taking GRANICIP 1MG TABLET, your symptoms may return. Ask for your doctor’s advice if you wish to stop taking this medicine.
Q: Can I take GRANICIP 1MG TABLET during heart disease?
A: GRANICIP 1MG TABLET should be used with caution in patients suffering from heart disease. Consult your doctor for advice before taking GRANICIP 1MG TABLET.
Q: What is the best time to take GRANICIP 1MG TABLET?
A: Always take GRANICIP 1MG TABLET as directed by your physician. GRANICIP 1MG TABLET can be taken with or without food. Your doctor will decide the correct dose and duration for you depending upon your conditions.
References
1. KD. Tripathi. Antiemetic, Prokinetic and Digestant Drug. Essentials of medical pharmacology. Seventh edition. 2013. Page-669.
2. NIH National Library of Medicine, National center for biotechnology information. Granisetron. Pubchem. [Accessed on 26th November 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Granisetron-hydrochloride
3. Anh L. Ngo, Vwaire Orhurhu, Ivan Urits, Edwin O. Delfin, Medha Sharma, Mark R. Jones, Omar Viswanath, Richard D. Urman. Extended release granisetron: Review of pharmacologic considerations and clinical role in the perioperative setting. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. September 2019. [Accessed on 26th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625288/
4. Matti Aapro. Granisetron: an update on its clinical use in the management of nausea and vomiting. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. [Accessed on 26th November 2022] https://pubmed.ncbi.nlm.nih.gov/15561811/
5. Generics [UK] Limited. Electronic Medicines Compendium (EMC). [Revised on Jan 2021] [Accessed on 26th November 2022] https://www.medicines.org.uk/emc/files/pil.2685.pdf
6. Atnahs Pharma UK Limited. Health Products Regulatory Authority (HPRA). [Revised in March 2021]. [Accessed on 26th November 2022] http://www.hpra.ie/img/uploaded/swedocuments/Licence_PA22657-003-003_23032021132538.pdf
7. Natco Pharma Ltd. Granisetron Tablets. Dailymed. [Revised in May 2022]. [Accessed on 26th November 2022] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=df4b6775-4337-41e0-815a-b064d98c3fe1
8. Aspen Pharmacare. Granisetron. [Revised in January 2022] [Accessed on 26th November 2022] https://pi-pil-repository.sahpra.org.za/wp-content/uploads/2022/03/1.3.2_Aspen-Granisetron_27-January-2022_EPIL.pdf
9. Atnahs Pharma UK Limited. Kytril (Granisetron). Pharmanovia. [Accessed on 26th November 2022] https://pharmanovia.com/product/kytril/
10. Drug Bank. Granisetron. [Accessed on 26th November 2022] https://go.drugbank.com/drugs/DB00889
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