GLIZID M TABLET 15'S(N)

Introduction About GLIZID M TABLET 15'S(N)

GLIZID M TABLET 15'S(N) contains Gliclazide, which belongs to the group of medicines called Antidiabetic agents. It is used in adults in the management of type II diabetes mellitus when diet, exercise, and lifestyle changes alone do not result in an adequate response.

Type II diabetes mellitus is a chronic disease associated with abnormally high levels of glucose in the blood. It is caused either by inadequate production of a hormone called insulin (produced by the pancreas to metabolize glucose) or by inadequate sensitivity of body cells to the actions of insulin.

During therapy with GLIZID M TABLET 15'S(N), your doctor might ask you to make certain lifestyle changes, such as following a healthy diet, regular physical exercise, and quitting alcohol consumption.

Before taking GLIZID M TABLET 15'S(N), inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any hormonal problems, genetic disorders (such as G6PD deficiency), or if you are malnourished, starved, or on an irregular diet.

GLIZID M TABLET 15'S(N) is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking GLIZID M TABLET 15'S(N) if you are pregnant, planning to become pregnant, or breastfeeding.

One of the most common side effects of taking GLIZID M TABLET 15'S(N) is hypoglycemia (low blood sugar levels), which can be identified through symptoms such as increased hunger, sweating, shakiness, weakness, or an irregular heartbeat. To avoid this, your doctor will periodically monitor your blood sugar levels and adjust the dose of GLIZID M TABLET 15'S(N) accordingly.

You can also carry a sugary snack (such as biscuits, glucose drinks, or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia. However, consult your doctor if there is no improvement in your condition. Other common side effects of taking GLIZID M TABLET 15'S(N) are headache, dizziness, and constipation.

Uses Of GLIZID M TABLET 15'S(N)

• Management of type II diabetes mellitus in adults

How GLIZID M TABLET 15'S(N) Works

GLIZID M TABLET 15'S(N) effectively controls blood sugar levels, where gliclazide makes the pancreas secrete more insulin to digest the circulating sugars (glucose) in the blood. It also makes the body more sensitive to insulin, which helps in utilizing the circulating blood glucose (sugars), leading to a decrease in blood glucose levels.

How to use GLIZID M TABLET 15'S(N)

Take GLIZID M TABLET 15'S(N) before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition. Continue to take GLIZID M TABLET 15'S(N) for the duration recommended by your doctor to achieve better control over blood sugar levels.

Side Effects Of GLIZID M TABLET 15'S(N)

How To Manage Side Effects

Constipation

Eat plenty of fiber-rich foods, such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

Diarrhea

Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-manage diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids, such as water or electrolytes. Applying a pain-relieving balm to your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Hypoglycemia

Have foods rich in sugars, such as fruit juices, glucose drinks, candies, honey, or biscuits. Check your blood sugar after 10 minutes. If you have not reached the optimum level, take another sugary snack or drink and check the blood sugar again. Consult your doctor if there is no improvement in your condition.

Warning & Precautions

Pregnancy

Contraindicated

GLIZID M TABLET 15'S(N) is generally not recommended for use by pregnant women. Therefore, consult your doctor before taking it.

Breastfeeding

Contraindicated

GLIZID M TABLET 15'S(N) is generally not recommended for use by breastfeeding women. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizzy or experience blurred vision after taking GLIZID M TABLET 15'S(N).

Alcohol

Consult your doctor

Avoid alcohol consumption while taking GLIZID M TABLET 15'S(N), as it could aggravate your existing condition.

Kidney

Consult your doctor

GLIZID M TABLET 15'S(N) is not recommended for use in patients with severe kidney disease. It should be used with caution in patients with decreased kidney function. Therefore, consult your doctor before taking it.

Liver

Consult your doctor

GLIZID M TABLET 15'S(N) is not recommended for use in patients with severe liver disease. It should be used with caution in patients with decreased liver function. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take GLIZID M TABLET 15'S(N) if you are allergic to Gliclazide or to any other medicines that belong to sulphonylureas (such as glibenclamide, glipizide).

Use In Pediatrics

Contraindicated

GLIZID M TABLET 15'S(N) is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before administration.

Use In Geriatrics

Use with Caution

GLIZID M TABLET 15'S(N) should be used with caution in elderly patients, especially in those who take medicines such as CNS depressants or beta-blockers. Therefore, consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking GLIZID M TABLET 15'S(N), inform your doctor if you are taking any of the following medicines, such as:

• other antidiabetic medications such as metformin, insulin, glipizide, glibenclamide, dapaglifozin, teneligliptin, etc.
• antifungal medicines (used to manage fungal infections) such as miconazole or fluconazole
• John’s Wort (a herbal preparation used to manage depression)
• antibiotics (used to manage bacterial infections) such as fluoroquinolones (Ex. ciprofloxacin, moxifloxacin), clarithromycin, co-trimoxazole, rifampicin, chloramphenicol, tetracyclines, or sulphonamides (Ex. sulphasalazine)
• medicines used to manage high blood pressure or heart failure, such as beta blockers (Ex. atenolol and propranolol) and ACE-inhibitors (Ex. captopril or enalapril)
• medicines used to manage stomach ulcers, such as ranitidine and famotidine
• medicines used to manage depression (such as moclobemide, isocarboxazid, phenelzine, and tranylcypromine)
• medicines used for pain relief (Ex. aspirin, phenylbutazone, ibuprofen, phenylbutazone, azapropazone)
• medicines containing alcohol, such as cough preparations
• medicines to manage mental illness (such as chlorpromazine, prochlorperazine, and lithium)
• corticosteroids (used to manage pain and inflammation) Ex. prednisolone, cortisone, and betamethasone
• medicines used to manage asthma (Ex. salbutamol, terbutaline)
• ritodrine (a medicine used to stop pre-mature labour)
• danazol (a medicine used to manage breast disorders, heavy menstrual bleeding, and endometriosis)
• medicines used for blood thinning (Ex. warfarin).
• diuretics (used to increase urine output and reduce edema) such as bendroflumethiazide, hydrochlorothiazide, and furosemide
• oral contraceptives (birth control pills) Ex. drospirenone, ethinylestradiol
• sulfinpyrazone (a medicine used to manage gout)
• aminoglutethimide (a medicine used to manage breast cancer or prostate cancer)
• thyroid hormones such as thyroxine (used to manage thyroid deficiency)
• octreotide (a medicine used to manage bleeding in the gut)
• testosterone (a hormonal medicine used to manage delayed puberty in men)
• cimetidine (a medicine used to manage stomach ulcers)
• clofibrate (a medicine used to manage high blood cholesterol levels)
• disopyramide (a medicine used for irregular heartbeats)
• laxatives (used to manage constipation) Ex. lactulose, ispaghula

Overdosage:

If you or anyone else accidentally took more of GLIZID M TABLET 15'S(N), consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose might include signs of low blood glucose levels such as weakness, sweating, trembling, a fast heartbeat, confusion, and double vision.

Synopsis

More Information

• Keep GLIZID M TABLET 15'S(N) out of reach of children
• Store GLIZID M TABLET 15'S(N) at room temperature

FAQs About GLIZID M TABLET 15'S(N)

Q: What is GLIZID M TABLET 15'S(N) used for?

A: GLIZID M TABLET 15'S(N) is an antidiabetic medicine used in the management of type II diabetes mellitus when diet, exercise, and lifestyle changes alone do not result in an adequate response.

Q: How and when should I take GLIZID M TABLET 15'S(N)?

A: Take GLIZID M TABLET 15'S(N) before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.

Q: How long should I take GLIZID M TABLET 15'S(N)?

A: You need to take GLIZID M TABLET 15'S(N) as long as your doctor prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.

Q: Can I stop taking GLIZID M TABLET 15'S(N) without consulting your doctor?

A: No. You should not stop taking GLIZID M TABLET 15'S(N) without consulting your doctor because it may lead to a reversal of symptoms. If you feel better after using GLIZID M TABLET 15'S(N), consult your doctor for advice. Your doctor might reduce the dose gradually before discontinuation of therapy.

Q: Will taking a higher dose of GLIZID M TABLET 15'S(N) be more effective?

A: No, taking a higher dose of GLIZID M TABLET 15'S(N) will not be effective; rather, it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: What should I do if I forget to take a dose of GLIZID M TABLET 15'S(N)?

A: If you forget to take a dose of GLIZID M TABLET 15'S(N), take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of GLIZID M TABLET 15'S(N) to compensate for a missed dose, as it could lead to toxicity.

Q: What precautions do I need to follow while taking GLIZID M TABLET 15'S(N)?

A: Before taking GLIZID M TABLET 15'S(N), inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have hormonal problems, genetic problems (surgery in the gut), or if you are malnourished. GLIZID M TABLET 15'S(N) is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking GLIZID M TABLET 15'S(N) if you are pregnant or planning to become pregnant. During therapy with GLIZID M TABLET 15'S(N), follow the diet and lifestyle changes instructed by your doctor. Always carry a sugary snack (such as biscuits, glucose drinks, or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia.

Q: Can I take medication for high blood pressure along with GLIZID M TABLET 15'S(N)?

A: No. It is not advisable to take medicines to control blood pressure while taking GLIZID M TABLET 15'S(N) without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with GLIZID M TABLET 15'S(N), as they have known interactions with GLIZID M TABLET 15'S(N).

Q: What should I do if I experience low blood sugar after taking GLIZID M TABLET 15'S(N)?

A: Low blood sugar is a common side effect of taking GLIZID M TABLET 15'S(N). Try to have sugar-rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. Check your blood sugar after 10 minutes. If you have not reached the optimum level, take another sugary snack or drink and check the blood sugar again. In cases of persistently low blood sugar levels, consult your doctor immediately.

Q: Can GLIZID M TABLET 15'S(N) cause dizziness?

 A: Yes. Dizziness is a common side effect of using GLIZID M TABLET 15'S(N). If you experience dizziness, lie down until it passes, then get up slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, and alcohol. Do not drive or use machinery to avoid accidents. Consult your doctor if you experience dizziness continuously for a long time after taking GLIZID M TABLET 15'S(N).

Q: Can GLIZID M TABLET 15'S(N) be taken with insulin?

A: Co-administration of GLIZID M TABLET 15'S(N) with insulin is considered risky as it increases the chances of hypoglycemia (decreased blood sugar levels). Consult your doctor before taking it.

Q: Can GLIZID M TABLET 15'S(N) be used in pregnant women?

No. GLIZID M TABLET 15'S(N) is not recommended for use by pregnant women. Therefore, consult your doctor for advice before taking.

References

1. K.D. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270-272.

2. Shinnya Miwa, Hirotaka Watada, Ohmura chie and Yasushi Tanaka. Efficacy and Safety of Once Daily Gliclazide (20 mg/day) Compared with Nateglinide. ScienceDirect.com. August 2004. [Accessed on 17th January 2024] https://www.researchgate.net/publication/8361650_Efficacy_and_Safety_of_Once_Daily_Gliclazide_20_mgday_Compared_with_Nateglinide

3. Les Laboratoires Servier. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 17th January 2024] https://www.medicines.org.uk/emc/files/pil.1321.pdf

4. Accord. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 17th January 2024] https://www.medicines.org.uk/emc/product/5883/pil#gref

5. Accord. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 17th January 2024] https://www.medicines.org.uk/emc/files/pil.2044.pdf

6. Balkanpharma-Dupnitsa AD. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 17th January 2024] https://www.medicines.org.uk/emc/files/pil.4991.pdf

7. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 17th January 2024] https://www.medicines.org.uk/emc/files/pil.13829.pdf

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Random Blood Sugar (RBS)
• Post Prandial Blood Sugar (PPBS)
• Insulin-Fasting
• Insulin Postprandial (PP)
• Vital Diabetes Care
• Extended Diabetes Care
• Advance Diabetes Care
• Comprehensive Diabetes Care

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 18 Jan 2024 | 04:19 PM(IST)