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Introduction About GLIPTAGREAT DM 500 TABLET
GLIPTAGREAT DM 500 TABLET is a combination of Dapagliflozin, metformin, and vildagliptin, which belongs to a group of medicines called Antidiabetic agents. It is used as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus (T2DM). Along with management, follow a regular exercise and diet plan as advised by the doctor to achieve better results.
Dapagliflozin increases urinary glucose excretion and reduces blood glucose levels. Metformin works to control blood sugar by helping insulin, naturally produced by your body, decrease the amount of sugar your liver makes and also decrease the amount of sugar your intestines absorb. Vildagliptin is a potent and selective dipeptidylpeptidase-4 (DPP-4) inhibitor that improves glycemic control. Vildagliptin inhibition of DPP-4 results in increased fasting and postprandial endogenous levels of the incretin hormones GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic polypeptide).
GLIPTAGREAT DM 500 TABLET is not recommended if you have type 1 diabetes, diabetic ketoacidosis, acute or chronic metabolic acidosis, a history of lactic acidosis, or severe dehydration. Before taking it, inform your doctor if you are scheduled for surgery, x-ray or scanning procedures, or vitamin B12 or folic acid deficiency. GLIPTAGREAT DM 500 TABLET is not recommended for pregnant and breastfeeding women. The safety and effectiveness of GLIPTAGREAT DM 500 TABLET in children and adolescents have not been established.
When taking GLIPTAGREAT DM 500 TABLET, alcohol consumption is not recommended. The most common side effects of taking GLIPTAGREAT DM 500 TABLET are low sugar levels, painful urination, repetitive urination, inflammation of the penis (in men), and allergic reactions. Contact your doctor if any of the above side effects worsen or persist for a longer duration.
Uses Of GLIPTAGREAT DM 500 TABLET
- It is used as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus (T2DM).
How GLIPTAGREAT DM 500 TABLET Works
GLIPTAGREAT DM 500 TABLET is a combination of dapagliflozin, metformin, and vildagliptin, which helps to lower blood glucose levels. Dapagliflozin works by inhibiting the reabsorption of glucose in the kidneys, causing excess glucose to be excreted through urine. By lowering blood glucose levels, dapagliflozin helps to improve glycemic control in patients with type 2 diabetes. Metformin works to control blood sugar by helping insulin, naturally produced by your body, decrease the amount of sugar your liver makes and also decrease the amount of sugar your intestines absorb. Vildagliptin is a potent and selective dipeptidylpeptidase-4 (DPP-4) inhibitor that improves glycemic control. Vildagliptin inhibition of DPP-4 results in increased fasting and postprandial endogenous levels of the incretin hormones GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic polypeptide).
How to use GLIPTAGREAT DM 500 TABLET
Take GLIPTAGREAT DM 500 TABLET as advised by your physician. Swallow GLIPTAGREAT DM 500 TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition. Do not stop taking GLIPTAGREAT DM 500 TABLET without informing your doctor.
Side Effects Of GLIPTAGREAT DM 500 TABLET
Common
- Low sugar levels
- Painful urination
- Repetitive urination
- Inflammation of the penis (in men)
- Allergic reaction
Stop taking GLIPTAGREAT DM 500 TABLET and consult your doctor immediately if you experience:
- Fever and/or chills, burning sensation when passing water (urinating), pain in your back or side (urinary tract infection)
- Swelling of the face, tongue, or throat, difficulties swallowing, hives, and breathing problems (angioedema)
How To Manage Side Effects
Hypoglycemia
Eat or drink 15 to 20 grams of fast-acting carbohydrates. These are sugary foods or drinks without protein or fat that are easily converted to sugar in the body. Have a snack or meal.
Warning & Precautions
Pregnancy
ContraindicatedGLIPTAGREAT DM 500 TABLET is not recommended for use by pregnant women. Consult your doctor before taking the medicine.
Breastfeeding
ContraindicatedGLIPTAGREAT DM 500 TABLET is not recommended for breastfeeding women as it may pass through breast milk. Consult your doctor before taking GLIPTAGREAT DM 500 TABLET.
Driving and Using Machines
Use with CautionDo not drive or use any tools or machines if you feel dizzy after taking GLIPTAGREAT DM 500 TABLET.
Alcohol
ContraindicatedConsumption of alcohol is not recommended while taking GLIPTAGREAT DM 500 TABLET.
Kidney
Consult your doctorGLIPTAGREAT DM 500 TABLET is not recommended for patients with kidney disease or impairment. It should be used with caution in patients with a history of kidney disease. Consult your doctor before taking GLIPTAGREAT DM 500 TABLET.
Liver
Consult your doctorGLIPTAGREAT DM 500 TABLET is not recommended for patients with severe liver dysfunction. It should be used with caution in patients with liver disease. Consult your doctor before taking GLIPTAGREAT DM 500 TABLET.
Allergy
ContraindicatedDo not take GLIPTAGREAT DM 500 TABLET if you are allergic (hypersensitive) to Dapagliflozin, Metformin, Vildagliptin, or any other ingredients of this medicine.
Heart Disease
Consult your doctorGLIPTAGREAT DM 500 TABLET is not recommended for use if you have cardiovascular problems or cardiorespiratory insufficiency. It should be used with caution if you have had a heart attack or stroke. Consult your doctor before taking GLIPTAGREAT DM 500 TABLET.
Use In Pediatrics
Consult your doctorThe safety and effectiveness of GLIPTAGREAT DM 500 TABLET in children and adolescents have not been established. Consult your doctor before taking the medicine.
Use In Geriatrics
Use with CautionGLIPTAGREAT DM 500 TABLET should be used with caution in elderly patients over 65 years of age. Consult your doctor before taking the medicine.
Others
GLIPTAGREAT DM 500 TABLET is not recommended for use if you have:
- Type 1 diabetes
- Diabetic ketoacidosis
- Acute or chronic metabolic acidosis
- A history of lactic acidosis
- Severe dehydration
Before taking GLIPTAGREAT DM 500 TABLET, inform your doctor if you:
- Are scheduled for surgery, x-rays, or scanning procedures
- Have a vitamin B12 or folic acid deficiency
Interactions
A. Drug-Drug interactions:
Before taking GLIPTAGREAT DM 500 TABLET, inform your doctor if you are taking any of the following medicines:
- Other diabetic medications (Ex. glyburide, insulin, and rosiglitazone)
- Water pills (diuretics) (Ex. furosemide)
- Birth control pills (Ex. ethinyl estradiol)
- Sympathomimetics (Ex. xylometazoline)
- Thyroid medicines (Ex, levothyroxine)
- Corticosteroids (Ex. prednisone)
- Anti-epileptic (Ex. phenytoin)
- Anti-lipemic (Ex. nicotinic acid)
- Anti-tubercular (Ex. isoniazid)
- Cardiovascular agents (Ex. nifedipine, digoxin, procainamide, quinidine, amiloride, and triamterene)
- Antimalarial (Ex. quinine)
- Anti-ulcers (Ex. cimetidine, ranitidine)
- Opioid analgesics (Ex. morphine)
- Antibiotics (Ex. trimethoprim, vancomycin)
- Blood thinners (Ex. warfarin)
Overdosage:
If you or anyone else takes too much of GLIPTAGREAT DM 500 TABLET, contact your doctor immediately or go to the nearest hospital right away. Symptoms of an overdose are muscle pain, mild and transient paraesthesia, fever, edema, and hypoglycemia.
Synopsis
| Drug | : | Dapagliflozin, Metformin, and Vildagliptin |
| Pharmacological Category | : | Sodium-glucose cotransporter 2 (SGLT2), Biguanides, and Dipeptide peptidase-4 (DPP-4) inhibitors |
| Therapeutic Indication | : | Type 2 Diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
Storage
- Keep GLIPTAGREAT DM 500 TABLET out of reach of children
- Store at a temperature below 25°C
FAQs About GLIPTAGREAT DM 500 TABLET
Q: What is GLIPTAGREAT DM 500 TABLET used for?
A: It is used as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus (T2DM). Along with management, follow a regular exercise and diet plan as advised by the doctor to achieve better results.
Q: Can I stop taking GLIPTAGREAT DM 500 TABLET without consulting your doctor?
A: No. Do not stop taking GLIPTAGREAT DM 500 TABLET without consulting your doctor because it may lead to unwanted side effects.
Q: Can I consume alcohol while taking GLIPTAGREAT DM 500 TABLET?
A: Consumption of alcohol is not recommended while taking GLIPTAGREAT DM 500 TABLET. Consult your doctor for advice before taking the medicine.
Q: Will taking a higher dose of GLIPTAGREAT DM 500 TABLET be more effective?
A: No, taking a higher dose of GLIPTAGREAT DM 500 TABLET will not be effective. Always take the dose as advised by your physician.
Q: How should I take GLIPTAGREAT DM 500 TABLET?
A: Take GLIPTAGREAT DM 500 TABLET as advised by your physician. Swallow GLIPTAGREAT DM 500 TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition. Do not stop taking GLIPTAGREAT DM 500 TABLET without informing your doctor.
Q: What are the common side effects of GLIPTAGREAT DM 500 TABLET?
A: The most common side effects of taking GLIPTAGREAT DM 500 TABLET are low sugar levels, painful urination, repetitive urination, inflammation of the penis (in men), and allergic reactions. Contact your doctor if any of the above side effects worsen or persist for a longer duration.
Q: Can GLIPTAGREAT DM 500 TABLET be used in pregnant women?
A: GLIPTAGREAT DM 500 TABLET is not recommended for pregnant women. Consult your doctor before taking the medicine.
Q: Can GLIPTAGREAT DM 500 TABLET be used for children?
A: The safety and effectiveness of GLIPTAGREAT DM 500 TABLET in children and adolescents have not been established. Consult your doctor before taking the medicine.
Q: Who should not take GLIPTAGREAT DM 500 TABLET?
A: GLIPTAGREAT DM 500 TABLET is not recommended for use if you have Type 1 diabetes, diabetic ketoacidosis, acute or chronic metabolic acidosis, a history of lactic acidosis, severe dehydration, kidney disease or impairment, severe liver dysfunction, cardiovascular problems or cardiorespiratory insufficiency, or if you are allergic to dapagliflozin, metformin, or Vildagliptin. Consult your doctor before taking it.
Q: What precautions must be taken while using GLIPTAGREAT DM 500 TABLET?
A: Before taking GLIPTAGREAT DM 500 TABLET, inform your doctor if you have vitamin B12 or folic acid deficiency, kidney disease, liver disease, heart attack or stroke, or if you are scheduled for surgery, x-ray, or scanning procedures.
References
1. KD Tripathi MD. Hormones and related drugs. Essentials of Medical Pharmacology. Seventh Edition. New Delhi, May 2013. Page – 274.
2. Kumar Gautam, Ratikanta Tripathy, Dayanidhi Meher, and Jyoti Prakash Sahoo. Dapagliflozin Versus Vildagliptin as an Adjuvant to Metformin in Patients With Type 2 Diabetes Mellitus: A Randomized, Open-Label Study. April 27th, 2023. [Accessed on 12th July 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224707/
3. Novartis Pharma AG. [Revised in July 2020] [Accessed on 12th July 2024] https://www.novartis.com/sg-en/sites/novartis_sg/files/Galvus-Jul2020.SIN-App051120.pdf
4. Strides Pharma Canada Inc. [Revised in February 2021] [Accessed on 12th July 2024] https://pdf.hres.ca/dpd_pm/00060230.PDF
5. AstraZeneca AB. European Medical Agency (EMA). [Accessed on 12th July 2024] https://www.ema.europa.eu/en/documents/product-information/forxiga-epar-product-information_en.pdf
6. Dapagliflozin, Metformin, and Vildagliptin. Leeford Healthcare Ltd. [Accessed on 12th July 20244] https://www.leeford.in/product/3347/dapaford-10-vdm
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Post Prandial Blood Sugar (PPBS)
- Insulin-Fasting
- Netmeds Diabetic Checkup
- Advance Diabetes Monitoring (Senior Female)
- Jaanch Diabetic Profile Basic
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