FEXUCLUE Tablet 10's

Introduction About FEXUCLUE TABLET

Fexuclue Tablet (Fexuprazan) is a modern acid-control medicine formulated for people who experience persistent acid-related discomfort despite lifestyle changes or conventional options. It belongs to a newer class called potassium-competitive acid blockers (P-CABs), developed to provide faster and more consistent gastric acid suppression. This makes Fexuclue particularly relevant for individuals with frequent heartburn, acid reflux–related symptoms, or conditions where sustained acid control is important for daily comfort and quality of life.

Fexuprazan works by directly blocking the H/K-ATPase (proton pump) in stomach parietal cells, the final step responsible for acid secretion. Clinical data show that P-CABs like fexuprazan can achieve rapid onset of acid suppression from the first dose and maintain stable gastric pH over 24 hours, including nighttime periods. Fexuclue is commonly considered for adults with gastro-esophageal reflux symptoms, acid-related gastritis, or those who require predictable, day-long acid control. It may also be suitable for patients who do not experience adequate symptom consistency with traditional proton pump inhibitors.

Fexuclue is usually taken once daily, with or without food, as advised by a healthcare professional. The tablet should be swallowed whole with water and taken at the same time each day for best results. Patients are advised not to crush or chew the tablet. During use, precautions such as limiting alcohol intake, avoiding very late-night meals, and reducing spicy or high-fat foods may help improve overall symptom control. Inform your doctor about any existing liver conditions or other long-term medicines before starting Fexuclue.

Commonly reported side effects are generally mild and may include headache, diarrhoea, abdominal discomfort, nausea, or bloating, which often resolve as the body adjusts. Use during pregnancy and breastfeeding should only be considered if clearly advised by a doctor, as human safety data are limited. Long-term or unsupervised use is not recommended without medical guidance. If symptoms persist, worsen, or new discomfort appears, timely medical consultation is important to ensure appropriate ongoing care.

Uses Of FEXUCLUE TABLET

• Manage acid-related digestive discomfort
• Manage post-meal stomach discomfort

Benefits of FEXUCLUE TABLET

Fexuclue Tablet for Acid Reflux Sensations

Fexuclue Tablet helps manage acid reflux, including chest burning, regurgitation, and post-meal discomfort. It works by balancing stomach acid levels, reducing the frequency and intensity of reflux episodes. 

With fast onset and long-lasting effect, it can be taken with or without food, offering flexible use. Combining it with simple lifestyle measures like smaller meals, avoiding spicy or oily foods, staying upright after eating, and limiting caffeine can further support comfort. 

How FEXUCLUE TABLET Works

Mechanism of Action of Fexuclue Tablet (Fexuprazan)

Fexuclue Tablet contains fexuprazan, a next-generation potassium-competitive acid blocker (P-CAB) that works by directly targeting acid-producing cells in the stomach. It selectively blocks the H/K-ATPase enzyme (proton pump) present on gastric parietal cells, which plays a key role in the final step of gastric acid secretion. 

Unlike conventional acid-suppressing medicines that require activation in an acidic environment, fexuprazan acts rapidly and reversibly by competing with potassium ions at the proton pump site. This results in fast, consistent, and sustained reduction of gastric acid output throughout the day and night.

By maintaining a more stable gastric pH, fexuprazan helps create a favorable environment for esophageal and gastric lining comfort, supports healing conditions associated with excess acid, and reduces acid-related discomfort after meals. Its predictable acid control profile also contributes to improved symptom consistency, even with once-daily dosing.

How to use FEXUCLUE TABLET

How to Take Fexuclue Tablet

• Take Fexuclue Tablet exactly as prescribed by your doctor. Do not change the dose on your own.
• Swallow the tablet whole with a glass of water. Do not crush, chew, or break it unless your doctor advises.
• It can be taken with or without food, but try to take it at the same time each day to maintain consistent acid control.
• Do not take more than the prescribed dose. Taking extra tablets will not increase effectiveness and may increase side effects.
• If you forget a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed one.
• Do not stop the medicine suddenly without consulting your doctor, especially if you have been taking it regularly.
• Follow your doctor’s instructions regarding duration of use, even if symptoms improve before completing the course.
• Report any unusual symptoms or persistent discomfort to your doctor promptly.

What if I forgot to take FEXUCLUE TABLET

• Take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose.
• If your next dose is due soon, skip the missed one and continue with your regular dosing schedule.
• Do not take two doses at the same time to make up for a forgotten tablet, as this may increase the chances of unwanted effects.
• Missing a single dose may reduce acid control for that day, but it usually does not cause serious concerns.
• Try to take Fexuclue Tablet at the same time each day to help maintain consistent stomach acid balance.
• Setting reminders or linking the dose with a daily routine (such as breakfast or bedtime) may help avoid missed doses.
• If you frequently forget to take your medicine, consult your doctor or pharmacist for guidance on improving adherence.
• Continue taking the medicine as advised, even if symptoms seem less noticeable after missing a dose.

Overdose

If you or anyone else accidentally took more Fexuclue Tablet than advised, consult your doctor immediately or visit the nearest hospital. Symptoms of taking more than the recommended dose may include headache, dizziness, nausea, stomach discomfort, or unusual digestive changes.

Side Effects Of FEXUCLUE TABLET

Common Side Effects of Fexuclue Tablet

• Headache
• Diarrhoea
• Nausea
• Abdominal discomfort or bloating
• Dizziness
• Mild digestive upset

When to Seek Medical Attention?

Stop taking Fexuclue Tablet and contact your doctor immediately if you experience any of the following side effects:

• Severe or persistent abdominal pain
• Black or bloody stools
• Persistent vomiting or vomiting blood
• Difficulty in swallowing or chest discomfort that worsens
• Sudden unexplained weight loss
• Signs of an allergic reaction such as skin rash, itching, swelling of the face or throat, or breathing difficulty

How To Manage Side Effects

Diarrhea

• Stay well hydrated:  sip water frequently to help replace fluid loss. Oral rehydration solutions (ORS) may be useful to maintain electrolyte balance.
• Eat light, easy-to-digest foods:  plain rice, curd (yogurt), bananas, toast, and boiled potatoes are commonly preferred during loose motions.
• Include curd or probiotics:  these may help support healthy gut bacteria and improve stool consistency.
• Avoid oily, spicy, or sugary foods: such foods can further irritate the digestive system.
• Drink clear fluids:  coconut water or diluted fruit juices may help replenish fluids gently.
• Rest adequately: allowing the body to rest may support recovery from digestive upset.
• Avoid caffeine and alcohol:  these may increase bowel movements and dehydration.

Stomach Upset

• Drink warm water – sipping warm water can help calm the stomach and support digestion.
• Ginger tea or ginger-infused water:  ginger is commonly used to ease nausea, bloating, and stomach discomfort.
• Eat light, bland foods: foods like rice, toast, bananas, or boiled potatoes are gentle on the stomach.
• Avoid spicy, oily, or heavy meals:  these may increase stomach irritation during digestive discomfort.
• Take small, frequent meals: eating smaller portions can reduce strain on digestion.
• Peppermint tea:  may help relax the digestive tract and reduce bloating or gas.
• Stay upright after meals:  avoid lying down immediately to reduce stomach discomfort.
• Limit caffeine and fizzy drinks: these may worsen bloating or acidity sensations.

Warning & Precautions

Pregnancy

Contraindicated

Fexuclue Tablet is not recommended for use during pregnancy. Therefore, consult your doctor before taking it.

Breastfeeding

Contraindicated

Fexuclue Tablet is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Fexuclue Tablet does not usually affect alertness. However, if you feel dizzy or unwell after taking it, avoid driving or operating machines.

Alcohol

Contraindicated

Avoid or limit alcohol consumption while taking Fexuclue Tablet, as alcohol may increase stomach discomfort.

Kidney

Use with Caution

Fexuclue Tablet should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it. 

Liver

Use with Caution

Fexuclue Tablet should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it. 

Allergy

Contraindicated

Do not take Fexuclue Tablet if you are allergic to its ingredients. 

Heart Disease

Use with Caution

Fexuclue Tablet should be used with caution in patients with heart-related conditions. Therefore, consult your doctor before taking it.

Use In Pediatrics

Contraindicated

Fexuclue Tablet is not recommended for use in children and adolescents below 18 years of age. Therefore, consult your doctor before taking it.

Use In Geriatrics

Use with Caution

Fexuclue Tablet should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.

Who should not take FEXUCLUE TABLET

Fexuclue Tablet is not recommended for use if you have:

• unresolved or unexplained severe gastrointestinal symptoms, such as persistent vomiting or unexplained weight loss, without prior medical evaluation

Safety Advice

• Avoid lying down immediately after taking the tablet; staying upright for at least 30 minutes may support better digestive comfort.
• If you experience changes in bowel habits that continue for several days, inform your doctor for further guidance.
• Do not stop taking the medicine suddenly without consulting your doctor, especially if it has been used regularly for a period of time.
• Keep a gap between Fexuclue Tablet and antacids or mineral supplements, if advised, to avoid interference with absorption.
• Monitor your body’s response during the first few days of use and report any unusual or persistent symptoms to your healthcare provider.
• Avoid self-medicating with pain relievers known to irritate the stomach unless approved by your doctor.
• If you are scheduled for medical tests or procedures, inform the healthcare professional that you are taking Fexuclue Tablet.
• Maintain regular follow-ups if the medicine is used for an extended duration, as advised by your doctor.

Diet and Lifestyle Advice

• Eat small, frequent meals instead of large portions to reduce stomach load.
• Prefer home-cooked, easily digestible foods such as rice, dal, vegetables, and fruits.
• Limit spicy, oily, fried, and very acidic foods, as these may increase stomach discomfort.
• Avoid late-night meals; keep at least a 2–3 hour gap between dinner and bedtime.
• Reduce intake of caffeine-containing drinks like coffee, strong tea, and energy drinks.
• Limit carbonated beverages and packaged foods that may trigger acidity sensations.
• Drink adequate water throughout the day, but avoid drinking large amounts during meals.
• Maintain a regular meal schedule to support stable digestive patterns.
• Sit upright during and after meals; avoid lying down immediately after eating.
• Elevate the head slightly while sleeping if you experience night-time discomfort.
• Manage stress through yoga, meditation, or breathing exercises, as stress may influence digestion.
• Avoid tight clothing around the abdomen, especially after meals.
• Maintain a healthy body weight, as excess weight may increase stomach pressure.
• Avoid smoking, as it may worsen digestive discomfort.
• Get adequate sleep and follow a consistent sleep routine.

1. Fexuclue Tablet Vs Pantoprazole

2. Fexuclue Tablet Vs Vonoprazan

Drug - Drug interaction

1. Antacids

• Interaction: Antacids may reduce the absorption of Fexuclue Tablet if taken at the same time.
• Management: Take Fexuclue Tablet at least 30–60 minutes before or after antacids to maintain effectiveness.

2. Warfarin and Other Blood Thinners

• Interaction: Fexuclue Tablet may alter the effect of blood-thinning medicines in some cases.
• Management: Your doctor may monitor blood clotting parameters (INR/PT) more closely if you use both medicines together.

3. Ketoconazole, Itraconazole, or Other Antifungals

• Interaction: Fexuclue Tablet may affect the absorption of these antifungal medicines.
• Management: Take these medicines 2 hours before or after Fexuclue Tablet, or as advised by your doctor.

4. Digoxin

• Interaction: Fexuclue Tablet may affect the absorption of digoxin, used for heart conditions.
• Management: Your doctor may monitor digoxin blood levels and adjust the dose if necessary.

5. Clopidogrel or Other Platelet Inhibitors

• Interaction: There is a potential interaction that may alter the effectiveness of these medicines.
• Management: Take both medicines under medical supervision and report any unusual bleeding or bruising.

6. Other Acid-Reducing Medicines (PPIs, H2 Blockers)

• Interaction: Concurrent use may either reduce or increase the effect of one or both medicines.
• Management: Only use together if specifically recommended by your doctor, with proper timing adjustments.

7. Certain Antibiotics (e.g., Amoxicillin, Clarithromycin)

• Interaction: Fexuclue Tablet may slightly alter the absorption of some antibiotics.
• Management: Take antibiotics 1–2 hours apart from Fexuclue Tablet to maintain full effect.

Drug - Food interaction

1. High-Fat Meals

• Interaction: Consuming very fatty meals may slow down the absorption of Fexuclue Tablet.
• Management: Take the tablet before meals or with light meals as advised by your doctor.

2. Caffeine-Containing Beverages (Coffee, Tea, Energy Drinks)

• Interaction: Excess caffeine may aggravate digestive discomfort or acid-related sensations.
• Management: Reduce intake of caffeinated drinks to support digestive comfort.

3. Carbonated Drinks and Fizzy Beverages

• Interaction: These can increase bloating or acid sensations in some individuals.
• Management: Prefer still water or non-carbonated drinks around the time of taking the tablet.

4. Very Spicy or Acidic Foods (Chili, Citrus, Tomato-Based Foods)

• Interaction: Such foods may temporarily increase stomach discomfort.
• Management: Limit spicy or highly acidic foods if you notice digestive discomfort after taking the medicine.

5. Grapefruit or Grapefruit Juice

• Interaction: Grapefruit can sometimes affect the metabolism of medicines, including Fexuclue Tablet.
• Management: Avoid grapefruit or consult your doctor before consuming grapefruit while on Fexuclue Tablet.

6. Large Meals

• Interaction: Eating very heavy meals may delay the onset of the tablet’s effect.
• Management: Eat smaller, frequent meals to support consistent stomach comfort.

Synopsis

More Information

FAQs About FEXUCLUE TABLET

References

1. Sun Pharmaceutical Industries Ltd. Fexuclue Tablet. [Accessed on 22nd December 2025]

2. Kang Nyeong Lee, Oh Young Lee, Hoon Jai Chun, Jin Il Kim, Sung Kook Kim, et. al. Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis. Pubmed Central. NIH. National Library of Medicine. [Revised in 28th November 2022] [Accessed on 22nd December 2025]

3. Gwang Ha Kim, Myung-Gyu Choi, Jin Il Kim, Soo Teik Lee, et. al. Efficacy and Safety of Fexuprazan in Patients with Acute or Chronic Gastritis. Pubmed Central. NIH. National Library of Medicine. [Revised in 15th February 2023] [Accessed on 22nd December 2025]

Useful Diagnostic Tests

• Complete Blood Count (CBC)
• Stool Complete Analysis