Glycomet GP 0.5mg Tablet 10'S

Introduction About GLYCOMET GP 0.5MG TABLET

Glycomet GP 0.5mg Tablet is a combination medication used to manage type 2 diabetes. It contains metformin and glimepiride, which work together to control blood sugar levels and improve the body's response to insulin. This medication is effective in helping diabetic patients achieve better glycemic control.

Glycomet GP 0.5mg Tablet should be taken with food. To get the best results, take it consistently at the same time every day. Your doctor will determine the appropriate dose for you, which may be adjusted over time based on your blood sugar levels and how the medication is working.

Continue taking this medication, even if you feel fine or your blood sugar levels are under control. Stopping it without your doctor's guidance can lead to an increase in blood sugar, putting you at risk of kidney damage, blindness, nerve issues, and limb loss. Keep in mind that this medication is just one part of your treatment plan, which should also include a healthy diet, regular exercise, and weight management as recommended by your doctor. Your lifestyle plays a crucial role in managing diabetes.

The most common side effects of this medicine include low blood sugar (hypoglycemia), stomach discomfort, nausea, dizziness, vomiting, headache, taste disturbance, diarrhea, stomach pain, loss of appetite and upper respiratory infections. To reduce the risk, ensure you have regular meals and always carry a quick source of glucose, like sugary snacks or fruit juice. Alcohol consumption can also increase the risk of low blood sugar, so it is best to avoid it. Some people may also experience weight gain while taking this medication.

You should avoid taking this medication if you have type 1 diabetes, diabetic ketoacidosis (high blood acid levels), or severe kidney or liver disease. Prior to using this medicine, inform your doctor if you have a history of heart disease, as it may not be appropriate for you. Pregnant or breastfeeding women should also consult their doctor's advice before use. Regular blood sugar monitoring is recommended, and your doctor may suggest additional blood tests to check your blood cell counts and liver function.

Uses Of GLYCOMET GP 0.5MG TABLET

• Type 2 diabetes mellitus

Benefits of GLYCOMET GP 0.5MG TABLET

1. Helps lower blood sugar levels
2. Improves insulin sensitivity and pancreatic function
3. Reduces the risk of complications related to diabetes
4. Effective in managing type 2 diabetes when used with a proper diet and exercise plan

How GLYCOMET GP 0.5MG TABLET Works

Glycomet GP 0.5 Tablet combines two active ingredients: Glimepiride and Metformin. Glimepiride stimulates the pancreas to release insulin, helping reduce blood sugar levels. Metformin improves the body's sensitivity to insulin and decreases glucose production in the liver thus helping to decrease blood sugar levels.

How to use GLYCOMET GP 0.5MG TABLET

How to Take Glycomet GP 0.5 Tablet?

• Typically, take once or twice daily with meal or as advised by your doctor
• Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
• It is recommended to take Glycomet GP 0.5mg Tablet with food to reduce the risk of stomach upset (such as nausea)
• Try to take the tablet at the same time each day to help remember and ensure consistency.

Dosage Instructions for Adults and Children:

For Adults:

• Typically, take once daily with food to reduce gastrointestinal discomfort.

For Children:

• Not recommended for children under 18 years of age. The safety and efficacy for pediatric use have not been established.

What if I forgot to take GLYCOMET GP 0.5MG TABLET

Missed Dosage instructions for Glycomet GP 0.5mg Tablet:

• Take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and go back to your regular schedule
• Do not take a double dose to make up for the missed one.

Overdose

Overdosage of Glycomet GP 0.5mg Tablet:

If you or anyone else accidentally take too much of Glycomet GP 0.5mg Tablet, consult and inform your doctor immediately or visit the nearby hospital. Symptoms of overdose are lactic Acidosis symptoms such as weakness, fatigue, difficulty breathing, dizziness, muscle pain or cramping and slow or irregular heartbeat, hypoglycemia (low blood sugar) symptoms such as sweating, tremors, dizziness or lightheadedness, confusion, rapid heartbeat, seizures, and loss of consciousness.

Side Effects Of GLYCOMET GP 0.5MG TABLET

Like all medicines, Glycomet GP 0.5mg Tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Glycomet GP 0.5mg Tablet are:

• low blood sugar (hypoglycemia)
• stomach discomfort
• nausea
• dizziness
• vomiting
• headache
• taste disturbance
• diarrhea
• stomach pain
• loss of appetite
• upper respiratory infections

When to consult your doctor?

• Severe Hypoglycemia (low Blood Sugar) symptoms such as sweating, shaking, confusion, dizziness, rapid heartbeat, blurry vision, headache, loss of consciousness.
• Lactic Acidosis symptoms such as muscle pain or weakness, difficulty breathing, stomach discomfort, dizziness, or feeling cold.
• Allergic Reactions symptoms such as rash, itching, swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing.
• Unexplained Weight Loss
• Gastrointestinal problems such as nausea, vomiting, diarrhea, severe dehydration
• Liver problems symptoms such as yellowing of the Skin or Eyes (Jaundice)
• Breathing Difficulties or Fatigue

How To Manage Side Effects

Warning & Precautions

Other Warnings for GLYCOMET GP 0.5MG TABLET

Before taking Glycomet GP 0.5mg Tablet, inform your doctor if you:

• are recovering from injury, operation, infections with fever, or from other forms of stress
• have glucose-6-phosphate dehydrogenase (G6PD) deficiency
• have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders)

Who should not take [GBNKEYWORD

Glycomet GP 0.5mg Tablet is generally not recommended for use if you have:

• type 1 diabetes mellitus
• diabetic ketoacidosis
• uncontrolled diabetes or ketoacidosis
• dehydration
• severe infection

Safety Advice

• Typically, take once or twice daily with meal or as advised by your doctor
• Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
• It is recommended to take Glycomet GP 0.5mg Tablet with food to reduce the risk of stomach upset (such as nausea)
• Try to take the tablet at the same time each day to help remember and ensure consistency.
• Follow the prescribed diet and exercise plan along with taking this medication for best results.
• Monitor your blood sugar levels regularly while taking this medicine.
• Avoid alcohol while taking this medication, as it can increase the risk of hypoglycemia or lactic acidosis.
• Your doctor might regularly monitor your kidney and liver function.
• Let your doctor know if you have kidney disease or any history of kidney problems, liver disease or a history of liver problems or heart problems or severe infection or dehydration.
• Let your doctor know If you are pregnant or planning to become pregnant or breastfeeding women.
• Do not suddenly stop taking the medication without consulting your doctor, as this can lead to uncontrolled blood sugar levels.
• If you experience nausea, vomiting, diarrhea, stomach upset, and dizziness, unusual tiredness, muscle pain, difficulty breathing, or a slow heart rate, seek medical attention immediately.
• Glycomet GP can interact with various medications, including diuretics, corticosteroids, thyroid medications, and other drugs (prescription or over-the-counter) you are taking.

Diet and Lifestyle Advice

Area	Recommendations
Balanced Meals	- Include a variety of whole foods: Focus on vegetables, lean proteins, whole grains, healthy fats, and fruits.
	- Choose low glycemic index (GI) foods: Foods like whole grains, legumes, non-starchy vegetables, and fruits like berries.
	- Limit refined carbs and sugar: Avoid sugary drinks, pastries, and white bread.
	- Incorporate fiber-rich foods: Oats, beans, lentils, and vegetables help regulate blood sugar levels.
	- Control carbohydrate intake: Spread carbs evenly throughout the day to avoid blood sugar spikes.
	- Healthy fats: Include sources of unsaturated fats such as avocado, olive oil, and nuts.
Portion Control	- Measure portion sizes: Use measuring cups, food scales, or visual cues (e.g., palm for protein, fist for veggies).
	- Mindful eating: Eat slowly and pay attention to hunger cues to avoid overeating.
	- Smaller, more frequent meals: Opt for 5-6 smaller meals rather than 3 large meals to help regulate blood sugar.
	- Limit high-calorie, low-nutrient foods: Such as chips, sugary snacks, and fried foods.
Lifestyle Changes	- Monitor blood sugar regularly: Track blood sugar levels to understand how foods, exercise, and stress impact it.
	- Maintain a healthy weight: Aim for gradual weight loss (5-10% of body weight) to improve insulin sensitivity.
	- Manage stress: Stress increases blood sugar levels; practice mindfulness, yoga, or relaxation techniques.
	- Get adequate sleep: Aim for 7-9 hours of sleep to help regulate blood sugar and insulin levels.
	- Stay hydrated: Drink plenty of water to help flush excess sugar through urine.
Safe Exercises	- Aerobic exercise: Aim for 150 minutes per week (e.g., brisk walking, swimming, cycling).
	- Strength training: Include muscle-strengthening exercises at least 2 days a week (e.g., resistance bands, weights).
	- Flexibility exercises: Stretching, yoga, and Pilates can improve flexibility and help reduce stress.
	- Low-impact activities: If you have joint issues, try walking, water aerobics, or cycling to minimize strain.
	- Monitor blood sugar during exercise: Check blood sugar before and after exercise, especially if on insulin.

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking Glycomet GP 0.5mg Tablet:

1. Other Antidiabetic Medications:

Interaction: Using other oral antidiabetic drugs (e.g., insulin, other sulfonylureas, thiazolidinediones, DPP-4 inhibitors, GLP-1 agonists) alongside Glycomet GP can increase the risk of hypoglycemia (low blood sugar).

Effect: Severe hypoglycemia can occur, which may result in symptoms like confusion, sweating, dizziness, and, if untreated, loss of consciousness or seizures.

Management: Regular monitoring of blood sugar levels is essential. Adjusting the dose of Glycomet GP or the other antidiabetic drug might be necessary to prevent hypoglycemia. Always consult your doctor for proper guidance.

2. Corticosteroids (e.g., Prednisone):

Interaction: Corticosteroids can increase blood sugar levels by impairing insulin action. This can counteract the blood sugar-lowering effects of Glycomet GP.

Effect: Elevated blood glucose levels and potential loss of glycemic control, leading to hyperglycemia.

Management: Close monitoring of blood sugar is required. Adjustments to the dose of Glycomet GP may be necessary. In some cases, insulin therapy might be considered during corticosteroid use.

3. Beta-blockers (e.g., Metoprolol, Atenolol):

Interaction: Beta-blockers can mask the symptoms of hypoglycemia (e.g., tremors, palpitations), making it harder to detect low blood sugar.

Effect: Difficulty in recognizing the signs of hypoglycemia, which could lead to more severe cases of low blood sugar.

Management: Blood sugar levels should be monitored more frequently. Patients should be educated about hypoglycemia and its silent symptoms. A dose adjustment of Glycomet GP might be needed based on blood sugar readings.

4. Angiotensin-converting enzyme (ACE) Inhibitors (e.g., Lisinopril):

Interaction: ACE inhibitors can lower blood pressure and have a potential to increase the glucose-lowering effect of Glycomet GP, leading to a higher risk of hypoglycemia.

Effect: Increased risk of hypoglycemia due to enhanced effect of Glycomet GP.

Management: Blood sugar monitoring should be done more frequently. Your doctor may adjust the dose of Glycomet GP to avoid hypoglycemia.

5. Diuretics (e.g., Hydrochlorothiazide):

Interaction: Thiazide diuretics can increase blood sugar levels and decrease the effectiveness of Glycomet GP by causing insulin resistance.

Effect: Increased risk of hyperglycemia, which may reduce the control of blood sugar levels.

Management: Regular monitoring of blood glucose levels is essential, and dose adjustments to Glycomet GP may be required. Alternative antihypertensive medications or diuretics with less effect on blood sugar may be considered.

6. Phenothiazines (e.g., Chlorpromazine):

Interaction: These antipsychotic medications may raise blood sugar levels by inhibiting insulin secretion, potentially interfering with the effectiveness of Glycomet GP.

Effect: Hyperglycemia due to reduced insulin secretion and increased insulin resistance.

Management: Close monitoring of blood sugar levels is essential, and Glycomet GP dosage adjustments may be necessary to maintain optimal blood glucose control.

7. Thyroid Medications (e.g., Levothyroxine):

Interaction: Thyroid hormone replacement therapy can affect blood sugar levels, either by improving or worsening glycemic control, depending on the dose and individual response.

Effect: Potential for either hypoglycemia or hyperglycemia, depending on thyroid hormone levels and Glycomet GP efficacy.

Management: Monitoring of blood glucose and thyroid function tests are essential. Dose adjustments may be needed based on thyroid hormone levels and glucose control.

8. Anticoagulants (e.g., Warfarin):

Interaction: Glycomet GP and warfarin may both affect the liver and increase the risk of bleeding.

Effect: Risk of bleeding complications, especially if hypoglycemia occurs along with anticoagulant use.

Management: Close monitoring of blood glucose and coagulation parameters is necessary. Regular INR testing should be conducted when both medications are used together.

9. Cimetidine (Antacid):

Interaction: Cimetidine can increase the levels of metformin in the blood by inhibiting its clearance from the kidneys. This may increase the risk of lactic acidosis, a rare but serious side effect of metformin.

Effect: Elevated risk of lactic acidosis, which can be life-threatening and may cause symptoms like abdominal discomfort, breathing difficulties, and muscle cramps.

Management: If cimetidine is needed, dosage adjustments may be required, and careful monitoring for signs of lactic acidosis should be done.

10. Alcohol:

Interaction: Alcohol can intensify the blood sugar-lowering effect of Glycomet GP, leading to hypoglycemia, especially when consumed on an empty stomach.

Effect: The risk of hypoglycemia increases, particularly after drinking alcohol, as the liver prioritizes metabolizing alcohol over maintaining blood sugar levels.

Management: Limit alcohol consumption and avoid drinking on an empty stomach. Regular monitoring of blood glucose is necessary, and patients should be educated about the risks of drinking while on Glycomet GP.

11. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) (e.g., Diclofenac):

Interaction: Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that can affect renal function, which may enhance the risk of lactic acidosis, a rare but serious side effect of Metformin. This can be particularly concerning if there is renal impairment. NSAIDs like Diclofenac may also interfere with the blood glucose-lowering effect of Gliclazide, potentially requiring closer monitoring of blood glucose levels.

Effect: NSAIDs may decrease renal function and may lead to increased blood sugar levels, potentially interfering with Glycomet GP's effectiveness in controlling blood sugar.

Management: Close monitoring of kidney function is recommended, especially in individuals with pre-existing renal disease or those who are dehydrated. Blood glucose levels should be closely monitored.

12. Antifungal Medications (e.g., Fluconazole):

Interaction: Fluconazole can increase the blood levels of Gliclazide due to inhibition of the liver enzyme CYP2C9 that metabolizes Gliclazide. This can lead to an increased risk of hypoglycemia (low blood sugar). Fluconazole may also slightly impair the renal clearance of Metformin, although this interaction is less significant compared to Gliclazide.

Effect: The main concern is an increased risk of hypoglycemia because Fluconazole can potentiate the effect of Gliclazide.

Management: Careful blood glucose monitoring is important. If necessary, the dose of Gliclazide should be adjusted, and caution should be taken when starting or discontinuing Fluconazole.

13. Antibiotic (e.g., Rifampicin):

Interaction: Rifampicin is a potent enzyme inducer and may increase the metabolism of Gliclazide, potentially leading to reduced blood glucose-lowering effectiveness. This can cause inadequate blood sugar control. Rifampicin can also affect the clearance of Metformin, though this interaction is typically less pronounced than with Gliclazide.

Effect: The primary concern with Rifampicin is that it may reduce the effectiveness of Gliclazide, leading to increased blood glucose levels.

Management: Patients may need closer monitoring of blood glucose levels and potential adjustment of Gliclazide doses when Rifampicin is started. If possible, alternative antibiotics may be considered for better glucose control.

Synopsis

Drug	:	Glimepiride, Metformin
Pharmacological Category	:	Sulfonylureas, Biguanides
Therapeutic Indication	:	Type II diabetes mellitus
Dosage Forms	:	Tablet

More Information

What are the key benefits of Glycomet GP 0.5mg Tablet, particularly in terms of reducing blood sugar, reducing diabetes complications, and improving insulin sensitivity?

• Helps Reduce Blood Sugar Levels: Glycomet GP 0.5mg contains a combination of Glimepiride and Metformin, which work together to lower blood glucose levels effectively. This helps individuals with type 2 diabetes maintain better control over their blood sugar.
• Improves Insulin Sensitivity: By improving the body’s response to insulin, Glycomet GP helps enhance the effectiveness of the insulin already produced, which is crucial for better glucose control.
• Reduce Diabetes Complications: Consistent use of Glycomet GP 0.5mg can help reduce the long-term complications of diabetes, such as nerve damage, kidney problems, and heart disease, by keeping blood sugar levels within a healthy range.
• Supports Weight Management: Metformin, one of the key ingredients in Glycomet GP, may also help with weight management by reducing appetite and promoting fat burning, which is an important aspect for individuals with diabetes.
• Safe and Effective: Glycomet GP 0.5mg is clinically proven to be effective for managing type 2 diabetes, and it is generally well-tolerated when used as prescribed.

Relevant Health Articles

Diabetes Care: Manage Blood Sugar Levels With Smart Carbohydrate Choices

Diabetic Diet Chart (1600 Calories, Vegetarian)

Yoga and Diabetes

How to self-monitor glucose levels at home

FAQs About GLYCOMET GP 0.5MG TABLET

References

1. KD Tripathi MD. Hormones and related drugs. Essentials of medical pharmacology. Seventh edition. New Delhi, May 2013. Page- 274.
2. Rakesh Kumar Sahay, Vinod Mittal, G Raja Gopal, Sunil Kota, Ghanshyam Goyal, Mahesh Abhyankar, Santosh Revenkar. Glimepiride and Metformin Combinations in Diabetes Comorbidities and Complications: Real-World Evidence. September 2020. [Accessed on 7th Feb 2025]  
3. Sanofi. Efficacy and Safety Comparison of Metformin/Glimepiride Combination Versus Each Compound Alone in New Diagnosed Type 2 Diabetes Patients (RECOMMEND). NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in January 2015] [Accessed on 7th Feb 2025]   
4. Torrent pharmaceuticals Ltd. Azulix MF. Metformin Hydrochloride Prolonged Release and Glimepiride Tablets I.P. [Revised in July 2019] [Accessed on 7th Feb 2025]
5. Sanofi-aventis group. Amaryl M. Glimepiride + Metformin. [Revised in May 2015] [Accessed on 7th Feb 2025]

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

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