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Introduction About GLZ XR 60MG TABLET
GLZ XR 60MG TABLET is used in adults in the management of type II diabetes mellitus when diet, exercise, and lifestyle changes alone do not result in an adequate response. It contains Gliclazide which belongs to the group of medicines called Antidiabetic agents. It effectively controls blood sugar levels, where gliclazide makes the pancreas secrete more insulin to digest the circulating sugars (glucose) in the blood. It also makes the body more sensitive to insulin, which helps in utilizing the circulating blood glucose (sugars), leading to a decrease in blood glucose levels.
During therapy with GLZ XR 60MG TABLET, your doctor might ask you to make certain lifestyle changes, such as following a healthy diet, regular physical exercise and quitting alcohol consumption. Before taking GLZ XR 60MG TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any hormonal problems, genetic disorders (such as G6PD deficiency), or if you are malnourished, starved, or on an irregular diet.
GLZ XR 60MG TABLET is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking GLZ XR 60MG TABLET if you are pregnant, planning to become pregnant, or breastfeeding women. The most common side effects of taking GLZ XR 60MG TABLET is hypoglycemia (low blood sugar levels), which can be identified through symptoms such as increased hunger, sweating, shakiness, weakness, or an irregular heartbeat. To avoid this, your doctor will periodically monitor your blood sugar levels and adjust the dose of GLZ XR 60MG TABLET accordingly.
Uses Of GLZ XR 60MG TABLET
- Used in the management of type II diabetes mellitus in adults
How GLZ XR 60MG TABLET Works
GLZ XR 60MG TABLET effectively controls blood sugar levels, where Gliclazide makes the pancreas secrete more insulin to digest the circulating sugars (glucose) in the blood. It also makes the body more sensitive to insulin, which helps in utilizing the circulating blood glucose (sugars), leading to a decrease in blood glucose levels.
How to use GLZ XR 60MG TABLET
- Take GLZ XR 60MG TABLET before meals or as advised by your physician
- Swallow the medicine with a glass of water. Do not crush or chew the medicine
- Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition
- Continue to take GLZ XR 60MG TABLET for the duration recommended by your doctor to achieve better control over blood sugar levels
Side Effects Of GLZ XR 60MG TABLET
Common side effects of GLZ XR 60MG TABLET:
- hypoglycemia (low blood sugar levels)
- dizziness
- stomach pain, indigestion, diarrhea, or constipation
Stop taking GLZ XR 60MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reaction (such as skin rash, swelling of the face, eyelids, lips, tongue, or throat that causes difficulty breathing or swallowing)
- signs of liver problems (such as fever, yellowing of the skin and whites of the eyes, weakness, fatigue, weight loss, and loss of appetite)
- signs of a severe decrease in blood sugar level (such as confusion, headache, excessive sweating, clammy skin, trembling, weakness, double vision, excessive hunger, nausea, vomiting, problems sleeping, feeling agitated, unable to concentrate, drowsiness, loss of consciousness, slowed reactions, depression, trouble seeing or speaking, paralysis, numbness, dizziness, hallucinations, difficulty breathing, slowed or faster heartbeat with chest pain)
Warning & Precautions
Pregnancy
ContraindicatedGLZ XR 60MG TABLET is not recommended for use by pregnant women.
Breastfeeding
ContraindicatedGLZ XR 60MG TABLET is not recommended for use by breastfeeding women.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel dizzy or experience blurred vision after taking GLZ XR 60MG TABLET.
Alcohol
Consult your doctorAvoid alcohol consumption while taking GLZ XR 60MG TABLET, as it could aggravate your existing condition.
Kidney
Consult your doctorGLZ XR 60MG TABLET is not recommended for use in patients with severe kidney disease. It should be used with caution in patients with decreased kidney function.
Liver
Consult your doctorGLZ XR 60MG TABLET is not recommended for use in patients with severe liver disease. It should be used with caution in patients with decreased liver function.
Allergy
ContraindicatedDo not take GLZ XR 60MG TABLET if you are allergic to Gliclazide or to any other medicines that belong to sulphonylureas (such as glibenclamide, glipizide).
Use In Pediatrics
ContraindicatedGLZ XR 60MG TABLET is not recommended for use in children and adolescents (aged below 18 years).
Use In Geriatrics
Use with CautionGLZ XR 60MG TABLET should be used with caution in elderly patients, especially in those who take medicines such as CNS depressants or beta-blockers.
Others
GLZ XR 60MG TABLET is not recommended for use if you:
- have type I diabetes (or insulin-dependent diabetes)
- have diabetic ketoacidosis (increased levels of sugar and ketone bodies in the blood)
- have a serious traumatic injury
- have G6PD deficiency (an inherited blood disorder)
- have porphyria (an inherited blood disorder)
Before taking GLZ XR 60MG TABLET, inform your doctor if you:
- are malnourished, starved, on an irregular diet, or feeling weak
- perform extreme physical exercises
- have hormonal problems (Ex. disorders of the pituitary gland, adrenal cortex, or thyroid gland)
Interactions
A. Drug-Drug interactions:
Before taking GLZ XR 60MG TABLET, inform your doctor if you are taking any of the following medicines, such as:
- Anti-diabetics (Ex. metformin, insulin, glipizide, glibenclamide, dapaglifozin, teneligliptin)
- Antifungals (Ex. miconazole, fluconazole)
- John’s Wort
- antibiotics (Ex. ciprofloxacin, moxifloxacin, clarithromycin, co-trimoxazole, rifampicin, chloramphenicol, tetracyclines)
- sulphonamides (Ex. sulphasalazine)
- Beta blockers (Ex. atenolol, propranolol)
- ACE-inhibitors (Ex. captopril, enalapril)
- H2 blockers (Ex. ranitidine, cimetidine, famotidine)
- Monoamine oxidase (MAO) inhibitor (Ex. moclobemide, isocarboxazid, phenelzine, tranylcypromine)
- NSAID’s (Ex. aspirin, phenylbutazone, ibuprofen, phenylbutazone, azapropazone)
- Cough preparations
- Antipsychotics (Ex. chlorpromazine, prochlorperazine, lithium)
- Corticosteroids (Ex. prednisolone, cortisone, betamethasone)
- Bronchodilators (Ex. salbutamol, terbutaline)
- β2-adrenoceptor agonist (Ex. ritodrine)
- Androgenic hormones (Ex. danazol)
- Anticoagulants (Ex. warfarin)
- Diuretics (Ex. bendroflumethiazide, hydrochlorothiazide, furosemide)
- Oral contraceptives (Ex. drospirenone, ethinylestradiol)
- Uricosurics (Ex. sulfinpyrazone)
- Nonsteroidal aromatase inhibitors (Ex. aminoglutethimide)
- Thyroid hormones (Ex. thyroxine)
- Octapeptides (Ex. octreotide)
- Androgen (Ex. testosterone)
- Anti-lipedmic agents (Ex. clofibrate)
- Class 1a anti-arrhythmic agents (Ex. disopyramide)
- Laxatives (Ex. lactulose, ispaghula)
Overdosage:
If you or anyone else accidentally took more of GLZ XR 60MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose might include signs of low blood glucose levels such as weakness, sweating, trembling, a fast heartbeat, confusion, and double vision.
Synopsis
| Drug | : | Gliclazide |
| Pharmacological Category | : | Sulfonylureas |
| Therapeutic Indication | : | Type II Diabetes Mellitus |
| Dosage Forms | : | Tablet, Capsule |
More Information
FAQs About GLZ XR 60MG TABLET
Q: What is GLZ XR 60MG TABLET used for?
A: GLZ XR 60MG TABLET is an antidiabetic medicine used in the management of type II diabetes mellitus when diet, exercise, and lifestyle changes alone do not result in an adequate response.
Q: How and when should I take GLZ XR 60MG TABLET?
A: Take GLZ XR 60MG TABLET before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.
Q: How long should I take GLZ XR 60MG TABLET?
A: You need to take GLZ XR 60MG TABLET as long as your doctor prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.
Q: Can I stop taking GLZ XR 60MG TABLET without consulting your doctor?
A: No. You should not stop taking GLZ XR 60MG TABLET without consulting your doctor because it may lead to a reversal of symptoms. If you feel better after using GLZ XR 60MG TABLET, consult your doctor for advice. Your doctor might reduce the dose gradually before discontinuation of therapy.
Q: Will taking a higher dose of GLZ XR 60MG TABLET be more effective?
A: No, taking a higher dose of GLZ XR 60MG TABLET will not be effective, rather, it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: What should I do if I forget to take a dose of GLZ XR 60MG TABLET?
A: If you forget to take a dose of GLZ XR 60MG TABLET, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of GLZ XR 60MG TABLET to compensate for a missed dose, as it could lead to toxicity.
Q: What precautions do I need to follow while taking GLZ XR 60MG TABLET?
A: Before taking GLZ XR 60MG TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have hormonal problems, genetic problems (surgery in the gut), or if you are malnourished. GLZ XR 60MG TABLET is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking GLZ XR 60MG TABLET if you are pregnant or planning to become pregnant. During therapy with GLZ XR 60MG TABLET, follow the diet and lifestyle changes instructed by your doctor. Always carry a sugary snack (such as biscuits, glucose drinks, or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia.
Q: Can I take medication for high blood pressure along with GLZ XR 60MG TABLET?
A: No. It is not advisable to take medicines to control blood pressure while taking GLZ XR 60MG TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with GLZ XR 60MG TABLET, as they have known interactions with GLZ XR 60MG TABLET.
Q: What should I do if I experience low blood sugar after taking GLZ XR 60MG TABLET?
A: Low blood sugar is a common side effect of taking GLZ XR 60MG TABLET. Try to have sugar-rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. Check your blood sugar after 10 minutes. If you have not reached the optimum level, take another sugary snack or drink and check the blood sugar again. In cases of persistently low blood sugar levels, consult your doctor immediately.
Q: Can GLZ XR 60MG TABLET cause dizziness?
A: Yes. Dizziness is a common side effect of using GLZ XR 60MG TABLET. If you experience dizziness, lie down until it passes, then get up slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, and alcohol. Do not drive or use machinery to avoid accidents. Consult your doctor if you experience dizziness continuously for a long time after taking GLZ XR 60MG TABLET.
Q: Can GLZ XR 60MG TABLET be taken with insulin?
A: Co-administration of GLZ XR 60MG TABLET with insulin is considered risky as it increases the chances of hypoglycemia (decreased blood sugar levels). Consult your doctor before taking it.
Q: Can GLZ XR 60MG TABLET be used in pregnant women?
A: No. GLZ XR 60MG TABLET is not recommended for use by pregnant women. Therefore, consult your doctor for advice before taking.
References
1. K.D. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270-272.
2. Shinnya Miwa, Hirotaka Watada, Ohmura chie and Yasushi Tanaka. Efficacy and Safety of Once Daily Gliclazide (20 mg/day) Compared with Nateglinide. ScienceDirect.com. August 2004. [Accessed on 17th January 2024] click here
3. Les Laboratoires Servier. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 17th January 2024] click here
4. Accord. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 17th January 2024] click here
5. Accord. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 17th January 2024] click here
6. Balkanpharma-Dupnitsa AD. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 17th January 2024] click here
7. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 17th January 2024] click here
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