Glycomet Gp4 Forte Tablet 10'S

Introduction About GLYCOMET GP4 FORTE TABLET

Glycomet Gp4 Forte Tablet is a commonly used oral antidiabetic medication that combines Glimepiride and Metformin. It is mainly prescribed for adults with type 2 diabetes mellitus, especially when diet, exercise, or a single medicine are not enough to control blood sugar levels. This combination works through a dual-action mechanism, helping to manage blood glucose effectively and safely.

Glycomet Gp4 Forte Tablet should be taken with food, at the same time each day for best effectiveness. Your doctor will prescribe the appropriate dose for you and may adjust it over time depending on how well your blood sugar is managed.

Common side effects of Glycomet Gp4 Forte Tablet include nausea, vomiting, diarrhea, stomach pain, dizziness, changes in taste, headache, upper respiratory tract infection and hypoglycemia (low blood sugar) with symptoms such as sweating, shakiness, headache, and confusion. To reduce the risk of low blood sugar, ensure you eat regular meals and always carry a quick source of glucose, such as sugary food or fruit juice, in case symptoms occur. Consuming alcohol can further increase your risk of hypoglycemia and should be avoided.

You should not use this medication if you have type 1 diabetes mellitus, diabetic ketoacidosis (a condition where there is too much acid in your blood), or if you suffer from severe kidney or liver problems. Inform your doctor if you have a history of heart disease, as this medication may not be appropriate for you. Pregnant or breastfeeding women should consult their doctor before starting this management. It is important to have your blood sugar checked regularly. Your doctor may also recommend blood tests to monitor your blood cell counts and liver function during management.

Uses Of GLYCOMET GP4 FORTE TABLET

• Type 2 diabetes mellitus 

Benefits of GLYCOMET GP4 FORTE TABLET

• Effective Blood Sugar Control:
  It helps lower and stabilize blood sugar levels by combining two active ingredients—glimepiride (stimulates pancreatic insulin release) and metformin (improves insulin sensitivity, reduces sugar production in the liver, and slows intestinal sugar absorption).
• Combination Therapy for Enhanced Effect:
  The dual-action approach is often more effective than either glimepiride or metformin alone, supporting better glycemic management and fewer blood sugar spikes.
• Reduced Risk of Complications:
  By controlling blood glucose, it can lower the risk of diabetes-related issues such as heart disease, kidney dysfunction, nerve damage, and vision loss when used as part of a comprehensive management plan with diet and exercise.
• Complementary to Lifestyle Measures:
  This medicine works best alongside a balanced diet, regular physical activity, and weight management, helping users maintain their management goals and health improvements more effectively.
• Potential for Improved Quality of Life:
  Regular and proper use may help people with type 2 diabetes live more active, healthy lives by minimizing glucose fluctuations and supporting to control long-term diabetes complications.

How GLYCOMET GP4 FORTE TABLET Works

• Glimepiride (Sulfonylurea):
  • Stimulates the pancreatic beta cells to release more insulin in response to elevated blood glucose.
  • Binds to ATP-sensitive potassium channels on the pancreatic cell membrane, causing cell depolarization and opening of calcium channels. This leads to increased insulin granule exocytosis.
  • The effect is glucose-dependent, which reduces the risk of very low blood sugar compared to older sulfonylureas.
• Metformin (Biguanide):
  • Primarily reduces glucose production in the liver (inhibits hepatic gluconeogenesis).
  • Delays intestinal glucose absorption, resulting in a slower increase in blood glucose after meals.
  • Increases insulin sensitivity in muscle and fat tissues, improving peripheral glucose uptake and utilization.
  • Activates AMP-activated protein kinase (AMPK) in liver and muscle cells, leading to reduced liver glucose synthesis and improved cellular response to insulin.

Synergistic Effect

Together, glimepiride and metformin provide:

• Improved fasting and post-meal blood sugar control compared to either drug alone.
• Better overall glycemic regulation with a reduced risk of diabetes complications (when combined with lifestyle measures).

How to use GLYCOMET GP4 FORTE TABLET

Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.

Dosage and Administration:

• The dosage is individualized and determined by your doctor based on your blood sugar levels and response to management.
• Typically, it is taken once or twice daily with meals, but always follow your doctor’s specific instructions.
• Do not take more than the prescribed dose, as this increases the risk of low blood sugar (hypoglycemia).

How to Take:

• Swallow the tablet whole with a sufficient amount of water. Do not break, chew, or crush the tablet.
• For best results, take it at the same time each day to maintain an even level of the medicine in your body.

Food and Timing Guidelines:

• Always take with food to minimize the risk of stomach upset and low blood sugar.
• Avoid alcohol, as it can increase the risk of hypoglycemia.

Tips for Swallowing and Handling:

• Swallow the tablet whole with water. Do not split, cut, or crush the tablet.
• Store at room temperature in a dry place, away from moisture, and out of reach of children.

Maximum Daily Dose and Safety Considerations:

• The maximum daily dose depends on the combination of glimepiride and metformin in the tablet (typically not exceeding 2 mg glimepiride and 2000 mg metformin in split doses per day, but always follow your healthcare provider’s recommendation).
• Overdose can cause serious complications like severe hypoglycemia and lactic acidosis. If you suspect an overdose, seek immediate medical attention.
• Regular monitoring of blood sugar is essential while on this medication.
• Do not stop taking the medicine without consulting your doctor, even if you feel well

Side Effects Of GLYCOMET GP4 FORTE TABLET

Like all medicines, Glycomet Gp4 Forte Tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Glycomet Gp4 Forte Tablet are:

• Nausea
• Vomiting
• Diarrhea
• Stomach pain
• Dizziness
• Changes in taste
• Headache
• Upper respiratory tract infection
• Hypoglycemia (low blood sugar) symptoms such as sweating, shakiness, headache, confusion

When to consult your doctor?

• Severe hypoglycemia (very low blood sugar) symptoms such as confusion, loss of consciousness, seizures, severe dizziness, sweating, shakiness, rapid heartbeat, or fainting.
• Lactic acidosis symptoms such as severe nausea or vomiting, persistent abdominal pain, muscle cramps, profound weakness or fatigue, difficulty breathing, a feeling of being severely unwell, slow, or irregular heartbeat, or a drop in body temperature.
• Severe allergic reactions symptoms such as sudden difficulty breathing, swelling of the face, lips, tongue, or throat, and widespread skin rash or hives.
• Serious liver or blood problems symptoms such as yellowing of the skin/eyes (jaundice), unusual bleeding or bruising, or severely decreased alertness.

How To Manage Side Effects

Headache

• Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
• Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
• Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
• Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
• Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

Nausea And Vomiting

• Eat Small, Frequent Meals: Avoid heavy or greasy foods. Opt for bland foods like crackers, toast, or bananas.
• Stay Hydrated: Sip on clear fluids like water, ginger tea, or electrolyte drinks, Avoid caffeinated and carbonated beverages.
• Ginger: Ginger is a natural remedy for nausea. Try ginger tea, ginger candies, or ginger ale (ensure it contains real ginger).
• Avoid Strong Odors: Minimize exposure to smells that might trigger nausea, such as perfumes or cooking odors.

Warning & Precautions

Pregnancy

Consult your doctor

Glycomet Gp4 Forte Tablet should not be taken during pregnancy unless specifically advised by your doctor. If you are pregnant or planning to become pregnant, consult your doctor before taking this medicine.                                     

Breastfeeding

Consult your doctor

It is not known if Glycomet Gp4 Forte Tablet passes into human milk. Discuss with your doctor about the safest options for controlling your blood glucose while breastfeeding. Consult your doctor before taking it.   

Driving and Using Machines

Use with Caution

Do not drive or operate heavy machinery if you feel dizziness or weakness or confused on this medication, as these may be signs of low blood sugar (hypoglycemia). If you experience such symptoms, avoid activities that require full attention.

Alcohol

Consult your doctor

Avoid alcohol consumption while taking Glycomet Gp4 Forte Tablet as it may increase your risk of hypoglycemia and lactic acidosis. 

Kidney

Consult your doctor

Glycomet Gp4 Forte Tablet is not advised for use in patients with severe kidney problems and should be used cautiously in those with mild to moderate kidney impairment. Kidney function should be monitored regularly. Consult your doctor before taking it.

Liver

Consult your doctor

Glycomet Gp4 Forte Tablet is not advised for use in patients with severe liver problems and should be used caution in patients with other liver problems. Liver function may need to be checked during management. Consult your doctor before taking it.  

Allergy

Contraindicated

Do not take this medicine if you are allergic to Glimepiride or Metformin, or any other ingredient in the tablet. 

Heart Disease

Consult your doctor

Glycomet Gp4 Forte Tablet is not recommended for patients with severe heart conditions such as recent heart attack or heart failure and should be used with caution in other heart conditions. Consult your doctor before taking this medicine.

Use In Pediatrics

Contraindicated

Glycomet Gp4 Forte Tablet is not advised for use in children and adolescents under 18 years, as safety and efficacy have not been established in this age group. Consult your pediatrician before giving it.  

Use In Geriatrics

Use with Caution

Elderly patients (65 years and above) should use this medicine cautiously, as they may be more susceptible to side effects like low blood sugar or kidney problems. Closer monitoring may be needed. Consult your doctor before taking it. 

Other Warnings for GLYCOMET GP4 FORTE TABLET

Before taking GLYCOMET GP4 FORTE TABLET inform your doctor if you:

• are recovering from injury, operation, infections with fever, or from other forms of stress
• have glucose-6-phosphate dehydrogenase (G6PD) deficiency
• have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders)

Who should not take GLYCOMET GP4 FORTE TABLET

GLYCOMET GP4 FORTE TABLET is not recommended for use, if you have:  

• type 1 diabetes mellitus
• diabetic ketoacidosis 
• uncontrolled diabetes or ketoacidosis 
• dehydration 
• severe infection

Diet and Lifestyle Advice

Additional Tips:

• Always carry a fast-acting sugar source (like fruit juice or glucose tablets) to raise blood sugar if hypoglycemia symptoms occur.
• Monitor your blood glucose regularly before and after exercise to understand how activity affects your sugar levels.
• Consistency in diet and exercise along with Glycomet Gp4 Forte Tablet  1mg enhances overall diabetes management and reduces complication risks.

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking Glycomet Gp4 Forte Tablet :

1. Diuretics (e.g., Thiazides like Hydrochlorothiazide)
   • Interaction: Thiazide diuretics can impair kidney function and may increase blood sugar levels, which can reduce the blood sugar-lowering effect of Glycomet Gp4 Forte Tablet .
   • Effects: Elevated blood sugar, dehydration, and increased risk of electrolyte imbalances such as low potassium (hypokalemia).
   • Management: Monitor blood glucose levels closely, adjust Glycomet Gp4 Forte Tablet  dosage if needed, and monitor electrolytes (potassium and sodium). Consider potassium-sparing diuretics if appropriate.
2. Other Antidiabetic Medications (e.g., Insulin, Pioglitazone)
   • Interaction: Concurrent use increases the risk of hypoglycemia (low blood sugar).
   • Effects: Symptoms of hypoglycemia such as sweating, shakiness, dizziness, confusion, headache.
   • Management: Frequent blood sugar monitoring, adjusting doses to reduce hypoglycemia, carry fast-acting glucose sources like sugary food or fruit juice.
3. Blood Pressure Medicines (e.g., ACE inhibitors like Captopril, Beta-blockers like Atenolol)
   • Interaction: Some blood pressure drugs may enhance or reduce Glycomet Gp4 Forte Tablet ’s effects or mask hypoglycemia symptoms.
   • Effects: Altered blood sugar control and possible unrecognized hypoglycemia due to masked symptoms like tremors or palpitations.
   • Management: Regular glucose monitoring and informing your doctor about all medications; adjust doses accordingly.
4. Antibiotics (e.g., Clarithromycin)
   • Interaction: May potentiate hypoglycemia risk when used with Glycomet Gp4 Forte Tablet .
   • Effects: Increased likelihood of low blood sugar episodes.
   • Management: Closely monitor blood glucose and seek medical advice if symptoms appear.
5. Drugs Affecting Liver or Kidney Function (e.g., Diclofenac, Ibuprofen, some diuretics)
   • Interaction: These may worsen kidney or liver function, increasing the risk of adverse effects or lactic acidosis.
   • Effects: Potential for serious toxicities and metabolic imbalances.
   • Management: Regular monitoring of liver and kidney function; adjust medication use carefully under medical supervision.
6. Oral Contraceptives, Phenytoin, Rifampicin
   • Interaction: These may decrease the blood sugar-lowering effect of Glycomet Gp4 Forte Tablet .
   • Effects: Possible loss of glycemic control with elevated blood sugar.
   • Management: Blood sugar monitoring and dose adjustment or alternative therapies as recommended by the doctor.

Drug - Food interaction

1. Alcohol
   • Interaction: Alcohol can increase the risk of hypoglycemia (low blood sugar) and lactic acidosis when taken with Glycomet Gp4 Forte Tablet .
   • Effects: Risk of very low blood sugar causing dizziness, confusion, sweating; and potentially life-threatening lactic acidosis. 
   • Management: Avoid all alcohol consumption while on this medication. If alcohol intake occurs, monitor blood sugar closely and seek medical advice if symptoms develop.
2. High-Carbohydrate Meals (Sugary or Starchy Foods)
   • Interaction: Consuming large amounts of sugar or carbohydrates can counteract the blood sugar-lowering effects of Glycomet Gp4 Forte Tablet .
   • Effects: Elevated post-meal blood glucose levels, reduced efficacy of the medication.
   • Management: Maintain a balanced, diabetes-appropriate diet with consistent carbohydrate intake as advised by your healthcare provider.
3. Foods High in Fiber (e.g., whole grains, vegetables)
   • Interaction: High-fiber foods can slow glucose absorption, which may alter the timing of blood sugar reduction by the medication.
   • Effects: More gradual lowering of blood sugar, potentially affecting timing of hypoglycemia risk.
   • Management: Continue a high-fiber diet as recommended, but closely monitor blood glucose to adjust medication timing if necessary.
4. Grapefruit and Grapefruit Juice
   • Interaction: Although not a major concern for glimepiride or metformin specifically, grapefruit may interfere with some medications' metabolism and could theoretically affect blood sugar control.
   • Effects: Potential change in drug blood levels causing altered effectiveness or side effects.
   • Management: Avoid or limit grapefruit products unless your doctor says otherwise.
5. Caffeine (Coffee, Tea, Energy Drinks)
   • Interaction: Caffeine may temporarily raise blood sugar levels or affect insulin sensitivity in some individuals.
   • Effects: Possible minor increases in blood glucose or fluctuations.
   • Management: Monitor your response to caffeine and maintain consistent intake; discuss with your doctor if unsure.
6. Vitamin B12-Rich Foods/Supplements
   • Interaction: Long-term use of metformin (part of Glycomet Gp4 Forte Tablet ) can reduce vitamin B12 absorption.
   • Effects: Risk of B12 deficiency leading to anemia or neuropathy if not managed.
   • Management: Ensure adequate dietary intake of vitamin B12 or consider supplements after consulting your doctor.

Synopsis

More Information

01.How does Glycomet Gp4 Forte Tablet compare to other antidiabetic medications with similar ingredients?

02.Why do doctors recommend combination medicines like Glycomet Gp4 Forte Tablet for certain diabetes patients?

• Improved Blood Sugar Control: Combination therapy uses drugs that work by different mechanisms to more effectively lower and stabilize blood glucose levels compared to using a single medication alone. For example, Glycomet Gp4 Forte Tablet  combines Glimepiride (stimulates insulin secretion) and Metformin (reduces liver glucose production and improves insulin sensitivity), providing a more comprehensive approach.
• Address Multiple Pathways: Diabetes is a complex condition affecting various metabolic pathways. Combining medications targets multiple aspects of the disease simultaneously, compensating for limitations of single drugs and enhancing overall efficacy.
• Reduce Drug Dosage and Side Effects: By using lower doses of two or more drugs, combination therapy can minimize the adverse effects associated with higher doses of single drugs, improving tolerability and patient adherence.
• Delay or reduce Complications: Better glycemic control through combination therapy reduces the risk or progression of diabetes-related complications such as heart disease, kidney damage, and nerve problems.
• Simplify management Regimen: Fixed-dose combination pills reduce the number of tablets a patient must take daily, improving medication adherence and convenience.
• Personalized management: Combination medicines enable doctors to tailor therapy to the specific needs, health status, and risk profile of the patient, including those with existing heart or kidney disease, or those who do not achieve targets with monotherapy.
• Recommended for Patients with High Blood Sugar or Complications Risk: For patients with type 2 diabetes inadequately controlled by monotherapy or at higher risk of complications, combination therapy is often necessary to achieve and maintain target glucose levels.

FAQs About GLYCOMET GP4 FORTE TABLET

Q: What is Glycomet Gp4 Forte Tablet used for?

A: Glycomet Gp4 Forte Tablet is used for the management of type 2 diabetes mellitus. It helps control blood sugar levels by combining two active ingredients, Glimepiride and Metformin, which work together to increase insulin release from the pancreas and reduce sugar production by the liver, improving overall glucose utilization.

Q: How does Glycomet Gp4 Forte Tablet work?

A: Glimepiride stimulates the pancreas to produce more insulin, helping lower blood sugar. Metformin decreases glucose production in the liver, slows glucose absorption from food, and improves the body's sensitivity to insulin, leading to better blood sugar control.

Q: How should I take Glycomet Gp4 Forte Tablet?

A: Take Glycomet Gp4 Forte Tablet exactly as prescribed by your doctor, usually once or twice daily with meals to reduce the risk of stomach upset and hypoglycemia. Swallow the tablet whole with water and maintain consistent timing for best results.

Q: What are the common side effects of Glycomet Gp4 Forte Tablet?

A: Common side effects include nausea, vomiting, diarrhea, stomach pain, dizziness, headache, and hypoglycemia (low blood sugar) which may present as sweating, shakiness, and confusion.

Q: Who should not take Glycomet Gp4 Forte Tablet?

A: It is not recommended for people with type 1 diabetes, diabetic ketoacidosis, severe kidney or liver disease, or those allergic to its ingredients. Pregnant or breastfeeding women should consult their doctor before use.

Q: Can I consume alcohol while taking Glycomet Gp4 Forte Tablet?

A: Alcohol should be avoided as it increases the risk of low blood sugar and lactic acidosis, a rare but serious side effect.

Q: What should I do if I miss a dose?

A: Take the missed dose as soon as you remember if it is not too close to the next dose. If it is near the time for your next dose, skip the missed one. Do not double the dose to make up for the missed tablet.

Q: Does Glycomet Gp4 Forte Tablet interact with other medications?

A: Yes, it can interact with diuretics, other antidiabetic drugs, blood pressure medicines, certain antibiotics, and others. Inform your doctor of all medications you are taking.

Q: What lifestyle changes are recommended with Glycomet Gp4 Forte Tablet?

A: Follow a balanced diet, maintain regular meals, exercise regularly, avoid alcohol, and monitor your blood sugar levels closely to support the effectiveness of the medication and reduce complications.

Q: How does Glycomet Gp4 Forte Tablet fit into everyday diabetes management?

A: Glycomet Gp4 Forte Tablet supports balanced blood glucose levels as part of a broader lifestyle plan that includes healthy eating, regular physical activity, and routine blood sugar monitoring. It works alongside diet and exercise to help manage type 2 diabetes effectively, reducing the risk of complications and promoting overall well-being.

Q: Is Glycomet Gp4 Forte Tablet suitable for everyone with diabetes?

A: Glycomet Gp4 Forte Tablet is mainly recommended for adults with type 2 diabetes. It is not suitable for children or individuals with type 1 diabetes. Suitability depends on your overall health status and should always be determined by your doctor after evaluating your medical history and current condition.

References

1. KD Tripathi MD. Hormones and related drugs. Essentials of medical pharmacology. Seventh edition. New Delhi, May 2013. Page – 274.

2. Rakesh Kumar Sahay, Vinod Mittal, G Raja Gopal, Sunil Kota, Ghanshyam Goyal, Mahesh Abhyankar, Santosh Revenkar. Glimepiride and Metformin Combinations in Diabetes Comorbidities and Complications: Real-World Evidence. September 2020. [Accessed on 10th November 2025]

3. Sanofi. Efficacy and Safety Comparison of Metformin/Glimepiride Combination Versus Each Compound Alone in New Diagnosed Type 2 Diabetes Patients (RECOMMEND). NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in January 2015] [Accessed on 10th November 2025] 

4. Torrent pharmaceuticals Ltd. Azulix MF. Metformin Hydrochloride Prolonged Release and Glimepiride Tablets I.P. [Revised in July 2019] [Accessed on 10th November 2025] 

5. Sanofi-aventis group. Amaryl M. Glimepiride + Metformin. [Revised in May 2015] [Accessed on 10th November 2025]

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 19 Nov 2024 | 10:35 AM(IST)