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Introduction About GAG SP TABLET

GAG SP TABLET is used to relieve inflammation and pain due to bone and soft tissue injuries in affected individuals. It is also used to reduce high temperatures and provide relief from cold (while sneezing) in affected individuals. This medicine is also indicated for use to resolve post-operative inflammation, oedema, and pain. It is also used to provide relief from illnesses such as headaches, moderate migraines, and musculoskeletal pain.

GAG SP TABLET is a combination of Aceclofenac, Paracetamol, and Serratiopeptidase, which belong to the group of medicines called Nonsteroidal anti-inflammatory agents, Analgesics and Antipyretics, and Proteolytic enzymes, respectively. It helps to reduce pain and inflammation by blocking certain chemical messengers in the brain, and it also promotes healing by breaking down abnormal proteins at the site of inflammation, thereby healing the infected site.

GAG SP TABLET is not recommended for use in patients allergic to Aceclofenac, Paracetamol, or Serratiopeptidase. It is also not recommended for use in patients with active or recurrent peptic ulcers or haemorrhages (bleeding), severe heart, liver, or kidney diseases. Before taking GAG SP TABLET, inform your doctor if you suffer from uncontrolled high blood pressure, diabetes, hyperlipidaemia (high-fat level in the blood), gastrointestinal diseases such as ulcerative colitis (inflammatory bowel disease), and/or aseptic meningitis (inflammation of the brain).

GAG SP TABLET is not recommended for use by pregnant and breastfeeding women. It is also not recommended for use in children and adolescents (below 18 years old). Consult your doctor before taking the medicine. The most common side effects of taking GAG SP TABLET are abdominal pain, nausea, vomiting, diarrhea, flatulence, constipation, indigestion, and/or dizziness. Consult and inform your doctor if any of these side effects get worse.

Uses Of GAG SP TABLET

It is used to:

Provides relief from inflammation and pain due to bone and soft tissue injuries
Reduces fever and provides relief from cold, post-operative inflammation, oedema, and pain
Relief from illnesses such as headaches, moderate migraines, and musculoskeletal pain

How GAG SP TABLET Works

GAG SP TABLET helps to reduce inflammation and provides relief from pain. Aceclofenac and paracetamol reduce pain and fever by blocking certain chemical messengers in the brain, and serratiopeptidase promotes healing by breaking down abnormal proteins at the site of inflammation, thereby healing the infected site.

How to use GAG SP TABLET

Take GAG SP TABLET as advised by your physician. Swallow GAG SP TABLET with a glass of water, and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.

Side Effects Of GAG SP TABLET

Common

Abdominal pain, nausea, vomiting, diarrhea, flatulence, constipation, and indigestion
Dizziness, drowsiness
Stomach upset
Lack of appetite

Uncommon

Inflammation of the stomach
Inflamed skin, itchy skin, red itchy welts, rash
Nephrotoxicity (deterioration of the kidney due to drugs) includes interstitial nephritis (kidney disorder), nephritic syndrome (kidney disease marked by blood in urine), and renal failure
Abnormal liver function, an inflamed liver, and signs of jaundice such as yellowing of the eyes and skin
Neurological effects such as visual disturbances, optic neuritis (inflammation of the optic nerve of the eye), headaches, paraesthesia (abnormal sensation), and reports of aseptic meningitis (inflammation of the brain) are especially common in patients with existing autoimmune disorders, such as sle and mixed connective tissue disorders, with symptoms( such as stiff neck, headache, nausea, vomiting, fever or disorientation, depression, confusion, hallucinations, tinnitus, vertigo, dizziness, malaise, fatigue, and drowsiness)
Haematological effects such as thrombocytopenia (low platelet level), neutropenia (low white blood cell count), agranulocytosis (a condition marked by an inability to make white blood cells), aplastic anemia (bone marrow disorder), and hemolytic anemia (red blood cell count)

Rare

Signs of exfoliative and bullous dermatoses (autoimmune skin disorders), including epidermal necrolysis and erythema multiforme, such as lesions that crust over, areas of thickened skin, fever, and weakness
Anaemia, signs of vasculitis (inflammation of blood vessels), such as fever, weakness, and weight loss
Signs of anaphylactic reaction (a life-threatening allergic reaction) such as lightheadedness, wheezing, and a fast heartbeat
Face swelling, visual disturbance, shortness of breath
Skin rash with disease or fever

Stop taking GAG SP TABLET and contact your doctor if you experience any of the following side effects:

Signs of serious skin reactions (exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis) such as skin rash and mucosal lesions

How To Manage Side Effects

Constipation

Increase fiber intake through fruits, vegetables, and whole grains. Stay hydrated by drinking plenty of water. Maintain regular meal times and avoid skipping meals. Exercise regularly to promote bowel movements. Establish a bathroom routine and avoid ignoring the urge to go. Avoid processed foods and prioritize probiotic-rich foods for gut health. Consult your doctor if constipation persists.

Diarrhea

Drink plenty of clear fluids, like water, diluted fruit juices, or oral rehydration solutions, to stay hydrated. Avoid caffeinated or alcoholic beverages, as they can worsen dehydration. Gradually take bland, low-fiber foods like bananas, rice, applesauce, and toast to help firm up stools. Probiotics, found in yogurt or supplements, may help restore the balance of gut bacteria. Practice good hand hygiene to prevent the spread of infection. Consult your doctor if diarrhea worsens.

Dizziness Or Drowsiness

Ensure proper hydration, as dehydration can cause dizziness. Avoid excessive caffeine, alcohol, and high-sodium foods, which can exacerbate symptoms. Engage in physical therapy or vestibular rehabilitation exercises designed to improve balance and reduce dizziness. Move slowly when changing positions, such as standing up or lying down, to avoid triggering dizziness. Practice relaxation techniques such as deep breathing, meditation, or yoga to manage stress, which can contribute to dizziness. Consult your doctor if dizziness persists.

Indigestion

Avoid trigger foods such as fatty, spicy, or acidic items. Eating slowly, chewing food thoroughly, and avoiding lying down immediately after meals can improve digestion. Reduce stress through relaxation techniques like meditation, yoga, or deep breathing, which can alleviate symptoms. Maintaining a healthy weight, quitting smoking, and limiting alcohol consumption are also beneficial. Drinking plenty of water helps digestion. Engaging in regular physical activity can help keep the digestive system active and reduce stress, which may improve symptoms. Consult your doctor if indigestion persists.

Nausea And Vomiting

Stay hydrated with small sips of clear fluids like water, ginger ale, or electrolyte solutions. Avoid consuming large meals; instead, opt for bland, easy-to-digest foods. Ginger, peppermint, or chamomile tea may help soothe the stomach. Rest in a comfortable position, preferably with your head elevated, to ease symptoms. Consult your doctor if nausea and vomiting persist.

Warning & Precautions

Pregnancy

Contraindicated

GAG SP TABLET is not recommended for use by pregnant women. Consult your doctor before taking the medicine.

Breastfeeding

Contraindicated

GAG SP TABLET is not recommended for use in breast-feeding women as it may pass through the breast milk. Consult your doctor before taking the medicine.

Driving and Using Machines

Contraindicated

Do not drive or operate any machines, as you may feel dizzy after taking GAG SP TABLET.

Alcohol

Contraindicated

Avoid consumption of alcohol while taking GAG SP TABLET, as it may cause liver damage.

Kidney

Contraindicated

GAG SP TABLET is not recommended for use in patients with moderate and severe renal impairment. Consult your doctor before taking the medicine.

Liver

Consult your doctor

GAG SP TABLET is not recommended for use in patients with severe liver impairment. It should be used with caution in patients with liver disease such as mild to moderate hepatic impairment, hepatic porphyria (a genetic disorder). Consult your doctor before taking the medicine.

Allergy

Contraindicated

Do not take GAG SP TABLET if you are allergic to Aceclofenac, Paracetamol, Serratiopeptidase, and/or any other ingredients of this medicine.

Lungs

Use with Caution

GAG SP TABLET should be used with caution in patients who have or have had a history of bronchial asthma. Consult your doctor before taking the medicine.

Heart Disease

Consult your doctor

GAG SP TABLET is not recommended for use in patients with severe heart disease. It should be used with caution in patients with mild-to-moderate congestive heart failure, ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease. Consult your doctor before taking the medicine.

Use In Pediatrics

Contraindicated

GAG SP TABLET is not recommended for use in children and adolescents (below 18 years). Consult your doctor before taking it.

Use In Geriatrics

Use with Caution

GAG SP TABLET should be used with caution with elderly patients. Consult your doctor before taking GAG SP TABLET.

Others

GAG SP TABLET is not recommended for use if you:

Have a history of or an active, recurrent peptic ulcer or hemorrhage (bleeding)
Have previously shown hypersensitive reactions to ibuprofen, aspirin, or other NSAIDs
Have a previous history of an anaphylactic reaction
Suffer from severe hypertension (high blood pressure)

Before taking GAG SP TABLET, inform your doctor if you:

Have uncontrolled high blood pressure
Have diabetes
Are a smoker
Suffer from hyperlipidemia
Have gastrointestinal bleeding, ulceration, or perforation
Have gastrointestinal diseases such as ulcerative colitis (inflammatory bowel disease)
Have systemic lupus erythematosus (autoimmune disorder)
Have mixed connective tissue disorders such as scleroderma and polymyositis
Have aseptic meningitis (inflammation of the brain)
Have bleeding disorders such as hemophilia, von Willebrand disease
Have signs of cerebrovascular bleeding, such as sudden, severe headaches or seizures
Are on diuretic therapy

Interactions

A. Drug-Drug Interactions:

NSAIDs (Ex. aspirin, naproxen, rofecoxib, ibuprofen, and diclofenac)
Antihypertensives (Ex. atenolol, metoprolol)
Diuretics (Ex. chlorothiazide, chlorthalidone)
Cardiac glycosides (Ex. digoxin)
Anti-manic (Ex. lithium)
Anti-rheumatic (Ex. methotrexate)
Immunosuppressants (Ex. ciclosporin and tacrolimus)
Anti-progestational steroids (Ex. mifepristone)
Corticosteroids (Ex. cortisone, prednisone, and prednisolone)
Anticoagulants (Ex. warfarin, rivaroxaban, dalteparin, enoxaparin, heparin, and dabigatran)
Antibiotics (Ex. ciprofloxacin and chloramphenicol)
Anti-retroviral (Ex. zidovudine)
Antidiabetic agents (Ex. biguanides, sulfonylureas)
Antiglaucoma agents (Ex. acetazolamide)
Anti-gout (Ex. probenecid)
Antiepileptic medicines (Ex. phenytoin, phenobarbital, carbamazepine)
Anti-tubercular (Ex. rifampicin)
Anti-depressant (Ex. St. John's wort)
Anti-platelet (Ex. clopidogrel)

Overdosage:

If you or anyone else accidentally takes too much of GAG SP TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose are headache, pallor, nausea, vomiting, epigastric pain, gastrointestinal irritation and bleeding, diarrhea, disorientation, excitation, drowsiness, dizziness, tinnitus, hypotension, respiratory depression, fainting, convulsions, anorexia, and/or abdominal pain.

Synopsis

Drug	:	Aceclofenac, Paracetamol, and Serratiopeptidase
Pharmacological Category	:	Nonsteroidal anti-inflammatory drugs, Analgesics and Antipyretics, Proteolytic enzymes
Therapeutic Indication	:	Inflammation and pain (due to bone and soft tissue injury), Fever, Postoperative inflammation, oedema, and Pain
Dosage Forms	:	Tablet

More Information

Storage

Keep the medicine out of the reach of children
Store GAG SP TABLET at room temperature

FAQs About GAG SP TABLET

Q: What GAG SP TABLET is used for?

A: GAG SP TABLET is a pain-relieving medicine. It relieves pain, inflammation, and swelling of muscles, joints, and bones in patients with arthritis, spondylitis, and sports injuries. It is also indicated for use to resolve post-operative inflammation, oedema, and pain. It also provides relief from headaches, moderate migraines, and musculoskeletal pain.

Q: Who should avoid taking GAG SP TABLET?

A: GAG SP TABLET is not recommended for use in patients allergic to aceclofenac, paracetamol, and serratiopeptidase. It is also not recommended for use in patients with active or recurrent peptic ulcer or hemorrhage (bleeding), severe heart, liver, or kidney disease, or pregnant or breastfeeding women. It is also not indicated for use in children and adolescents (aged below 18 years).

Q: What are the side effects of GAG SP TABLET?

A: The most common side effects of taking GAG SP TABLET are abdominal pain, nausea, vomiting, diarrhea, flatulence, constipation, indigestion, and/or dizziness. Consult and inform your doctor if any of these symptoms get worse.

Q: What happens if you take more GAG SP TABLET than your required dose?

A: If you or anyone else accidentally takes too much of GAG SP TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are liver damage, headache, pallor, nausea, vomiting, epigastric pain, gastrointestinal irritation and bleeding, diarrhea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, hypotension, respiratory depression, fainting, convulsions, anorexia, and abdominal pain.

Q: Can GAG SP TABLET be taken by pregnant or breastfeeding women?

A: No, GAG SP TABLET is not recommended for use in pregnant and breastfeeding women since it may affect the fetus and nursing child. Consult your doctor before taking this medicine.

Q: Is GAG SP TABLET an antibiotic?

A: No. GAG SP TABLET is not an antibiotic medicine. It helps to alleviate pain, inflammation, swelling, and fever.

Q: Is GAG SP TABLET a steroid tablet?

A: No. GAG SP TABLET is not a steroid medicine. It is a non-steroidal anti-inflammatory drug and analgesic medicine used to manage pain, inflammation, and swelling of muscles, joints, and bones; resolve post-operative inflammation, oedema, and pain, and relieve headache, moderate migraine, and musculoskeletal pain.

Q: Does GAG SP TABLET make you sleepy?

A: GAG SP TABLET may cause drowsiness in some individuals. However, it may not affect everyone. If you experience sleepiness, restrict yourself from driving or handling heavy tools or machines. Avoid alcohol consumption, as it could aggravate drowsiness.

Q: Can I take GAG SP TABLET along with other pain killers?

A: Avoid concomitant usage of GAG SP TABLET with other pain killers without consulting your doctor, as they may damage your gastrointestinal lining.

Q: Can I take GAG SP TABLET for menstrual pain?

A: GAG SP TABLET may be taken for menstrual pain. However, it's important to take it under the guidance of a healthcare professional and follow the prescribed dosage.

Q: Can GAG SP TABLET be used for tooth pain?

A: GAG SP TABLET can be used for dental pain, including toothaches. However, it is predominantly used for musculoskeletal pain. Therefore, consult your doctor before taking it.

Q: Can GAG SP TABLET be used in diabetic patients?

A: It is better to consult your doctor before taking GAG SP TABLET if you are diabetic. Inform your doctor about all antidiabetic medicines that you currently take to avoid drug interactions.

Q: Can GAG SP TABLET be taken without meals?

A: GAG SP TABLET must be taken with meals to avoid gastrointestinal irritation.

Q: Can GAG SP TABLET be used for fever?

A: GAG SP TABLET is effective in lowering fever, but it should not be used without a doctor's prescription. Your healthcare provider will guide you on the usage of this medication, taking into consideration your specific condition and its severity.

Q: Can I take a double dose of GAG SP TABLET to achieve fast results?

A: Do not consume a double dose of GAG SP TABLET, as it may lead to unwanted side effects. Your doctor will decide the correct dose for you, depending on your age and disease condition. If the prescribed dose is not resulting in adequate results, consult your doctor for advice.

Q: How do I order GAG SP TABLET from Netmeds?

A: Ordering GAG SP TABLET online from Netmeds in India is simple. If you wish to buy GAG SP TABLET on Netmeds, you need a prescription from a registered medical practitioner. You can visit the website, search for the product, add it to your cart, and proceed with the checkout process. Netmeds has made buying online medicines easier for consumers and is one of India's leading online pharmacies.

References

1. KD. Tripathi. Aspects of Pharmacotherapy, Clinical Pharmacology and Drug Development, and Nonsteroidal Anti-Inflammatory Drugs and Antipyretic-Analgesics. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 71, 204 & 206.

2. Manju Tiwari. The role of serratiopeptidase in the resolution of inflammation. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in May 2017] [Accessed on 3rd July 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032259/

3. Ciplamed. MOVEXX SP Tablets [Revised in September 2023] [Accessed on 3rd July 2024] https://www.ciplamed.com/product-index/Movexx-SP

4. Laboratories BTT. Electronic Medicines Compendium (EMC). [Revised in January 2016] [Accessed on 3rd July 2024] https://www.medicines.org.uk/emc/files/pil.2389.pdf

5. Narankaa Pharma. ACEDUOZ. [Accessed on 3rd July 2024] https://cdn.pixelbin.io/v2/catalog-cloud/ccprod/original/products/assets/item/free/original/WYNw3K0jI9B-ace-b.jpg

6. Aden Healthcare. Kedac SP. [Accessed on 3rd July 2024] https://www.adenhealthcare.com/product/acelofenac-100mg-paracetamol-500mg-serratiopeptidase-10mg

7. Chemo Healthcare Pvt. Ltd., ACIKY-SP TABS. [Accessed on 3rd July 2024] https://chemohealthcare.com/Products1.html#Ana

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Author Details

Written By Dr. N. Sai Swaroop - Pharm.D

Reviewed For Accuracy By Dr. Srikar Modepu - MBBS, MD (Diabetology)

Last updated on 04 Jul 2024 | 10:30 AM(IST)

Lab updated