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Introduction About FERPILL KIT TABLET

FERPILL KIT TABLET is a combination of Clomifene Citrate and Estradiol Valerate which belongs to the group of medicines called Ovulation stimulants and Hormone Replacement Therapy (HRT) respectively. FERPILL KIT TABLET is used in the management of female infertility in patients who have polycystic ovarian syndrome (PCOS).

Polycystic ovarian syndrome (PCOS) is a hormonal disorder which is common among women of reproductive age. Women having PCOS may suffer from disturbed menstrual periods or excess male hormone (androgen) levels. The ovaries may generate numerous small collections of fluid (follicles/cysts) and fail to regularly release eggs.

FERPILL KIT TABLET is not recommended for use in patients having liver or heart diseases, breast cancer, hormone-sensitive cancer, unexplained menstrual bleeding, excessive thickening of the womb lining, blood clot in a vein, blood clotting disorder, Lapp lactase deficiency, glucose-galactose malabsorption and post-menopausal women.

FERPILL KIT TABLET should be used with caution in patients who have lung or kidney diseases, fibroids in the womb, polycystic ovaries, swollen ovaries, growth of the womb lining outside your womb, high blood pressure, diabetes, gall bladder stones, migraine or severe headaches, epilepsy (fits), systemic lupus erythematosus, increased levels of fat, and diseases of eardrum and hearing.

FERPILL KIT TABLET should not be taken by pregnant or breastfeeding women. FERPILL KIT TABLET is not intended for use in children and should be used with caution in elderly patients.

The most common side effects of taking FERPILL KIT TABLET are flushing of the skin, pain or discomfort in the lower part of the stomach, weight gain, swelling, nausea, vomiting, increased pain with periods, heavy periods or bleeding between periods, painful breasts, headache, or feeling bloated and distended. Ask for your doctor’s advice if any of these worsen or doesn’t improve while taking FERPILL KIT TABLET.

Uses Of FERPILL KIT TABLET

Manage female infertility in the patients who have polycystic ovarian syndrome (PCOS)

How FERPILL KIT TABLET Works

FERPILL KIT TABLET helps in managing female infertility where Clomifene is an Ovulation stimulant which acts on the pituitary gland and stimulates the release of various hormones such as gonadotropin, follicle-stimulating hormone (FSH), and luteinizing hormone (LH).

The release of these hormones leads to the development and maturation of the ovarian follicles, ovulation (release of the egg by the ovary), and development and function of the corpus luteum (formed every month in women of childbearing age), thus resulting in pregnancy.

Clomifene also has an antiestrogenic effect i.e., it affects the volume of uterine thickness which is essential for pregnancy. Estradiol is a Hormone Replacement Therapy which consists of a female hormone called estrogen which reverses the effect of clomifene and helps in maintaining the pregnancy.

How to use FERPILL KIT TABLET

Take FERPILL KIT TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of FERPILL KIT TABLET for you depending upon your age, body weight and disease condition.

Side Effects Of FERPILL KIT TABLET

Common

flushing of the skin
discomfort or pain in the lower part of the stomach
weight gain
swelling
nausea, vomiting
increased pain with periods
heavy periods or bleeding between periods
painful breasts
headache
feeling bloated and distended, flatulence
leg cramps
feeling week
rash or itching

Uncommon

feeling tensed
balance problems or feeling dizzy (vertigo)
tiredness or having difficulty in sleeping (insomnia)
feeling depressed, mood or behaviour changes
hypersensitivity (allergic) reaction such as skin rash, itching, skin redness, hives
painful reddish skin nodules (erythema nodosum)
vaginal thrush (vaginal infection due to a fungus)
high blood pressure
swelling of the ankles, feet or fingers, water retention (oedema)
peripheral vascular disease (cold feet, leg numbness, shiny skin on legs)
varicose veins
blood clots affecting the veins of the legs or lungs
gall bladder disorder
back pain
indigestion
nervousness
dizziness
problems with your sight
faster heartbeat (palpitations)

Rare

Fits
cloudy lenses in the eye (cataracts)
visual changes such as reduced vision, pain in the eyes and difficulty to see some colours
intolerance to contact lenses
pre-menstrual tension (PMT)
feeling anxious
migraine
excessive hair growth, acne
muscle cramps
vaginal discharge
swelling of the breasts
change in sex drive

Stop taking FERPILL KIT TABLET and inform your doctor if you experience any of the following side effects:

swelling of the skin around the face and neck, difficulty breathing
signs of heart attack (chest pain, spreading pain, from chest to your arms, jaw, neck, back and stomach, feeling lightheaded, dizzy, sweating)
heavy, irregular, painful periods
signs of stroke (numbness, weakness or paralysis on one side of the body, sudden blurred vision, slurred speech, confusion, unsteadiness)
vaginal bleeding and abdominal pain during pregnancy (ectopic pregnancy)
breast cancer (lumps in the breast, breast tenderness)
abnormal growth or cancer of the lining of the womb (abnormal bleeding, postmenopausal bleeding, painful intercourse, difficult urination)
ovarian cancer (constant discomfort in the lower abdomen, persistent stomach bloating, enlarged abdomen or a lump felt on lying down, difficulty eating and feeling full quickly, frequent urination)
blood clots in the veins of the legs or lungs (pain, swelling in legs)
probable memory loss
blurred vision or spots or flashes in front of the eyes
over-stimulation of the ovary (pain in the pelvis, stomach or calf, swelling or feeling bloated, passing less urine, increase in weight, difficulty in breathing)
liver problems leading to jaundice (yellow discolouration of the skin and whites of the eye)
psychosis (mental illness)
signs of jaundice (yellowing of skin or the whites of your eyes)

How To Manage Side Effects

Bloating

Eat smaller and frequent meals. Eat and drink slow, and exercise regularly. If the symptom does not improve, consult with your doctor.

Headache

Try to take rest and don’t involve yourself in exertive activities. Apply a pain-relieving balm on your forehead. If the symptom does not improve, consult with your doctor.

Nausea And Vomiting

Take FERPILL KIT TABLET with, or just after meals. Stick to simple meals. Avoid eating rich or spicy food. If the symptom does not improve, consult with your doctor.

Drink clear or ice-cold drinks, eat light, bland foods and avoid fried, oily, or sweet foods while you take FERPILL KIT TABLET. If the symptom does not improve, consult with your doctor.

Stomach Pain

Try to rest and relax. Eat and drink slow or try to have smaller and frequent meals while taking FERPILL KIT TABLET. Keep a heat pad on your stomach. If the symptom does not improve, consult with your doctor.

Warning & Precautions

Pregnancy

Contraindicated

FERPILL KIT TABLET is not recommended for use in pregnant women. Consult your doctor before taking it.

Breastfeeding

Contraindicated

FERPILL KIT TABLET is not recommended for use in breast-feeding women. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or use machines if you feel blurring of vision after taking FERPILL KIT TABLET.

Alcohol

Contraindicated

Avoid the consumption of alcohol while taking FERPILL KIT TABLET as it may increase the chances of getting a stroke.

Kidney

Use with Caution

FERPILL KIT TABLET should be used with caution in patients having kidney diseases which cause fluid retention. Consult your doctor before taking [GNBKEYWORD].

Liver

Consult your doctor

FERPILL KIT TABLET is not recommended for use in patients who have or had liver disease, and whose liver function tests are not yet normal. It should be used with caution in patients having a benign liver tumour. Consult your doctor before taking FERPILL KIT TABLET.

Allergy

Contraindicated

Do not take FERPILL KIT TABLET if you are allergic to Clomifene Citrate or Estradiol Valerate.

Lungs

Use with Caution

FERPILL KIT TABLET should be used with caution for patients having lung diseases such as asthma. Consult your doctor before taking it.

Heart Disease

Consult your doctor

FERPILL KIT TABLET is not recommended for use in patients who have or had heart diseases such as heart attack, stroke or angina. It should be used with caution in patients having fluid retention due to heart disease. Consult your doctor before taking FERPILL KIT TABLET.

Use In Pediatrics

Contraindicated

FERPILL KIT TABLET is not intended for use in children. Consult your doctor for advice.

Use In Geriatrics

Consult your doctor

FERPILL KIT TABLET should be used with caution in elderly women. Your doctor will decide the correct dose and duration of the management with FERPILL KIT TABLET for you depending on your age, health condition and body weight. Consult your doctor for advice.

Others

FERPILL KIT TABLET is not recommended for use if you:

have or had breast cancer or are at risk of it
have or had hormone-sensitive cancer or are at risk of it
have unexplained menstrual bleeding
have unmanageed excessive thickening of the womb lining (endometrial hyperplasia)
have or had a blood clot in a vein (thrombosis)
have blood clotting disorder
have Lapp lactase deficiency
have glucose-galactose malabsorption
have porphyria
are a post-menopausal woman

Before taking FERPILL KIT TABLET tell your doctor if you have or ever had:

fibroids in the womb (uterus)
polycystic ovaries
swollen ovaries
growth of the womb lining outside your womb (endometriosis)
high blood pressure
diabetes
gall bladder stones
migraine or severe headaches
epilepsy (fits)
systemic lupus erythematosus
increased levels of fat
diseases of eardrum and hearing

Interactions

A. Drug – Drug Interactions:

Inform your physician if you are taking any of the following drugs before taking FERPILL KIT TABLET:

barbiturates, phenytoin, primidone, carbamazepine, oxcarbazepine, topiramate, felbamate (used to manage epilepsy)
rifampicin, rifabutin (used to manage tuberculosis)
nevirapine, nelfinavir, efavirenz, ritonavir (used in managing HIV infections)
St. John’s Wart (herbal medicine)
combination regimen ombitasvir/paritaprevir/ritonavir with or without dasabuvir as well as regimen glecaprevir/pibrentasvir (used to manage Hepatitis C)
griseofulvin, ketoconazole, fluconazole, itraconazole, voriconazole (used to manage fungal infections)
clarithromycin, erythromycin (used in managing bacterial infections)
verapamil, diltiazem (used to manage certain heart diseases, high blood pressure)

B. Drug – Food Interactions:

avoid the consumption of grapefruit juice with FERPILL KIT TABLET

Overdosage:

If you or anyone else accidentally take too much of FERPILL KIT TABLET, consult your doctor immediately or visit the nearby hospital. The symptoms of overdosage of [GBNKEYWWORD] are nausea, vomiting, irregular bleeding, or over stimulation of ovaries (mild to moderate abdominal pain, tenderness in the area of ovaries, bloating, increase in waist size).

Synopsis

Drug	:	Clomifene Citrate, Estradiol Valerate
Pharmacological Category	:	Ovulation stimulants, Hormone Replacement Therapy
Therapeutic Indication	:	Infertility in women having PCOS
Dosage Forms	:	Tablet

More Information

Keep FERPILL KIT TABLET out of reach of children
Store below 25°C

FAQs About FERPILL KIT TABLET

Q: What is FERPILL KIT TABLET and why is it prescribed?

A: FERPILL KIT TABLET is a combination of Clomifene Citrate and Estradiol Valerate which belongs to the group of medicines called Ovulation stimulants and Hormone Replacement Therapy (HRT) respectively. It is used in the management of female infertility in patients who have polycystic ovarian syndrome (PCOS).

Q: Can I undergo surgery while taking FERPILL KIT TABLET?

A: If you plan to have surgery, inform the surgeon that you are taking FERPILL KIT TABLET. You may be asked to stop taking FERPILL KIT TABLET about 4 to 6 weeks before the operation to reduce the risk of a blood clot. Consult with your doctor.

Q: Can FERPILL KIT TABLET be given to pregnant and breastfeeding women?

A: FERPILL KIT TABLET is not recommended for use in pregnant and breast-feeding women. If you become pregnant while taking FERPILL KIT TABLET you must contact your doctor immediately.

Q: What other precautions should be taken while taking FERPILL KIT TABLET?

A: FERPILL KIT TABLET contains Estradiol which is a hormone replacement therapy consisting of a female hormone called estrogen. While taking FERPILL KIT TABLET you should watch out for signs of diseases such as breast cancer, ovarian cancer, endometriosis, heart diseases, and blood clots in veins. The risks of these diseases depend upon your age, disease condition and dosage of FERPILL KIT TABLET. Ask for your doctor’s advice.

Q: How to manage if I forget to take a dose of FERPILL KIT TABLET?

A: If you forget a dose of FERPILL KIT TABLET, talk to your doctor as changes might be required in your management cycle. Do not take a double dose of FERPILL KIT TABLET to make up for a forgotten tablet.

References

1. K.D. Tripathi. Estrogens, Progestins and Contraceptives. Essentials of medical pharmacology. Seventh edition. 2013. Page – 308 & 312.

2. Fariba Seyedoshohadaei, Laleh Tangestani, Farnaz Zandvakili, Naser Rashadmanesh. Comparison of the Effect of Clomiphene- Estradiol Valerate vs Letrozole on Endometrial Thickness, Abortion and Pregnancy Rate in Infertile Women with Polycystic Ovarian Syndrome. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. August 2006. [Accessed on 22nd July 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028483/

3. NIH National Library of Medicine, National center for biotechnology information. Pubchem. Estradiol. [Accessed on 22nd July 2022]. https://pubchem.ncbi.nlm.nih.gov/compound/Estradiol

4. NIH National Library of Medicine, National center for biotechnology information. Pubchem. Clomifene. [Accessed on 22nd July 2022]. https://pubchem.ncbi.nlm.nih.gov/compound/Clomifene

5. Bayer. Electronic Medicines Compendium (EMC). [Revised in June 2022]. [Accessed on 22nd July 2022]. https://www.medicines.org.uk/emc/files/pil.1417.pdf

6. Abbott Biologicals BV. Electronic Medicines Compendium (EMC). [Revised in March 2022]. [Accessed on 22nd July 2022]. https://www.medicines.org.uk/emc/files/pil.1174.pdf

7. Patheon France SAS. Health Products Regulatory Authority (HPRA). [Revised in June 2021]. [Accessed on 22nd July 2022]. http://www.hpra.ie/img/uploaded/swedocuments/62ee0bc2-beca-4599-9deb-77f927626c4c.pdf, https://www.mayoclinic.org/diseases-conditions/pcos/symptoms-causes/syc-20353439

Useful Diagnostic Tests

Hysteroscopy
Hysterosonography
Ovulation Testing
Hormone Testing

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed For Accuracy By Dr. M N Himaja - MBBS

Last updated on 17 Feb 2023 | 04:13 PM(IST)

Lab updated