Febrex Plus Delicious Rose Flavour Syrup 60ml

Introduction About FEBREX PLUS SYRUP

FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP is a combination of Chlorpheniramine, Paracetamol and Phenylephrine which belongs to the group of medicines called Antihistamines, Analgesics and Nasal decongestants respectively.

 It is used to relieve the symptoms of allergic rhinitis (hay fever), common cold, other upper respiratory allergies, like headache, facial congestion and pressure, nasal congestion, runny nose, sneezing, minor aches and pains, itching of the nose, throat, or eyes, and watery eyes. It can also be used as an adjunct with antibiotics in sinusitis, tonsillitis, and otitis media.

FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP is not recommended for use in children (aged less than 2 months). Before taking FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP, inform your doctor if you have any kidney, liver, heart, thyroid, or lung problems, diabetes, or glaucoma. FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP should be used with caution in pregnant and breastfeeding women, so consult your doctor before taking it.

Common  side effects of taking FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP are vomiting, nausea, allergic reaction, sleepiness, and headache. Contact your doctor if any of the above side effects worsen.

Uses Of FEBREX PLUS SYRUP

It is used:

• to relieve the symptoms of allergic rhinitis, common cold, or other upper respiratory allergies
• as an adjunct with antibiotics in sinusitis, tonsillitis and otitis media

Benefits of FEBREX PLUS SYRUP

1. Helps Reduce Fever

The Paracetamol component supports effective temperature control, helping bring down fever and restore comfort.

2. Provides Relief from Nasal Congestion

Phenylephrine helps shrink swollen nasal passages, easing blocked nose and improving airflow.

3. Reduces Cold-Related Discomfort

Helps minimize head heaviness, sinus pressure, and general discomfort associated with upper respiratory congestion.

4. Controls Allergic Symptoms

Chlorpheniramine helps reduce excessive sneezing, runny nose, watery eyes, and itching, improving overall comfort.

5. Supports Better Breathing

By reducing nasal obstruction and swelling, the medicine helps children breathe more easily, especially during sleep.

6. Provides Multi-Symptom Relief in a Single Dose

Addresses fever, congestion, and allergy symptoms together, reducing the need for multiple medicines when medically appropriate.

7. Formulated in Child-Friendly Suspension Form

The liquid form makes it easier for children to swallow, ensuring accurate dose measurement and better acceptance.

How FEBREX PLUS SYRUP Works

1. Paracetamol (Acetaminophen): How It Works

• Central Analgesic Action:
  Paracetamol works mainly in the brain and spinal cord, where it inhibits cyclooxygenase (COX) enzymes involved in the formation of prostaglandins—chemicals responsible for pain and fever signaling.
• Fever-Reducing Effect (Antipyretic):
  It resets the hypothalamic thermostat in the brain, helping the body regulate temperature more efficiently.
  This leads to gradual cooling via increased heat loss (e.g., sweating, vasodilation).
• No Significant Anti-inflammatory Effect:
  Unlike NSAIDs, it does not strongly act on peripheral COX enzymes.

2. Phenylephrine Hydrochloride: How It Works

• Selective Alpha-1 Adrenergic Receptor Agonist:
  It activates α1-receptors in the blood vessels of the nasal mucosa.
• Vasoconstriction Effect:
  Tightens swollen blood vessels inside the nose → reduces fluid leakage → helps shrink nasal congestion.
• Restores Airflow Through the Nasal Passage:
  Decreases swelling and opens nasal airways by reducing blood flow to inflamed nasal tissues.

3. Chlorpheniramine Maleate (CPM): How It Works

• Histamine H1 Receptor Blocker:
  CPM blocks histamine from attaching to H1 receptors in nasal passages, throat, and eyes.
• Reduces Allergic Response:
  ↓ sneezing
  ↓ runny nose
  ↓ watery eyes
  ↓ itching
• Sedative Antihistamine Effect:
  CPM crosses the blood–brain barrier → causes mild drowsiness in some children (a class effect of older antihistamines).

How to use FEBREX PLUS SYRUP

1. How to Administer

• Shake the bottle well before every use to ensure uniform mixing.
• Use the provided measuring cup, dropper, or oral syringe for accurate dosing.
• Give the dose by mouth, directly or mixed with a small amount of water (if advised).

2. When to Give the Dose

• Follow the schedule recommended by the doctor (usually given at evenly spaced intervals).
• Do not exceed the prescribed number of doses in 24 hours.

3. Important Usage Instructions

• Do not give along with other paracetamol-containing products unless a doctor confirms safety.
• Avoid combining with other cold/cough syrups, as ingredient overlap is common.
• Ensure the child stays well hydrated during the course.
• Keep track of doses in a daily medication chart to avoid accidental overuse.

What if I forgot to take FEBREX PLUS SYRUP

• Give the missed dose as soon as you remember.
• If it is almost time for the next dose, skip the missed dose.
• Do not double the dose to make up for a missed one.

Overdose

If you or anyone else accidentally took too much of FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP, contact your doctor immediately or visit nearby hospital.

Side Effects Of FEBREX PLUS SYRUP

Common

• nausea
• sleepiness
• headache

When to consult a doctor?

• allergic reactions (skin rash, itching, hives, swollen face, lips, or tongue)
• breathing problems
• vision changes
• cold, clammy skin
• dizziness
• increased heart rate, irregular heartbeat
• high blood pressure
• hallucinations, fits, shaking
• trouble urinating or change in the amount of urine
• extreme tiredness
• vomiting
• pain or cough gets worse
• fever worsening
• cough comes back or occurs with rash or headache that persists
• redness or swelling

Warning & Precautions

Pregnancy

Consult your doctor

FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP should be used in pregnant women only if considered clearly necessary by your doctor. Consult your doctor before taking it.

Breastfeeding

Consult your doctor

FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP should be used in breastfeeding women only if considered clearly necessary by your doctor. Consult your doctor before taking it.

Driving and Using Machines

Use with Caution

Do not drive or use any machines during management with FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP. Consult your doctor for advice.

Alcohol

Consult your doctor

Avoid consumption of alcohol with FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP. It should be used with caution in patients with alcohol dependence. Consult your doctor before taking FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP.

Kidney

Use with Caution

FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP should be used with caution in patients having kidney dysfunction and urinary retention. Consult your doctor before taking it.

Liver

Consult your doctor

FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP is not recommended for use in patients with liver insufficiency, failure or active liver disease. FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP should be used with caution in patients with liver dysfunction. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP if you are allergic to Chlorpheniramine, Paracetamol, Phenylephrine, or any other ingredients of this medicine.

Lungs

Use with Caution

FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP should be used with caution in patients with chronic bronchitis, asthma, bronchiectasis, and cough that lasts long, or that occurs with too much phlegm. Consult your doctor before taking it.

Heart Disease

Contraindicated

FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP is not recommended in patients with severely high blood pressure or any other cardiovascular problems. Consult your doctor before taking it.

Use In Pediatrics

Consult your doctor

FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP is not recommended for use in children (aged less than 2 years). Your doctor will prescribe the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before taking it.

Use In Geriatrics

Use with Caution

FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP should be used with caution in elderly patients as they may be at a greater risk of getting side effects. Consult your doctor before taking it.

Other Warnings for FEBREX PLUS SYRUP

Before taking FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP, inform your doctor if you:

• have intestinal obstruction
• smoke or consume tobacco

Who should not take FEBREX PLUS SYRUP

FEBREX PLUS DELICIOUS ROSE FLAVOUR SYRUP is not recommended for use if you have:

• diabetes
• overactive thyroid
• a condition in which there is increased pressure inside your eye
• seizures
• an enlarged prostate gland
• phaeochromocytoma (a tumor in adrenal gland)
• a blood clot that obstructs a vein

Drug - Drug interaction

1. Interactions Related to Paracetamol

a) Medicines That Increase Liver Toxicity

These may heighten the risk of liver strain when taken with paracetamol:

• Anti-tuberculosis medicines (e.g., isoniazid)
• Certain anti-seizure medicines (e.g., phenytoin, carbamazepine)
• Rifampicin
• Barbiturates
• Chronic alcohol-containing formulations

b) Blood Thinners

• Warfarin and other anticoagulants may have enhanced bleeding tendency with frequent paracetamol use.

2. Interactions Related to Phenylephrine

a) Antidepressants

• MAO inhibitors (MAOIs): May cause severe increase in blood pressure when combined with phenylephrine.
• Tricyclic antidepressants (TCAs): May increase phenylephrine’s effect on heart rate and BP.

b) Medicines for High Blood Pressure

• Beta-blockers
• Other antihypertensive agents
  These may interfere with phenylephrine’s activity and lead to blood pressure changes.

c) Other Nasal Decongestants

• Oxymetazoline
• Xylometazoline
• Pseudoephedrine
  Using additional stimulatory decongestants can intensify cardiovascular stimulation and raise BP.

3. Interactions Related to Chlorpheniramine Maleate

a) Sedative Medicines

These may increase drowsiness:

• Benzodiazepines
• Sleep medications
• Opioid analgesics
• Certain antipsychotics

b) Other Antihistamines

Can increase drowsiness, dry mouth, and reduced alertness.

c) Medicines With Anticholinergic Effects

• Some antidepressants
• Antipsychotics
• Bladder relaxants
  Using together may intensify dry mouth, blurred vision, constipation, or urinary retention.

4. Alcohol-Containing Medicines

Combination may increase sedation (due to chlorpheniramine) and raise liver strain (due to paracetamol).

5. Enzyme-Inducing Medicines

Drugs that increase liver enzyme activity may reduce paracetamol’s effectiveness and increase formation of toxic metabolites:

• Phenytoin
• Carbamazepine
• Phenobarbital

Synopsis

More Information

1. Unique Insights Into Its Formulation

a) Triple-Action Symptom Management

Although each ingredient has its own pharmacological classification, the combination is designed to address fever, nasal congestion, and allergic components of common colds in a coordinated manner. This helps improve comfort in children experiencing multiple overlapping symptoms.

b) Paediatric-Specific Suspension Design

• This formulation provides higher concentration per mL, reducing the volume required per dose.
• This is particularly useful in children who struggle with larger dosing volumes.
• The suspension base helps ensure uniform dispersion of ingredients to achieve consistent dosing accuracy when shaken properly.

c) Taste-Masking Technology

Many paediatric suspensions apply taste-masking to improve acceptance, ensuring the child does not reject or spit out the dose, which can affect the therapeutic response.

2. Pharmacological Depth (Beyond Standard Explanations)

a) Paracetamol

• Works centrally within the hypothalamus where it modulates the COX-enzymes involved in prostaglandin synthesis, helping regulate body temperature.
• Unlike NSAIDs, it does not significantly affect peripheral prostaglandin activity, making it gentler on the stomach.

b) Phenylephrine

• Acts on α-1 adrenergic receptors in nasal blood vessels, reducing local swelling.
• This vasoconstriction helps restore airflow in irritated nasal mucosa.
• It also avoids sedation, making it suitable for daytime symptom management.

c) Chlorpheniramine Maleate

• Blocks H1-histamine receptors, reducing sneezing, tearing, runny nose, and itching.
• Its mild sedative effect can help calm irritability in some children, especially at nighttime.

3. Clinical Context and Practical Usage Insights

a) Role in Pediatric Symptom Clusters

Children often present with fever + runny nose + congestion simultaneously.
Febrex Plus Delicious Rose Flavour Syrup simplifies symptom relief by combining multiple ingredients, reducing the need for separate medicines.

b) Importance of Using a Child-Specific Dropper or Syringe

To avoid overdose in paediatric care:

• Use the proper measuring syringe, not household spoons.
• Shake the bottle well to evenly distribute active ingredients.

c) Therapeutic Window Awareness

Each component has a different peak onset:

• Paracetamol peaks in 30–60 minutes.
• Phenylephrine provides congestion relief within 15–30 minutes.
• Chlorpheniramine effects start within 30 minutes and last longer.

Understanding this helps caregivers know which symptoms may improve first.

FAQs About FEBREX PLUS SYRUP

References

1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Allergic Rhinitis. Pharmacotherapy Handbook. Ninth edition. Page- 813.

2. Kiran, M., Vakharia, M., Pawaskar, L., & Sheikh, S. Efficacy and safety of a fixed dose combination of paracetamol, chlorpheniramine maleate and phenylephrine in management of common cold: a phase IV, open-labelled, multi-centric study. International Journal of Basic & Clinical Pharmacology. 2018. [Accessed on 13th May 2026]

3. PubChem Compound Summary for CID 2725, Chlorpheniramine. National Center for Biotechnology Information. June 2022. [Accessed on 13th May 2026]

4. Centaur Pharma. Chlorpheniramine + Paracetamol + Phenylephrine. [Accessed on 13th May 2026]

5. Pharmasynth Formulation Ltd. Chlorpheniramine + Paracetamol + Phenylephrine. [Accessed on 13th May 2026]

6. Zuventus Healthcare Ltd. Chlorpheniramine + Paracetamol + Phenylephrine. [Accessed on 13th May 2026]

7. Ticoma Pharmacia. Chlorpheniramine + Paracetamol + Phenylephrine. [Accessed on 13th May 2026]

8. Wellona Pharma. Chlorpheniramine + Paracetamol + Phenylephrine. [Accessed on 13th May 2026]

9. Comed Chemicals. Chlorpheniramine + Paracetamol + Phenylephrine. [Accessed on 13th May 2026]

10. Kepler healthcare Pvt. Ltd. Chlorpheniramine + Paracetamol + Phenylephrine. [Accessed on 13th May 2026] 

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Rajnikant - MBBS, MD (Physiology)

Last updated on 13 May 2026 | 11:04 AM(IST)