Glycomet Trio 1mg Tablet 10'S

Introduction About GLYCOMET TRIO 1MG TABLET

Glycomet Trio 1mg Tablet is a combination medicine formulated for adults with type 2 diabetes mellitus to help maintain stable blood sugar levels. It is particularly useful for individuals whose blood sugar is not adequately managed by diet, exercise, or single-drug therapy. The tablet combines glimepiride, metformin and voglibose, offering a triple-action benefit stimulating insulin release, improving insulin sensitivity, and slowing carbohydrate absorption to reduce sudden sugar spikes after meals.

This medicine is ideal for patients who require enhanced blood sugar control throughout the day, especially those prone to post-meal glucose fluctuations. Glycomet Trio 1mg should be taken orally with meals to maximize effectiveness and reduce the risk of stomach discomfort or hypoglycaemia. Following a balanced diet, regular exercise, and consistent meal timings enhances the overall benefits of the medicine.

Before using Glycomet Trio 1mg, patients should be aware of certain precautions. It is not recommended during pregnancy or breastfeeding, as it may harm the baby or pass into breast milk. Individuals with severe kidney, liver, heart, or lung conditions should avoid this medicine unless specifically advised by their doctor. Patients should also inform their healthcare provider if they have a history of digestive disorders, irregular meal patterns, or frequent hypoglycaemia episodes.

Common side effects may include stomach pain, diarrhoea, bloating, nausea, dizziness, or mild low blood sugar symptoms. Regular blood sugar monitoring is essential to ensure safe and effective therapy. In case of severe dizziness, sweating, or unusual fatigue, prompt medical attention is advised. Always follow the prescribed dosage and directions for use and never adjust the dose without consulting your doctor.

Uses Of GLYCOMET TRIO 1MG TABLET

• Type II diabetes mellitus

Benefits of GLYCOMET TRIO 1MG TABLET

Glycomet Trio 1mg Tablet: Effective Management of Type 2 Diabetes Mellitus

Glycomet Trio 1mg Tablet is a combination anti-diabetic medication containing metformin, glimepiride, and voglibose. It is especially effective for adults with type 2 diabetes mellitus whose blood sugar is not adequately controlled by diet, exercise, or single or dual anti-diabetic therapy. The tablet works through three mechanisms: improving insulin sensitivity, stimulating the pancreas to produce more insulin, and decreasing the absorption of glucose from the intestines. By offering comprehensive blood sugar control throughout the day, Glycomet Trio 1mg helps patients maintain healthier glucose levels, reducing both fasting and post-meal glucose surges

Glycomet Trio 1mg Tablet: Reduces Risk of Diabetes-Related Complications

By providing effective and sustained blood sugar management, Glycomet Trio 1mg lowers the risk of long-term complications associated with type 2 diabetes. Proper glycemic control reduces the likelihood of developing diabetic complications such as neuropathy (nerve damage), nephropathy (kidney disease), retinopathy (eye damage), and cardiovascular problems. Consistent use of this medication as part of a comprehensive diabetes management plan (including diet and exercise) not only preserves organ function but also promotes overall health and helps prevent the progression of diabetes-related complications.

Glycomet Trio 1mg Tablet: Helps Delay Post-Meal Blood Sugar Spikes

A unique benefit of Glycomet Trio 1mg is its inclusion of voglibose, which acts by slowing down carbohydrate digestion and absorption in the intestines. This helps minimize sudden increases in blood glucose levels after meals, known as postprandial spikes. By ensuring smoother and more stable blood sugar profiles after eating, the medication assists in preventing damaging blood sugar fluctuations, which are a major contributor to diabetic complications.

How GLYCOMET TRIO 1MG TABLET Works

Mechanism of Glycomet Trio 1 mg Tablet

Glycomet Trio Tablet works through a triple-action mechanism to help manage blood sugar levels in adults with type 2 diabetes. It combines glimepiride, metformin and voglibose, each targeting different aspects of blood sugar control:

1. Glimepiride – Stimulates the pancreas to release insulin, which helps move sugar from the blood into the cells for energy.
2. Metformin – Reduces glucose production in the liver and enhances the body’s sensitivity to insulin, improving sugar utilization.
3. Voglibose – Slows the breakdown and absorption of carbohydrates in the intestines, preventing sudden post-meal sugar spikes.

Together, these actions stabilize blood sugar throughout the day, reduce fluctuations after meals and support better long-term sugar management when combined with proper diet and exercise.

How Glycomet Trio 1mg Supports Post-Meal Sugar Levels

Glycomet Trio 1mg Tablet helps manage the sudden rise in blood sugar that often occurs after meals, also known as postprandial glucose spikes. Its three active components work in synergy:

• Voglibose slows the breakdown and absorption of carbohydrates in the intestines, preventing a rapid surge in blood sugar after eating.
• Glimepiride stimulates the pancreas to release insulin right when your body needs it, helping process the sugar from meals efficiently.
• Metformin reduces excess glucose production by the liver, ensuring overall balance in blood sugar levels.

By controlling post-meal spikes, Glycomet Trio 1mg supports smoother glucose levels throughout the day and contributes to better long-term blood sugar management when combined with a proper diet and lifestyle.

How to use GLYCOMET TRIO 1MG TABLET

Glycomet Trio 1mg dosage instructions

• Take Glycomet Trio 1mg tablet exactly as prescribed by your doctor.
• Usually taken once daily with food to minimize stomach upset.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• Take the tablet at the same time each day to maintain consistent blood sugar levels.
• Do not exceed the dose prescribed by your healthcare provider.
• Follow your doctor’s instructions on dosage adjustments based on your blood sugar monitoring.

Important Tips on Glycomet Trio 1mg Tablet Administration

• Always take the medication with or immediately before meals to improve absorption and reduce gastrointestinal side effects.
• Maintain regular meal timings to prevent low blood sugar (hypoglycemia).
• Carry a fast-acting sugar source like candy or fruit juice to manage sudden low blood sugar symptoms.
• Avoid alcohol as it can increase the risk of hypoglycemia and lactic acidosis.
• Inform your doctor about all other medications you are taking to avoid drug interactions.

How to Take Glycomet Trio Tablet for Best Results

• Follow a consistent daily schedule, ideally with meals for optimal blood sugar control.
• Combine the medication with diet and exercise as advised by your healthcare provider.
• Regularly monitor your blood glucose levels to assess effectiveness and adjust dosage if needed under medical supervision.
• Do not stop taking the medication without consulting your doctor even if you feel well or your blood sugar improves.

What if I forgot to take GLYCOMET TRIO 1MG TABLET

• Take the missed dose as soon as you remember, preferably with food.
• If it is almost time for your next scheduled dose, skip the missed dose.
• Do not take a double dose to make up for the missed one.
• Skipping doses repeatedly may affect your blood sugar control.
• Monitor your blood sugar if you miss a dose and watch for any unusual symptoms.
• If you frequently forget doses, set reminders or alarms to take the medicine on time.
• Consult your doctor if multiple doses are missed or if your blood sugar becomes unstable.

Overdose

If you or anyone else accidentally takes too much of GLYCOMET TRIO 1MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are hypoglycaemia (low blood sugar), lactic acidosis, pancreatitis (inflammation of the pancreas), abdominal discomfort, and/or diarrhoea.

Side Effects Of GLYCOMET TRIO 1MG TABLET

Common Side Effects of GLYCOMET TRIO 1MG TABLET:

• nausea
• vomiting
• diarrhoea
• abdominal pain
• loss of appetite
• metallic taste
• hypoglycaemia (low blood sugar)

When to Seek Medical Attention?

Stop taking GLYCOMET TRIO 1MG TABLET and contact your doctor immediately if you experience any of the following side effects:

• Severe hypoglycaemia (very low blood sugar level)
• Signs of lactic acidosis (lactic acid built up in the bloodstream) such as exhaustion or extreme fatigue, body weakness, diarrhoea, and/or headache

How To Manage Side Effects

Diarrhea

• Maintain good hydration by drinking plenty of fluids like water or oral rehydration solutions.
• Avoid dairy products and high-fiber foods during episodes of diarrhea.
• Eat a bland diet including bananas, rice, applesauce, and toast (BRAT diet) to soothe the digestive system.
• Avoid alcohol, caffeine, and fatty or greasy foods that can aggravate diarrhea.
• If diarrhea lasts more than a couple of days or is severe, consult your doctor for advice.

Nausea And Vomiting

• Take the medication with or immediately before meals to reduce stomach irritation.
• Drink plenty of water throughout the day to stay hydrated.
• Avoid fatty, spicy or heavy meals that may worsen nausea.
• If nausea persists, eat small frequent meals instead of large ones.

Stomach Pain

• Take the tablet with food to minimize abdominal discomfort.
• Avoid lying down immediately after taking the medication to reduce stomach irritation.
• Use warm compresses on the abdomen for relief if pain occurs.
• Monitor your symptoms; mild pain often improves as your body adjusts to the medication.f

Warning & Precautions

Pregnancy

Contraindicated

GLYCOMET TRIO 1MG TABLET should not be used during pregnancy as it may pose risks to the unborn baby.

Breastfeeding

Contraindicated

This medicine is not advised for mothers because its components can pass into breast milk and may harm the nursing infant.

Driving and Using Machines

Use with Caution

Avoid driving or operating heavy machinery if you experience dizziness, drowsiness, or slowed reactions due to low blood sugar while taking GLYCOMET TRIO 1MG TABLET.

Alcohol

Contraindicated

Alcohol intake should be avoided while using this medicine as it may increase the risk of a sudden drop in blood sugar levels.

Kidney

Consult your doctor

GLYCOMET TRIO 1MG TABLET is not recommended for patients with severe kidney problems and should be used with caution in those with mild to moderate kidney conditions. 

Liver

Consult your doctor

This medicine is not recommended for patients with severe liver disorders and must be used cautiously in cases of mild to moderate liver disease.

Allergy

Contraindicated

Do not take GLYCOMET TRIO 1MG TABLET if you are allergic to glimepiride, metformin, voglibose, any sulfonylureas/sulphonamides, or other ingredients in this medicine.

Lungs

Contraindicated

GLYCOMET TRIO 1MG TABLET is not recommended for use in patients with acute or chronic respiratory conditions including respiratory failure. 

Heart Disease

Contraindicated

GLYCOMET TRIO 1MG TABLET should not be used in individuals with heart conditions such as recent heart attack or heart failure.              

Use In Pediatrics

Contraindicated

GLYCOMET TRIO 1MG TABLET is not advised for children and adolescents under 18 years as its safety and efficacy have not been established. 

Use In Geriatrics

Use with Caution

Elderly patients (65 years and above) should take this medicine cautiously and under close medical supervision.  

Other Warnings for GLYCOMET TRIO 1MG TABLET

Before taking GLYCOMET TRIO 1MG TABLET, inform your doctor if you:

• Recently experienced trauma or injury
• Have undergone or are scheduled for surgery
• Suffer from febrile infections, persistent fever, or uncontrolled diabetes
• Are undernourished or have irregular eating habits, such as skipping meals
• Have an imbalance between physical activity and carbohydrate intake
• Have hypothyroidism (underactive thyroid gland)
• Have a history of laparotomy (abdominal surgery) or ileus (interrupted intestinal movement)
• Have chronic intestinal disorders that affect digestion or nutrient absorption
• Currently have a fever

Who should not take [GBNKEYWORD

GLYCOMET TRIO 1MG TABLET is not recommended for use if you:

• Have any acute form of metabolic acidosis, including lactic acidosis, diabetic ketoacidosis or diabetic pre-coma.
• Are experiencing acute conditions like severe dehydration, major infections or shock.
• Have severe ketosis, which is a serious complication of diabetes.
• Are in a diabetic coma.
• Have experienced severe infections before or after surgery.
• Have suffered from major trauma.
• Have a gastrointestinal blockage (intestinal obstruction).

Safety Advice

• Take the medicine exactly as prescribed by your doctor and at the same time each day.
• Always consume the tablet with food to reduce the risk of stomach discomfort or low blood sugar.
• Keep a regular check on your blood sugar levels as advised by your healthcare professional.
• Carry a source of fast-acting sugar (like glucose tablets or candy) in case of sudden low blood sugar.
• Stay hydrated and drink enough water throughout the day unless otherwise advised.
• Avoid sudden changes in your diet or exercise routine without consulting your doctor.
• Inform your doctor about all other medicines, supplements, or herbal products you are using.
• Attend regular follow-up appointments to monitor kidney, liver, and blood sugar health.
• Do not stop or change the dose on your own without medical guidance.

Diet and Lifestyle Advice

• Include more fibre-rich foods like vegetables, whole grains, and pulses to support stable blood sugar levels.
• Limit the intake of sugary drinks, desserts, and processed foods high in refined carbohydrates.
• Eat small, balanced meals at regular intervals to avoid sudden spikes or drops in blood sugar.
• Include lean proteins (like fish, eggs, tofu, and legumes) to maintain energy and satiety.
• Incorporate healthy fats from sources like nuts, seeds, and olive oil in moderation.
• Engage in at least 30 minutes of light-to-moderate physical activity daily, like walking or cycling, as advised by your doctor.
• Manage stress through yoga, meditation, or deep breathing exercises to help control blood sugar fluctuations.
• Ensure adequate sleep and maintain a consistent sleep schedule for better metabolic balance.
• Avoid smoking or exposure to second-hand smoke, as it can worsen blood sugar and heart health.
• Limit caffeine and prefer water or unsweetened beverages to stay hydrated.

1. How effective is Glycomet Trio 1mg compared to single ingredient anti-diabetic drugs?

2. How does Glycomet Trio 1mg compare with Glimepiride and Metformin combination tablets?

Drug - Drug interaction

1. Insulin or Other Anti-Diabetic Medicines

• Interaction: Using GLYCOMET TRIO 1MG TABLET with insulin, sulfonylureas, or other oral anti-diabetics can increase the risk of hypoglycaemia.
• Management: Monitor blood sugar closely and watch for signs like dizziness, sweating, or shakiness. Your doctor may adjust the dose to prevent low sugar episodes.

2. Beta-Blockers (e.g., Atenolol, Metoprolol, Propranolol)

• Interaction: These heart medications can mask the warning signs of low blood sugar, such as rapid heartbeat.
• Management: Check blood sugar regularly and be alert for other symptoms of hypoglycaemia like sweating, dizziness, or confusion.

3. Diuretics (Water Pills like Furosemide, Hydrochlorothiazide)

• Interaction: May reduce the effectiveness of GLYCOMET TRIO 1MG TABLET and increase the risk of high blood sugar.
• Management: Regular blood sugar monitoring is recommended, and your doctor may adjust your diabetes medicine if needed.

4. Corticosteroids (e.g., Prednisone, Dexamethasone)

• Interaction: These medicines can raise blood sugar levels and reduce the effectiveness of anti-diabetic therapy.
• Management: Blood sugar checks may be required more frequently. Your doctor might modify the dose of your diabetes medicine temporarily.

5. Thyroid Medications (Levothyroxine)

• Interaction: Can decrease the blood sugar-lowering effect of GLYCOMET TRIO 1MG TABLET.
• Management: Your doctor may adjust your dose based on blood sugar reports if you are taking thyroid medications.

6. ACE Inhibitors (e.g., Enalapril, Ramipril)

• Interaction: These blood pressure medicines can sometimes enhance the blood sugar-lowering effect, increasing hypoglycaemia risk.
• Management: Monitor sugar levels and report any low blood sugar symptoms to your doctor promptly.

7. Anticonvulsants (Phenytoin, Carbamazepine)

• Interaction: These medicines may reduce the effect of GLYCOMET TRIO 1MG TABLET, leading to high blood sugar levels.
• Management: Blood sugar monitoring and possible dose adjustment are advised during concurrent use.

8. Antibiotics (Fluoroquinolones like Ciprofloxacin, Levofloxacin)

• Interaction: May cause fluctuations in blood sugar (both high and low).
• Management: Check your blood sugar regularly during antibiotic therapy and inform your doctor of any abnormal readings.

9. Antifungal Medicines (e.g., Fluconazole, Ketoconazole)

• Interaction: Can increase the blood sugar-lowering effect of glimepiride, raising the risk of hypoglycaemia.
• Management: Blood sugar should be monitored more frequently, and your doctor may adjust the dosage if needed.

Drug - Food interaction

1. High-Sugar Foods (e.g., sweets, sugary drinks, desserts)

• Interaction: These can raise blood sugar levels suddenly, reducing the effectiveness of the medicine.
• Management: Limit intake of sweets, candies, and sugary beverages. Focus on balanced meals to maintain stable blood sugar.

2. High-Fat Meals (e.g., fried foods, heavy cream dishes)

• Interaction: May slow down the absorption of voglibose and increase the risk of digestive discomfort like gas or bloating.
• Management: Prefer light, low-fat meals, especially when taking the medicine, to improve tolerance and effectiveness.

3. Skipping Meals or Irregular Eating Patterns

• Interaction: Increases the risk of hypoglycaemia because glimepiride works to lower sugar even without food intake.
• Management: Eat meals at consistent times and avoid skipping meals to maintain steady blood sugar.

4. High-Fiber Foods (e.g., raw vegetables, bran, oats)

• Interaction: Very high fibre intake may slightly slow down the absorption of the medicine, but usually, it does not affect effectiveness significantly.
• Management: Consume fibre in moderation and maintain a balanced diet as recommended by your doctor.

5. Grapefruit or Grapefruit Juice

• Interaction: May interfere with the metabolism of some components, increasing the risk of low blood sugar in rare cases.
• Management: Limit or avoid grapefruit products while on this medication unless your doctor approves.

6. Caffeinated Beverages (e.g., coffee, energy drinks)

• Interaction: Excess caffeine can increase blood sugar fluctuations and may mask hypoglycaemia symptoms.
• Management: Consume caffeine in moderation and avoid high-sugar caffeinated drinks.

7. Processed and Refined Foods (e.g., white bread, chips, fast foods)

• Interaction: Can cause rapid blood sugar spikes and reduce the long-term benefits of the medicine.
• Management: opt for whole grains, fresh vegetables, and lean proteins to maintain better sugar control.

Synopsis

More Information

FAQs About GLYCOMET TRIO 1MG TABLET

References

1. KD Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of Medical Pharmacology. Seventh Edition. 2019. Page – 270, 275, 277. 

2. Kalra S, Das AK, Priya G, Ghosh S, Mehrotra RN, Das S, Shah P, Bajaj S, Deshmukh V, Sanyal D, Chandrasekaran S, Khandelwal D, Joshi A, Nair T, Eliana F, Permana H, Fariduddin MD, Shrestha PK, Shrestha D, Kahandawa S, Sumanathilaka M, Shaheed A, Rahim AA, Orabi A, Al-Ani A, Hussein W, Kumar D, Shaikh K. Fixed-dose combination in management of type 2 diabetes mellitus. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. [Revised in November 2020] [Accessed on 3rd August 2025] 

3. Windlas Biotech Private Limited. Amaryl MV 1mg, Amaryl MV 2mg. [Revised in March 2021] [ [Accessed on 3rd August 2025] 

4. Primus Remedies Pvt. Ltd. Voglow GM1 Fort. [Accessed on 3rd August 2025] 

5. Eris Lifesciences. Glimisave MV 1.3 F, Glimisave MV 2 forte, Glimisave MV 3.3, Glimisave MV 3.3 F. [Accessed on 3rd August 2025] 

6. Leeford Healthcare Ltd. VOGLIMET-GM FORTE. [Accessed on 3rd August 2025] 

7. Ikon Remedies Pvt. Ltd. Voglicon-GM Tablets. [Accessed on 3rd August 2025] 

User Feedback

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Random Blood Sugar (RBS)
• Post Prandial Blood Sugar (PPBS)
• Insulin-Fasting
• Insulin Postprandial (PP)
• Vital Diabetes Care
• Extended Diabetes Care
• Advance Diabetes Care
• Comprehensive Diabetes Care

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 05 Aug 2025 | 09:43 AM(IST)