Galvus Met 50/500mg Tablet 15'S

Introduction About GALVUS MET 50/500MG TABLET

GALVUS MET 50/500MG TABLET is a combination of two medicines Vildagliptin and Metformin which helps to manage high blood sugar levels in adults with type 2 diabetes mellitus. It is generally used when diet, exercise and a single diabetes medicine are not enough to control blood sugar. This tablet helps support the body's natural insulin function and reduce the amount of sugar produced by the liver.     

This medicine is often advised for people who have consistently high blood sugar levels, especially after meals or in the morning. Vildagliptin works by helping the pancreas release insulin when needed, while Metformin helps the body use insulin more effectively and lowers sugar production in the liver. Together they offer balanced support for blood sugar control throughout the day.  

GALVUS MET 50/500MG TABLET should be taken with meals usually once or twice a day as directed by a doctor. Taking it with food helps reduce the chance of side effects like stomach upset. The tablet should be swallowed whole with water. Patients should avoid alcohol, dehydration and skipping meals while using this tablet. Regular checkups are important to monitor blood sugar levels, kidney health, and overall response to the medicine.

Use of this tablet during pregnancy or breastfeeding should only be done after medical advice. Some common side effects may include nausea, stomach discomfort, diarrhea, or a metallic taste in the mouth. These usually improve with time. If you feel unusually weak, short of breath, or have ongoing stomach issues, talk to your doctor. Always follow the prescribed dose and do not stop or change your medicine without medical guidance.

Uses Of GALVUS MET 50/500MG TABLET

• Helps support healthy blood sugar levels in adults
• Aids in improving the body's response to natural insulin

Benefits of GALVUS MET 50/500MG TABLET

How GALVUS MET 50/500MG TABLET Supports Healthy Blood Sugar Levels

GALVUS MET 50/500MG TABLET combines two active ingredients - Vildagliptin and Metformin which work together to help manage blood sugar levels. Vildagliptin belongs to a class of medicines known as DPP-4 inhibitors, which helps the body release insulin more effectively in response to meals, while Metformin helps reduce the amount of sugar the liver produces and the absorption of sugar from food.

When used alongside a balanced diet and regular physical activity, GALVUS MET 50/500MG TABLET supports the body's natural ability to maintain healthy blood sugar levels throughout the day. It is particularly beneficial for individuals looking for a dual-action solution to manage their blood glucose levels without needing multiple medications.

Role of GALVUS MET 50/500MG TABLET in Enhancing the Body’s Insulin Response

One of the key benefits of GALVUS MET 50/500MG TABLET is its ability to improve the body's response to insulin a hormone that plays a vital role in regulating blood sugar. Vildagliptin in GALVUS MET 50/500MG TABLET enhances the body’s insulin secretion after meals, while Metformin helps the cells use insulin more efficiently.  

This insulin-sensitizing effect of Metformin, combined with Vildagliptin’s ability to boost insulin production helps the body better manage fluctuations in blood sugar levels. By improving insulin efficiency, GALVUS MET 50/500MG TABLET helps support overall metabolic balance, making it easier for individuals to manage their energy levels and feel more balanced throughout the day.

Why GALVUS MET 50/500MG TABLET is Often Recommended for Dual Therapy

GALVUS MET 50/500MG TABLET is often recommended as part of a dual therapy approach when a single medication is not sufficient to control blood sugar levels. The combination of Vildagliptin and Metformin addresses multiple factors that contribute to high blood sugar such as insulin resistance, glucose production by the liver and the body's ability to use insulin effectively.

How GALVUS MET 50/500MG TABLET Works

GALVUS MET 50/500MG TABLET action on glucose levels

GALVUS MET 50/500MG TABLET works through a dual mechanism to support healthy glucose levels in the body. It contains two key ingredients: Metformin and Vildagliptin that target different aspects of glucose regulation.

• Metformin helps reduce the production of glucose by the liver and lowers the absorption of glucose from food. It also improves the body's sensitivity to insulin, allowing cells to use glucose more effectively.
• Vildagliptin a DPP-4 inhibitor, supports the body’s natural incretin hormones. These hormones signal the pancreas to release insulin in response to meals and reduce the release of glucose from the liver when it's not needed.

Together, these actions help the body manage both fasting and post-meal blood sugar levels, making GALVUS MET 50/500MG TABLET a valuable option in a broader lifestyle and monitoring plan.

How GALVUS MET 50/500MG TABLET Supports the Body’s Natural Insulin Function

GALVUS MET 50/500MG TABLET helps enhance the body's natural ability to use insulin more efficiently with the action of ingredients that work in synergy:

• Vildagliptin increases the availability of incretin hormones that stimulate insulin release after meals. This supports a more timely and appropriate insulin response based on glucose levels.

• Metformin improves insulin sensitivity in muscle and fat cells, allowing the body to utilize available insulin more effectively.

This dual action not only supports healthier blood sugar levels but also helps the body respond to insulin naturally, aligning with how the body is designed to maintain balance.

How to use GALVUS MET 50/500MG TABLET

Recommended dose of GALVUS MET 50/500MG TABLET

• The usual recommended dose of GALVUS MET 50/500MG TABLET is once or twice daily, depending on individual health needs and medical guidance.
• The dose may vary based on factors such as current blood sugar levels, age, and dietary habits.
• It is important to follow the dose as advised by your healthcare provider and not change it without consultation.
• The tablet should be swallowed whole with water—do not crush or chew.
• Consistency is key—take I    t at the same time(s) each day for best results.

Best time to take GALVUS MET 50/500MG TABLET for sugar control

• GALVUS MET 50/500MG TABLET is generally recommended to be taken with meals to help reduce the chance of stomach discomfort and support better glucose response.
• If prescribed once daily, it is usually taken with the largest meal of the day (typically breakfast or dinner).
• When prescribed twice a day, it is taken with morning and evening meals.
• Taking the tablet with food supports steady blood sugar levels throughout the day and reduces gastrointestinal side effects.
• Avoid skipping meals while on this tablet, as it may affect blood sugar balance.

Should GALVUS MET 50/500MG TABLET Be Taken With or Without Food?

• GALVUS MET 50/500MG TABLET should be taken with food—this is important to help minimize stomach upset, especially due to the Metformin component.
• Taking it alongside a meal enhances tolerance and absorption while supporting post-meal blood sugar control.
• Avoid taking it on an empty stomach unless specifically advised by your doctor.
• For those with sensitive digestion, pairing the tablet with a balanced meal (including complex carbs and proteins) may help.
• Drinking a full glass of water with the tablet is also advisable unless otherwise directed.

What if I forgot to take GALVUS MET 50/500MG TABLET

• If you miss a dose of GALVUS MET 50/500MG TABLET, take it as soon as you remember, preferably with food.
• However, if it's almost time for your next scheduled dose, skip the missed one—do not double the dose to make up for it.
• Taking two doses too close together may increase the risk of side effects like stomach upset or low blood sugar especially if combined with other medications or insufficient food intake.
• To avoid missing doses, try to take GALVUS MET 50/500MG TABLET at the same time every day, preferably with your main meal(s) to help improve effectiveness and reduce gastrointestinal discomfort.
• If you frequently forget doses, it may help to set a daily reminder or use a pill organizer.
• Always follow your healthcare provider’s instructions and let them know if you miss doses often—they may help you adjust your routine for better results.

Overdose

In case of an overdose of GALVUS MET 50/500MG TABLET, the primary concern is the risk of lactic acidosis due to the Metformin component, which can be life-threatening. Symptoms may include nausea, vomiting, abdominal pain, dizziness, fatigue and difficulty breathing. If an overdose occurs, it is essential to seek immediate medical help. Treatment may involve hemodialysis to remove Metformin from the system. To prevent overdose always take the prescribed dosage and avoid taking extra doses. If a dose is missed do not double the dose - consult your healthcare provider for guidance. 

Side Effects Of GALVUS MET 50/500MG TABLET

Common Side Effects of GALVUS MET 50/500MG TABLET:

• diarrhea
• stomach pain
• loss of appetite
• metallic taste
• low blood glucose
• joint pain, tiredness
• constipation
• swollen hands, ankles, or feet (oedema)

Stop taking GALVUS MET 50/500MG TABLET and contact your doctor immediately if you experience any of the following side effects:

• symptoms of lactic acidosis (such as vomiting, stomach pain, decreased heartbeat, difficulty breathing, muscle cramps, general weakness with severe tiredness, or reduced body temperature)
• signs of an inflamed pancreas (severe and persistent pain in the abdomen with or without nausea or vomiting)

Warning & Precautions

Pregnancy

Monitoring required

GALVUS MET 50/500MG TABLET is not recommended for pregnant women unless it is considered necessary.

Breastfeeding

Contraindicated

GALVUS MET 50/500MG TABLET is not recommended for use by breastfeeding women.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you experience dizziness after taking GALVUS MET 50/500MG TABLET.

Alcohol

Consult your doctor

Consumption of alcohol is not recommended during management with GALVUS MET 50/500MG TABLET since it may increase the risk of lactic acidosis.

Kidney

Consult your doctor

GALVUS MET 50/500MG TABLET is not recommended in patients with severely reduced kidney function.

Liver

Consult your doctor

GALVUS MET 50/500MG TABLET is not recommended in patients with liver disease.

Allergy

Contraindicated

Do not take GALVUS MET 50/500MG TABLET if you are allergic (hypersensitive) to Metformin, Vildagliptin or any other ingredients of this medicine.

Heart Disease

Contraindicated

GALVUS MET 50/500MG TABLET is not recommended in patients who recently had a heart attack or heart failure or any signs of heart problems such as serious blood circulation problems or difficulty breathing.  

Use In Pediatrics

Contraindicated

GALVUS MET 50/500MG TABLET is not recommended for use in children and adolescents less than 18 years of age due to a lack of safety and effectiveness.  

Use In Geriatrics

Use with Caution

GALVUS MET 50/500MG TABLET should be used with caution in elderly patients above 65 years of age, especially in patients with impaired kidney function. Your doctor will adjust the dose depending on kidney function, and your kidney function will be monitored regularly.

Other Warnings for GALVUS MET 50/500MG TABLET

Before taking GALVUS MET 50/500MG TABLET, inform your doctor if you have or had:

• pancreatic disease
• Vitamin B12 deficiency
• Malnutrition with adrenal or pituitary insufficiency

Who should not take [GBNKEYWORD

GALVUS MET 50/500MG TABLET is not recommended for you if you have:

• Type 1 diabetes mellitus
• Uncontrolled diabetes
• Severe infection or seriously dehydrated
• are going to have a contrast x-ray (a specific type of x-ray involving an injectable dye

Safety Advice

Important Safety Advice for GALVUS MET 50/500MG TABLET

When using GALVUS MET 50/500MG TABLET, which combines Vildagliptin and Metformin, it's essential to follow these important safety guidelines to ensure effective treatment and avoid potential risks:

1. Monitor for Signs of Low Blood Sugar
   GALVUS MET 50/500MG TABLET can cause low blood sugar (hypoglycemia), particularly when combined with other diabetes medications like insulin or sulfonylureas. Symptoms may include dizziness, shaking, sweating, or confusion. If you experience any of these symptoms, check your blood sugar and treat accordingly.
2. Stay Hydrated
   Staying hydrated is particularly important while taking Metformin as it can help avoid dehydration, which can increase the risk of side effects such as kidney problems and lactic acidosis. Drink plenty of fluids throughout the day.
3. Avoid Sudden Changes in Diet
   Significant changes in your diet, such as drastically reducing your carbohydrate intake or consuming a high-fat meal, can affect your blood sugar levels. Try to follow a consistent, well-balanced diet as advised by your healthcare provider to ensure GALVUS MET 50/500MG TABLET works effectively.
4. Regular Blood Glucose Monitoring
   Regular blood sugar checks are crucial to track how well the medication is controlling your diabetes. Your doctor may adjust your dosage based on these results, ensuring that you maintain optimal blood sugar levels and avoid complications.
5. Inform Your Doctor of Any Health Changes
   If you develop any new medical conditions, especially liver or heart problems, be sure to discuss these with your doctor. Such changes may affect how your body responds to GALVUS MET 50/500MG TABLET, and your doctor may need to adjust your treatment plan.

Diet and Lifestyle Advice

Maintain a Balanced Diet While Taking GALVUS MET 50/500MG TABLET

A balanced diet is crucial for managing diabetes and supporting the effectiveness of GALVUS MET 50/500MG TABLET. The medication works best when combined with proper nutrition, as it helps to regulate blood sugar levels. Here's how you can maintain a balanced diet:

• Include a variety of foods: Aim for meals that include a mix of whole grains, lean proteins, healthy fats, and plenty of non-starchy vegetables. Foods like leafy greens, whole grains (e.g., brown rice, quinoa), lean meats (chicken, fish), and healthy fats (olive oil, nuts) can help stabilize blood sugar.
• Focus on fiber-rich foods: Fiber helps control blood sugar levels by slowing the absorption of sugar into your bloodstream. Include high-fiber foods such as beans, lentils, vegetables, and whole grains in your daily meals.
• Limit processed and sugary foods: Avoid foods high in refined sugars and simple carbohydrates, like sugary snacks, soft drinks, and white bread. These can cause blood sugar spikes and interfere with the action of GALVUS MET 50/500MG TABLET.
• Portion control: Even healthy foods can affect blood sugar if consumed in large amounts. Focus on appropriate portion sizes to maintain balanced blood sugar levels.

Importance of Consistent Meal Timing with GALVUS MET 50/500MG TABLET

Taking GALVUS MET 50/500MG TABLETt consistently and at the right time can make a significant difference in how well it works to manage your blood sugar levels. Here's why meal timing is important:

• Avoiding large fluctuations in blood sugar: Eating meals at regular intervals helps to prevent sudden spikes or drops in blood sugar levels. This is especially important when you’re on medication like GALVUS MET 50/500MG TABLET, which is designed to help control post-meal blood sugar.
• Best times to take GALVUS MET 50/500MG TABLET: It's generally advised to take GALVUS MET 50/500MG TABLET with food, preferably during or after meals. This helps reduce stomach upset, especially with Metformin, one of the active ingredients. It also helps ensure a smoother absorption of the medication.
• Spacing out meals: If you’re on a medication plan that includes GALVUS MET 50/500MG TABLET, try to avoid skipping meals or eating irregularly. Aim for three balanced meals per day with healthy snacks in between if needed. This consistency supports blood sugar control and prevents the overproduction of insulin in response to hunger.

By sticking to a regular eating schedule, you can support the effectiveness of GALVUS MET 50/500MG TABLET and improve your blood sugar management.

Exercise and Physical Activity Tips While on GALVUS MET 50/500MG TABLET

Regular physical activity is an important part of diabetes management and can enhance the effectiveness of GALVUS MET 50/500MG TABLET in controlling blood sugar. Here are some exercise tips to consider:

• Start slowly: If you’re new to exercise or haven't been active for a while, begin with light activities like walking, swimming, or yoga. Gradually increase the intensity and duration over time as your body adapts.
• Aim for 150 minutes of moderate exercise per week: The general recommendation for people with diabetes is to aim for at least 30 minutes of moderate exercise, such as brisk walking or cycling, five days a week. This can help improve insulin sensitivity and aid in blood sugar control.
• Include strength training: Adding muscle-building activities, like light weights or resistance bands, two or more days a week can also help improve insulin sensitivity and muscle health.
• Monitor your blood sugar: Exercise can lower your blood sugar, so it’s important to check your levels before and after physical activity, especially if you’re on diabetes medication. If your blood sugar drops too low, it’s important to treat it quickly with a small snack or drink that contains sugar.
• Stay hydrated: Exercise can lead to dehydration, so make sure to drink plenty of water before, during, and after your workout to stay hydrated.

Regular physical activity not only helps control blood sugar levels but also boosts energy, reduces stress, and promotes overall well-being. Speak with your healthcare provider before starting any new exercise regimen to ensure it’s safe and suitable for your health condition.

GALVUS MET 50/500MG TABLET for Long-Term Diabetes Management

GALVUS MET 50/500MG TABLET, a combination of Vildagliptin and Metformin, plays a vital role in long-term diabetes management by effectively controlling blood glucose levels. Vildagliptin, a DPP-4 inhibitor, enhances insulin secretion in response to food intake, while Metformin improves insulin sensitivity, particularly in the liver and muscle cells. Clinical studies have shown that this combination significantly reduces HbA1c levels, with research indicating an average reduction of up to 1.5% in HbA1c after 24 weeks of use. Additionally, GALVUS MET 50/500MG TABLET helps minimize post-meal glucose spikes and provides cardiovascular benefits, which are critical for long-term diabetic patients at risk of heart disease. Studies suggest that Metformin's role in weight management and preventing obesity-related complications makes it an excellent choice for sustained diabetes control. Regular use of GALVUS MET 50/500MG TABLET, alongside a healthy diet and exercise, can help prevent long-term complications like retinopathy and nephropathy.

GALVUS MET 50/500MG TABLET vs. Janumet What Patients Need to Know

Drug - Drug interaction

GALVUS MET 50/500MG TABLET may interact with various medications that can influence its effect or increase the risk of side effects. Understanding these interactions helps in safer use and better treatment outcomes.

1. Other Antidiabetic Agents (e.g., Sulfonylureas, Insulin)

• Interaction: May increase the risk of low blood sugar (hypoglycemia) when used together.
• Management: Regular blood glucose monitoring is advised. Dosage of the other antidiabetic agents may need adjustment based on blood sugar trends.

2. Diuretics (e.g., Furosemide, Hydrochlorothiazide)

• Interaction: Can reduce Metformin’s effect and may increase the risk of dehydration and kidney strain.
• Management: Maintain adequate hydration and monitor kidney function regularly. Blood sugar levels may need closer observation.

3. ACE Inhibitors/ARBs (e.g., Enalapril, Losartan)

• Interaction: May enhance the blood glucose-lowering effect, increasing the risk of hypoglycemia.
• Management: Regular glucose monitoring is recommended. Watch for signs of low blood sugar, especially when starting or changing doses.

4. Beta-Blockers (e.g., Atenolol, Metoprolol)

• Interaction: Can mask symptoms of hypoglycemia like tremors and palpitations.
• Management: Educate patients to recognize alternative signs of low blood sugar such as sweating and dizziness. Monitor blood glucose more frequently.

5. Corticosteroids (e.g., Prednisolone)

• Interaction: May reduce the effectiveness of GALVUS MET 50/500MG TABLET by increasing blood sugar levels.
• Management: Blood sugar levels should be checked regularly, and antidiabetic medication may need to be temporarily adjusted.

6. Radiographic Contrast Media

• Interaction: Use of iodinated contrast in imaging procedures can temporarily affect kidney function, increasing the risk of lactic acidosis with Metformin.
• Management: Discontinue Metformin before the procedure and restart only after kidney function has been reassessed and is stable.

Always inform your healthcare provider about all the medicines, supplements, and herbal products you are taking. This helps to adjust therapy as needed and avoid potential risks. Carry a medication list during medical visits for better care coordination.

Drug - Food interaction

Certain foods and dietary habits can influence how GALVUS MET 50/500MG TABLET works in the body. Being aware of these interactions can help improve effectiveness and reduce the risk of side effects.                

1. High-Sugar or Refined Carbohydrate Foods

• Interaction: Foods with high glycemic index (like white bread, sugary snacks, sweetened drinks) can lead to blood sugar spikes that counteract the benefits of the medication.
• Management: Choose low glycemic index foods, whole grains, legumes, vegetables, and lean proteins to help maintain stable blood sugar levels along with medication.

2. Caffeine-Containing Beverages (e.g., Coffee, Energy Drinks)

• Interaction: While not directly interacting with the drug, excessive caffeine can cause dehydration or affect appetite and digestion.
• Management: Consume caffeine in moderation and ensure proper hydration throughout the day, especially if taking Metformin which can affect fluid balance.

3. High-Fat or Heavy Meals

• Interaction: Large, high-fat meals may delay gastric emptying and affect the absorption rate of the tablet. They may also spike post-meal glucose levels.
• Management: Maintain a balanced, moderate-fat diet and avoid overeating. Stick to small, frequent meals rich in fiber and low in saturated fats to support consistent blood sugar control

Synopsis

More Information

FAQs About GALVUS MET 50/500MG TABLET

References

1. Novartis Pharma GmbH. Electronic Medicines Compendium (EMC) [Revised in August 2021] [Accessed on 30th June 2025]
2. Metformin Prescribing Information USFDA. Revised in April 2017. [Accessed on 30th June 2025]. 
3. A randomized controlled clinical trial of vildagliptin plus metformin combination therapy in patients with type II diabetes mellitus. NIH. National Library of Medicine. [Revised in February 2014]. [Accessed on 30th June 2025]            

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 01 Jul 2025 | 10:46 AM(IST)