Name: Glimestar M1 Tablet 10'S
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Introduction About GLIMESTAR M1 TABLET

Glimestar M1 Tablet is a combination of Glimepiride and Metformin, commonly prescribed to manage blood sugar levels in patients with type 2 diabetes. This tablet helps to regulate blood glucose levels, improving overall health and well-being for diabetic patients.

Glimestar M1 tablet should be taken with food. To get the maximum benefit, take it consistently at the same time each day. Your doctor will determine the appropriate dosage for you, which may be adjusted periodically based on your blood sugar levels and how well the medication is working.

Continue taking this medication as prescribed, even if you feel fine or your blood sugar levels are under control. Discontinuing it without your doctor's approval could lead to an increase in blood sugar, putting you at risk for kidney damage, vision loss, nerve issues, and possible limb loss. Keep in mind that this medication is just one part of a comprehensive management plan, which should also include a balanced diet, regular physical activity, and weight management as recommended by your doctor. A healthy lifestyle is crucial in managing diabetes.

Common side effect of this medication includes nausea, dizziness, taste changes, diarrhea, stomach pain, headache, and upper respiratory tract infection. Some people may find that they put on weight with this medicine. The most frequent side effect of this medicine is low blood glucose (hypoglycemia). It is important to be aware of the symptoms of low blood sugar, such as sweating, dizziness, headaches, and shaking, and know how to manage them. To help reduce this, ensure you have regular meals and always carry a quick source of glucose, like sugary foods or fruit juice. Additionally, drinking alcohol can increase the risk of hypoglycemia and should be avoided.

This medication should not be taken if you have type 1 diabetes mellitus, diabetic ketoacidosis (high blood acid levels), or severe kidney or liver disease. Before starting the medication, inform your doctor if you have a history of heart disease, as it may not be appropriate for you. Pregnant or breastfeeding women should consult their doctor before using it. Regular blood sugar monitoring is recommended, and your doctor may also suggest tests to check your blood cell counts and liver function.

Uses Of GLIMESTAR M1 TABLET

Type 2 diabetes mellitus

Benefits of GLIMESTAR M1 TABLET

Helps to lower blood sugar levels in type 2 diabetes: The combination of Glimepiride and Metformin in Glimestar M1 is designed to help control blood sugar levels in patients with type 2 diabetes. Glimepiride works by increasing insulin production from the pancreas, while Metformin improves insulin sensitivity and reduces glucose production by the liver.
Combines the benefits of Glimepiride and Metformin for better control: Glimepiride and Metformin are two commonly prescribed medications for managing type 2 diabetes. The synergistic effects of these two drugs in Glimestar M1 provide enhanced blood sugar control, reducing the need for multiple medications, which makes treatment more convenient for patients.
Supports overall metabolic health: Besides controlling blood sugar, Metformin can also help with weight management and may have heart-protective benefits, reducing the risk of complications like heart disease, which is common in individuals with diabetes. The combination also works to improve insulin sensitivity, supporting better overall metabolic function.
Reduces the risk of complications associated with diabetes: By helping to maintain normal blood glucose levels, Glimestar M1 can potentially lower the risk of serious complications that arise from poorly controlled diabetes, such as nerve damage, kidney disease, and retinopathy.

How GLIMESTAR M1 TABLET Works

The Glimestar M1 Tablet is a combination medication that contains two active ingredients: Glimepiride and Metformin. Glimepiride is an oral sulfonylurea that works by stimulating the pancreas to release more insulin, helping to lower blood sugar levels. Metformin, on the other hand, improves insulin sensitivity, reduces glucose production in the liver, and enhances the uptake of glucose by muscle cells. Together, these medications help manage type 2 diabetes by improving blood sugar control through different mechanisms, ensuring better regulation of glucose levels throughout the day.

How to use GLIMESTAR M1 TABLET

Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.

How to Take Glimestar M1 tablet?

Take one tablet daily with meal to reduce the chance of stomach upset.
Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
For best results, take the tablet at the same time each day.

What if I forgot to take GLIMESTAR M1 TABLET

If you forget to take your dose, take it as soon as you remember.
Do not take two doses to make up for a missed dose. This could increase your risk of side effects.
If it is almost time for your next dose, skip the missed dose and take your regular dose at the usual time.

Side Effects Of GLIMESTAR M1 TABLET

Like all medicines, Glimestar M1 tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Glimestar M1 tablet are:

Nausea
Dizziness
Taste changes
Diarrhea
Stomach pain
Headache
Upper respiratory tract infection

When to consult your doctor?

Severe Hypoglycemia (Low Blood Sugar) symptoms such as shaking, sweating, confusion, dizziness, hunger, rapid heartbeat, or blurred vision
Lactic Acidosis symptoms such as muscle pain or weakness, difficulty breathing, feeling cold, dizziness, or feeling very tired.
Severe Allergic Reactions symptoms such as rash, itching, swelling (especially of the face, tongue, or throat), difficulty breathing, or tightness in the chest
Severe abdominal pain symptoms such as intense stomach pain, nausea, vomiting
Jaundice symptoms such as yellowing of your skin or the whites of your eyes
Kidney problems or liver problems symptoms such as dark urine or unusual tiredness

How To Manage Side Effects

Diarrhea

Drink Fluids: Drink clear fluids such as water, broths, and oral rehydration solutions (ORS).
Electrolytes: If you are losing a lot of fluids (for example, from frequent diarrhea), consider drinking an electrolyte solution to help replenish lost minerals like potassium and sodium.
BRAT Diet: Try to take Bananas, Rice (white rice), Apple sauce and Toast (plain, without butter) to control diarrhoea management.
Avoid Certain Foods: While recovering avoid the following food items such as fatty, greasy, or fried foods, spicy foods, dairy products (especially if you have a temporary lactose intolerance), caffeinated drinks and alcohol and artificial sweeteners like sorbitol.
Over-the-Counter Medications: You can take over-the-counter anti-diarrheal medications such as loperamide, Bismuth subsalicylate if appropriate for you. Follow the recommended dosage.

Dizziness Or Drowsiness

Sit or Lie Down: If you feel dizzy, sit down or lie down immediately to prevent falling. Keep your head still and close your eyes if needed.
Hydrate: Dehydration can cause dizziness, so drink water or electrolyte-replenishing drinks like sports drinks.
Avoid Sudden Movements: When standing or sitting, do so slowly to avoid triggering dizziness. Take your time when getting up.
Eat Small, Regular Meals: Low blood sugar can cause dizziness, so eat small meals throughout the day and avoid skipping meals.
Fresh Air: Sometimes dizziness can be alleviated by taking slow, deep breaths in a well-ventilated area.

Headache

Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

Nausea And Vomiting

Eat Small, Frequent Meals: Avoid heavy or greasy foods. Opt for bland foods like crackers, toast, or bananas.
Stay Hydrated: Sip on clear fluids like water, ginger tea, or electrolyte drinks, Avoid caffeinated and carbonated beverages.
Ginger: Ginger is a natural remedy for nausea. Try ginger tea, ginger candies, or ginger ale (ensure it contains real ginger).
Avoid Strong Odors: Minimize exposure to smells that might trigger nausea, such as perfumes or cooking odors.

Glimestar M1 tablet is not recommended for use in elderly patients (aged 75 years or above) and should be used with caution in elderly patients (aged 65 years or above), especially in patients with impaired kidney function. Your doctor may assess your kidney function more frequently during management with Glimestar M1 tablet.

Other Warnings for GLIMESTAR M1 TABLET

Before taking Glimestar M1 tablet inform your doctor if you:

are recovering from injury, operation, infections with fever, or from other forms of stress
have glucose-6-phosphate dehydrogenase (G6PD) deficiency
have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders)

Who should not take [GBNKEYWORD

Glimestar M1 tablet is not recommended for use, if you have:

type 1 diabetes mellitus
diabetic ketoacidosis
uncontrolled diabetes or ketoacidosis
dehydration
severe infection

Safety Advice

Follow your doctor's instructions regarding the exact dosage.
Do not exceed the recommended daily dosage.
Take one tablet daily with meal to reduce the chance of stomach upset.
Swallow the tablet whole with a glass of water. Do not crush or chew the medication.
For best results, take the tablet at the same time each day.
It is important to stay well-hydrated, particularly when managing blood sugar levels, as dehydration can impact the effectiveness of your medication.
Limit or avoid alcohol consumption, as it can affect blood sugar regulation and may raise the chance of side effects.
Be mindful of any side effects, such as nausea, dizziness, or low blood sugar (hypoglycemia). If you notice any unusual symptoms, reach out to your doctor right away.
If you have a history of kidney or liver problems, make sure to inform your doctor before starting Glimestar M1. Your doctor may need to modify the dosage or monitor your condition more closely.
If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking Glimestar M1, as it may not be appropriate during pregnancy or lactation.
Make sure to inform your doctor about all other medications you are currently taking, including over-the-counter drugs and supplements. Some medications might interact with Glimestar M1 and impact its effectiveness.
Do not suddenly stop taking the medication without consulting your doctor, as this can lead to uncontrolled blood sugar levels.
Make sure to keep regular follow-up appointments with your doctor to track your progress and adjust your medication as needed.

Diet and Lifestyle Advice

What dietary recommendations and lifestyle changes can complement the use of Glimestar M1 Tablet for effective diabetes management?

Dietary Tip	Explanation	Foods to Include	Foods to Avoid/Limit
Monitor Carbohydrate Intake	Controlling carbs helps maintain stable blood sugar levels. Focus on complex carbs that digest slowly.	Whole grains (brown rice, oats), legumes (lentils, chickpeas), vegetables (broccoli, spinach).	Refined carbs (white bread, pastries, sugary drinks).
Choose High-Fiber Foods	Fiber helps control blood sugar levels by slowing digestion and improving insulin sensitivity.	Vegetables (leafy greens, carrots), fruits (apples, berries), whole grains, legumes.	Low-fiber processed foods (chips, white rice, white bread).
Focus on Lean Proteins	Lean protein helps control hunger and supports muscle health without spiking blood sugar.	Skinless poultry, fish, tofu, legumes, eggs, low-fat dairy.	Fatty meats (bacon, sausages, full-fat cheeses).
Healthy Fats in Moderation	Healthy fats can help improve insulin sensitivity and lower inflammation.	Avocados, nuts, seeds, olive oil, fatty fish (salmon, mackerel).	Trans fats (margarine, processed snacks), excessive saturated fats (fried foods).
Regular, Balanced Meals	Eating smaller, balanced meals throughout the day helps avoid spikes in blood sugar.	Three balanced meals plus healthy snacks (nuts, yogurt) every 3–4 hours.	Skipping meals, overeating, or large meals that cause sugar spikes.
Include Low-Glycemic Index (GI) Foods	Low-GI foods are digested more slowly, helping control blood sugar levels.	Whole grains (quinoa, barley), non-starchy vegetables, legumes, fruits like apples and pears.	High-GI foods (white bread, sugary cereals, potatoes).
Limit Sugary Beverages	Sugary drinks cause rapid blood sugar spikes and provide little nutritional value.	Water, herbal teas, unsweetened almond milk, sparkling water with a splash of lemon.	Soda, fruit juices with added sugar, sweetened teas.
Stay Hydrated	Proper hydration supports kidney function and overall health, which is important in diabetes management.	Water, unsweetened herbal tea, flavored water with cucumber or mint.	Sugary drinks, excessive caffeine.
Limit Alcohol Consumption	Alcohol can interfere with blood sugar levels, especially when combined with diabetes medication.	Drink in moderation (if at all), and always with food to avoid hypoglycemia.	Heavy drinking or binge drinking.
Meal Timing and Consistency	Consistent meal timing helps regulate blood sugar levels and works well with medications like Glimestar M1, which may lower blood sugar.	Regular meals and snacks at the same time every day.	Irregular eating patterns or long periods of fasting.
Monitor Portion Sizes	Overeating can lead to blood sugar fluctuations. Portion control is key for stable blood sugar levels.	Use smaller plates, measure food portions, and avoid second servings.	Large portions, especially of high-calorie or high-carb foods.

Exercise Tips

Exercise Type	Benefits for Diabetes Management	Recommended Duration/Frequency	Example Activities
Aerobic Exercise	Improves blood sugar control, enhances insulin sensitivity	30 minutes, 5 days a week	Walking, Cycling, Swimming, Jogging
Strength Training	Builds muscle mass, increases resting metabolic rate, controls blood sugar	2-3 times per week, focusing on major muscle groups	Weightlifting, Resistance Bands, Bodyweight Exercises (squats, lunges)
High-Intensity Interval Training (HIIT)	Increases calorie burn, improves insulin sensitivity, reduces body fat	20-30 minutes, 3 times a week	Short bursts of sprinting followed by rest, Jump rope intervals
Flexibility and Balance Exercises	Improves mobility, reduces risk of injury, helps manage blood sugar fluctuations	2-3 times a week	Yoga, Pilates, Tai Chi, Stretching routines
Low-Impact Activities	Gentle on the joints, helps with blood sugar regulation without stress	30-60 minutes, 3-5 times a week	Walking, Water Aerobics, Cycling on a stationary bike
Group Exercise or Social Sports	Encourages consistency, increases motivation, improves cardiovascular health	2-3 times a week	Dance classes, Group cycling, Tennis, Soccer

Why Choose Glimestar M1 Tablet?

1. Effective Combination Therapy

Glimepiride is a sulfonylurea that helps stimulate the pancreas to release more insulin, which helps lower blood sugar levels.
Metformin works by reducing the amount of sugar released by the liver and improving the body’s response to insulin.
Combining these two medications allows for better overall blood sugar control by addressing the problem from two different angles.

2. Convenient Dosage Form

The tablet combines both Glimepiride and Metformin into one pill, making it easier for patients to adhere to their medication regimen. This reduces the need for taking multiple pills throughout the day.

3. Helps with Insulin Sensitivity

Metformin is known for improving insulin sensitivity, which is essential for type 2 diabetics whose bodies do not use insulin efficiently. This helps to lower overall blood glucose levels and reduces insulin resistance.

4. Reduces the Risk of Complications

Proper management of blood glucose levels helps in reducing the risk of long-term complications such as nerve damage, kidney problems, and cardiovascular issues that are common in uncontrolled diabetes.

5. Weight Neutral or Weight Loss Effect

Unlike some diabetes medications that may cause weight gain, Metformin has been associated with either weight neutrality or modest weight loss, which is beneficial for individuals with type 2 diabetes who are often overweight.

6. Well-Established Medication

Both Glimepiride and Metformin have been used for many years and have a long track record of safety and efficacy when used appropriately.

7. Improved Glycemic Control

The combination of Glimepiride and Metformin can provide enhanced glycemic control compared to either medication alone, especially for patients who need both insulin secretion and insulin sensitivity improvement.

8. Convenience for Patients

For patients already using both medications separately, the combination tablet offers the convenience of fewer doses, making it easier to manage their diabetes and improve adherence to management.

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking Glimestar M1 tablet:

1. Insulin

Interaction: Combining insulin with Glimestar M1 can increase the risk of hypoglycemia.
Effect: The combination of insulin and Glimestar M1 can lead to more potent blood sugar-lowering effects, potentially causing hypoglycemia, particularly if insulin doses are not adjusted.
Management: Close monitoring of blood glucose levels is necessary when combining insulin with Glimestar M1. Dose adjustments for either insulin or Glimestar M1 may be required to prevent hypoglycemia.

2. Beta-Blockers (e.g., Propranolol, Atenolol)

Interaction: Beta-blockers may mask the symptoms of hypoglycemia, making it difficult for patients to recognize low blood sugar.
Effect: Beta-blockers can reduce the symptoms of hypoglycemia (such as shaking, tachycardia, and anxiety) while not altering the actual blood glucose levels. This can delay the detection and treatment of hypoglycemia.
Management: Patients should be educated on the risk of undetected hypoglycemia and advised to monitor blood sugar levels more frequently, especially when starting or adjusting beta-blocker therapy.

3. ACE Inhibitors (e.g., Enalapril, Lisinopril)

Interaction: ACE inhibitors can increase the blood-sugar-lowering effect of Glimestar M1.
Effect: ACE inhibitors may lower blood pressure and improve kidney function, which can enhance the blood sugar-lowering effect of Metformin and Glimepiride, potentially leading to hypoglycemia.
Management: Regular monitoring of blood glucose is recommended when starting or adjusting ACE inhibitor therapy. Dosage adjustments for Glimestar M1 may be needed if significant hypoglycemia occurs.

4. Diuretics (e.g., Furosemide, Hydrochlorothiazide)

Interaction: Diuretics, especially thiazide diuretics, may increase blood sugar levels, which can counteract the effectiveness of Glimestar M1 in controlling blood sugar.
Effect: Diuretics can increase blood sugar by reducing insulin sensitivity and causing fluid and electrolyte imbalances, potentially leading to hyperglycemia.
Management: Blood glucose should be monitored closely when using diuretics. If hyperglycemia occurs, the dose of Glimestar M1 may need to be adjusted.

5. Sulfonamides (e.g., Trimethoprim-Sulfamethoxazole)

Interaction: Sulfonamides can potentiate the hypoglycemic effect of Glimestar M1.
Effect: Sulfonamides may enhance the blood sugar-lowering effects of Glimepiride, increasing the risk of hypoglycemia.
Management: Patients should be monitored for signs of hypoglycemia, especially when starting sulfonamide therapy. Dosage adjustments may be required for Glimestar M1 if hypoglycemia is observed.

6. Corticosteroids (e.g., Prednisone)

Interaction: Corticosteroids can increase blood sugar levels and counteract the blood sugar-lowering effect of Glimestar M1.
Effect: Corticosteroids, such as Prednisone, can raise blood glucose levels and may lead to hyperglycemia (high blood sugar), diminishing the effectiveness of Metformin and Glimepiride in controlling blood sugar.
Management: Patients on corticosteroids should monitor their blood sugar levels closely. Doses of Glimestar M1 may need to be adjusted temporarily during corticosteroid therapy. Consult with the healthcare provider to adjust the dose of the diabetes medications.

Synopsis

Drug	:	Glimepiride, Metformin
Pharmacological Category	:	Sulfonylureas, Biguanides
Therapeutic Indication	:	Type II diabetes mellitus
Dosage Forms	:	Tablet

More Information

Storage

Store Glimestar M1 tablet at room temperature, typically between 20-25°C
Keep this medication away from direct sunlight, heat sources, and humidity to maintain its effectiveness
Store the medications in a safe location, out of reach of children and pets
Never freeze Glimestar M1 tablet, as freezing can damage the medication

FAQs About GLIMESTAR M1 TABLET

Q: What is Glimestar M1 Tablet used for?

A: Glimestar M1 Tablet is commonly prescribed for the management of type 2 diabetes mellitus. It helps in controlling blood sugar levels by combining two medications: Glimepiride (which stimulates insulin production) and Metformin (which helps improve insulin sensitivity).

Q: How should I take Glimestar M1 Tablet?

A: The typical dosage of Glimestar M1 Tablet is one tablet per day, usually taken with meals to reduce the risk of gastrointestinal side effects. Your healthcare provider will determine the exact dosage based on your individual needs.

Q: What are the possible side effects of Glimestar M1 Tablet?

A: Common side effects of Glimestar M1 Tablet may include nausea, diarrhea, stomach upset, or headache. Serious side effects like hypoglycemia (low blood sugar) and lactic acidosis (a rare but serious condition) may also occur. Always consult your doctor if you experience unusual symptoms.

Q: Can Glimestar M1 Tablet be taken during pregnancy?

A: Glimestar M1 Tablet should generally be avoided during pregnancy, especially during the first trimester, unless explicitly prescribed by a doctor. Always inform your doctor if you are pregnant or planning to become pregnant before starting this medication.

Q: What should I do if I miss a dose of Glimestar M1 Tablet?

A: If you miss a dose of Glimestar M1 Tablet, take it as soon as you remember unless it’s almost time for your next dose. Do not take two doses at once to make up for a missed dose.

Q: Can Glimestar M1 Tablet interact with other medications?

A: Yes, Glimestar M1 Tablet can interact with other medications, including blood pressure medications, diuretics, and other diabetes treatments. It is important to inform your doctor about all the medications and supplements you are taking.

Q: Are there any dietary restrictions while taking Glimestar M1 Tablet?

A: While taking Glimestar M1 Tablet, it is important to follow a balanced diet that is suitable for managing diabetes. Limit the intake of sugary foods and follow your doctor dietary recommendations to help maintain stable blood sugar levels.

Q: How does Glimestar M1 Tablet help manage Type 2 diabetes?

A: Glimestar M1 Tablet combines the effects of Glimepiride and Metformin. Glimepiride helps increase insulin production from the pancreas, while Metformin improves the body’s response to insulin, leading to better control over blood glucose levels.

Q: Can Glimestar M1 Tablet cause weight gain?

A: Metformin is generally weight-neutral, and Glimepiride may cause mild weight gain due to its insulin-stimulating effects. However, the overall effect of Glimestar M1 Tablet on weight varies from person to person.

Q: What should I do if I experience symptoms of low blood sugar while taking Glimestar M1 Tablet?

A: If you experience symptoms of hypoglycemia, such as dizziness, sweating, shaking, or confusion, you should immediately consume a fast-acting source of glucose like fruit juice, candy, or glucose tablets. Contact your doctor if you have frequent episodes of low blood sugar.

Q: How should I store Glimestar M1 Tablet?

A: Store the tablet in a cool, dry place, away from direct sunlight, and out of reach of children.

Q: Can Glimestar M1 Tablet be used to treat type 1 diabetes?

A: No, Glimestar M1 Tablet is typically used to manage type 2 diabetes, not type 1 diabetes.

Q: Can I stop taking the tablet if my blood sugar is normal?

A: Do not stop taking the tablet without consulting your doctor, even if your blood sugar is normal.

Q: Is Glimestar M1 Tablet suitable for people with kidney disease?

A: Glimestar M1 may not be suitable for people with kidney disease. Consult your doctor before using it if you have kidney issues.

Q: Where can I buy Glimestar M1 Tablet online?

A: You can buy Glimestar M1 Tablet online at Netmeds. Just visit their website and search for the product, and you will find options to purchase it directly from there.

References

1. KD Tripathi MD. Hormones and related drugs. Essentials of medical pharmacology. Seventh edition. New Delhi, May 2013. Page – 274.

2. Rakesh Kumar Sahay, Vinod Mittal, G Raja Gopal, Sunil Kota, Ghanshyam Goyal, Mahesh Abhyankar, Santosh Revenkar. Glimepiride and Metformin Combinations in Diabetes Comorbidities and Complications: Real-World Evidence. September 2020. [Accessed on March 24th, 2025]

3. Sanofi. Efficacy and Safety Comparison of Metformin/Glimepiride Combination Versus Each Compound Alone in New Diagnosed Type 2 Diabetes Patients (RECOMMEND). NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in January 2015] [Accessed on March 24th, 2025]

4. Torrent pharmaceuticals Ltd. Azulix MF. Metformin Hydrochloride Prolonged Release and Glimepiride Tablets I.P. [Revised in July 2019] [Accessed on March 24th, 2025]

5. Sanofi-aventis group. Amaryl M. Glimepiride + Metformin. [Revised in May 2015] [Accessed on March 24th, 2025]

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Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 25 Mar 2025 | 09:45 AM(IST)

Lab updated