Gemer P 2mg Tablet 10'S

Introduction About GEMER P 2MG TABLET

Gemer P 2mg Tablet is a combination of three active ingredients such as Glimepiride, Metformin, and Pioglitazone which belongs to the group of medicines called Antidiabetic agents. This medicine helps lower blood sugar in adults with type 2 diabetes when taken along with a healthy diet and exercise. This formulation works by enhancing insulin sensitivity, promoting better glucose control, and helping to lower excess blood sugar.

Take Gemer P 2 Table exactly as prescribed by your doctor. It should be taken with food to reduce stomach discomfort. If you miss a dose, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed dose and resume your usual schedule. Do not take a double dose. An overdose can cause low blood sugar (hypoglycemia).

The most common side effects of this medicine includes nausea, diarrhea, stomach pain, headache, bone fracture, and respiratory tract infection. Taking this medication alongside other antidiabetic drugs, alcohol, or skipping meals may cause some individuals to experience hypoglycemia (low blood sugar). It's important to regularly monitor your blood sugar levels while taking this medication.

Before taking this medication, inform your doctor if you have any kidney, liver, or heart problems. Pregnant or breastfeeding women should consult their doctor before taking this medicine. Your doctor will conduct kidney function tests before beginning the management. It's also advised to avoid excessive alcohol consumption while taking this medication, as it may increase the chance of side effects.

Uses Of GEMER P 2MG TABLET

• Type 2 diabetes mellitus

Benefits of GEMER P 2MG TABLET

01) Supports improved blood sugar control: Gemer P 2mg helps in managing the body's insulin sensitivity and glucose utilization, contributing to more balanced blood sugar levels.

02) Combination therapy for effective action: The combination of Glimepiride, Metformin, and Pioglitazone targets different pathways to enhance insulin sensitivity and reduce the body's resistance to insulin.

03) Helps in reducing high blood sugar: By improving how your body utilizes insulin and glucose, it may support overall well-being for those experiencing fluctuations in blood sugar levels.

How GEMER P 2MG TABLET Works

Gemer P 2mg Tablet works by combining three active ingredients such as glimepiride, metformin, and pioglitazone which helps to regulate blood sugar levels in people with type 2 diabetes. Glimepiride stimulates the pancreas to release more insulin, while Metformin enhances the body’s sensitivity to insulin and reduces the amount of glucose produced by the liver. Pioglitazone improves insulin sensitivity in muscle and fat cells, allowing the body to use insulin more effectively. Together, these ingredients work synergistically to lower blood sugar levels, improving glucose control and reducing the risk of complications associated with diabetes.

The Multifaceted Action of Gemer P in Blood Sugar Control

Gemer P combines Glimepiride, Metformin, and Pioglitazone to tackle blood sugar from different angles: Glimepiride helps the pancreas release more insulin. Metformin reduces sugar production by the liver and makes cells more sensitive to insulin. Pioglitazone improves the body’s response to insulin and helps cells take in glucose more effectively. Together, they provide a comprehensive way to lower blood sugar.

The Role of Glimepiride in Enhancing Insulin Secretion

Glimepiride stimulates the pancreas to release more insulin, which helps lower blood sugar. It works by blocking certain channels on the pancreas that allow it to release insulin when needed, especially after eating.

How Metformin Reduces Hepatic Glucose Production

Metformin helps reduce the amount of glucose produced by the liver, which can raise blood sugar. It also improves the body’s ability to use insulin more effectively, making it easier for cells to absorb glucose from the blood.

Pioglitazone’s Role in Improving Insulin Sensitivity

Pioglitazone helps the body use insulin more effectively by making muscle and fat cells more sensitive to it. This means the body can better take up glucose from the blood and use it for energy, helping to lower blood sugar levels.

How to use GEMER P 2MG TABLET

Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.

How to Take Gemer P 2mg Tablet Correctly:

• Swallow the tablet whole with a glass of water.
• Do not crush or chew the tablet, as it may affect how the medication works.
• Follow your doctor’s instructions carefully regarding how much to take and when to take it.

Recommended Dosage of Gemer P 2mg Tablet:

• The typical starting dose is 1 tablet per day.
• Your doctor may adjust the dosage based on your blood sugar levels and response to the medication.
• Do not exceed the prescribed dose.

Should I Take Gemer P Tablet with or without Food?

• Gemer P can be taken with or without food, but it’s often recommended to take it with food to reduce the chance of stomach upset.
• Take it at the same time every day to help you remember.

Best Time to Take Gemer P Tablet for Maximum Effect:

• Take Gemer P once a day, usually with breakfast or the first meal of the day.
• Consistency is key, so try to take it at the same time every day for the best results.

What if I forgot to take GEMER P 2MG TABLET

• If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose.
• Do not take two doses at the same time to make up for a missed dose.
• If you're unsure or have missed more than one dose, talk to your doctor for guidance.

Side Effects Of GEMER P 2MG TABLET

Like all medicines, Gemer P 2mg Tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Gemer P 2mg tablet are:

• Nausea
• Diarrhea
• Stomach pain
• Headache
• Bone fracture
• Respiratory tract infection

When to consult your doctor?

• Severe hypoglycemia (Low Blood Sugar) symptoms such as confusion, dizziness, shaking, sweating, fast heartbeat, headache, and blurred vision
• Allergic reactions symptoms such as rash, itching, swelling of the face, lips, tongue, or throat, difficulty breathing, and tightness in the chest
• Lactic acidosis symptoms such as muscle pain or weakness, feeling cold, trouble breathing, dizziness, slow or irregular heartbeats, nausea, and vomiting
• Severe liver problems symptoms such as yellowing of the skin or eyes (jaundice), dark urine, persistent nausea, vomiting, or loss of appetite
• Severe Swelling or fluid retention symptoms such as swelling of the hands, feet, or ankles, unexplained weight gain, and difficulty breathing
• Heart Failure symptoms such as shortness of breath, fatigue, swelling in the legs, or rapid weight gain
• Severe Abdominal Pain or Diarrhea symptoms such as severe stomach pain, persistent diarrhea, and blood in stools

How To Manage Side Effects

Headache

• Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
• Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
• Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
• Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
• Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

Nausea And Vomiting

• Eat Small, Frequent Meals: Avoid heavy or greasy foods. Opt for bland foods like crackers, toast, or bananas.
• Stay Hydrated: Sip on clear fluids like water, ginger tea, or electrolyte drinks, Avoid caffeinated and carbonated beverages.
• Ginger: Ginger is a natural remedy for nausea. Try ginger tea, ginger candies, or ginger ale (ensure it contains real ginger).
• Avoid Strong Odors: Minimize exposure to smells that might trigger nausea, such as perfumes or cooking odors.

Warning & Precautions

Pregnancy

Consult your doctor

There are no adequate human data to determine the safety of Gemer P 2mg tablet during pregnancy. If you are pregnant or planning to become pregnant, Consult your doctor before taking it.

Breastfeeding

Consult your doctor

It is not known if Gemer P 2mg Tablet passes into human milk and whether it can harm your baby. Talk to your doctor about the best way to control your blood glucose levels while breastfeeding. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or operate heavy machinery if your ability is affected by Gemer P 2mg tablet. If you experience symptoms of low blood sugar (e.g., dizziness, confusion), avoid activities that require full attention.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking Gemer P 2mg tablet as it may increase the risk of hypoglycemia (low blood sugar) and other unwanted side effects.

Kidney

Consult your doctor

Gemer P 2mg tablet is not recommended for use in patients with severe kidney problems and should be used with caution in patients with other kidney problems. Your doctor may monitor your kidney function regularly. Consult your doctor before taking it.

Liver

Consult your doctor

Gemer P 2mg tablet is not recommended for use in patients with severe liver problems and should be used with caution in patients with other liver problems. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take Gemer P 2mg tablet if you are allergic to Glimepiride, Metformin, Pioglitazone, or any other ingredient of this medicine

Heart Disease

Consult your doctor

Gemer P 2mg tablet is not recommended for use in patients with severe heart problems such as heart failure and should be used with caution in patients with other heart conditions. Consult your doctor before taking it.

Use In Pediatrics

Contraindicated

Gemer P 2mg tablet is not recommended for use in children and adolescents (under 18 years of age). The safety and efficacy of this medication have not been established in pediatric populations. Consult your pediatrician before giving it.

Use In Geriatrics

Use with Caution

Gemer P 2mg tablet should be used with caution in elderly patients (aged 65 years and above). Older adults may be more susceptible to side effects, such as low blood sugar or kidney problems, and may require closer monitoring. Consult your doctor before taking it.

Other Warnings for GEMER P 2MG TABLET

Before taking Gemer P 2mg tablet, inform your doctor if you:

• are recovering from any injury, operation, infections or from any form of stress
• have G6PD deficiency
• are on fating or malnourished, starved, on an irregular diet, or feeling weak
• perform extreme physical exercises without proper carbohydrate intake
• are severely dehydrated
• have hormonal problems
• have edema (swelling of body parts)
• smoke
• have special type of diabetic eye disease called macular oedema  
• have cysts on your ovaries (polycystic ovarian syndrome)
• previously had stroke
• have anemia  
• have any bone problems or at risk of developing bone fractures
• are a premenopausal woman
• have thyroid problems

Who should not take [GBNKEYWORD

Gemer P 2mg tablet is not recommended for use if you:

• have type I diabetes mellitus (insulin dependent diabetes)
• have lactic acidosis (build-up of lactic acid in the body)
• have diabetic ketoacidosis
• have bladder cancer
• pass bloody urine

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking Gemer P 2mg tablet:

1. Diuretics (e.g., Thiazides like Hydrochlorothiazide)

• Interaction: Thiazide diuretics can reduce kidney function and may increase blood sugar levels, counteracting the blood sugar-lowering effect of Gemer P.
• Effects: Elevated blood sugar, dehydration, and increased risk of electrolyte imbalances like low potassium (hypokalemia).
• Management: Monitor blood glucose levels closely, adjust the dosage of Gemer P as needed, and monitor electrolytes (especially potassium and sodium). Consider using a potassium-sparing diuretic if required.

2. Insulin and Other Oral Antidiabetic Agents

• Interaction: Using Gemer P in combination with other antidiabetic agents (like insulin or other sulfonylureas) may increase the risk of hypoglycemia (low blood sugar).
• Effects: Symptoms of hypoglycemia, including dizziness, confusion, sweating, and fainting.
• Management: Monitor blood glucose levels frequently. Adjust the dosage of insulin or other oral antidiabetic agents to reduce the risk of hypoglycemia.

3. Beta-blockers (e.g., Metoprolol, Atenolol)

• Interaction: Beta-blockers can mask the symptoms of hypoglycemia, such as tremors and palpitations, making it harder to recognize low blood sugar.
• Effects: Increased risk of severe hypoglycemia because the warning signs are blunted.
• Management: Monitor blood glucose levels more frequently, especially when starting or adjusting beta-blockers. Patients should be educated on recognizing less common symptoms of hypoglycemia, such as confusion or fatigue.

4. Corticosteroids (e.g., Prednisone)

• Interaction: Corticosteroids can increase blood glucose levels, reducing the effectiveness of Gemer P in controlling blood sugar.
• Effects: Elevated blood sugar, potentially leading to hyperglycemia and poor blood sugar control.
• Management: Adjust the dosage of Gemer P or other antidiabetic agents during corticosteroid therapy. Monitor blood glucose levels closely and consider using insulin for short-term management.

5. ACE Inhibitors (e.g., Enalapril, Lisinopril)

• Interaction: ACE inhibitors can enhance the blood sugar-lowering effect of Metformin (one of the components of Gemer P), but may also increase the risk of lactic acidosis when used with Metformin in patients with kidney issues.
• Effects: Hypoglycemia in some cases, especially in the elderly or those with kidney impairment.
• Management: Regular monitoring of kidney function and blood glucose levels. Adjust dosage of Gemer P as necessary.

6. Rifampin

• Interaction: Rifampin may reduce the effectiveness of Gemer P by increasing the metabolism of pioglitazone (another component of Gemer P), which could lead to decreased blood sugar control.
• Effects: Elevated blood glucose levels due to reduced effectiveness of pioglitazone.
• Management: Monitor blood sugar levels closely. The dosage of Gemer P may need to be adjusted if rifampin is used. Consider an alternative antibiotic if necessary.

7. Warfarin (and other Anticoagulants)

• Interaction: Pioglitazone may affect the metabolism of warfarin, leading to an increased or decreased anticoagulant effect.
• Effects: Increased risk of bleeding or clotting, depending on the change in warfarin levels.
• Management: Monitor INR (International Normalized Ratio) closely and adjust the dose of warfarin as needed. Frequent blood tests are required to ensure safe anticoagulation therapy.

8. Furosemide (Loop Diuretics)

• Interaction: Furosemide can cause dehydration and electrolyte imbalances (particularly low potassium), which can worsen the side effects of Gemer P (especially hypoglycemia).
• Effects: Elevated blood sugar, dehydration, and electrolyte disturbances like hypokalemia.
• Management: Monitor electrolytes (especially potassium) and kidney function. Adjust the dose of Gemer P and diuretics as needed. Ensure proper hydration.

9. CYP450 Inhibitors (e.g., Ketoconazole, Fluconazole)

• Interaction: CYP450 inhibitors can increase the concentration of pioglitazone in the body by inhibiting its metabolism, potentially increasing the risk of side effects like fluid retention and weight gain.
• Effects: Increased side effects, including swelling, weight gain, and possibly worsening heart failure.
• Management: Monitor for signs of fluid retention (e.g., swelling of the legs, difficulty breathing). Consider adjusting the dosage of Gemer P and monitoring for any adverse effects closely.

10. Sulfonamides (e.g., Trimethoprim/Sulfamethoxazole)

• Interaction: Sulfonamides can increase the effects of Gemer P and enhance the risk of hypoglycemia due to interactions with glimepiride.
• Effects: Increased risk of hypoglycemia, leading to dizziness, confusion, and fainting.
• Management: Monitor blood glucose levels more frequently and adjust the dose of Gemer P as necessary. Educate patients on recognizing the signs of low blood sugar.

11. Phenothiazines (e.g., Chlorpromazine)

• Interaction: Phenothiazines can increase blood sugar levels, reducing the effectiveness of Gemer P.
• Effects: Elevated blood sugar, leading to hyperglycemia.
• Management: Monitor blood glucose levels closely and adjust the dosage of Gemer P if necessary. Consider alternative medications for managing conditions if needed.

Drug - Food interaction

1. Grapefruit Juice

• Interaction: Grapefruit juice may increase the plasma concentration of glimepiride by inhibiting its metabolism.
• Effects: Increased risk of hypoglycemia.
• Management: Limit the intake of grapefruit or grapefruit juice while taking Gemer P. Monitor blood glucose levels closely.

Synopsis

More Information

1. Diet and Exercise Tips:

Diet Tips for Better Blood Sugar Control:

1. Avoid high glycemic index (GI) foods: Foods like refined carbs and sugary snacks can cause rapid spikes in blood sugar. Instead, focus on low GI foods like whole grains, non-starchy vegetables, and legumes.
2. Eat smaller, more frequent meals: Eating balanced meals every 3-4 hours helps keep blood sugar levels stable.
3. Pair carbohydrates with protein and healthy fats: This can slow the digestion of carbs and prevent blood sugar spikes. For example, pair whole grain toast with avocado and a boiled egg.

Exercise Tips:

• Aerobic exercise (e.g., brisk walking, cycling) helps improve cardiovascular health and insulin sensitivity.
• Strength training helps build muscle mass, which can improve glucose uptake and insulin sensitivity.
• Flexibility exercises like yoga or stretching can help reduce stress and improve overall mobility.
• Post-meal walks are especially effective in lowering blood sugar levels after eating.

Stress Management:

• Chronic stress can cause an increase in blood sugar, so managing stress is crucial for diabetes control.
• Mindfulness, deep breathing, and yoga are effective techniques for lowering stress and improving glucose control.
• Take time for relaxation and mental well-being. Sleep hygiene also plays a major role in stress reduction and glucose management.

FAQs About GEMER P 2MG TABLET

References

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270, 275 & 277.

2. Jeong Mi Kim, Sang Soo Kim, Jong Ho Kim, Mi Kyung Kim, Tae Nyun Kim, Soon Hee Lee, Chang Won Lee, Ja Young Park, Eun Sook Kim, Kwang Jae Lee, Young Sik Choi, Duk Kyu Kim and In Joo Kim. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2019. [Accessed on 23rd May 2025] 

3. Brown & Burk UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 23rd May 2025]

4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 23rd May 2025] 

5. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 23rd May 2025]

6. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in August 2020] [Accessed on 23rd May 2025]

7. Cipla Ltd. TRIEXER ER Tablets (Glimepiride + Pioglitazone hydrochloride + Metformin hydrochloride). Ciplamed. [Revised in September 2020] [Accessed on 23rd May 2025]

8. Central Drugs Standard Control Organization. FDC of Glimepiride (1mg/2mg) + Pioglitazone (15mg) + Metformin (500mg E.R) Tablet. August 2005. [Accessed on 23rd May 2025]

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 24 May 2025 | 09:35 AM(IST)