FEBURIC 40mg Tablet 15's

Introduction About FEBURIC 40MG TABLET

Feburic 40mg tablet is a prescription medication formulated for managing elevated uric acid levels commonly associated with gout and related conditions. Gout is a form of arthritis caused by the buildup of uric acid crystals in the joints, leading to intense pain, swelling, and inflammation. Feburic contains febuxostat, a potent xanthine oxidase inhibitor that effectively reduces the production of uric acid in the body. This medication is particularly beneficial for adults who have not responded well to allopurinol or cannot take it due to intolerance or side effects.

Feburic 40mg is ideal for patients diagnosed with gout, hyperuricemia, or uric acid nephrolithiasis, and those at risk of tumour lysis syndrome due to rapid cell breakdown. It is typically taken once daily, with or without food, and should be swallowed whole with water. Consistency in dosing time and adherence to the prescribed regimen are essential for optimal control of uric acid levels and prevention of gout flare-ups. Patients are advised to maintain adequate hydration and follow lifestyle recommendations, such as a low-purine diet, to enhance treatment efficacy.

Before starting Feburic, patients should inform their healthcare provider about existing kidney, liver, or heart conditions and any allergies to febuxostat or allopurinol. This medication is not recommended for use during pregnancy or breastfeeding due to insufficient safety data. Patients should use caution when driving or operating machinery until they understand how Feburic affects them, as dizziness and drowsiness possible side effects. Regular monitoring of liver function and uric acid levels is recommended during therapy to detect adverse reactions early.

Common side effects of Feburic 40mg include nausea, dizziness, skin rash, headache, and gastrointestinal discomfort. More serious but rare adverse effects include liver problems, severe allergic reactions, or heart-related symptoms, which require immediate medical attention. Patients experiencing any unusual symptoms or side effects should contact their healthcare provider promptly. With proper use under medical supervision, Feburic 40mg can significantly improve quality of life by reducing gout attacks and managing uric acid levels effectively.

Uses Of FEBURIC 40MG TABLET

• Management of gout and hyperuricemia (increased uric acid levels in the body) in adults

Benefits of FEBURIC 40MG TABLET

Feburic 40mg tablet for Hyperuricemia treatment

Hyperuricemia is a condition characterized by excessive uric acid in the blood, which can lead to gout and kidney problems. Feburic 40mg tablet is prescribed for lowering uric acid levels effectively by selectively inhibiting xanthine oxidase, the enzyme responsible for uric acid production. Controlling hyperuricemia with Feburic helps reduce uric acid crystal deposition and related complications. Doctors may monitor uric acid levels regularly during treatment to ensure optimal results and adjust dosages if necessary.

Feburic 40mg tablet for gout management

Feburic 40mg tablet is used to manage gout, a painful form of arthritis caused by high levels of uric acid in the blood. The active ingredient, febuxostat, works by inhibiting the enzyme xanthine oxidase, which is responsible for producing uric acid. By reducing uric acid levels, Feburic helps prevent the formation of uric acid crystals in joints and tissues, thereby lowering the risk of painful gout attacks and inflammation. Regular use under medical supervision can reduce the frequency and severity of gout flares and protect joint health over time.

Feburic 40mg tablet for Uric acid nephrolithiasis

Uric acid nephrolithiasis refers to kidney stones caused by high concentrations of uric acid in the urine. Feburic 40mg lowers serum uric acid levels by blocking the enzyme that forms uric acid, thus reducing the amount that can crystallize and form stones. By maintaining uric acid in a soluble form, Feburic helps prevent the formation of these stones and supports kidney health. This medication is often recommended as part of a broader management plan that includes hydration and dietary changes to reduce stone risk.

Feburic 40mg tablet for Tumour lysis syndrome

Tumour lysis syndrome (TLS) occurs when large numbers of cancer cells die rapidly, releasing uric acid into the bloodstream, which can cause kidney damage. Feburic 40mg helps manage uric acid levels in TLS by reducing uric acid production, minimizing the risk of uric acid crystallization and kidney injury. It is used as part of supportive care during cancer treatment to protect kidney function. Feburic’s ability to quickly lower serum uric acid makes it beneficial in acute settings like TLS under close medical supervision.

How FEBURIC 40MG TABLET Works

Feburic 40mg Tablet Mechanism

Feburic 40mg contains febuxostat, which works by selectively blocking the enzyme xanthine oxidase. This enzyme helps produce uric acid in the body. By inhibiting it, Feburic reduces uric acid levels in the blood, helping prevent the buildup of uric acid crystals that cause gout and related problems. This targeted action makes it effective for managing high uric acid and gout symptoms safely.

How to use FEBURIC 40MG TABLET

How to take Febuxostat 40mg

• Take one 40mg tablet of Feburic once daily, at the same time each day for best results.
• You may take it with or without food according to your preference or doctor’s advice.
• Swallow the tablet whole with a glass of water; do not crush or chew it.
• Continue taking the medication regularly even if you feel better to prevent gout attacks.
• Your doctor may adjust your dose to 80mg once daily if uric acid levels are not adequately controlled after two weeks.
• Avoid skipping doses; if you miss one, take it as soon as you remember unless it’s close to the next dose do not double dose.
• Drink plenty of water daily to help reduce uric acid and support kidney health.
• Regular blood tests may be necessary to monitor liver function and uric acid levels during treatment.
• Consult your doctor immediately if you experience severe side effects or symptoms of liver issues.
• Do not stop taking Feburic without consulting your healthcare provider, even if symptoms improve.

What if I forgot to take FEBURIC 40MG TABLET

• If you miss a dose of Feburic 40mg Tablet, take it as soon as you remember.
• If it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule
• Do not take two tablets together to make up for the missed dose.
• Missing doses regularly can reduce the effectiveness of the medicine in controlling uric acid levels.
• Try to take the tablet at the same time every day to help you remember better.

Overdose

If an overdose of Feburic 40mg tablet occurs, seek immediate medical advice from your doctor without delay. Prompt consultation is important to ensure appropriate care and management.

Side Effects Of FEBURIC 40MG TABLET

Common side effects of Feburic 40mg tablet:

• Diarrhoea
• Headache
• Skin rashes
• Increased liver enzymes detected in blood tests
• Nausea
• Increase in gout symptoms
• Edema (Localized swelling due to fluid retention)
• tiredness

When to Seek Medical Attention?

Stop taking Feburic 40mg tablet and inform your doctor immediately, if you experience any of the following side effects:

• Severe allergic reactions (such as skin rashes, blisters, nodules, itching, swelling of limbs and face, difficulties in breathing, fever, enlargement of lymph nodes)
• Stevens-Johnson-Syndrome (symptoms include reddish target-like spots or circular patches often with central blister on the trunk, ulcers in the mouth, throat, nose, genitals and conjunctivitis, with widespread blistering or peeling of the skin)
• Severe muscle cramps

How To Manage Side Effects

Headache

• Stay Hydrated: Dehydration is a common cause of headaches. Drink enough water throughout the day and avoid excess caffeine or alcohol.
• Cold or Warm Compress: Apply a cold pack on your forehead for tension or migraine-type headaches. Use a warm compress or heating pad on the back of the neck for stress-related headaches.
• Rest in a Quiet, Dark Room: Bright light and noise can worsen headaches. Resting in a calm, dark room often helps reduce discomfort.
• Massage and Relaxation: Gently massage your temples, neck, and shoulders to ease tension. Practice deep breathing, yoga, or meditation for relaxation.
• Ginger Tea: Ginger has natural anti-inflammatory properties that may reduce headache pain. Drink a cup of warm ginger tea for soothing relief.
• Peppermint Oil or Balm: Applying diluted peppermint oil on the temples or forehead can give a cooling effect. This may help in reducing tension headaches.
• Follow a Regular Sleep Schedule: Poor or irregular sleep often triggers headaches. Maintain a consistent bedtime and avoid late-night screen use.

Skin rash Or Itching

• Cold Compress: Apply a clean, cold, damp cloth or ice pack wrapped in a towel to the rash for 10–15 minutes. This helps reduce itching, swelling, and redness.
• Aloe Vera Gel: Fresh aloe vera has cooling and healing properties. Apply a thin layer to the rash area to soothe irritation.
• Oatmeal Bath: Add a cup of finely ground oatmeal to lukewarm bath water. Soaking in it for 15–20 minutes helps calm itching and inflammation.
• Coconut Oil: Virgin coconut oil works as a natural moisturizer. It can soothe dry, irritated skin and reduce mild redness.
• Chamomile or Green Tea Compress: Soak a cloth in cooled chamomile or green tea and apply to the rash. This can relieve irritation and promote skin healing.
• Avoid Irritants: Do not use strong soaps, detergents, or perfumes on the affected area. Wear loose cotton clothing to avoid friction and sweating.
• Keep Skin Moisturized: Apply gentle, fragrance-free moisturizers to prevent dryness. Hydrated skin heals faster and itches less.

Tiredness

• Get Adequate Sleep: Aim for 7–9 hours of good-quality sleep each night. Keep a regular sleep schedule and avoid late-night screen use.
• Stay Hydrated: Dehydration can cause tiredness and weakness. Drink plenty of water throughout the day and limit sugary or caffeinated drink
• Balanced Diet: Eat meals rich in whole grains, fruits, vegetables, and lean protein. Avoid processed foods, excess sugar, and heavy meals that can make you sluggish.
• Light Physical Activity: Short walks, stretching, or yoga can improve blood circulation and energy levels. Avoid over-exercising, which can worsen fatigue.
• Manage Stress: Practice deep breathing, meditation, or relaxation exercises. Stress can contribute to both physical and mental tiredness.
• Limit Caffeine Late in the Day: Caffeine in the afternoon or evening can disturb sleep and increase fatigue the next day.
• Take Short Breaks During Work: Avoid sitting for long hours. Stand, stretch, or walk for a few minutes every hour to stay refreshed.

Warning & Precautions

Pregnancy

Contraindicated

Do not use Feburic 40mg tablet if you are pregnant or suspect you might be, as it is unknown whether this medication could impact the developing baby. Always consult a healthcare professional before use during pregnancy.  

Breastfeeding

Contraindicated

Since it is not known if Feburic passes into breast milk, avoid using this tablet while breastfeeding unless advised by a medical expert.

Driving and Using Machines

Use with Caution

Exercise caution when driving or handling heavy machinery if you experience symptoms such as blurred vision, dizziness, sleepiness, or any other side effects that may impair concentration during treatment with Feburic 40mg.

Kidney

Use with Caution

Use Feburic 40mg with caution if you have kidney disease. It is essential to consult your doctor for personalized advice before starting this medication.

Liver

Use with Caution

Caution is advised for patients with liver disorders. Seek medical guidance from your physician prior to taking Feburic 40mg.

Allergy

Contraindicated

Do not take Feburic 40mg if you have a known allergy to Febuxostat or allopurinol

Heart Disease

Use with Caution

Consult your doctor before use if you have a history of heart problems, including heart failure, as special precautions may be required.

Use In Pediatrics

Contraindicated

Feburic 40mg is not recommended for children and adolescents under 18 years old due to insufficient safety information. Please consult a healthcare provider before use in this age group.

Other Warnings for FEBURIC 40MG TABLET

Before taking Feburic 40mg tablet, inform your doctor if you:

• have high uric acid levels as a result of Lesch-Nyhan syndrome (a rare inherited condition in which there is too much uric acid in the blood)

Safety Advice

• Take Regular Blood Tests:  Periodic monitoring of liver function, kidney function, and uric acid levels is important while on Feburic.
• Avoid Self-Medication: Do not combine with other uric acid-lowering medicines without your doctor’s approval.
• Watch for Allergic Reactions:  Stop taking the tablet and seek medical attention if you notice severe rash, itching, or swelling.
• Start Slowly if Needed:  For some patients, doctors may start at a lower dose and increase gradually to reduce side effects.
• Report Flare-Ups:  Sometimes gout attacks can temporarily worsen at the start; inform your doctor rather than stopping the medicine.
• Avoid High-Purine Supplements:  Supplements like yeast extract or high-protein powders may interfere with uric acid control.
• Inform Before Surgery:  Let your surgeon or dentist know you are taking Feburic, as it may affect certain blood tests or medications used during procedures.
• Store Safely:  Keep the medicine in its original packaging to protect from moisture and contamination.

Diet and Lifestyle Advice

• Follow a Low-Purine Diet: Reduce foods that are high in purines, such as red meat, organ meats (liver, kidney), sardines, mackerel, and anchovies. Choose lean meats, eggs, low-fat dairy, and plant-based proteins instead.
• Stay Hydrated: Drink at least 8–10 glasses of water daily to help flush uric acid from your body. Avoid sugary drinks and sodas, as they can increase uric acid levels.
• Maintain a Healthy Weight: Overweight and obesity increase uric acid levels and gout risk. Combine a balanced diet with regular physical activity to achieve and maintain a healthy weight.
• Include Anti-Inflammatory Foods: Eat foods like berries, cherries, citrus fruits, green leafy vegetables, and omega-3-rich foods (like flaxseeds and walnuts) to support joint health.
• Moderate Caffeine Intake: Small amounts of coffee or tea are generally safe but avoid excessive consumption that may cause dehydration.
• Regular Physical Activity: Engage in light-to-moderate exercises such as walking, swimming, or yoga. Avoid high-impact exercises during a gout flare-up to prevent joint stress.
• Monitor Symptoms and Flare-Ups: Keep a diary of foods, drinks, and activities that trigger symptoms. Share this information with your doctor to adjust treatment and lifestyle guidance.
• Avoid Crash Diets or Fasting: Rapid weight loss or prolonged fasting can temporarily increase uric acid and trigger attacks. Focus on gradual, sustainable dietary changes.

1. Feburic 40mg Tablet vs. Allopurinol for uric acid control

2. Feburic 40mg Tablet and Uloric Tablet

Drug - Drug interaction

1. Azathioprine

• Interaction: Taking Feburic with azathioprine can significantly increase the levels of azathioprine in the body, leading to serious side effects like low blood counts.
• Management: This combination is not recommended. Your doctor may suggest an alternative uric acid-lowering medicine instead.

2. Mercaptopurine

• Interaction: Feburic can increase mercaptopurine levels, causing harmful effects on the bone marrow.
• Management: Avoid using both medicines together. If necessary, your doctor will monitor blood counts very closely or suggest another option.

3. Theophylline

• Interaction: Feburic may increase the concentration of theophylline, a medicine used for asthma or breathing problems. This can raise the risk of side effects like nausea, irregular heartbeat, or seizures.
• Management: If both medicines must be used, your doctor may adjust the dose of theophylline and monitor closely.

4. Anti-cancer medicines (e.g., Cyclophosphamide)

• Interaction: Feburic may interfere with the metabolism of certain chemotherapy drugs, possibly leading to more side effects.
• Management: Doctors generally avoid combining them or take extra precautions by monitoring blood tests.

5. Blood thinners (e.g., Warfarin)

• Interaction: Feburic may slightly increase the effect of warfarin, raising the risk of bleeding.
• Management: If you are on warfarin, your doctor will monitor your blood clotting tests (INR) more often when starting Feburic.

6. Heart medicines (e.g., Rosuvastatin, Atorvastatin, or other statins)

• Interaction: Feburic can increase the level of certain cholesterol-lowering medicines in the blood, possibly raising the risk of muscle pain or weakness.
• Management: Dose adjustment of statins or regular monitoring may be required. Report any unusual muscle symptoms to your doctor.

7. Painkillers (NSAIDs like Ibuprofen, Naproxen)

• Interaction: These are often used during gout flare-ups. Although safe with Feburic, using them for a long time may affect the kidneys.
• Management: Short-term use is usually fine, but long-term use should be guided by your doctor, especially if you have kidney problems.

Drug - Food interaction

1. High-purine foods (red meat, organ meat, seafood)

• Interaction: These foods increase uric acid production, making the medicine less effective.
• Management: Reduce intake of foods like liver, kidney, sardines, anchovies, and red meat. Choose lean proteins like chicken or plant-based options.

2. Sugary drinks (colas, sweetened juices, energy drinks)

• Interaction: Fructose-rich drinks raise uric acid levels and may counteract Feburic’s benefits.
• Management: Replace sugary drinks with water, herbal teas, or unsweetened beverages to support uric acid control.

3. Caffeine (coffee, tea, energy drinks)

• Interaction: Excess caffeine may contribute to dehydration, which can worsen gout symptoms.
• Management: Moderate caffeine intake is generally safe, but make sure to drink enough water throughout the day.

4. Low-fluid intake

• Interaction: Not drinking enough water can reduce uric acid excretion and increase gout flare-ups.
• Management: Drink 8–10 glasses of water daily to help flush out uric acid and improve Feburic’s effectiveness.

5. High-fat foods (fried items, processed snacks, full-fat dairy)

• Interaction: High-fat meals may slow medicine absorption and also worsen uric acid levels.
• Management: Prefer light, balanced meals with more fruits, vegetables, and whole grains to support overall health.

Synopsis

More Information

FAQs About FEBURIC 40MG TABLET

References

1. KD. Tripathi. Essentials of Medical Pharmacology. 7th Edition. Anti-rheumatoid and Anti-gout agents. Page-217.

2. Febuxostat. National Library of Medicine. National Center for Biotechnology Information. StatPearls. [Revised in May 2024]. [Accessed on 23rd September 2025]

3. Febuxostat 80 mg film-coated tablets and Febuxostat 120 mg film-coated tablets. Rivopharm. EMC. UK. [Revised in April 2023]. [Accessed on 23rd September 2025]

4. Febuxostat Tablets 40 mg. Skybiotech Life Sciences Private Limited. [Revised in April 2023]. [Accessed on 23rd September 2025]

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Author Details

Written By Srilekha. R - B.Pharm

Reviewed For Accuracy By Dr. Srikar Modepu - MBBS, MD (Diabetology)

Last updated on 23 Aug 2024 | 04:34 PM(IST)