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FERINJECT 1000 Injection 20ml

Iron Supplement/Anae...
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    Introduction About FERINJECT 1000 INJECTION

    FERINJECT 1000 INJECTION contains Ferric carboxymaltose, which belongs to the group of medicines called Iron replacement medicines. It is used to manage iron deficiency anaemia (IDA) in adults and in children (above 14 years of age) who are unable to take iron supplements orally, have an intolerance to oral iron supplements, need a rapid iron supplement in the body, or have non-dialysis-dependent chronic kidney disease.

    Iron deficiency anaemia is a condition in which the body lacks enough amount of iron, which is essential for the production of red blood cells and transport of oxygen in the body.

    Your doctor may advise you to take relevant tests to understand your existing condition. Before receiving FERINJECT 1000 INJECTION, inform your doctor if you are pregnant, planning to get pregnant, or breastfeeding.

    FERINJECT 1000 INJECTION is not recommended for use in children and adolescents (under 14 years of age), and it should be used with caution in elderly patients (aged 65 years or above). Consult your doctor before receiving FERINJECT 1000 INJECTION.

    The most common side effects of receiving FERINJECT 1000 INJECTION may include headache, dizziness, flushing, high blood pressure, nausea, and injection or infusion site reactions. Consult your physician if any of the symptoms worsen. 

    Uses Of FERINJECT 1000 INJECTION

    • Manages iron deficiency anaemia   

    How FERINJECT 1000 INJECTION Works

    FERINJECT 1000 INJECTION contains iron (III) hydroxide complexed with a carbohydrate polymer called carboxymaltose, which is capable of releasing iron. The iron released from the complex helps in the synthesis of haemoglobin and increases red blood cell count. As a result, it manages iron deficiency anaemia.

    How to use FERINJECT 1000 INJECTION

    FERINJECT 1000 INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous injection or infusion. Your physician will decide the correct dose and duration for you depending upon your age, body weight, and severity of the condition.

    Side Effects Of FERINJECT 1000 INJECTION

    Common

    • Headache
    • Dizziness
    • Flushing
    • High blood pressure
    • Nausea
    • Injection/infusion site reactions
    • Low levels of phosphorous in the blood

    Uncommon

    • Numbness
    • Prickling or tingling sensation of the skin
    • Change in taste sensation
    • Increased heart rate
    • Low blood pressure
    • Difficulty breathing
    • Vomiting
    • Indigestion
    • Stomach pain
    • Constipation
    • Diarrhoea
    • Itching
    • Redness of the skin
    • Skin rash
    • Muscle or joint pain
    • Back pain
    • Pain in the arms or the legs
    • Muscle spasms
    • Fever
    • Tiredness
    • Chest pain
    • Swelling of the hands and feet, and chills

    Rare

    • Inflammation of the vein
    • General feeling of discomfort
    • Anxiety
    • Fainting or feeling faint
    • Wheezing
    • Flatulence
    • Rapid swelling of the face, mouth, tongue, or throat, which may cause difficulty in breathing
    • Paleness and discoloration of the skin in other areas of the body than the injected site

    Contact your doctor immediately if you experience any of the following side effects:

    • Symptoms of serious allergic reaction or Kounis syndrome (such as rashes, itching, swelling of the face, lips, mouth, tongue, throat, or body causing difficulty in breathing or wheezing and chest pain)
    • Severe or life-threatening allergic reactions called anaphylactic reactions, which can be associated with heart problems, circulation problems (low blood pressure), and loss of consciousness
    • Sign of a decrease in blood phosphorus causing softening of bones (osteomalacia). Symptoms include worsening of tiredness, muscle or bone pain (pain in arms or legs, joints, or back), and may lead to fractures
    • Signs of high blood pressure (such as facial flushing, dizziness, or nausea)
    • Skin irritation and brownish discolouration of the skin at the injected site

    How To Manage Side Effects

    Constipation

    Take fiber-rich foods in your diet, such as fresh fruits, vegetables, and whole-grain cereals, and drink plenty of fluids. Consult your doctor if the constipation does not improve.

    Diarrhea

    Drink lots of fluids, such as water or fruit juices, to keep yourself hydrated. Avoid eating high-fat or spicy foods. If the diarrhea does not improve, consult your doctor.

    Headache

    Take a rest and relax. Drink plenty of fluids, such as water. Apply a pain-relieving balm on the forehead if necessary. Consult your doctor if your headache does not improve.

    Nausea And Vomiting

    Stick to simple meals. Avoid eating oily, fried, or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if nausea and vomiting do not improve.

    Stomach Pain

    Try to take a rest and relax. Eat and drink slowly, or try to have smaller and more frequent meals. Keep a heat pad on your stomach. If the stomach pain does not improve, consult your doctor.

    Warning & Precautions

    Pregnancy

    Monitoring required

    FERINJECT 1000 INJECTION should be used with caution in pregnant women only if considered clearly necessary. Inform your doctor if you are pregnant, think you may be pregnant, or are planning to have a baby. Consult your doctor before receiving FERINJECT 1000 INJECTION. 

    Breastfeeding

    Consult your doctor

    If you are breastfeeding, consult your doctor for advice before receiving FERINJECT 1000 INJECTION. It is unlikely that FERINJECT 1000 INJECTION represents a risk to the breastfed child. 

    Driving and Using Machines

    Safe

    FERINJECT 1000 INJECTION is unlikely to impair the ability to drive or operate machines.

    Kidney

    Use with Caution

    FERINJECT 1000 INJECTION should be used with caution in patients with chronic kidney disease who are dependent on haemodialysis management. Consult your doctor before receiving FERINJECT 1000 INJECTION. 

    Liver

    Use with Caution

    FERINJECT 1000 INJECTION should be used with caution in patients with liver disease. Consult your doctor before receiving FERINJECT 1000 INJECTION.

    Allergy

    Contraindicated

    Do not receive FERINJECT 1000 INJECTION if you are allergic to ferric carboxymaltose or any of the other ingredients of this medicine or if you have experienced serious allergic reactions to other injectable iron preparations.

    Lungs

    Use with Caution

    FERINJECT 1000 INJECTION should be used with caution in patients with severe asthma. Consult your doctor before receiving FERINJECT 1000 INJECTION.

    Use In Pediatrics

    Contraindicated

    FERINJECT 1000 INJECTION is not recommended for use in children (under 14 years of age). Consult the child's doctor for advice on how to manage the condition.

    Use In Geriatrics

    Use with Caution

    FERINJECT 1000 INJECTION should be used with caution in elderly patients (aged 65 years or above). Consult your doctor before receiving FERINJECT 1000 INJECTION.

    Others

    FERINJECT 1000 INJECTION is not recommended for use if you have:

    • Anaemia not caused by iron deficiency
    • Iron overload (too much iron in your body) or disturbances in the utilization of iron

    Before receiving FERINJECT 1000 INJECTION, inform your doctor if you have:

    • Systemic lupus erythematosus
    • Rheumatoid arthritis
    • Eczema or other allergies
    • An infection
    • Low levels of phosphate in the blood
    • High blood pressure

    Interactions

    A. Drug-Drug interactions:

    Before receiving FERINJECT 1000 INJECTION, inform your doctor if you are using or have recently taken any other medicines, including prescription and non-prescription medicines and vitamins or herbal supplements. 

    • Oral iron preparations such as ferrous ascorbate, ferrous sulphate, ferric citrate (used to manage low levels of iron in the body)

    Overdosage:

    FERINJECT 1000 INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.  

    Synopsis

    Drug :   Ferric carboxymaltose
    Pharmacological Category :   Iron replacement medicines
    Therapeutic Indication :   Iron Deficiency Anemia (IDA)
    Dosage Forms :   Injection

    More Information

    Storage

    • Keep FERINJECT 1000 INJECTION out of reach of children
    • Store at room temperature

    FAQs About FERINJECT 1000 INJECTION

    Q: What is the use of FERINJECT 1000 INJECTION?

    A: FERINJECT 1000 INJECTION is used to correct iron deficiency anaemia (IDA) in adults and in children (above 14 years of age).

    Q: How long does it take for FERINJECT 1000 INJECTION to improve hemoglobin levels?

    A: It takes a few weeks for FERINJECT 1000 INJECTION to improve your hemoglobin levels, but some people may notice an improvement in their symptoms within a few days.

    Q: How does FERINJECT 1000 INJECTION work?

    A: FERINJECT 1000 INJECTION contains iron (III) hydroxide complexed with a carbohydrate polymer called carboxymaltose, which is capable of releasing iron. The iron released from the complex helps in the synthesis of haemoglobin and increases red blood cell count. As a result, it manages iron deficiency anaemia.  

    Q: Is FERINJECT 1000 INJECTION safe to use in patients with liver problems?

    A: FERINJECT 1000 INJECTION should be used with caution in patients with liver disease. Consult your doctor before receiving it.

    Q: What are the common side effects of FERINJECT 1000 INJECTION?

    A: The most common side effects of using FERINJECT 1000 INJECTION may include headache, dizziness, flushing, high blood pressure, nausea, and injection or infusion site reactions. Consult your physician if any of the symptoms worsen.

    Q: Is FERINJECT 1000 INJECTION safe to use in patients with kidney problems?

    A: FERINJECT 1000 INJECTION should be used with caution in patients with chronic kidney disease who are dependent on haemodialysis management. Consult your doctor before receiving FERINJECT 1000 INJECTION. 

    Q: Who should avoid receiving FERINJECT 1000 INJECTION?

    A: FERINJECT 1000 INJECTION is not recommended for use in patients with evidence of iron overload or disturbances in the utilization of iron, anaemia not attributed to iron deficiency (microcytic anaemia) and with known allergies to ferric carboxymaltose or serious allergies to other parenteral iron products.

    Q: Is FERINJECT 1000 INJECTION safe to use in elderly patients?

    A: FERINJECT 1000 INJECTION should be used with caution in elderly patients (aged 65 years or above). Your doctor may monitor you carefully during administration and a certain time after administration of FERINJECT 1000 INJECTION.

    Q: Can FERINJECT 1000 INJECTION be used during pregnancy?

    A: FERINJECT 1000 INJECTION should be used with caution in pregnant women only if clearly advised by your doctor. Inform your doctor if you are pregnant, think you may be pregnant, or are planning to have a baby.

    Q: Does FERINJECT 1000 INJECTION affect my ability to drive?

    A: FERINJECT 1000 INJECTION is unlikely to impair the ability to drive or operate machines.

    Q: Can FERINJECT 1000 INJECTION cause nausea and vomiting?

    A: Yes, FERINJECT 1000 INJECTION causes nausea and vomiting. Stick to simple meals. Avoid eating oily, fried, or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.

    Q: Is FERINJECT 1000 INJECTION safe to use in patients with lung problems?

    A: FERINJECT 1000 INJECTION should be used with caution in patients with severe asthma. Consult your doctor before receiving.

    Q: Can I take other medicines with FERINJECT 1000 INJECTION?

    A: Before using FERINJECT 1000 INJECTION, inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription, vitamin supplements, or herbal products.

    Q: Can FERINJECT 1000 INJECTION cause an allergic reaction?

    A: Yes, do not receive FERINJECT 1000 INJECTION if you are allergic to ferric carboxymaltose or any of the other ingredients of this medicine or if you have experienced serious allergic reactions to other injectable iron preparations.

    References

    1. KD. Tripathi. Haematinics and Erythropoietin. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 605

    2. Joao Ricardo Friedrischa and Rodolfo Delfini Cancadob. Intravenous ferric carboxymaltose for the management of iron deficiency anemia. NIH. National Library of Medicine, National Center for Biotechnology Information. PMC PubMed Central. October 2015. [Accessed on 31st July 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678908/

    3. American Regent, Inc. Safety and Tolerability of Ferric Carboxymaltose (FCM) Versus Standard of Care in treating Iron Deficiency Anemia. NIH. U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in February 2018] [Accessed on 31st July 2024] https://clinicaltrials.gov/ct2/show/NCT00703937

    4. Vifor France. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 31st July 2024] https://www.medicines.org.uk/emc/files/pil.5910.pdf

    5. Vifor (International) Inc., U.S. Food & Drug Administration. [Revised in April 2021] [Accessed on 31st July 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/203565s014lbl.pdf

    Useful Diagnostic Tests

    • Complete Blood Count (CBC)/ Hemogram
    • Ferritin /Iron, Serum
    • Iron Studies
    • Iron Deficiency Profile
    • Total Iron Binding Capacity- Tibc
    • Unsaturated Iron Binding Capacity (Uibc)
    • Ferritin
    • Iron Studies With Ferritin

    Author Details

    Written By Dr. N. Sai Swaroop - Pharm.D
    Reviewed For Accuracy By Dr. Shruthi Raikar - BDS
    Last updated on 01 Aug 2024 | 05:06 PM(IST)
    Lab updated