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Introduction About GLIMISAVE MV
GLIMISAVE MV is a combination of Glimepiride, Metformin, and Voglibose, which belongs to the group of medicines called Antidiabetic agents. GLIMISAVE MV is used in adults to manage type 2 diabetes mellitus when diet, exercise, and single-agent or second-line therapy with two drugs are insufficient to adequately control blood sugar levels.
GLIMISAVE MV is not recommended for use in patients allergic to glimepiride, metformin, voglibose, and/or other sulfonylureas or sulphonamides. It is also not recommended for use in patients with acute conditions (such as dehydration or severe infection), severe ketosis (a severe complication of diabetes), severe trauma, lung problems (such as acute or chronic respiratory failure), heart problems (such as acute or chronic cardiac failure or recent myocardial infarction), and/or severe kidney or liver problems.
Before taking GLIMISAVE MV, inform your doctor if you recently had trauma and/or have febrile infections, fever, uncontrolled diabetes, hypothyroidism (underactive thyroid), chronic intestinal disease, fever, or other kidney or liver problems.
GLIMISAVE MV is not recommended for use in pregnant and breastfeeding women since it may cause harm to the developing foetus or nursing child.
GLIMISAVE MV is also not recommended for use in children and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged 75 years or older) after consulting the doctor.
The most common side effects of GLIMISAVE MV are nausea and vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, and/or hypoglycemia (low blood sugar). Consult your doctor if any of these side effects worsen.
Uses Of GLIMISAVE MV
- To manage type 2 diabetes mellitus in adults when diet, exercise, and a single agent or second line of therapy with two drugs are insufficient to adequately control blood sugar levels.
How GLIMISAVE MV Works
GLIMISAVE MV is used to manage type 2 diabetes mellitus, where glimepiride lowers blood glucose levels by increasing the amount of insulin released by the pancreas. Metformin works by decreasing glucose production in the liver and the amount of glucose absorbed by the stomach and intestine. It also helps to restore the body’s response to insulin, and voglibose works by inhibiting the alpha-glucosidase enzyme, which breaks down complex carbohydrates into simple sugars. Thus, voglibose slows down the digestion and absorption of carbohydrates in the small intestine. This leads to a reduction in blood glucose levels in individuals with type 2 diabetes mellitus.
How to use GLIMISAVE MV
Take GLIMISAVE MV as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
Side Effects Of GLIMISAVE MV
Common
- nausea, vomiting, diarrhea, abdominal pain, and loss of appetite
- metallic taste
- hypoglycaemia (low blood sugar)
Rare
- signs of hypersensitivity reactions (immune-mediated allergic reactions) such as rash, itching
- headache
- anaemia, thrombocytopenia (low platelet count), and leucopenia (low white blood cell count)
Stop taking GLIMISAVE MV and contact your doctor immediately if you experience any of the following side effects:
- severe hypoglycemia (very low blood sugar level)
- signs of lactic acidosis (lactic acid built up in the bloodstream) such as exhaustion or extreme fatigue, body weakness, diarrhea, and/or headache
- signs of an allergic, pseudo-allergic, or hypersensitivity reaction such as itching, rash, red itchy welts, shortness of breath, and/or low blood pressure
How To Manage Side Effects
Diarrhea
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to manage diarrhea. Consult and inform your doctor if the symptoms worsen.
Nausea And Vomiting
Take GLIMISAVE MV with or just after a meal. Stick to simple meals. Avoid eating oil-rich or spicy foods, sugary snacks, and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Inform your doctor if the condition worsens.
Warning & Precautions
Pregnancy
ContraindicatedGLIMISAVE MV is not recommended for use during pregnancy since it may cause harm to the foetus. Consult your doctor before taking GLIMISAVE MV.
Breastfeeding
ContraindicatedGLIMISAVE MV is not recommended for use in breastfeeding women since the medicine may pass through breast milk and may cause harm to the nursing child. Consult your doctor before taking GLIMISAVE MV.
Driving and Using Machines
ContraindicatedDo not drive or operate any machines if you experience impaired alertness or reactions (due to hypoglycemia) while taking GLIMISAVE MV.
Alcohol
ContraindicatedDo not consume alcohol while taking GLIMISAVE MV since it may reduce your blood sugar level.
Kidney
Consult your doctorGLIMISAVE MV is not recommended in patients with severe renal failure. It should be used with caution in patients with other kidney diseases. Consult your doctor before taking the medicine.
Liver
Consult your doctorGLIMISAVE MV is not recommended for use in patients with severe liver disease. It should be used with caution in patients with other liver diseases. Consult your doctor before taking the medicine.
Allergy
ContraindicatedDo not take GLIMISAVE MV if you are allergic to glimepiride, metformin, voglibose, other sulfonylureas/sulphonamides, and/or any other ingredients of this medicine.
Lungs
ContraindicatedGLIMISAVE MV is not recommended for use in patients with lung problems such as acute or chronic respiratory failure. Consult your doctor before taking GLIMISAVE MV.
Heart Disease
ContraindicatedGLIMISAVE MV) is not recommended in patients with heart problems such as acute or chronic cardiac failure or recent myocardial infarction. Consult your doctor before taking GLIMISAVE MV.
Use In Pediatrics
ContraindicatedGLIMISAVE MV is not recommended for use in children and adolescents (aged below 18 years) since the safety and effectiveness of the medicine are not established. Consult your doctor before taking GLIMISAVE MV.
Use In Geriatrics
Use with CautionGLIMISAVE MV should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking GLIMISAVE MV.
Others
GLIMISAVE MV is not recommended for use if you:
- suffer from any acute type of metabolic acidosis (the buildup of excess acid in the body), such as lactic acidosis, diabetic ketoacidosis, and/or diabetic precoma
- suffer from acute conditions such as dehydration, severe infection, and shock
- have severe ketosis (a severe complication of diabetes)
- are in a state of diabetic coma
- had severe infections before or after the operation
- had severe trauma
- have gastrointestinal obstruction
Before taking GLIMISAVE MV, inform your doctor if you:
- recently had trauma
- had or scheduled for any surgery
- suffer from febrile infections, fever, and/or uncontrolled diabetes
- are undernourished and/or have irregular mealtimes or skipped meals
- suffer from an imbalance between physical exertion and carbohydrate intake
- have hypothyroidism (underactive thyroid)
- have a history of laparotomy (a surgical incision done into the abdominal cavity for diagnosing a condition) and/or ileus (interrupted movement of the intestines)
- suffer from chronic intestinal disease (accompanied by disturbances in digestion and absorption)
- suffer from fever
Interactions
A. Drug- Drug interactions:
Before taking GLIMISAVE MV, inform your doctor if you are taking any of the following medicines:
- medicine used to manage bacterial infections (Ex. rifampicin, ciprofloxacin, clarithromycin, sulfacetamide, minocycline, and chloramphenicol)
- medicine used to manage fungal infections (Ex. fluconazole, isavuconazole, and miconazole)
- oral antidiabetics and insulin (medicines used to manage high blood sugar) Ex. glipizide, glyburide diazoxide
- medicines used to manage cancer (Ex. cyclophosphamide, trofosfamide, vandetanib, crizotinib, olaparib)
- disopyramide (medicine used to manage an irregular heartbeat)
- fenyramidol (a medicine used to relax muscles)
- pentoxifylline (a medicine used to improve blood flow through the arteries)
- medicine used to manage joint pain (Ex. phenylbutazone, oxyphenbutazone, and probenecid sulfinpyrazone)
- azapropazone (a medicine used to manage fertility)
- tritoqualine (a medicine used to manage allergies)
- acetazolamide (a medicine used to manage glaucoma)
- corticosteroids (medicines used to manage inflammation) Ex. prednisolone, methylprednisolone
- diuretics (medicine used to manage water retention in the body) Ex. furosemide
- adrenaline (a medicine used to manage serious diseases such as shock)
- glucagon (a medicine used to manage severe low blood sugar)
- laxatives (medicines used to manage constipation): Ex. bisacodyl
- nicotinic acid (medicine used to manage niacin deficiency)
- anabolic steroids (synthetic male sex hormones) Ex. testosterone
- phenothiazines (medicine used to manage mental illness) Ex. chlorpromazine
- phenytoin and fenfluramine (medicines used to manage seizures)
- H2 receptor antagonists (medicine used to manage acidity and heartburn) Ex. cimetidine ranitidine
- trimethoprim (used to manage urinary tract infections)
- ranolazine (medicine used to manage chest pain)
- dolutegravir (a medicine used to manage HIV infection)
- cimetidine (used to manage ulcers)
- verapamil (used to manage irregular heartbeats)
- epinephrine (used in emergencies to manage life-threatening allergic reactions)
- fibrate derivatives (used to lower high triglyceride levels) Ex. clofibrate, fenofibrate
- medicine used to manage depression, such as monoamine oxidase inhibitors (Ex. phenelzine, selegiline)
- salicylates (medicine used to manage pain) Ex. aspirin
- medicine used to manage high blood pressure, such as alpha blockers (Ex. doxazosin, prazosin
- anticoagulants (medicines used to manage the clotting of blood), Ex. warfarin
Overdosage:
If you or anyone else accidentally takes too much of GLIMISAVE MV, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose are hypoglycemia (low blood sugar), lactic acidosis, pancreatitis (inflammation of the pancreas), abdominal discomfort, and/or diarrhea.
Synopsis
| Drug | : | Glimepiride, Metformin, Voglibose |
| Pharmacological Category | : | Antidiabetic Agents |
| Therapeutic Indication | : | Type 2 diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
- Keep GLIMISAVE MV out of reach of children
- Do not store GLIMISAVE MV above 25°C
FAQs About GLIMISAVE MV
Q: What is GLIMISAVE MV used for?
A: GLIMISAVE MV is used in adults to manage type 2 diabetes mellitus when diet, exercise, and single-agent or second-line therapy with two drugs are insufficient to adequately control blood sugar levels.
Q: How does GLIMISAVE MV work?
A: GLIMISAVE MV is used to manage type 2 diabetes mellitus, where glimepiride lowers blood glucose levels by increasing the amount of insulin released by the pancreas. Metformin works by decreasing glucose production in the liver and the amount of glucose absorbed by the stomach and intestine. It also helps to restore the body’s response to insulin, and voglibose works by inhibiting the alpha-glucosidase enzyme, which breaks down complex carbohydrates into simple sugars. Thus, voglibose slows down the digestion and absorption of carbohydrates in the small intestine. This leads to a reduction in blood glucose levels in individuals with type 2 diabetes mellitus.
Q: What are the side-effects of GLIMISAVE MV?
A: The most common side-effects of GLIMISAVE MV are nausea and vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, and/or hypoglycemia (low blood sugar). Consult your doctor if any of these side effects worsen.
Q: How do I take GLIMISAVE MV?
A: Take GLIMISAVE MV as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
Q: What happens if GLIMISAVE MV is taken at more than its required dosage?
A: If you or anyone else accidentally takes too much of GLIMISAVE MV, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose are hypoglycemia (low blood sugar), lactic acidosis, pancreatitis (inflammation of the pancreas), abdominal discomfort, and/or diarrhea.
References
1. KD Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of Medical Pharmacology. Seventh Edition. 2019. Page – 270, 275, 277.
2. Kalra S, Das AK, Priya G, Ghosh S, Mehrotra RN, Das S, Shah P, Bajaj S, Deshmukh V, Sanyal D, Chandrasekaran S, Khandelwal D, Joshi A, Nair T, Eliana F, Permana H, Fariduddin MD, Shrestha PK, Shrestha D, Kahandawa S, Sumanathilaka M, Shaheed A, Rahim AA, Orabi A, Al-Ani A, Hussein W, Kumar D, Shaikh K. Fixed-dose combination in management of type 2 diabetes mellitus. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. [Revised in November 2020] [Accessed on 26th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842427/
3. Windlas Biotech Private Limited. Amaryl MV 1mg, Amaryl MV 2mg. [Revised in March 2021] [ [Accessed on 26th November 2022]. https://www.sanofi.in/dam/jcr:99ce79b7-f940-4c0e-ae78-225fbf7b45b3/Amaryl%20MV%20PI.pdf
4. Primus Remedies Pvt. Ltd. Voglow GM1 Fort. [Accessed on 26th November 2022]. https://primusremedies.com/Products_list_26-10-2022.pdf
5. Eris Lifesciences. Glimisave MV 1.3 F, Glimisave MV 2 forte, Glimisave MV 3.3, Glimisave MV 3.3 F. [Accessed on 26th November 2022]. https://eris.co.in/all-brands/
6. Leeford Healthcare Ltd. VOGLIMET-GM FORTE. [Accessed on 26th November 2022]. https://www.leeford.in/product/843/voglimet-gm-forte
7. Ikon Remedies Pvt. Ltd. Voglicon-GM Tablets. [Accessed on 26th November 2022]. https://www.ikonremedies.com/product/voglicon-gm-tablets/
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Random Blood Sugar (RBS)
- Post Prandial Blood Sugar (PPBS)
- Insulin – Fasting
- Insulin Postprandial (PP)
- Vital Diabetes Care
- Extended Diabetes Care
- Advance Diabetes Care
- Comprehensive Diabetes Care
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