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Introduction About EXAPRIDE 250 Y CARTRIDGE
EXAPRIDE 250 Y CARTRIDGE contains Exenatide which belongs to the group of medicines called Antihyperglycemic agents. It is used to manage blood sugar levels in adults with type 2 diabetes in combination with metformin and sulfonylurea, when metformin or sulfonylurea plus diet and exercise have failed to adequately control blood sugar levels. EXAPRIDE 250 Y CARTRIDGE is also used to improve blood sugar control in adults with type 2 diabetes in combination with insulin glargine (with or without metformin) when insulin glargine (with or without metformin) plus diet and exercise have failed to adequately control blood sugar levels.
Avoid taking meals before receiving EXAPRIDE 250 Y CARTRIDGE. This medicine is not recommended if you have diabetic ketoacidosis and type 1 diabetes. Before receiving EXAPRIDE 250 Y CARTRIDGE, inform your doctor if you have or had severe problems with stomach (gastroparesis), severe vomiting, diarrhea, dehydration or a history of pancreatitis. There are no adequate and well-controlled studies of EXAPRIDE 250 Y CARTRIDGE use in pregnant women. Hence it should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. This medicine should be administered with caution in breastfeeding women.
The most common side effects of receiving EXAPRIDE 250 Y CARTRIDGE are nausea, vomiting, diarrhea, feeling jittery, dizziness, headache, acid stomach, heartburn and injection site reactions (rash, itching, bruising). Consult your doctor if any of the above side effects persists for a longer duration.
Uses Of EXAPRIDE 250 Y CARTRIDGE
- It is used to manage blood sugar levels in adults with type 2 diabetes in combination with metformin, sulfonylurea and insulin glargine (with or without metformin), when metformin, sulfonylurea, insulin glargine, diet and exercise have failed to adequately control blood sugar levels
How EXAPRIDE 250 Y CARTRIDGE Works
EXAPRIDE 250 Y CARTRIDGE is a GLP-1 receptor agonist that mimics several antihyperglycemic actions of incretins. This stimulates in vivo secretion of insulin from pancreatic beta cells by mechanisms involving cyclic AMP and or other intracellular signaling pathways. Hence EXAPRIDE 250 Y CARTRIDGE improves glycemic control by reducing fasting and postprandial glucose concentrations in patients with type 2 diabetes.
How to use EXAPRIDE 250 Y CARTRIDGE
EXAPRIDE 250 Y CARTRIDGE will be administered under the skin (as subcutaneous injection) in your upper leg (thigh), stomach area (abdomen), or upper arm by your doctor or nurse. It will not be administered into a vein or muscle. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Side Effects Of EXAPRIDE 250 Y CARTRIDGE
Common
- nausea
- vomiting
- diarrhea
- feeling jittery
- dizziness
- headache
- acid stomach, heartburn
- injection site reactions (rash, itching, bruising)
- hypoglycaemia
Uncommon
- decreased kidney function
- dehydration, generally associated with nausea, vomiting and/or diarrhoea
- unusual taste in the mouth
- burping
- sleepiness
- hair loss
- weight decreased
- delay in the emptying of the stomach
- inflamed gallbladder
- gallstones
Rare
- intestinal obstruction (blockage in intestine)
Stop receiving EXAPRIDE 250 Y CARTRIDGE and contact your doctor immediately if you experience any of the following side effects such as:
- severe allergic reactions (swelling of the face, tongue or throat, rashes, itching and rapid swelling of the tissues of the neck, face, mouth or throat, difficulty to swallow, hives and difficulties to breathe)
- severe and persistent stomach pain, with or without vomiting (inflammation of the pancreas)
How To Manage Side Effects
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Consult your doctor if your headache worsens.
Nausea And Vomiting
Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your vomiting worsens.
Warning & Precautions
Pregnancy
Consult your doctorThere are no adequate and well-controlled studies of EXAPRIDE 250 Y CARTRIDGE use in pregnant women. It should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus.
Breastfeeding
Use with CautionEXAPRIDE 250 Y CARTRIDGE should be used with caution if you are a breastfeeding woman. Consult your doctor before receiving the medicine.
Driving and Using Machines
Use with CautionEXAPRIDE 250 Y CARTRIDGE has minor influence on the ability to drive and use machines. When it is used in combination with a sulphonylurea, it may cause hypoglycaemia.
Alcohol
Consult your doctorTell your doctor if you have a history of alcoholism.
Kidney
Consult your doctorEXAPRIDE 250 Y CARTRIDGE is not recommended for use if you have severe kidney disease or are on dialysis. It should be used with caution if you have or had kidney disorder or kidney transplant. Consult your doctor for advice.
Allergy
ContraindicatedDo not receive EXAPRIDE 250 Y CARTRIDGE if you are allergic to Exenatide or any other ingredients of this medicine.
Heart Disease
Use with CautionEXAPRIDE 250 Y CARTRIDGE should be used with caution if you have or had current or history of heart failure, heart disease, angina, heart rhythm disturbances, myocardial infarction or high heart rate (fast pulse). Consult your doctor for advice.
Use In Pediatrics
Consult your doctorThere is no experience with EXAPRIDE 250 Y CARTRIDGE in children and adolescents less than 18 years and therefore, use of this medicine is not recommended in this age group.
Use In Geriatrics
Use with CautionEXAPRIDE 250 Y CARTRIDGE should be used with caution in patients above 65 years of age. Consult your doctor for advice.
Others
EXAPRIDE 250 Y CARTRIDGE is not recommended for use if you:
- have diabetic ketoacidosis (accumulation of ketones in the blood and urine)
- have type 1 diabetes
Before receiving EXAPRIDE 250 Y CARTRIDGE inform your doctor if you have or had:
- severe problems with your stomach (gastroparesis) or food digestion
- severe vomiting, diarrhea or dehydration
- history of pancreatitis (inflammation of the pancreas)
- stones in gallbladder (gallstones)
- history of alcoholism
- high blood triglyceride levels
- a personal history of fainting spells
- electrolyte disturbances
- medullary thyroid cancer
- Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- been diagnosed with pituitary or adrenal failure
- eating disorders, are on a special diet, or often skip meals
Interactions
A. Drug-Drug interactions:
Before receiving EXAPRIDE 250 Y CARTRIDGE, inform your doctor if you are taking any of the following medicines such as:
- glyburide, gliclazide, glimepiride (used to manage blood glucose levels)
- birth control pill (oral contraceptive)
- antibiotic (used to manage infections)
- warfarin (used for blood clot)
- digoxin (used for heart diseases and heart rhythm disturbances)
- lisinopril (used to manage hypertension)
- acetaminophen (used for pain and fever)
- lovastatin (used to manage cholesterol levels)
- antivirals (used for HIV infection)
- diuretics (water pills)
Overdosage:
EXAPRIDE 250 Y CARTRIDGE will be administered by your doctor or nurse, so it is unlikely to cause an overdose. However, if you experience vomiting, dizziness, or symptoms of low blood sugar, consult your doctor immediately or nearby hospital.
Synopsis
| Drug | : | Exenatide |
| Pharmacological Category | : | Antihyperglycemic agents |
| Therapeutic Indication | : | Used to manage blood sugar levels in adults with type 2 diabetes |
| Dosage Forms | : | Prefilled Syringe |
More Information
- Keep EXAPRIDE 250 Y CARTRIDGE out of reach of children
- Store EXAPRIDE 250 Y CARTRIDGE at 2-8 ºC
FAQs About EXAPRIDE 250 Y CARTRIDGE
Q: What is EXAPRIDE 250 Y CARTRIDGE used for?
A: It is used to manage blood sugar levels in adults with type 2 diabetes in combination with metformin, sulfonylurea and insulin glargine (with or without metformin), when metformin, sulfonylurea, insulin glargine, diet and exercise have failed to adequately control blood sugar levels.
Q: How and when to take EXAPRIDE 250 Y CARTRIDGE?
A: EXAPRIDE 250 Y CARTRIDGE can be receivied preferably after meals. EXAPRIDE 250 Y CARTRIDGE will be administered under the skin (as subcutaneous injection) in the upper leg (thigh), stomach area (abdomen), or upper arm by your doctor or nurse. It will not be administered into a vein or muscle. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: What are the most common side effects of taking EXAPRIDE 250 Y CARTRIDGE?
A: The most common side effects of receiving EXAPRIDE 250 Y CARTRIDGE are nausea, vomiting, diarrhea, feeling jittery, dizziness, headache, acid stomach, heartburn and injection site reactions (rash, itching, bruising). Consult your doctor if any of the above side effects persists for a longer duration.
Q: What precautions do I need to follow while receiving EXAPRIDE 250 Y CARTRIDGE?
A: Before receiving EXAPRIDE 250 Y CARTRIDGE, inform your doctor if you have or had severe problems with stomach (gastroparesis), severe vomiting, diarrhea, dehydration or a history of pancreatitis.
Q: Can EXAPRIDE 250 Y CARTRIDGE be used in pregnant women?
A: There are no adequate and well-controlled studies of EXAPRIDE 250 Y CARTRIDGE use in pregnant women. Hence it should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus.
Q: What will happen if I consume a high dose of EXAPRIDE 250 Y CARTRIDGE than prescribed by my doctor?
A: EXAPRIDE 250 Y CARTRIDGE will be administered by your doctor or nurse, so it is unlikely to cause an overdose. However, if you experience vomiting, dizziness, or symptoms of low blood sugar, consult your doctor immediately or nearby hospital.
Q: Can I consume alcohol while receiving EXAPRIDE 250 Y CARTRIDGE?
A: Avoid consumption of alcohol while receiving EXAPRIDE 250 Y CARTRIDGE as it could reduce the effectiveness of EXAPRIDE 250 Y CARTRIDGE.
Q: Is it safe to use EXAPRIDE 250 Y CARTRIDGE in patients with heart problems?
A: EXAPRIDE 250 Y CARTRIDGE should be used with caution if you have or had current or history of heart failure, heart disease, angina, heart rhythm disturbances, myocardial infarction or high heart rate (fast pulse). Consult your doctor for advice.
Q: Is it safe to use EXAPRIDE 250 Y CARTRIDGE on elderly patients?
A: EXAPRIDE 250 Y CARTRIDGE should be used with caution in patients above 65 years of age. Consult your doctor for advice.
Q: Can EXAPRIDE 250 Y CARTRIDGE cause dizziness?
A: Yes. Dizziness is a common side effect of using EXAPRIDE 250 Y CARTRIDGE. In case you experience dizziness, lie down until it passes, then get up slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Consult your doctor if you experience dizziness continuously for a long time after taking EXAPRIDE 250 Y CARTRIDGE.
References
1. K.D. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 258.
2. Amanda Bridges, Karlyle G. Bistas, Tibb F. Jacobs. Exenatide. National library of medicine. [Accessed on December 20th 2023] https://www.ncbi.nlm.nih.gov/books/NBK518981/#:~:text=Exenatide%20is%20a%20GLP%2D1,emptying%2C%20and%20reduce%20food%20intake.
3. AstraZeneca Canada Inc. December 18, 2019. [Revised on September 23rd, 2023] [Accessed on December 20th 2023] https://www.astrazeneca.ca/content/dam/az-ca/downloads/productinformation/byetta-product-monograph-en.pdf
4. Amylin Pharmaceuticals. [Revised on October, 2009] [Accessed on December 20th 2023] https://www1.ndmctsgh.edu.tw/pharm/pic/medinsert/005BYE01E.pdf
5. AstraZeneca AB. [Accessed on December 20th 2023] https://www.ema.europa.eu/en/documents/product-information/byetta-epar-product-information_en.pdf
6. AstraZeneca Canada Inc. [Revised on December 24, 2018] [Accessed on December 20th 2023] https://pdf.hres.ca/dpd_pm/00048994.PDF
Useful Diagnostic Tests
- HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
- Blood Glucose Fasting (FBS)
- Post Prandial Blood Sugar (PPBS)
- Insulin-Fasting
- Netmeds Diabetic Checkup
- Advance Diabetes Monitoring (Senior Female)
- Jaanch Diabetic Profile Basic
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