Glinate MF 60/500mg Tablet 10'S

Introduction About GLINATE MF 60/500MG TABLET

GLINATE MF 60/500MG TABLET is a combination of Metformin and Nateglinide which belongs to the group of medicines called Antidiabetic agents. It is used in the management of type 2 diabetes in adult patients.

GLINATE MF 60/500MG TABLET is not recommended for use in patients with severe liver problems, type 1 diabetes, diabetic ketoacidosis. Consult your doctor before taking it.

GLINATE MF 60/500MG TABLET is not recommended for use in pregnant and breastfeeding women. Consult your doctor before taking it.

GLINATE MF 60/500MG TABLET is not recommended for use in children and adolescents (under 18 years of age). It should be used with caution in elderly patients. Consult your doctor before taking it.

The most common side effects of taking GLINATE MF 60/500MG TABLET are nausea, stomach upset, sweating, diarrhoea, dizziness, shaking, weakness, hunger, feeling heartbeat fast, tiredness. Contact your doctor if any of the symptoms worsen.

Uses Of GLINATE MF 60/500MG TABLET

• Used in the management of type 2 diabetes in adult patients

How GLINATE MF 60/500MG TABLET Works

GLINATE MF 60/500MG TABLET effectively controls blood glucose levels where Metformin is an antidiabetic medicine. It makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells to utilize more amount of the circulating blood glucose, thereby reducing blood sugar levels. Additionally, it also manages glucose production by the liver and reduces its absoprtion in the body. Nateglinide works by stimulating the pancreas to produce insulin more quickly, which helps to keep blood sugar levels under control after meals.

How to use GLINATE MF 60/500MG TABLET

Take GLINATE MF 60/500MG TABLET preferably with meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.

Side Effects Of GLINATE MF 60/500MG TABLET

How To Manage Side Effects

Diarrhea

Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-manage diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not drink alcohol, as it can aggravate your dizziness. Contact your doctor if your dizziness did not improve.

Indigestion

Eat smaller and frequent meals. Eat and drink slowly and exercise regularly. Contact your doctor if indigestion persists.

Nausea And Vomiting

Take GLINATE MF 60/500MG TABLET with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if your nausea worsens.

Skin rash Or Itching

Avoid hot bath because hot water can irritate your skin further. Do not scratch the affected area. Use sunscreen and wear protective clothing while going outside. Use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if your rashes worsen.

Stomach Pain

Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on your stomach. Contact your doctor if the stomach pain worsens.

Warning & Precautions

Pregnancy

Contraindicated

GLINATE MF 60/500MG TABLET is not recommended for use during pregnancy. Consult your doctor before taking it.

Breastfeeding

Contraindicated

GLINATE MF 60/500MG TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines after taking GLINATE MF 60/500MG TABLET as it reduces your ability to concentrate or react due to low blood sugar (hypoglycaemia).

Alcohol

Consult your doctor

Avoid excessive alcohol consumption while taking GLINATE MF 60/500MG TABLET, as it may lead to a decrease in blood sugar levels.

Kidney

Contraindicated

GLINATE MF 60/500MG TABLET is not recommended for use in patients with severe kidney problems (including kidney infections). Therefore, consult your doctor before taking it.

Liver

Consult your doctor

GLINATE MF 60/500MG TABLET is not recommended for use in patients with severe liver problems. GLINATE MF 60/500MG TABLET should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.

Allergy

Contraindicated

Do not take GLINATE MF 60/500MG TABLET if you are allergic to Metformin, Nateglinide, or any of the other ingredients of this medicine.

Lungs

Contraindicated

GLINATE MF 60/500MG TABLET is not recommended for use in patients with severe infection of lungs or respiratory tract. Therefore, consult your doctor before taking it.

Heart Disease

Contraindicated

GLINATE MF 60/500MG TABLET is not recommended for use in patients with heart problems (such as acute heart failure or a recent heart attack). Therefore, consult your doctor before taking it.

Use In Pediatrics

Contraindicated

GLINATE MF 60/500MG TABLET is not recommended for use in children and adults under 18 years of age. Consult your doctor before taking it.

Use In Geriatrics

Use with Caution

GLINATE MF 60/500MG TABLET should be used with caution in elderly patients (aged 65 years and above) due to increased risk of low blood sugar. Consult your doctor before taking it.

Interactions

A. Drug-Drug interactions:

Before taking GLINATE MF 60/500MG TABLET, inform your doctor if you are taking any of the following medicines, such as:

• Other medicines used to manage diabetes (Ex. teneligliptin, rosiglitazone, pioglitazone, glimepiride)
• Diuretics (used to reduce edema and to manage hypertension) Ex. furosemide, hydrochlorothiazide
• Medicines used to manage pain and inflammation (such as ibuprofen, celecoxib, aspirin, prednisone and cortisone)
• Medicines used to manage high blood pressure (such as atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, telmisartan)
• Medicines used to manage asthma (Ex. salbutamol or terbutaline)
• Corticosteroids (used to manage pain and inflammation) Ex. hydrocortisone, prednisolone
• Verapamil (a medicine used to manage heart problems)
• Rifampicin (a medicine used to manage tuberculosis)
• Cimetidine (a medicine used to manage stomach ulcer)
• Dolutegravir (a medicine used to manage HIV infection)
• Ranolazine (a medicine used to manage chest pain)
• Trimethoprim (a medicine used to manage bacterial infection)
• Vandetanib, crizotinib and olaparib (medicines used to manage cancer)
• Isavuconazole, fluconazole (a medicine used to manage fungal infection)
• Non-steroidal anti-inflammatory agents (medicines used to manage muscle and joint pain) Ex. aceclofenac, diclofenac
• Monoamine oxidase inhibitors (medicines used to manage depression) Ex. isocarboxazid, phenelzine
• Beta blockers or ACE inhibitors, diuretics (used to manage high blood pressure and certain heart conditions) Ex. propranolol, captopril, furosemide
• Medicines used to manage dyslipidemia (Ex. gemfibrozil)
• Medicines used to manage chronic gout (Ex. sulfinpyrazone)
• Medicines used to manage asthma (Ex. salbutamol)
• Anabolic hormones Ex. methandrostenolone (used to manage post-menopausal osteoporosis and pituitary-deficient dwarfism)
• St. John’s Wort, also known as Hypericum perforatum (an herbal medicine used to manage depression)
• Somatropin (used to manage growth hormone deficiency)
• Medicines used to manage acromegaly (Ex. lanreotide and octreotide)
• Medicines used to manage tuberculosis (Ex. rifampin)
• Medicines used to manage seizures (Ex. phenytoin)

Overdosage:

If you or anyone else accidentally take too much of GLINATE MF 60/500MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose include low blood sugar symptoms such as sweating, dizziness, shaking, weakness, hunger, feeling your heart beating fast, tiredness, nausea, vomiting, Stomach pain, Muscle Cramps, Feeling Generally unwell with severe tiredness and difficulty in breathing, eat or drink something containing sugar. If you feel as if you are about to have a severe hypoglycaemic attack (which may lead to loss of consciousness or fits), contact your doctor immediately.

Synopsis

More Information

• Keep GLINATE MF 60/500MG TABLET out of the sight and reach of children
• Store GLINATE MF 60/500MG TABLET below 30°C

FAQs About GLINATE MF 60/500MG TABLET

Q: How long should I take GLINATE MF 60/500MG TABLET?

A: You need to take GLINATE MF 60/500MG TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: What is the best time to take GLINATE MF 60/500MG TABLET?

A: GLINATE MF 60/500MG TABLET must be taken with meals to avoid gastrointestinal side effects.

Q: What to do if I forgot to take a dose of GLINATE MF 60/500MG TABLET?

A: If you forgot to take a dose of GLINATE MF 60/500MG TABLET, take it as soon as you remember. However, if it is time for the next dose of GLINATE MF 60/500MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of GLINATE MF 60/500MG TABLET to compensate the missed ones.

Q: Can I stop taking GLINATE MF 60/500MG TABLET without consulting your doctor?

A: No. You should not stop taking GLINATE MF 60/500MG TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using GLINATE MF 60/500MG TABLET, consult your doctor for advice.

Q: Will taking a higher dose of GLINATE MF 60/500MG TABLET be more effective?

A: No, taking a higher dose of GLINATE MF 60/500MG TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: What precautions do I need to follow while taking GLINATE MF 60/500MG TABLET?

A: Before taking GLINATE MF 60/500MG TABLET inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have any severe systemic infections or are severely dehydrated due to excessive vomiting or diarrhea recently. Along with the therapy, follow the diet and lifestyle changes advised by your doctor to achieve better results. Consult your doctor before taking GLINATE MF 60/500MG TABLET if you are pregnant or breastfeeding.

Q: Can I take medication for high blood pressure along with GLINATE MF 60/500MG TABLET?

A: It is not advisable to take medicines to control blood pressure while taking GLINATE MF 60/500MG TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with GLINATE MF 60/500MG TABLET as they have known interactions with GLINATE MF 60/500MG TABLET.

Q: What should I do if I experience low blood sugar after taking GLINATE MF 60/500MG TABLET?

A: GLINATE MF 60/500MG TABLET is unlikely to cause low blood sugar unless combined with other anti-diabetic medicine. However, if you experience any signs of low blood sugar levels (such as increased hunger, sweating, shakiness, weakness or an irregular heartbeat), consume a sugary snack or sugar drink immediately. Consult your doctor if the symptom did not improve.

Q: Can GLINATE MF 60/500MG TABLET be taken with insulin?

A: Co-administration of GLINATE MF 60/500MG TABLET with insulin is considered risky as they are increased chances of hypoglycemia (decreased blood sugar levels). Consult your doctor before taking it.

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275.

2. Alvin C. Powers and David D’Alessio. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. 2018. Page – 863.

3. Calette Corcoran; Tibb F. Jacobs. Metformin. StatPearls [Internet]. NIH. National Library of Medicine. National center for biotechnology information. PMC. PubMed Central. [Revised on May 2022]. [Accessed on 18th January 2024] https://www.ncbi.nlm.nih.gov/books/NBK518983/#article-25065.s3

4. Shuyan Gu, Jihao Shi, Zhiliu Tang, Monika Sawhney, Huimei Hu, Lizheng Shi, Vivian Fonseca, Hengjin Dong. Comparison of Glucose Lowering Effect of Metformin and Acarbose in Type 2 Diabetes Mellitus: A Meta-Analysis. PLOS ONE. May 2015. [Accessed on 18th January 2024] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126704

5. Nicholas Tentolouris, Christina Voulgari and Nicholas Katsilambros. A review of nateglinide in the management of patients with type 2 diabetes. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. December 2007. [Accessed on 18th January 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2350129/

6. Carola Saloranta, Kenneth Hershon, Michele Ball, Sheila Dickinson, David Holmes. Efficacy and Safety of Nateglinide in Type 2 Diabetic Patients with Modest Fasting Hyperglycemia. The Journal of Clinical Endocrinology & Metabolism. September 2002. [Accessed on 18th January 2024] https://academic.oup.com/jcem/article/87/9/4171/2846581

7. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 18th January 2024] https://www.medicines.org.uk/emc/files/pil.594.pdf

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9. Merck Santé S.A.S. U.S. Food & Drug Administration. [Revised in April 2017] [Accessed on 18th January 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf

10. Franco Indian Pharmaceuticals Pvt Ltd. GLYCIPHAGE® GLYCIPHAGE 850® GLYCIPHAGE 250®TABLETS. (ORAL ANTI-HYPERGLYCEMIC AGENT). [Accessed on 18th January 2024] http://diabetix-francoindian.com/glyciphage.html

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12. Nateglinide. DailyMed: National Library of Medicine: National Institute of Health. [Revised in November 2021] [Accessed on 18th January 2024] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f7b28951-76d2-cabd-64a1-b74aa225c6e9

Useful Diagnostic Tests

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Random Blood Sugar (RBS)
• Post Prandial Blood Sugar (PPBS)
• Insulin – Fasting
• Insulin Postprandial (PP)
• Vital Diabetes Care
• Extended Diabetes Care
• Advance Diabetes Care
• Comprehensive Diabetes Care

Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 18 Jan 2024 | 04:15 PM(IST)