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Introduction About GLYNASE 5MG TABLET
GLYNASE 5MG TABLET contains Glipizide, which belongs to the group of medicines called Antidiabetic agents. It is used in adults in the management of type II diabetes mellitus when diet, exercise, and lifestyle changes alone do not result in an adequate response.
Type II diabetes mellitus is a chronic disease associated with abnormally high levels of glucose in the blood. It is caused either by inadequate production of a hormone called insulin (produced by the pancreas to metabolize glucose) or by inadequate sensitivity of body cells to the actions of insulin.
Before taking GLYNASE 5MG TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any hormonal problems, genetic disorders (such as G6PD deficiency), or if you are malnourished, starved, or on an irregular diet.
GLYNASE 5MG TABLET is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking GLYNASE 5MG TABLET if you are pregnant, planning to become pregnant, or breastfeeding.
One of the most common side effects of taking GLYNASE 5MG TABLET is hypoglycemia (low blood sugar levels), which can be identified through symptoms such as increased hunger, dizziness, sweating, shakiness, headache, confusion, and visual disturbances. To avoid this, your doctor will periodically monitor your blood sugar levels and adjust the dose of GLYNASE 5MG TABLET accordingly.
You can also carry a sugary snack (such as biscuits, glucose drinks, or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia. However, consult your doctor if there is no improvement in your condition. Other common side effects of taking GLYNASE 5MG TABLET are nausea, diarrhea, and stomach pain. Consult your doctor if they trouble you.
Uses Of GLYNASE 5MG TABLET
- Management of type II diabetes mellitus
How GLYNASE 5MG TABLET Works
GLYNASE 5MG TABLET effectively controls blood sugar levels, where glipizide makes the pancreas secrete more insulin to digest the circulating sugars (glucose) in the blood. It also helps the body cells use insulin effectively, thereby reducing blood glucose levels.
How to use GLYNASE 5MG TABLET
Take GLYNASE 5MG TABLET before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition. Continue to take GLYNASE 5MG TABLET for the duration recommended by your doctor to achieve better control over blood sugar levels.
Side Effects Of GLYNASE 5MG TABLET
Common
- hypoglycemia (low blood sugar levels)
- nausea
- diarrhea, stomach pain
Uncommon
- dizziness, drowsiness
- feeling shaky
- blurred vision
- vomiting
- jaundice (yellowing of the skin and eyes, itching, and dark urine)
- eczema (skin inflammation)
Rare
Stop taking GLYNASE 5MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reaction (such as skin rash, swelling of the face, eyelids, lips, tongue, or throat that causes difficulty breathing or swallowing)
- signs of a severe decrease in blood sugar level (such as confusion, headache, excessive sweating, clammy skin, trembling, weakness, double vision, excessive hunger, nausea, vomiting, problems sleeping, feeling agitated, unable to concentrate, drowsiness, loss of consciousness, slowed reactions, depression, trouble seeing or speaking, paralysis, numbness, dizziness, hallucinations, difficulty breathing, slowed or faster heartbeat with chest pain)
How To Manage Side Effects
Diarrhea
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-manage diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Hypoglycemia
Have foods rich in sugars, such as fruit juices, glucose drinks, candies, honey, or biscuits. Check your blood sugar after 10 minutes. If you have not reached the optimum level, take another sugary snack and check your blood sugar again. Consult your doctor if there is no improvement in your condition.
Warning & Precautions
Pregnancy
ContraindicatedGLYNASE 5MG TABLET is generally not recommended for use by pregnant women. Therefore, consult your doctor before taking it.
Breastfeeding
ContraindicatedGLYNASE 5MG TABLET is generally not recommended for use by breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Use with CautionGLYNASE 5MG TABLET does not affect your ability to drive or operate any tools or machines. However, avoid driving or handling heavy tools or machines if your ability is affected by GLYNASE 5MG TABLET.
Alcohol
Use with CautionAvoid alcohol consumption while taking GLYNASE 5MG TABLET, as it could aggravate your existing condition.
Kidney
ContraindicatedGLYNASE 5MG TABLET is not recommended for use in patients with kidney problems. Therefore, consult your doctor before taking it.
Liver
ContraindicatedGLYNASE 5MG TABLET is not recommended for use in patients with liver problems. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take GLYNASE 5MG TABLET if you are allergic to Glipizide or to any other medicines that belong to sulphonylureas (such as glibenclamide and gliclazide).
Use In Pediatrics
ContraindicatedGLYNASE 5MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before administration.
Use In Geriatrics
Use with CautionGLYNASE 5MG TABLET should be used with caution with elderly patients. Therefore, consult your doctor before taking it.
Others
GLYNASE 5MG TABLET is not recommended for use if you:
- have type I diabetes (or insulin-dependent diabetes)
- have diabetic ketoacidosis (increased levels of sugar and ketone bodies in the blood)
- have diabetic coma or pre-coma
- have a serious traumatic injury
Before taking GLYNASE 5MG TABLET, inform your doctor if you:
- have problems in the adrenal or pituitary gland
- are about to have a major surgery
- recently met with any major accidents
- have a fever or severe infections
- have G6PD deficiency (an inherited blood disorder)
- are malnourished, starved, on an irregular diet, or feeling weak
Interactions
A. Drug-Drug interactions:
Before taking GLYNASE 5MG TABLET, inform your doctor if you are taking any of the following medicines, such as:
- antifungal medicines (used to manage fungal infections) such as miconazole or fluconazole
- antibiotics (used to manage bacterial infections) such as fluoroquinolones (Ex. ciprofloxacin, moxifloxacin), clarithromycin, co-trimoxazole, rifampicin, chloramphenicol, tetracyclines, or sulphonamides (Ex. sulphasalazine)
- medicines used to manage high blood pressure or heart failure, such as beta blockers (Ex. atenolol and propranolol) and ACE-inhibitors (Ex. captopril or enalapril)
- medicines used to manage stomach ulcers, such as ranitidine, famotidine, and cimetidine
- medicines used to manage depression (such as moclobemide, isocarboxazid, phenelzine, and tranylcypromine)
- medicines used for pain relief (Ex. aspirin, phenylbutazone, ibuprofen, phenylbutazone, azapropazone)
- medicines to manage mental illness (such as chlorpromazine, prochlorperazine, and lithium)
- corticosteroids (used to manage pain and inflammation) Ex. prednisolone, cotisone, and betamethasone
- medicines used to manage asthma (Ex. salbutamol, terbutaline)
- danazol (a medicine used to manage breast disorders, heavy menstrual bleeding, and endometriosis)
- medicines used for blood thinning (Ex. warfarin)
- diuretics (used to increase urine output and reduce edema) such as bendroflumethiazide, hydrochlorothiazide, and furosemide
- oral contraceptives (birth control pills) Ex. drospirenone, ethinylestradiol
- sulfinpyrazone, probenecid (medicines used to manage gout)
- thyroid hormones such as thyroxine (used to manage thyroid deficiency)
- phenytoin (a medicine used to manage epilepsy)
- Clofibrate and nicotinic acid (medicines used to manage high blood cholesterol levels)
- isoniazid (a medicine used to manage tuberculosis)
B. Drug-Food Interactions:
Food may delay the absorption of GLYNASE 5MG TABLET in the body. Therefore, take GLYNASE 5MG TABLET 30 minutes before the meal.
Overdosage:
If you or anyone else accidentally took more GLYNASE 5MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose might include signs of low blood glucose levels such as weakness, sweating, trembling, a fast heartbeat, confusion, and double vision.
Synopsis
| Drug | : | Glipizide |
| Pharmacological Category | : | Sulfonylureas |
| Therapeutic Indication | : | Type II Diabetes Mellitus |
| Dosage Forms | : | Tablet |
More Information
- Keep GLYNASE 5MG TABLET out of reach of children
- Store GLYNASE 5MG TABLET at room temperature
FAQs About GLYNASE 5MG TABLET
Q: What is GLYNASE 5MG TABLET used for?
A: GLYNASE 5MG TABLET is an antidiabetic medicine used in the management of type II diabetes mellitus when diet, exercise, and lifestyle changes alone do not result in an adequate response.
Q: How and when to take GLYNASE 5MG TABLET?
A: Take GLYNASE 5MG TABLET before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.
Q: How long should I take GLYNASE 5MG TABLET?
A: You need to take GLYNASE 5MG TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.
Q: Can I stop taking GLYNASE 5MG TABLET without consulting your doctor?
A: No. You should not stop taking GLYNASE 5MG TABLET without consulting your doctor because it may lead to a reversal of symptoms. If you feel better after using GLYNASE 5MG TABLET, consult your doctor for advice. Your doctor might reduce the dose gradually before discontinuation of therapy.
Q: Will taking a higher dose of GLYNASE 5MG TABLET be more effective?
A: No, taking a higher dose of GLYNASE 5MG TABLET will not be effective; rather, it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: What should I do if I forget to take a dose of GLYNASE 5MG TABLET?
A: If you forget to take a dose of GLYNASE 5MG TABLET, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of GLYNASE 5MG TABLET to compensate for a missed dose, as it could lead to toxicity.
Q: What precautions do I need to follow while taking GLYNASE 5MG TABLET?
A: Before taking GLYNASE 5MG TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you are pregnant or breastfeeding. Always carry a sugary snack (such as biscuits, glucose drinks, or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia.
Q: Can I take medication for high blood pressure along with GLYNASE 5MG TABLET?
A: No. It is not advisable to take medicines to control blood pressure while taking GLYNASE 5MG TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with GLYNASE 5MG TABLET, as they have known interactions with GLYNASE 5MG TABLET.
Q: What should I do if I experience low blood sugar after taking GLYNASE 5MG TABLET?
A: Low blood sugar is a common side effect of taking GLYNASE 5MG TABLET. Try to have sugar-rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. Check your blood sugar after 10 minutes. If you have not reached the optimum level, take another sugary snack and check your blood sugar again. In case of persistently low blood sugar levels, consult your doctor immediately.
Q: Can GLYNASE 5MG TABLET cause dizziness?
A: Yes. Dizziness is a common side effect of using GLYNASE 5MG TABLET. If you experience dizziness, lie down until it passes, then get up slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, and alcohol. Do not drive or use machinery to avoid accidents. Consult your doctor if you experience dizziness continuously for a long time after taking GLYNASE 5MG TABLET.
Q: Can GLYNASE 5MG TABLET be taken with insulin?
A: Co-administration of GLYNASE 5MG TABLET with insulin is considered risky as it increases the chances of hypoglycemia (decreased blood sugar levels). Consult your doctor before taking it.
Q: Can GLYNASE 5MG TABLET be used in pregnant women?
A: No. GLYNASE 5MG TABLET is not recommended for use in pregnant women. Therefore, consult your doctor for advice before taking it.
References
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270-272.
2. Ricardo Correa; Bryan S. Quintanilla Rodriguez; Thomas M. Nappe. Glipizide. State Pearls. NIH. National Library of Medicine. National Center for Biotechnology Information. July 2022. [Accessed on 19th January 2024]. https://www.ncbi.nlm.nih.gov/books/NBK459177/
3. E Wåhlin-Boll, L Groop, S Karhumaa, P H Groop, K J Tötterman, A Melander. Therapeutic equivalence of once- and thrice-daily glipizide. NIH. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. 1986. [Accessed on 19th January 2024]. https://pubmed.ncbi.nlm.nih.gov/3536529/
4. Pharmacia Italia S.p.a., Ascoli Piceno Plant. Electronic Medicines Compendium (EMC). [Revised in February 2018] [Accessed on 19th January 2024]. https://www.medicines.org.uk/emc/files/pil.1687.pdf
5. Pfizer Ltd. U.S. Food & Drug Administration. [Revised in October 2015] [Accessed on 19th January 2024]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020329s029lbl.pdf
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Random Blood Sugar (RBS)
- Post Prandial Blood Sugar (PPBS)
- Insulin – Fasting
- Insulin Postprandial (PP)
- Vital Diabetes Care
- Extended Diabetes Care
- Advance Diabetes Care
- Comprehensive Diabetes Care
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