Gluconorm G2 Forte Tablet 15'S

Introduction About GLUCONORM G2 FORTE TABLET

Gluconorm G2 Forte Tablet is designed to support blood sugar management in adults with type 2 diabetes when lifestyle changes and single medications do not achieve adequate control. This tablet combines two antidiabetic agents such as Glimepiride and Metformin that work together to help regulate glucose levels. Glimepiride stimulates the pancreas to increase insulin production and improves the body’s efficiency in using insulin, while Metformin reduces the amount of glucose produced by the liver and released into the bloodstream. This balanced combination aids in maintaining more stable blood sugar levels as part of a comprehensive diabetes management plan. 

Gluconorm G2 Forte Tablet should be taken with food to help minimize stomach discomfort. For optimal results, take the tablet consistently at the same time each day. Your doctor will determine the most suitable dose based on your blood sugar levels and may adjust it periodically to ensure effective management.

Continue taking this medicine consistently, even if you feel well or your blood sugar levels are within the recommended range. Stopping the medication without consulting your doctor can lead to an increase in blood sugar levels, which may increase the risk of complications such as kidney damage, vision loss, nerve issues, and limb problems. Remember, this medicine is only one part of a comprehensive care plan that should also include a balanced diet, regular physical activity, and weight management as advised by your doctor. Your lifestyle choices play a crucial role in managing diabetes effectively.

The most common side effect of Gluconorm G2 Forte Tablet are taste changes, nausea, diarrhea, vomiting, stomach pain, headache, indigestion, upper respiratory tract infection, dizziness, weakness, bloating. Be aware of the signs of low blood glucose levels, which can include sweating, dizziness, headache, and shaking, and understand how to manage these symptoms effectively. To helps to reduce low blood sugar, maintain regular meal times and always keep a quick source of glucose on hand, such as sugary snacks or fruit juice. Avoid alcohol, as it can increase the chance of experiencing low blood sugar. Additionally, some individuals may notice weight gain while taking this medication.

You should avoid taking Gluconorm G2 Forte Tablet if you have type 1 diabetes mellitus, diabetic ketoacidosis (high acid levels in your blood), or severe liver or kidney disease. Before starting this medicine, inform your doctor if you have a history of heart disease, as it may not be suitable for you. Pregnant or breastfeeding women should also consult their doctor prior to use. Regular monitoring of your blood sugar levels is important during management, and your doctor may recommend periodic blood tests to check liver function and blood cell counts to ensure safety. 

Uses Of GLUCONORM G2 FORTE TABLET

• Type 2 diabetes mellitus

Benefits of GLUCONORM G2 FORTE TABLET

1) Helps maintain stable blood sugar levels for effective diabetes management:
Gluconorm G2 Forte Tablet combines Glimepiride and Metformin to support balanced blood glucose levels, which is essential for managing type 2 diabetes and reducing fluctuations that can harm health.

2) Improves insulin production and enhances insulin sensitivity:
Glimepiride stimulates the pancreas to release more insulin, while Metformin helps the body use insulin more efficiently, working together to better regulate blood sugar.

3) Reduces excessive glucose production by the liver:
Metformin in Gluconorm G2 Forte decreases the amount of sugar the liver releases into the bloodstream, helping to lower overall blood sugar levels.

4) Supports a once-daily dosing routine for better management adherence:
The controlled-release formulation provides steady glucose control throughout the day, making it easier to take consistently and improve adherence to your management plan.

5) Part of a comprehensive diabetes care plan including diet and exercise:
This medication works best when combined with a healthy diet, regular physical activity, and frequent monitoring of blood sugar to helps to reduce diabetes-related complications.

How GLUCONORM G2 FORTE TABLET Works

Gluconorm G2 Forte helps manage blood glucose levels by simultaneously stimulating insulin secretion and improving insulin sensitivity, offering a comprehensive approach to diabetes management.

Key Components & Their Functions

• Glimepiride:
  Glimepiride stimulates the beta cells in the pancreas to release more insulin, a hormone essential for lowering blood sugar. It helps the body use insulin more efficiently, facilitating glucose uptake by cells and reducing blood glucose levels.
• Metformin:
  Metformin reduces hepatic glucose production, decreasing the amount of sugar released by the liver into the bloodstream. It also delays intestinal absorption of glucose and enhances muscle and fat cell sensitivity to insulin, improving glucose utilization and overall glycemic control.

Role of Glimepiride in Blood Sugar Regulation

Glimepiride acts by promoting endogenous insulin release which directly lowers blood sugar. This is especially helpful in patients whose pancreas still produces insulin but insufficiently. It enhances insulin activity at target tissues, helping reduce both fasting and postprandial glucose levels.

Role of Metformin in Glucose Control

Metformin primarily decreases excessive glucose production by the liver and slows glucose absorption in the intestines. It does not increase insulin secretion but improves peripheral insulin sensitivity, which helps cells absorb and utilize glucose effectively, reducing hyperglycemia.

Enhancing Insulin Sensitivity with Gluconorm G2 Forte

The combination of Glimepiride and Metformin synergistically enhances insulin sensitivity by supporting the pancreas to produce adequate insulin and helping body tissues respond better to insulin, which is crucial for effective blood sugar regulation in type 2 diabetes.

Dual Action for Effective Sugar Management

By targeting two different but complementary pathways such as pancreatic insulin secretion and hepatic glucose production. Gluconorm G2 Forte provides improved and stable glycemic control compared to either drug alone. This dual approach helps reduce both fasting and post-meal blood sugar levels, thereby supporting long-term diabetes care alongside diet and exercise.

How to use GLUCONORM G2 FORTE TABLET

Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.

Recommended Dosage and Administration of Gluconorm G2 Forte Tablet

• Gluconorm G2 Forte Tablet is usually prescribed to be taken once daily with food, preferably at the same time each day to maximize its effectiveness and minimize side effects.
• The exact dose and frequency depend on your individual blood sugar levels, medical condition, and response to management. Your doctor will decide and may adjust the dosage over time as needed.
• Swallow the tablet whole with a glass of water. Do not crush or chew the tablet to ensure the controlled-release formulation works properly.

Dosage Schedule and Timing

• Taking the tablet with meals, typically breakfast or dinner, helps reduce gastrointestinal discomfort such as nausea or stomach upset.
• Consistency in timing supports stable blood glucose control, so taking it every day at the same time is recommended.
• Avoid skipping doses; if a dose is missed, take it as soon as you remember unless it is nearly time for the next dose, do not double up.

Tips for Taking Gluconorm G2 Forte Safely

• Always follow your doctor’s instructions precisely regarding dosage and duration.
• Maintain a healthy diet and regular exercise routine alongside medication for optimal blood sugar management.
• Carry a quick source of glucose, such as fruit juice or candies, to manage potential low blood sugar (hypoglycemia).
• Avoid alcohol consumption, as it can increase the risk of hypoglycemia.
• Inform your healthcare provider about other medicines or health conditions you have to avoid drug interactions and contraindications.

Important Precautions During Administration

• Gluconorm G2 Forte is not suitable for type 1 diabetes, diabetic ketoacidosis, or severe kidney/liver disease.
• Pregnant or breastfeeding women should consult their doctor before taking this medicine.
• Regular monitoring of blood glucose levels is essential, along with periodic blood tests to check liver function and blood counts as advised by your doctor.
• Recognize symptoms of low blood sugar (sweating, dizziness, headache, shaking) and know how to respond promptly.

Side Effects Of GLUCONORM G2 FORTE TABLET

Like all medicines, Gluconorm G2 Forte Tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Gluconorm G2 Forte Tablet are:

• Taste changes
• Nausea
• Diarrhea
• Vomiting
• Stomach pain
• Headache
• Indigestion
• Upper respiratory tract infection
• Dizziness
• Weakness
• Bloating

When to consult your doctor?

• Lactic acidosis symptoms such as severe vomiting, stomach pain, muscle cramps, extreme tiredness, difficulty breathing, cold or blue skin, and a slow or irregular heartbeat
• Severe hypoglycemia (low blood sugar) symptoms such as confusion, sweating, shaking, dizziness, headache, weakness, sudden mood changes, or loss of consciousness.
• Liver problems symptoms such as yellowing of the skin or eyes (jaundice)
• Kidney problems symptoms such as persistent stomach pain or dark-colored urine
• Allergic reactions symptoms such as rash, itching, swelling (especially of the face/tongue/throat), severe dizziness, or difficulty breathing
• Blood disorders symptoms such as unexplained bruising or bleeding, persistent sore throat, fever

How To Manage Side Effects

Diarrhea

• Stay Hydrated: Drink plenty of clear fluids like water, oral rehydration solutions, or clear broths to replace lost fluids and reduce dehydration.
• Eat Light, Simple Foods: Choose bland foods such as bananas, rice, toast, or applesauce. Avoid fatty, spicy, or high-fiber foods until your symptoms improve.
• Rest: Give your body time to recover by resting as much as possible.
• Avoid Dairy and Caffeine: These can sometimes make diarrhea worse, so limit milk, cheese, coffee, and caffeinated drinks until you feel better.
• Monitor Symptoms: If diarrhea lasts more than a couple of days, becomes severe, or is accompanied by symptoms like fever, blood in the stool, or dehydration (such as dizziness or decreased urination), contact your doctor.

Headache

• Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
• Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
• Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
• Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
• Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

Nausea And Vomiting

• Eat Small, Frequent Meals: Avoid heavy or greasy foods. Opt for bland foods like crackers, toast, or bananas.
• Stay Hydrated: Sip on clear fluids like water, ginger tea, or electrolyte drinks, Avoid caffeinated and carbonated beverages.
• Ginger: Ginger is a natural remedy for nausea. Try ginger tea, ginger candies, or ginger ale (ensure it contains real ginger).
• Avoid Strong Odors: Minimize exposure to smells that might trigger nausea, such as perfumes or cooking odors.

Warning & Precautions

Pregnancy

Contraindicated

Gluconorm G2 Forte Tablet is generally not recommended during pregnancy. While human studies are limited, animal research has indicated potential harmful effects on the developing fetus. If you are pregnant or planning to become pregnant, inform your Gynecologist before taking this medicine.

Breastfeeding

Contraindicated

Gluconorm G2 Forte Tablet is not recommended for use in breastfeeding women because this medicine may pass into breast milk and could pose a risk to the baby. Consult your Gynecologist before taking this medication.

Driving and Using Machines

Use with Caution

Gluconorm G2 Forte can cause low blood sugar (hypoglycemia), leading to dizziness, drowsiness, or confusion. These symptoms can impair your ability to drive or operate machinery safely. Do not drive if you experience such effects, and keep glucose sources like juice or sweets nearby.

Alcohol

Contraindicated

Avoid alcohol consumption during management as it can increase the risk of hypoglycemia and serious complications like ketoacidosis.

Kidney

Consult your doctor

Gluconorm G2 Forte should be used with caution in patients with kidney problems and is not recommended for patients with severe kidney problems. Regular monitoring of kidney function is advised. Consult your Nephrologist before taking this medication.

Liver

Consult your doctor

Gluconorm G2 Forte Tablet should be used with caution in patients with liver problems and is not recommended for severe liver problems. Liver function tests should be monitored regularly. Consult your Hepatologist before taking this medication.

Allergy

Contraindicated

Do not take Gluconorm G2 Forte Tablet if you are allergic to Glimepiride or Metformin, or any other ingredients of this medicine.

Heart Disease

Contraindicated

Gluconorm G2 Forte tablet is not recommended for use in patients with history of heart disease, recent heart attack, or heart failure. Consult your Cardiologist before taking this medication.

Use In Pediatrics

Contraindicated

Gluconorm G2 Forte is not recommended for use in children and adolescents under 18 years old. Consult your pediatrician before giving it.

Use In Geriatrics

Use with Caution

Gluconorm G2 Forte Tablet should be used with caution in elderly patients. Older adults may be more sensitive to side effects such as hypoglycemia and kidney or liver dysfunction. Dose adjustments and careful monitoring are recommended for the elderly. Consult your Geriatrician before taking this medication. 

Other Warnings for GLUCONORM G2 FORTE TABLET

Before taking GLUCONORM G2 FORTE TABLET inform your doctor if you:

• are recovering from injury, operation, infections with fever, or from other forms of stress
• have glucose-6-phosphate dehydrogenase (G6PD) deficiency
• have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders)

Who should not take [GBNKEYWORD

GLUCONORM G2 FORTE TABLET is not recommended for use, if you have:

• type 1 diabetes mellitus
• diabetic ketoacidosis
• uncontrolled diabetes or ketoacidosis
• dehydration
• severe infection

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking Gluconorm G2 Forte Tablet:

1. Insulin and Other Antidiabetic Medications

Interaction: When taken with other blood sugar-lowering medicines such as insulin, Pioglitazone, or other oral hypoglycemics.
Effects: Increased risk of hypoglycemia (low blood sugar), causing symptoms like sweating, dizziness, shaking, and confusion.
Management: Monitor blood sugar levels closely. Adjust doses under medical supervision to avoid hypoglycemia.

2. Beta-Blockers (e.g., Atenolol) and Other Antihypertensives

Interaction: Beta-blockers and some blood pressure medications can mask symptoms of hypoglycemia and alter drug efficacy.
Effects: May reduce awareness of low blood sugar episodes, increasing risk of severe hypoglycemia.
Management: Regular blood sugar monitoring is essential. Inform your doctor about all medicines to adjust management if necessary.

3. Corticosteroids and Diuretics (e.g., Thiazides)

Interaction: These drugs may reduce the effectiveness of Gluconorm G2 Forte by causing increased blood sugar levels (hyperglycemia).
Effects: Loss of blood sugar control, requiring dose adjustment.
Management: Blood glucose levels should be regularly monitored. Your doctor may adjust your antidiabetic dosage.

4. Antibiotics (e.g., Clarithromycin, Doxycycline, Ofloxacin)

Interaction: Certain antibiotics can increase the effects of Gluconorm G2 Forte, raising hypoglycemia risk.
Effects: Enhanced blood sugar lowering effect, causing unexpected hypoglycemia.
Management: Monitor blood glucose more frequently during antibiotic use, and notify your physician if hypoglycemia symptoms occur.

5. Cimetidine

Interaction: Cimetidine may inhibit the metabolism of Glimepiride, increasing its concentration.
Effects: Increased hypoglycemic effects, raising side effect risk.
Management: Dose adjustments might be necessary; close monitoring is recommended.

6. Oral Contraceptives and Estrogens

Interaction: These can decrease the blood sugar-lowering effect of Gluconorm G2 Forte, causing hyperglycemia.
Effects: Reduced glycemic control.
Management: Regular blood sugar monitoring and possible dose modifications.

7. Thyroid Medications (e.g., Levothyroxine)

Interaction: Thyroid hormones may increase blood sugar levels, reducing the effectiveness of Gluconorm G2 Forte.
Effects: Potential elevated blood glucose and reduced efficacy.
Management: Periodic blood sugar tests and dose adjustments as needed.

8. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Salicylates (Aspirin)

Interaction: These drugs may potentiate hypoglycemia when taken with Gluconorm G2 Forte.
Effects: Increased risk of low blood sugar episodes.
Management: Monitor blood glucose levels carefully; adjust doses under medical advice.

9. Probenecid and Other Drugs Influencing Kidney Function

Interaction: May affect renal clearance of Gluconorm components, increasing drug levels and toxicity risk.
Effects: Higher chance of side effects including hypoglycemia or lactic acidosis.
Management: Kidney function tests and dose adjustment recommended.

Drug - Food interaction

1. Alcohol

Interaction: Alcohol can interfere with blood sugar regulation when taking Gluconorm G2 Forte.
Effects: Increases the risk of hypoglycemia (low blood sugar) and lactic acidosis, a rare but serious side effect.
Management: Avoid alcohol consumption while on this medication. If alcohol is consumed, monitor blood sugar closely and seek medical advice if symptoms of low blood sugar appear.

2. High-Carbohydrate Meals or Sugary Foods

Interaction: Consuming large amounts of high-carb or sugary foods can affect blood sugar control when on Gluconorm G2 Forte.
Effects: May cause blood sugar spikes, reducing the medication’s effectiveness.
Management: Maintain a balanced diet with controlled carbohydrate intake as advised by your healthcare provider to enhance management outcomes.

3. Grapefruit and Grapefruit Juice

Interaction: Grapefruit may interfere with the metabolism of various drugs and could potentially affect blood sugar levels.
Effects: May increase drug concentration, potentially leading to hypoglycemia or other side effects.
Management: Limit or avoid grapefruit and its juice while on this medication. Consult your doctor for personalized advice.

4. Food Intake Timing

Interaction: Taking Gluconorm G2 Forte without food can impact drug absorption and increase side effects.
Effects: Increased risk of stomach upset and hypoglycemia.
Management: Always take the tablet with or immediately after meals to reduce gastrointestinal discomfort and maintain steady blood sugar control.

5. Caffeine-Containing Beverages

Interaction: Excessive caffeine intake (coffee, tea, energy drinks) may affect blood sugar levels.
Effects: Can cause fluctuations in blood sugar, making diabetes harder to control.
Management: Consume caffeine in moderation and monitor blood sugar levels regularly.

6. High-Fat Meals

Interaction: High-fat meals may slow gastric emptying and affect how the medicine is absorbed.
Effects: Potential variability in blood sugar control due to delayed medication absorption.
Management: Follow a balanced diet as recommended by your healthcare provider to promote consistent medication effects.

7. Licorice and Herbal Supplements

Interaction: Certain herbal products like licorice may affect blood sugar and interact with diabetes medications.
Effects: Can either raise or lower blood sugar unpredictably.
Management: Inform your doctor about any herbal supplements you take to assess potential interactions.

Synopsis

More Information

1. How does Gluconorm G2 Forte Tablet fit into a comprehensive self-care regimen that includes diet, exercise, and regular blood glucose monitoring?

FAQs About GLUCONORM G2 FORTE TABLET

References

1. KD Tripathi MD. Hormones and related drugs. Essentials of medical pharmacology. Seventh edition. New Delhi, May 2013. Page – 274.

2. Rakesh Kumar Sahay, Vinod Mittal, G Raja Gopal, Sunil Kota, Ghanshyam Goyal, Mahesh Abhyankar, Santosh Revenkar. Glimepiride and Metformin Combinations in Diabetes Comorbidities and Complications: Real-World Evidence. September 2020. [Accessed on Accessed on July 26th, 2025]

3. Sanofi. Efficacy and Safety Comparison of Metformin/Glimepiride Combination Versus Each Compound Alone in New Diagnosed Type 2 Diabetes Patients (RECOMMEND). NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in January 2015] [Accessed on July 26th, 2025] 

4. Torrent pharmaceuticals Ltd. Azulix MF. Metformin Hydrochloride Prolonged Release and Glimepiride Tablets I.P. [Revised in July 2019] [Accessed on July 26th, 2025] 

5. Sanofi-aventis group. Amaryl M. Glimepiride + Metformin. [Revised in May 2015] [Accessed on July 26th, 2025]

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 28 Jul 2025 | 03:24 PM(IST)