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Introduction About GEMGET 1000 INJECTION
GEMGET 1000 INJECTION contains Gemcitabine which belongs to the group of medicines called Antimetabolites. GEMGET 1000 INJECTION is used in the management of non-small cell lung cancer (alone or combined with cisplatin), pancreatic cancer, breast cancer (with paclitaxel), ovarian cancer (with carboplatin) and bladder cancer (with cisplatin).
Cancer is a disease in which there is uncontrollable growth of some of the body’s cells that spread to other parts of the body. During GEMGET 1000 INJECTION management, your doctor might ask you to take certain blood tests to check your blood cell count, kidney function or liver function.
Avoid drinking alcohol during GEMGET 1000 INJECTION management as it can make you feel sleepy. Before receiving GEMGET 1000 INJECTION, inform your doctor if you had or are going to have radiotherapy, have been vaccinated recently or if you have any liver, kidney or heart diseases.
GEMGET 1000 INJECTION is not recommended for use in pregnant women, breastfeeding women, children and adolescents (under 18 years of age). Consult your doctor before receiving it.
The most common side effects of receiving GEMGET 1000 INJECTION are vomiting, constipation, hair loss, poor appetite, headache, insomnia, cough, itching, sweating, etc. Contact your doctor if any of the symptoms or side effects bother you.
Uses Of GEMGET 1000 INJECTION
Used in the management of:
- non-small cell lung cancer (alone or with cisplatin)
- pancreatic cancer
- breast cancer (with paclitaxel)
- ovarian cancer (with carboplatin)
- bladder cancer (with cisplatin)
How GEMGET 1000 INJECTION Works
GEMGET 1000 INJECTION kills the dividing cancer cells by inhibition of their DNA (hereditary material) synthesis.
How to use GEMGET 1000 INJECTION
GEMGET 1000 INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and surface area and disease condition.
Side Effects Of GEMGET 1000 INJECTION
Common
- vomiting, nausea, constipation, diarrhoea
- hair loss
- liver problems
- blood or protein in urine, abnormal urine test
- swollen ankles, fingers, feet, face
- poor appetite
- headache
- insomnia, sleepiness
- cough, runny nose
- itching, sweating
- muscle or back pain
- fever, weakness, chills, infections
Uncommon
- scarring of air sacs of the lungs
- wheezing
- scarring of the lungs seen as abnormal chest X ray/scan
- heart, kidney or liver failure
- stroke
Rare
- low blood pressure
- skin scaling, ulceration or blistering
- skin sloughing and severe blistering
- injection site reactions
- radiation recall (a skin rash like severe sunburn which can occur on skin that has been exposed to radiotherapy in the past)
- fluid in the lungs
- radiation toxicity (scarring of the air sacs of the lung related to radiation therapy)
- gangrene of fingers or toes
- inflammation of the blood vessels
Stop receiving GEMGET 1000 INJECTION and contact your doctor immediately if you experience any of the following side effects:
- allergic reactions (mild to moderate skin rash, fever, itching)
- low haemoglobin (tiredness, feeling faint, easy breathlessness, paleness)
- low platelet count (bleeding from the gums, nose or mouth, any bleeding that would not stop, reddish or pinkish urine, unexpected bruising)
- low white blood cell count with fever, sweating or other signs of infection
- stomatitis (pain, redness, swelling, mouth ulcers)
- mild breathing trouble
- irregular heartbeat
- capillary leak syndrome (generalised swelling, shortness of breath, weight gain due to fluid leakage from small blood vessels into tissues)
- posterior reversible encephalopathy syndrome (headache with vision changes, confusion, seizures or fits)
- thrombotic microangiopathy and haemolytic uraemic syndrome (extreme tiredness and weakness, bruises, low or no urine output, signs of infection)
How To Manage Side Effects
Nausea:
Take regular sips of a cold drink. Have ginger or peppermint tea. Stick to simple meals. Avoid eating oily or spicy foods. If symptom persists, contact your doctor.
Vomiting:
Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like it – no need to eat or avoid any specific foods. If symptom persists, contact your doctor.
Diarrhea:
Drink fluids such as water or fruit juices so that you are sufficiently hydrated. If symptom persists, contact your doctor.
Constipation:
Have plenty of fiber rich foods like fresh fruits, vegetables, cereals and drink ample amount of water. Exercise more regularly. If symptom persists, contact your doctor.
Poor appetite:
Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Eat a protein-rich or other healthy snack such as dried fruit and nuts. If symptom persists, contact your doctor.
Headache:
Drink plenty of water and get adequate rest. Try to be relaxed and stress free. Take medicine for headache after asking your doctor. If symptom persists, contact your doctor.
Skin rash:
Avoid hot showers to manage further irritation of skin. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. If symptom persists, contact your doctor.
Warning & Precautions
Pregnancy
GEMGET 1000 INJECTION is not recommended for use in pregnancy. Consult your doctor before receiving it.
Breastfeeding
GEMGET 1000 INJECTION is not recommended for use in breastfeeding women. Consult your doctor before receiving it.
Driving and Using Machines
Do not drive or operate any machines if you feel sleepy after receiving GEMGET 1000 INJECTION.
Alcohol
Do not consume alcohol during the management with GEMGET 1000 INJECTION as it can make you feel sleepy.
Kidney
GEMGET 1000 INJECTION should be used with caution in patients who had or have any kidney diseases. Contact your doctor before receiving it.
Liver
GEMGET 1000 INJECTION should be used with caution in patients who had or have any liver diseases. Contact your doctor before receiving it.
Allergy
Do not receive GEMGET 1000 INJECTION if you are allergic to gemcitabine or any of the other ingredients of this medicine.
Heart Disease
GEMGET 1000 INJECTION should be used with caution in patients who had or have any heart or vascular diseases. Contact your doctor before receiving it.
Others
Before receiving GEMGET 1000 INJECTION, inform your doctor if you:
- had or are about to have radiotherapy
- have been vaccinated recently
Use in paediatrics:
GEMGET 1000 INJECTION is not recommended for use in children and adolescents (under 18 years of age) due to insufficient data on safety and efficacy. Consult your child’s doctor for advice.
Use in geriatrics:
No dose adjustment of GEMGET 1000 INJECTION is required for elderly patients, however, consult your doctor before receiving it.
Interactions
A. Drug - Drug interactions:
Before receiving GEMGET 1000 INJECTION, inform your doctor if you are taking, have taken or might take any other medicine, including prescription, non-prescription or any herbal medicine.
Overdosage:
GEMGET 1000 INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience anything unusual.
Synopsis
| Drug | : | Gemcitabine |
| Pharmacological Category | : | Pyrimidine antagonists |
| Therapeutic Indication | : | Cancer management |
| Dosage Forms | : | Injection |
More Information
- Keep GEMGET 1000 INJECTION out of reach of children
- Store GEMGET 1000 INJECTION between 25°C
FAQs About GEMGET 1000 INJECTION
Can GEMGET 1000 INJECTION cause hearing loss?
According to some studies, GEMGET 1000 INJECTION is ototoxic, which means it can cause hearing or balance problems. Consult your doctor if you experience any problems with hearing during this management.
How long do I need to take GEMGET 1000 INJECTION?
You usually have GEMGET 1000 INJECTION as a course of several cycles of management. This means that you receive the medicine and then rest to allow your body to recover. Usually, a cycle of GEMGET 1000 INJECTION is over 3 to 4 weeks (21 to 28 days), but your doctor will determine the duration of management according to your condition.
Is it safe to have a baby during management with GEMGET 1000 INJECTION?
For women, GEMGET 1000 INJECTION is not recommended for use if you are pregnant or planning for a baby. Men are advised not to father a child during and up to 6 months after management with GEMGET 1000 INJECTION. You may want to seek counselling on sperm storage before starting your management. Consult your doctor for advice.
Can I receive GEMGET 1000 INJECTION if I got recently vaccinated?
Before receiving GEMGET 1000 INJECTION, inform your doctor if you recently got vaccinated as it can affect the number of blood cells that are tested during this management. Consult your doctor for advice.
Can I drive a car during management with GEMGET 1000 INJECTION?
GEMGET 1000 INJECTION may make you feel sleepy, especially if you have consumed any alcohol. Do not drive a car until you are sure that this management has not made you feel sleepy. Consult your doctor if you feel any side effect during management with GEMGET 1000 INJECTION that may stop you from driving or using machines.
References
1. KD. Tripathi. Chemotherapy of Neoplastic Diseases. Essentials of Medical Pharmacology. Eighth edition. 2019. Page – 924.
2. Alliance for Clinical Trials in Oncology. Gemcitabine Alone or in Combination With Other Chemotherapy Drugs in Treating Patients With Metastatic Cancer of the Pancreas. NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in July 2016] [Accessed on 8th November 2022] https://clinicaltrials.gov/ct2/show/NCT00012220
3. El Karak F, Flechon A. Gemcitabine in bladder cancer. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. December 2007. [Accessed on 8th November 2022] https://pubmed.ncbi.nlm.nih.gov/18035967/
4. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in November 2019] [Accessed on 8th November 2022] https://www.medicines.org.uk/emc/files/pil.2490.pdf
5. Sun Pharmaceutical Industries Europe BV. Electronic Medicines Compendium (EMC). [Revised in December 2018] [Accessed on 8th November 2022] https://www.medicines.org.uk/emc/files/pil.7298.pdf
6. Pfizer Ltd. Gemcitabine. [Revised in June 2019] [Accessed on 8th November 2022] https://labeling.pfizer.com/ShowLabeling.aspx?format=PDF&id=4464
Useful Diagnostic Tests
- Complete Blood Count (CBC)
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