FEBUTAZ 40 Tablet 15's

Introduction About FEBUTAZ 40 TABLET

FEBUTAZ 40 Tablet contains Febuxostat 40 mg medication primarily used to support the management of elevated uric acid levels in adults. Elevated uric acid can arise due to metabolic imbalances and FEBUTAZ helps by modulating the enzyme responsible for uric acid production, thereby assisting in maintaining balanced serum uric acid levels. This makes it a suitable option for adults who require ongoing support for uric acid regulation, especially when lifestyle measures alone do not achieve the desired balance.    

This medication is ideal for adults diagnosed with persistent hyperuricemia, particularly those who need to regulate uric acid levels under medical guidance. FEBUTAZ works by inhibiting xanthine oxidase, an enzyme involved in the production of uric acid, helping to maintain healthier uric acid levels over time.   

It is typically taken once daily with or without food as advised by a healthcare professional. Consistent use as per the prescribed schedule is important for optimal support. 

When using FEBUTAZ 40, patients should adhere strictly to the dosage instructions provided by their healthcare provider. It is important to inform your doctor about any other medications you are taking to avoid potential interactions. Certain precautions include avoiding use during pregnancy and breastfeeding unless explicitly recommended by a physician. Patients with liver or kidney concerns should be monitored closely while using this medication. The common side effects may include mild stomach discomfort, nausea, or headache, which generally resolve without needing to stop the medication.    

Uses Of FEBUTAZ 40 TABLET

• Helps in the management of elevated uric acid levels in adults (in conditions like chronic hyperuricemia)

Benefits of FEBUTAZ 40 TABLET

FEBUTAZ 40 Tablet supports effective management of elevated uric acid levels in the body. It benefits include:

1. Helps regulate uric acid levels: By reducing the production of uric acid FEBUTAZ aids in maintaining a healthy balance, which is essential for overall metabolic wellness

2. Supports kidney health: Lowering uric acid can reduce the strain on kidneys, helping to maintain proper kidney function

3. Suitable for patients with certain kidney issues: FEBUTAZ can be a preferred option when some other uric acid regulators may not be suitable

4. Improves quality of life: By managing uric acid levels patients may experience fewer flare-ups and discomfort related to excess uric acid

How FEBUTAZ 40 TABLET Works

FEBUTAZ 40 helps manage high uric acid levels in the body. It works by blocking an enzyme called xanthine oxidase. This enzyme is responsible for turning certain natural substances (called purines) into uric acid.

When xanthine oxidase is active more uric acid gets produced. FEBUTAZ slows down this enzyme, which helps reduce the amount of uric acid formed in the blood. As a result, uric acid levels can stay within a healthier range over time.

By helping to control how much uric acid the body makes, FEBUTAZ supports better metabolic balance and can be an important part of a long-term plan for individuals dealing with high uric acid concerns.

How to use FEBUTAZ 40 TABLET

Recommended Dosage and Administration of FEBUTAZ 40

• Take FEBUTAZ 40 Tablet once daily, or as advised by your healthcare provider
• Follow the exact dose and duration recommended. Do not change it without medical guidance
• Swallow the tablet whole with a glass of water
• Do not crush, chew, or split the tablet unless instructed by your doctor
• Regular blood tests may be recommended to monitor uric acid levels and adjust dosage if needed

Best time to take Febutaz 40 tablet

• Can be taken at any consistent time of day, morning or evening works best
• Choose a time you can stick to daily to avoid missing doses

Should you take FEBUTAZ 40 before or after food?

• FEBUTAZ 40 can be taken with or without food
• Taking it after a meal may help reduce chances of mild stomach discomfort
• Choose the option that feels most comfortable unless your doctor advises otherwise. Food does not affect how the medicine works in the body

What if I forgot to take FEBUTAZ 40 TABLET

• If you miss a dose of FEBUTAZ 40, take it as soon as you remember
• If it is almost time for your next scheduled dose, skip the missed dose
• Do not take two doses at the same time to make up for the missed one
• Maintaining a regular daily routine helps in getting the most benefit from the medicine
• If you frequently forget doses, consider setting a reminder or alarm or speaking with your healthcare provider about tips to stay consist

Overdose

• Taking more than the prescribed dose of FEBUTAZ 40 may increase the risk of side effects
• Signs of overdosage are not always obvious but may include unusual tiredness, stomach discomfort, dizziness, or other unexpected symptoms
• If an accidental overdose occurs, contact your doctor or visit the nearest medical facility immediately
• Keep the medication out of reach of children and never share it with others, even if they have similar symptoms
• Do not attempt to "correct" missed doses by taking more than recommended

Side Effects Of FEBUTAZ 40 TABLET

Common side effects of FEBUTAZ 40 Tablet:

• diarrhea
• headache
• skin rashes
• abnormal liver test results
• nausea
• increase in gout symptoms
• edema (localised swelling)

When to seek medical attention?

Stop taking FEBUTAZ 40 TABLET and inform your doctor immediately, if you experience any of the following side effects:

• Severe allergic reactions (such as skin rashes, blisters, nodules, itching, swelling of limbs and face, difficulties in breathing, fever, enlargement of lymph nodes)
• Stevens-Johnson-Syndrome (symptoms include reddish target-like spots or circular patches often with central blister on the trunk, ulcers in the mouth, throat, nose, genitals and conjunctivitis, with widespread blistering or peeling of the skin)
• Severe muscle cramps

How To Manage Side Effects

Diarrhea

• Stay well-hydrated by drinking small sips of water throughout the day to prevent dehydration.
• Eat a bland, low-fiber diet (e.g., plain rice, toast, bananas) until the symptoms settle.
• Avoid spicy, oily, or rich foods that may irritate the stomach.
• If diarrhea persists for more than 2–3 days, consult your doctor for further evaluation.

Headache

• Ensure you are getting enough rest and sleep each night.
• Drink plenty of fluids, as dehydration can make headaches worse.
• Try to stay in a quiet, dimly lit environment if the headache feels intense.
• If your doctor approves, you may use a mild pain reliever that is safe for you.
• Report persistent or severe headaches to your healthcare provider.

Nausea And Vomiting

• Take FEBUTAZ 40 after a light meal or snack, unless advised otherwise.
• Avoid strong smells or rich foods that might worsen nausea.
• Eat small, frequent meals instead of large ones.
• Sipping on ginger tea or sucking on mint lozenges may help reduce queasiness.
• If nausea interferes with daily activities, inform your doctor for further guidance.

Warning & Precautions

Pregnancy

Consult your doctor

It is not known whether Febuxostat could affect the growing baby. Consult your doctor before taking FEBUTAZ 40 TABLET if you are pregnant or think you may be pregnant.

Breastfeeding

Consult your doctor

It is not known whether Febuxostat could pass through the breast milk. Consult your doctor before taking FEBUTAZ 40 TABLET if you are a breastfeeding women.

Driving and Using Machines

Use with Caution

Do not drive or handle any heavy tools or machines if you experience blurred vision, dizziness, sleepiness or any other side effects that can affect your ability to concentrate while undergoing therapy with FEBUTAZ 40 TABLET.

Kidney

Use with Caution

FEBUTAZ 40 TABLET should be used with caution in patients with kidney diseases.

Liver

Use with Caution

FEBUTAZ 40 TABLET should be used with caution in patients with liver diseases.

Allergy

Contraindicated

Do not take FEBUTAZ 40 TABLET if you are allergic to Febuxostat or any other ingredients of this medicine.

Heart Disease

Use with Caution

FEBUTAZ 40 TABLET should be used with caution in patients with heart problems (such as heart failure).

Use In Pediatrics

Contraindicated

FEBUTAZ 40 TABLET is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data.

Other Warnings for FEBUTAZ 40 TABLET

Before taking FEBUTAZ 40 TABLET, inform your doctor if you:

• have high uric acid levels as a result of Lesch-Nyhan syndrome (a rare inherited condition in which there is too much uric acid in the blood)
• have thyroid problems

Safety Advice

Precautions to follow while taking FEBUTAZ 40

When using FEBUTAZ 40 Tablet (Febuxostat) it is important to follow certain precautions to ensure safe and effective use. This medicine is intended for uric acid regulation and specific health conditions may require closer monitoring.

• Inform your doctor about any history of liver, kidney or heart-related conditions before starting FEBUTAZ
• Do not stop or adjust the dose on your own. Follow your healthcare provider’s instructions strictly
• Take regular blood tests to monitor uric acid levels and liver function while on long-term therapy
• If you experience skin rashes, swelling or shortness of breath contact your doctor immediately
• Take FEBUTAZ at the same time each day for consistent results
• Avoid high-purine foods and alcohol which can reduce the effectiveness of the medication
• Pregnant or breastfeeding individuals should use this medicine only if advised by a healthcare professional

Heart Health Precautions While Taking FEBUTAZ

FEBUTAZ 40 has been associated with cardiovascular concerns in certain individuals, especially those with pre-existing heart disease. Monitoring and awareness are key to reducing any potential risk.

• Discuss any history of heart problems, such as chest pain, stroke, high blood pressure, or irregular heartbeat with your doctor before starting FEBUTAZ.
• Individuals with known cardiovascular disease may need an alternative treatment or additional monitoring
• Watch for symptoms like chest discomfort, dizziness, or unusual tiredness while on the medication and report them promptly
• Regular blood pressure and cholesterol monitoring may be recommended during treatment
• Maintain a heart-healthy lifestyle, including a balanced diet, physical activity, and stress management
• Do not skip follow-up visits, especially if you have a history of heart attack or stroke

Diet and Lifestyle Advice

Taking FEBUTAZ 40 Tablet is just one part of managing uric acid levels. A supportive diet and healthy lifestyle can improve outcomes and reduce the chances of sudden uric acid spikes.  

Dietary Recommendations:

1. Follow a low-purine diet:
Limit intake of high-purine foods such as red meat, organ meats (liver, kidney), sardines, anchovies, and shellfish.

2. Choose plant-based proteins:
Incorporate lentils, tofu, and beans in moderation. These are less likely to raise uric acid levels than animal proteins.

3. Increase fiber intake:
Whole grains, fresh fruits, and vegetables help in metabolism and support kidney function.

4. Stay well-hydrated:
Drink at least 8–10 glasses of water daily (unless advised otherwise). Hydration helps the kidneys flush out excess uric acid.

5. Limit alcohol consumption:
Especially avoid beer and spirits, as they may interfere with uric acid balance and reduce the effectiveness of FEBUTAZ.

6. Cut back on sugary beverages:
Avoid soft drinks and energy drinks with high fructose content, as they may raise uric acid levels.

Lifestyle Tips

1. Maintain a healthy weight:
Obesity is linked with increased uric acid levels. Gradual weight loss through proper diet and exercise is encouraged.

2. Exercise regularly:
Aim for at least 30 minutes of moderate activity (like brisk walking, swimming, or cycling) most days of the week. Avoid overexertion, which may trigger flare-ups in some cases.

3. Avoid crash diets or fasting:
These can raise uric acid levels suddenly and are not recommended while using FEBUTAZ.

4. Monitor your health:
Attend regular follow-ups for uric acid level checks, kidney function, and overall well-being.

How FEBUTAZ 40 Supports Safe Uric Acid Control in CKD Patients?

For patients with Chronic Kidney Disease (CKD), managing uric acid is crucial because elevated levels can put additional strain on already compromised kidneys. FEBUTAZ works by selectively inhibiting the enzyme responsible for uric acid production, helping maintain a balanced uric acid level.

What makes FEBUTAZ particularly useful for CKD patients is its unique metabolic pathway. Unlike some other uric acid regulators that rely heavily on kidney elimination, FEBUTAZ is primarily processed by the liver. This means it can be safer and more effective for patients with reduced kidney function, as the kidneys are less burdened during medication elimination.

Regular monitoring by healthcare providers is important when using FEBUTAZ in CKD patients to ensure optimal dosing and to avoid any potential side effects. Alongside medication, lifestyle and dietary adjustments play an important role in managing uric acid and supporting kidney health.

Differences Between FEBUTAZ and Other Uric Acid Regulators for Kidney Patients

Drug - Drug interaction

FEBUTAZ 40 Tablet may interact with certain medications, which could affect how either drug works or increase the risk of side effects. It is important to inform your doctor or pharmacist about all the medicines you are currently taking, including prescription drugs, over-the-counter products, vitamins or herbal supplements.

1. Azathioprine

• Interaction: Co-administration may lead to increased azathioprine toxicity, including bone marrow suppression.
• Management: Avoid using together. Alternative uric acid-lowering therapy may be recommended. Use only under close medical supervision with frequent blood count monitoring if necessary.

2. Mercaptopurine

• Interaction: FEBUTAZ may increase blood levels of mercaptopurine, raising the risk of severe toxicity (e.g., bone marrow suppression).
• Management: Contraindicated unless supervised in a specialized setting. Dose adjustment and strict monitoring may be needed if used together.

3. Theophylline

• Interaction: FEBUTAZ may increase serum theophylline levels, possibly intensifying its effects or side effects (e.g., tremors, insomnia, nausea).
• Management: Use with caution. Monitor theophylline levels if both drugs are needed. Watch for symptoms of theophylline toxicity.

4. Didanosine

• Interaction: May result in elevated Didanosine exposure when combined with FEBUTAZ
• Management: Avoid co-administration if possible. Consider dose adjustment or use of an alternative agent.

5. Warfarin and Other Vitamin K Antagonists

• Interaction: FEBUTAZ may slightly enhance the anticoagulant effect of warfarin, increasing bleeding risk.
• Management: Monitor INR (blood clotting test) more frequently when starting or adjusting FEBUTAZ in patients on warfarin. No dose change typically required unless INR fluctuates.

6. NSAIDs (e.g., Ibuprofen, Naproxen)

• Interaction: Concomitant use may increase the risk of kidney stress, especially in patients with pre-existing kidney concerns
• Management: Use the lowest effective NSAID dose. Ensure hydration and renal function monitoring, especially in long-term use

7. Rosiglitazone (Antidiabetics)

• Interaction: FEBUTAZ may increase plasma levels of rosiglitazone via CYP2C8 inhibition
• Management: Monitor blood glucose closely and consider adjusting the antidiabetic dose if needed

Drug - Food interaction

1. High-Purine Foods

(Examples: Red meat, organ meats, shellfish, anchovies, sardines, certain legumes)

• Interaction: These foods may contribute to increased uric acid levels, which may counteract the benefits of FEBUTAZ.
• Management: Patients are advised to follow a low-purine diet as recommended by their doctor or dietitian to support uric acid control.

2. Caffeine (Coffee, Energy Drinks)

• Interaction: Excessive caffeine may dehydrate the body, which can potentially trigger uric acid imbalances.
• Management: Stay adequately hydrated. Moderate caffeine consumption is typically safe unless advised otherwise by a healthcare provider.

Synopsis

More Information

FAQs About FEBUTAZ 40 TABLET

References

1. KD. Tripathi. Essentials of Medical Pharmacology. 7th Edition. Anti-rheumatoid and Anti-gout agents. Page-217.

2. Febuxostat. National Library of Medicine. National Center for Biotechnology Information. StatPearls. [Revised in May 2024]. [Accessed on 20th May 2025] 

3. Febuxostat 80 mg film-coated tablets and Febuxostat 120 mg film-coated tablets. Rivopharm. EMC. UK. [Revised in April 2023]. [Accessed on 20th May 2025] 

4. Febuxostat Tablets 40 mg. Skybiotech Life Sciences Private Limited. [Revised in April 2023]. [Accessed on 20th May 2025] 

Useful Diagnostic Tests

• Uric Acid - Serum
• Basic Arthritis Care

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Srikar Modepu - MBBS, MD (Diabetology)

Last updated on 21 May 2025 | 12:28 PM(IST)